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$258+ Cheap flights from Mississippi to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/10. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — PTY
Jan 26 — Feb 21
Sun 1/26
Sun 2/2
1 adult, Economy
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Cheap flight deals from Mississippi to Panama

Discover tips and strategies to find the most affordable flight options for your journey from Mississippi (USMS) to Panama (PA0). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$433
(United Airlines)

One-way from

$258
(Delta)
From Mississippi to Panama
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One-way flight from Mississippi to Panama
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Find flight deals from Mississippi to Panama

Cheapest flights from Mississippi to Panama
Explore the most affordable flight options available from Mississippi to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/159:15 amMOB - PTY
1 stop6h 57mUnited Airlines
Mon 4/2810:00 amPTY - MOB
1 stop8h 08mUnited Airlines
Deal found 1/21$433
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1512:46 pmMOB - PTY
2 stops23h 29mAmerican Airlines
Mon 4/281:15 pmPTY - MOB
2 stops22h 43mAmerican Airlines
Deal found 1/21$442
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/262:47 pmMEM - PTY
2 stops21h 28mAmerican Airlines
Mon 3/313:30 pmPTY - MEM
2 stops19h 06mAmerican Airlines
Deal found 1/21$474
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/54:26 pmJAN - PTY
2 stops19h 54mAmerican Airlines
Tue 11/112:45 pmPTY - JAN
2 stops19h 57mAmerican Airlines
Deal found 1/20$482
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/511:35 amJAN - PTY
1 stop7h 03mUnited Airlines
Tue 11/114:40 pmPTY - JAN
1 stop19h 33mUnited Airlines
Deal found 1/20$493
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/202:05 pmBTR - PTY
1 stop28h 32mUnited Airlines
Tue 4/297:55 amPTY - BTR
1 stop10h 17mUnited Airlines
Deal found 1/21$508
This United deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/46:45 amMEM - PTY
1 stop9h 22mUnited Airlines
Sun 3/97:55 amPTY - MEM
1 stop14h 05mUnited Airlines
Deal found 1/21$529
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/315:55 amMOB - PTY
1 stop6h 59mDelta
Sat 8/98:05 amPTY - MOB
1 stop8h 41mDelta
Deal found 1/20$540
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/216:22 pmBTR - PTY
2 stops17h 53mAmerican Airlines
Wed 4/301:15 pmPTY - BTR
2 stops26h 34mAmerican Airlines
Deal found 1/21$552
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/712:12 pmMEM - PTY
1 stop6h 49mDelta
Tue 2/113:27 pmPTY - MEM
1 stop8h 50mDelta
Deal found 1/21$569
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/76:20 pmGPT - PTY
2 stops20h 05mAmerican Airlines
Fri 3/141:05 pmPTY - GPT
2 stops23h 08mAmerican Airlines
Deal found 1/20$702
This Mytrip deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/78:57 amMEM - PTY
2 stops11h 03mMultiple Airlines
Fri 3/146:30 pmPTY - MEM
2 stops29h 07mMultiple Airlines
Deal found 1/21$713

Find flights from Mississippi to Panama within your budget

Customize your flight search to find flights from Mississippi to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Tue 4/15

9:15 am-4:12 pm

1 stop6h 57m

Panama City Tocumen Intl

Mon 4/28

10:00 am-6:08 pm

1 stop8h 08m

$433

MobilePanama City

MOB - PTY

MOBPTY

Mobile

Tue 4/15

12:46 pm-12:15 pm

2 stops23h 29m

Panama City Tocumen Intl

Mon 4/28

1:15 pm-11:58 am

2 stops22h 43m

$442

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Wed 3/26

2:47 pm-12:15 pm

2 stops21h 28m

Panama City Tocumen Intl

Mon 3/31

3:30 pm-10:36 am

2 stops19h 06m

$474

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Sun 4/20

2:05 pm-6:37 pm

1 stop28h 32m

Panama City Tocumen Intl

Tue 4/29

7:55 am-6:12 pm

1 stop10h 17m

$508

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Tue 3/4

6:45 am-5:07 pm

1 stop9h 22m

Panama City Tocumen Intl

Sun 3/9

7:55 am-10:00 pm

1 stop14h 05m

$529

Baton RougePanama City

BTR - PTY

BTRPTY

Baton Rouge Ryan

Mon 4/21

6:22 pm-12:15 pm

2 stops17h 53m

Panama City Tocumen Intl

Wed 4/30

1:15 pm-3:49 pm

2 stops26h 34m

$552

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Fri 2/7

12:12 pm-8:01 pm

1 stop6h 49m

Panama City Tocumen Intl

Tue 2/11

3:27 pm-11:17 pm

1 stop8h 50m

$569

GulfportPanama City

GPT - PTY

GPTPTY

Gulfport Biloxi Regional

Fri 3/7

6:20 pm-3:25 pm

2 stops20h 05m

Panama City Tocumen Intl

Fri 3/14

1:05 pm-12:13 pm

2 stops23h 08m

$702

MemphisPanama City

MEM - PTY

MEMPTY

Memphis

Fri 3/7

8:57 am-9:00 pm

2 stops11h 03m

Panama City Tocumen Intl

Fri 3/14

6:30 pm-11:37 pm

2 stops29h 07m

$713

JacksonPanama City

JAN - PTY

JANPTY

Jackson-Evers Intl

Fri 3/7

11:57 am-5:07 pm

1 stop28h 10m

Panama City Tocumen Intl

Fri 3/14

3:40 pm-1:23 pm

1 stop21h 43m

$936

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 14 results
1
2

Best time to book a flight from Mississippi to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Mississippi to Panama

Get recent, data-driven insights about flights from Mississippi to Panama including ideal travel times, pricing trends, and more.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 21, 2025.
Get a feel of what it's like to fly with United Airlines and American Airlines from Mississippi to Panama by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,521 reviews
Delta
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,984 reviews
Delta
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Mississippi to Panama that include hotel bookings?

    Yes. In addition to deals on Mississippi to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Panama.

  • Can I find deals for business class flights from Mississippi to Panama?

    Yes. Cheapflights offers flight deals from Mississippi to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mississippi to Panama (average of $478). Flying from Mississippi to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Panama

Discover the top 2 airlines that operate flights from Mississippi to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$354Average$510FlexibilityNo cancel feeOn-time69%
DeltaCheapest$397Average$433FlexibilityNo cancel feeOn-timeN/A
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