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$242+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — PTY
Apr 6 — Apr 131
Sun 4/6
Sun 4/13
1 adult, Economy
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Cheap flight deals from Mississippi to Panama

Keep the following information in mind while searching for Mississippi to Panama flight deals. Data was last updated April 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$383
(United Airlines)

One-way from

$242
(Delta)
Provider with most accurate pricing for Jackson-Evers Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Panama City Tocumen Intl flights.
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From Mississippi to Panama
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One-way flight from Mississippi to Panama
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Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2025.

This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/149:20 amMOB - PTY
1 stop9h 17mUnited Airlines
Wed 5/217:55 amPTY - MOB
1 stop14h 05mUnited Airlines
Deal found 3/31$383
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1510:53 amJAN - PTY
2 stops25h 26mAmerican Airlines
Thu 5/221:20 pmPTY - JAN
2 stops20h 21mAmerican Airlines
Deal found 3/31$410
This United deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/2711:59 amJAN - PTY
1 stop28h 13mUnited Airlines
Sun 5/47:55 amPTY - JAN
1 stop8h 10mUnited Airlines
Deal found 4/1$412
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:51 pmMOB - PTY
2 stops17h 28mAmerican Airlines
Wed 5/211:20 pmPTY - MOB
2 stops10h 34mAmerican Airlines
Deal found 3/31$428
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/166:21 pmGPT - PTY
2 stops17h 58mAmerican Airlines
Fri 5/231:20 pmPTY - GPT
2 stops20h 47mAmerican Airlines
Deal found 4/1$428
This United deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/226:30 amMEM - PTY
1 stop9h 42mUnited Airlines
Tue 4/297:55 amPTY - MEM
1 stop8h 25mUnited Airlines
Deal found 3/31$437
This United Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/162:01 pmGPT - PTY
1 stop26h 11mUnited Airlines
Fri 5/233:20 pmPTY - GPT
1 stop28h 34mUnited Airlines
Deal found 4/1$438
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/285:51 amMEM - PTY
1 stop6h 28mAmerican Airlines
Thu 7/31:50 pmPTY - MEM
2 stops19h 48mAmerican Airlines
Deal found 4/1$458
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/266:00 amMEM - PTY
1 stop6h 55mDelta
Sat 5/37:30 amPTY - MEM
1 stop9h 17mDelta
Deal found 3/31$473
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/155:05 amBTR - PTY
1 stop9h 09mUnited Airlines
Thu 5/227:55 amPTY - BTR
1 stop11h 33mUnited Airlines
Deal found 3/31$475
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:34 pmMEM - PTY
2 stops26h 36mMultiple Airlines
Wed 5/213:20 amPTY - MEM
2 stops14h 09mMultiple Airlines
Deal found 3/31$484
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1512:56 pmBTR - PTY
2 stops23h 23mAmerican Airlines
Thu 5/221:20 pmPTY - BTR
2 stops26h 40mAmerican Airlines
Deal found 3/31$498

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
Use the filters below to find and compare flights from Mississippi to Panama that are best for you.

Fly from

Mississippi

Fly to

Panama

Route

Depart

Return

Price

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Wed 5/14

9:20 am-6:37 pm

1 stop9h 17m

Panama City Tocumen Intl

Wed 5/21

7:55 am-10:00 pm

1 stop14h 05m

$383

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Thu 5/15

10:53 am-12:19 pm

2 stops25h 26m

Panama City Tocumen Intl

Thu 5/22

1:20 pm-9:41 am

2 stops20h 21m

$410

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Sun 4/27

11:59 am-4:12 pm

1 stop28h 13m

Panama City Tocumen Intl

Sun 5/4

7:55 am-4:05 pm

1 stop8h 10m

$412

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Wed 5/14

6:51 pm-12:19 pm

2 stops17h 28m

Panama City Tocumen Intl

Wed 5/21

1:20 pm-11:54 pm

2 stops10h 34m

$428

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Fri 5/16

6:21 pm-12:19 pm

2 stops17h 58m

Panama City Tocumen Intl

Fri 5/23

1:20 pm-10:07 am

2 stops20h 47m

$428

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Tue 4/22

6:30 am-4:12 pm

1 stop9h 42m

Panama City Tocumen Intl

Tue 4/29

7:55 am-4:20 pm

1 stop8h 25m

$437

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Fri 5/16

2:01 pm-4:12 pm

1 stop26h 11m

Panama City Tocumen Intl

Fri 5/23

3:20 pm-7:54 pm

1 stop28h 34m

$438

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Wed 5/28

5:51 am-12:19 pm

1 stop6h 28m

Panama City Tocumen Intl

Thu 7/3

1:50 pm-9:38 am

2 stops19h 48m

$458

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Sat 4/26

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Sat 5/3

7:30 am-4:47 pm

1 stop9h 17m

$473

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Thu 5/15

5:05 am-2:14 pm

1 stop9h 09m

Panama City Tocumen Intl

Thu 5/22

7:55 am-7:28 pm

1 stop11h 33m

$475

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 17 results
1
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Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Panama

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 1, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and American Airlines from Mississippi to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,898 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,615 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,898 reviews

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Mississippi to Panama one-way?

    The cheapest airlines for a one-way flight from Mississippi to Panama are Delta ($242), United Airlines ($452), and American Airlines ($515).

  • Can I find deals for flights from Mississippi to Panama that include hotel bookings?

    Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

  • Can I find deals for business class flights from Mississippi to Panama?

    Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Panama

Discover the top 2 airlines that operate flights from Mississippi to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$377Average$417FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$384Average$523FlexibilityNo cancel feeOn-time69%

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