Panama

$222+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Jan 26 — Feb 21
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Panama with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Panama

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Panama (PA0). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$469
(United)

One-way from

$222
(American Airlines)
From Missouri to Panama
One-way flight from Missouri to Panama

Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This United deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/126:15 amSTL - PTY
1 stop12h 23mUnited Airlines
Thu 3/203:40 pmPTY - STL
1 stop18h 11mUnited Airlines
Deal found 1/21$469
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/125:06 amSTL - PTY
2 stops9h 26mAmerican Airlines
Thu 3/201:05 pmPTY - STL
2 stops19h 04mAmerican Airlines
Deal found 1/20$473
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:30 amMCI - PTY
1 stop12h 07mUnited Airlines
Mon 10/63:40 pmPTY - MCI
1 stop18h 00mUnited Airlines
Deal found 1/19$501
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/196:15 amSGF - PTY
1 stop9h 52mUnited Airlines
Wed 2/264:40 pmPTY - SGF
2 stops22h 54mUnited Airlines
Deal found 1/21$546
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/204:28 pmSGF - PTY
2 stops20h 02mAmerican Airlines
Thu 2/274:40 pmPTY - SGF
2 stops19h 50mAmerican Airlines
Deal found 1/21$566
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/811:04 amSTL - PTY
1 stop7h 57mDelta
Wed 2/123:27 pmPTY - STL
1 stop9h 09mDelta
Deal found 1/20$569
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/205:40 pmSGF - PTY
1 stop25h 21mDelta
Wed 2/263:27 pmPTY - SGF
1 stop7h 55mDelta
Deal found 1/21$571
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/35:35 amMCI - PTY
1 stop7h 27mDelta
Sat 2/88:05 amPTY - MCI
1 stop8h 01mDelta
Deal found 1/20$601
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/207:01 amMCI - PTY
1 stop7h 49mAmerican Airlines
Mon 2/244:40 pmPTY - MCI
1 stop8h 52mAmerican Airlines
Deal found 1/20$611
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1612:15 pmSTL - PTY
3 stops35h 05mMultiple Airlines
Sat 2/223:19 amPTY - STL
3 stops33h 11mMultiple Airlines
Deal found 1/19$735
This Avianca deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/28:15 amSTL - PTY
2 stops15h 05mAvianca
Sun 2/96:30 pmPTY - STL
2 stops16h 54mAvianca
Deal found 1/21$813
This Mytrip deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/154:17 pmMCI - PTY
3 stops31h 03mMultiple Airlines
Fri 2/213:19 amPTY - MCI
3 stops35h 49mMultiple Airlines
Deal found 1/21$859

Find flights from Missouri to Panama within your budget

Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/12

6:15 am-6:38 pm

1 stop12h 23m

Panama City Tocumen Intl

Thu 3/20

3:40 pm-9:51 am

1 stop18h 11m

$469

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 4/21

6:00 am-12:51 pm

1 stop6h 51m

Panama City Tocumen Intl

Sat 4/26

8:05 am-4:27 pm

1 stop8h 22m

$489

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 5/25

6:36 pm-4:12 pm

2 stops21h 36m

Panama City Tocumen Intl

Thu 5/29

3:20 pm-2:25 pm

2 stops23h 05m

$506

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/26

5:37 pm-1:30 pm

2 stops18h 53m

Panama City Tocumen Intl

Thu 3/13

3:30 pm-1:00 pm

2 stops21h 30m

$514

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Wed 2/19

6:15 am-5:07 pm

1 stop9h 52m

Panama City Tocumen Intl

Wed 2/26

4:40 pm-2:34 pm

2 stops22h 54m

$546

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Thu 2/20

4:28 pm-1:30 pm

2 stops20h 02m

Panama City Tocumen Intl

Thu 2/27

4:40 pm-11:30 am

2 stops19h 50m

$566

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Thu 2/20

5:40 pm-8:01 pm

1 stop25h 21m

Panama City Tocumen Intl

Wed 2/26

3:27 pm-10:22 pm

1 stop7h 55m

$571

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sat 2/15

7:00 am-8:01 pm

1 stop12h 01m

Panama City Tocumen Intl

Sat 2/22

3:27 pm-11:54 pm

1 stop9h 27m

$601

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 2/20

6:37 pm-1:30 pm

2 stops17h 53m

Panama City Tocumen Intl

Mon 2/24

4:40 pm-11:58 am

2 stops20h 18m

$616

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/15

1:00 pm-12:10 am

3 stops35h 10m

Panama City Tocumen Intl

Sat 5/17

3:20 am-6:27 pm

2 stops15h 07m

$761

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 19 results
1
2

Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Panama

Get recent, data-driven insights about flights from Missouri to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Panama?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.

When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 21, 2025.
Peruse reviews from past customers who have flown with United Airlines, American Airlines and Delta from Missouri to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good
8,521 reviews

Crew

8.6

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

8.0
Very good
8,521 reviews
8.0
Very good
8,521 reviews

Crew

8.6

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.4
Good
8,985 reviews
8.0
Very good
8,521 reviews

Crew

8.6

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.2
Good
10,000 reviews
8.0
Very good
8,521 reviews

Crew

8.6

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

6.9
Okay
2,579 reviews
8.0
Very good
8,521 reviews

Crew

8.6

Overall

8.0

Food

7.3

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines to fly from Missouri to Panama one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $222. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Missouri to Panama for a low price.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$389Average$543FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$421Average$575FlexibilityNo cancel feeOn-time71%
DeltaCheapest$437Average$621FlexibilityNo cancel feeOn-timeN/A
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.