$243+ Cheap flights from Missouri to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Missouri to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to Panama
Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated April 1, 2025.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $426 (American Airlines) |
One-way from | $243 (Delta) |
Popular in | December |
Cheapest in | April |
Average price | $531 |
Find flight deals from Missouri to Panama
Cheapest flights from Missouri to PanamaExplore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2025.
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2025.
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca Connect deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 6/16
4:37 pm-1:00 pm
2 stops20h 23m
Panama City Tocumen Intl
Mon 6/23
1:50 pm-8:46 am
2 stops18h 56m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 4/14
8:00 am-6:37 pm
2 stops10h 37m
Panama City Tocumen Intl
Thu 6/12
7:55 am-4:53 pm
1 stop8h 58m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 5/12
7:06 pm-12:48 pm
1 stop17h 42m
Panama City Tocumen Intl
Mon 5/19
2:13 pm-11:38 pm
1 stop9h 25m
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Wed 4/30
5:45 am-12:55 pm
1 stop7h 10m
Panama City Tocumen Intl
Wed 5/7
2:13 pm-11:59 pm
1 stop9h 46m
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Sun 4/13
5:36 pm-12:15 pm
2 stops18h 39m
Panama City Tocumen Intl
Thu 4/17
1:15 pm-9:06 am
2 stops19h 51m
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Sun 4/13
8:45 am-2:14 pm
1 stop29h 29m
Panama City Tocumen Intl
Wed 4/16
10:00 am-10:19 pm
1 stop12h 19m
SpringfieldPanama City
SGF - PTY
SGFPTY
Springfield-Branson
Fri 5/2
8:50 am-4:12 pm
1 stop7h 22m
Panama City Tocumen Intl
Sun 5/11
7:55 am-10:15 pm
1 stop14h 20m
SpringfieldPanama City
SGF - PTY
SGFPTY
Springfield-Branson
Fri 5/2
6:38 pm-12:15 pm
2 stops17h 37m
Panama City Tocumen Intl
Sun 5/11
1:20 pm-10:51 am
2 stops21h 31m
Kansas CityPanama City
MCI - PTY
MCIPTY
Kansas City
Thu 6/5
5:46 am-12:10 am
2 stops18h 24m
Panama City Tocumen Intl
Sun 6/8
3:20 am-10:41 pm
2 stops19h 21m
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 5/6
6:10 pm-9:10 pm
3 stops27h 00m
Panama City Tocumen Intl
Wed 7/9
3:20 am-6:32 pm
2 stops15h 12m
Best time to book a flight from Missouri to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Panama
What is the cheapest month to book a flight from Missouri to Panama?
Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to PA?
Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2025.
When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
Rainfall in Panama by month
Plan your trip to Panama by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.
Temperature in Panama by month
Plan your trip to Panama by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
Entertainment
Food
Boarding
Crew
Comfort
Reviews
Aaron,Oct 2024
LAX - LHR
Overall
Entertainment
Food
Boarding
Crew
Comfort
Reviews
Aaron,Oct 2024
LAX - LHR
Overall
Entertainment
Food
Boarding
Crew
Comfort
Reviews
Aaron,Oct 2024
LAX - LHR
Overall
Entertainment
Food
Boarding
Crew
Comfort
Reviews
Aaron,Oct 2024
LAX - LHR
Overall
Entertainment
Food
Boarding
Crew
Comfort
Reviews
Aaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Missouri to Panama
Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$417 | Average$565 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$437 | Average$584 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$440 | Average$583 | FlexibilityNo cancel fee | On-time71% |