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$242+ Cheap flights from Missouri to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
abr. 27 — may. 41
dom. 4/27
dom. 5/4
1 adult, Economy
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Cheap flight deals from Missouri to Panama

Keep the following information in mind while searching for Missouri to Panama flight deals. Data was last updated abril 22, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$373
(United Airlines)

One-way from

$242
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$531
Provider with most accurate pricing for Kansas City-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Panama City Tocumen Intl flights.
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From Missouri to Panama
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One-way flight from Missouri to Panama
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Highest demand for flights based on searches. 14% potential increase in price ($105 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Missouri to Panama

Cheapest flights from Missouri to Panama
Explore the most affordable flight options available from Missouri to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 22, 2025.

This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/28:25 amSTL - PTY
1 stop10h 12mUnited Airlines
mié. 6/187:55 amPTY - STL
1 stop14h 20mUnited Airlines
Deal found 4/21$373
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/46:00 amSTL - PTY
1 stop6h 48mDelta
mar. 6/172:23 pmPTY - STL
1 stop18h 00mDelta
Deal found 4/21$393
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/226:33 pmMCI - PTY
2 stops18h 27mAmerican Airlines
mar. 6/241:50 pmPTY - MCI
2 stops20h 28mAmerican Airlines
Deal found 4/22$397
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/16:20 pmSTL - PTY
1 stop17h 59mAmerican Airlines
dom. 6/151:50 pmPTY - STL
2 stops19h 36mAmerican Airlines
Deal found 4/21$404
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/66:10 pmMCI - PTY
1 stop24h 27mUnited Airlines
vie. 6/133:20 pmPTY - MCI
2 stops23h 05mUnited Airlines
Deal found 4/22$456
This Kissandfly.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/228:25 amMCI - PTY
1 stop29h 49mLufthansa
mar. 6/243:20 pmPTY - MCI
1 stop25h 22mLufthansa
Deal found 4/22$489
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/66:10 pmSTL - PTY
2 stops30h 00mMultiple Airlines
jue. 5/83:20 amPTY - STL
2 stops29h 55mMultiple Airlines
Deal found 4/22$506
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/58:35 amSGF - PTY
1 stop10h 02mUnited Airlines
jue. 6/1210:00 amPTY - SGF
1 stop8h 31mUnited Airlines
Deal found 4/22$521
This Avianca Connect deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/226:00 amMCI - PTY
2 stops18h 10mMultiple Airlines
lun. 6/233:25 amPTY - MCI
2 stops18h 36mMultiple Airlines
Deal found 4/22$684
This Avianca deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/39:50 amSTL - PTY
2 stops14h 20mAvianca
dom. 6/158:10 pmPTY - STL
2 stops37h 46mAvianca
Deal found 4/21$2,304

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 22, 2025.
Use the filters below to find and compare flights from Missouri to Panama that are best for you.

Fly from

Missouri

Fly to

Panama

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

lun. 6/2

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

mié. 6/18

7:55 am-10:15 pm

1 stop14h 20m

$373

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mié. 6/4

6:00 am-12:48 pm

1 stop6h 48m

Panama City Tocumen Intl

mar. 6/17

2:23 pm-8:23 am

1 stop18h 00m

$393

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

dom. 6/22

6:33 pm-1:00 pm

2 stops18h 27m

Panama City Tocumen Intl

mar. 6/24

1:50 pm-10:18 am

2 stops20h 28m

$397

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

dom. 6/1

6:20 pm-12:19 pm

1 stop17h 59m

Panama City Tocumen Intl

dom. 6/15

1:50 pm-9:26 am

2 stops19h 36m

$404

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

vie. 6/6

6:10 pm-6:37 pm

1 stop24h 27m

Panama City Tocumen Intl

vie. 6/13

3:20 pm-2:25 pm

2 stops23h 05m

$456

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

dom. 6/22

8:25 am-2:14 pm

1 stop29h 49m

Panama City Tocumen Intl

mar. 6/24

3:20 pm-4:42 pm

1 stop25h 22m

$489

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 5/6

6:10 pm-12:10 am

2 stops30h 00m

Panama City Tocumen Intl

jue. 5/8

3:20 am-9:15 am

2 stops29h 55m

$506

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

jue. 6/5

8:35 am-6:37 pm

1 stop10h 02m

Panama City Tocumen Intl

jue. 6/12

10:00 am-6:31 pm

1 stop8h 31m

$521

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

dom. 6/22

6:00 am-12:10 am

2 stops18h 10m

Panama City Tocumen Intl

lun. 6/23

3:25 am-10:01 pm

2 stops18h 36m

$684

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

mar. 6/3

9:50 am-12:10 am

2 stops14h 20m

Panama City Tocumen Intl

dom. 6/15

8:10 pm-9:56 am

2 stops37h 46m

$2,304

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 11 results
1
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Best time to book a flight from Missouri to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama

What is the cheapest month to book a flight from Missouri to Panama?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PA?

Find hourly flight availability from Missouri to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated abril 22, 2025.

When flying from Missouri to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated abril 22, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,683 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,319 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Lufthansa
6.7
Okay
7,020 reviews
Delta
8.0
Very good
7,920 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Missouri to Panama that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama.

  • Can I find deals for business class flights from Missouri to Panama?

    Yes. Cheapflights offers flight deals from Missouri to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama (average of $478). Flying from Missouri to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama

Discover the top 3 airlines that operate flights from Missouri to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$397Average$569FlexibilityNo cancel feeOn-time69%
DeltaCheapest$437Average$573FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$440Average$576FlexibilityNo cancel feeOn-time71%

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