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$218+ Cheap flights from Mexico City (MEX) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — PTY
Feb 27 — Mar 61
Thu 2/27
Thu 3/6
1 adult, Economy
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Cheap flight deals from Mexico City to Panama

Keep the following information in mind while searching for Mexico City to Panama flight deals. Data was last updated February 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$383
(Kiwi.com)

One-way from

$218
(Cheapflightsfares)

Popular in

July

Cheapest in

February

Average price

$433

Good round-trip deal

$391 or less

Good one-way deal

$259 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Panama City Tocumen Intl flights.
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From Mexico City Benito Juarez to Panama
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One-way flight from Mexico City Benito Juarez to Panama
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Highest demand for flights based on searches. 9% potential increase in price ($52 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Price to beat on a round-trip flight from Mexico City Benito Juarez to Panama.
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Price to beat on a one-way flight from Mexico City Benito Juarez to Panama.
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Find flight deals from Mexico City to Panama

Cheapest flights from Mexico City to Panama
Explore the most affordable flight options available from Mexico City to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2025.

This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/29:30 pmMEX - PTY
1 stop12h 23mMultiple Airlines
Wed 4/97:11 amPTY - MEX
1 stop7h 44mMultiple Airlines
Deal found 2/21$383
This Priceline deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2212:40 amMEX - PTY
1 stop8h 00mAvianca
Tue 4/19:50 amPTY - MEX
1 stop14h 10mAvianca
Deal found 2/20$419
This Copa Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/202:00 amMEX - PTY
Nonstop3h 46mCopa Airlines
Tue 5/69:28 pmPTY - MEX
Nonstop3h 47mCopa Airlines
Deal found 2/21$485
This Aeromexico deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aeromexico is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/148:55 amMEX - PTY
Nonstop3h 52mAeromexico
Wed 8/203:02 pmPTY - MEX
Nonstop3h 38mAeromexico
Deal found 2/20$510
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/117:10 amMEX - PTY
2 stops20h 02mUnited Airlines
Sat 3/2210:55 pmPTY - MEX
1 stop12h 15mUnited Airlines
Deal found 2/21$1,238
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1312:45 pmMEX - PTY
2 stops24h 47mAmerican Airlines
Sun 3/163:30 pmPTY - MEX
2 stops18h 25mAmerican Airlines
Deal found 2/21$1,775

Find flights from Mexico City to Panama within your budget

Customize your flight search to find flights from Mexico City to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.

Fly from

Mexico City

Fly to

Panama

Route

Depart

Return

Price

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Wed 4/2

9:30 pm-10:53 am

1 stop12h 23m

Panama City Tocumen Intl

Wed 4/9

7:11 am-1:55 pm

1 stop7h 44m

$383

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sat 3/22

12:40 am-9:40 am

1 stop8h 00m

Panama City Tocumen Intl

Tue 4/1

9:50 am-11:00 pm

1 stop14h 10m

$419

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Sun 4/20

2:00 am-6:46 am

Nonstop3h 46m

Panama City Tocumen Intl

Tue 5/6

9:28 pm-12:15 am

Nonstop3h 47m

$485

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 8/14

8:55 am-1:47 pm

Nonstop3h 52m

Panama City Tocumen Intl

Wed 8/20

3:02 pm-5:40 pm

Nonstop3h 38m

$510

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 3/11

7:10 am-4:12 am

2 stops20h 02m

Panama City Tocumen Intl

Sat 3/22

10:55 pm-10:10 am

1 stop12h 15m

$1,238

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 3/13

12:45 pm-2:32 pm

2 stops24h 47m

Panama City Tocumen Intl

Sun 3/16

3:30 pm-8:55 am

2 stops18h 25m

$1,775

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Tue 3/18

12:40 am-9:40 am

1 stop8h 00m

$218

Mexico CityPanama City

MEX - PTY

MEXPTY

Mexico City Benito Juarez

Thu 6/12

1:40 am-6:24 am

Nonstop3h 44m

$510

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Best time to book a flight from Mexico City to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Mexico City to Panama

Get recent, data-driven insights about flights from Mexico City to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Mexico City to Panama?

Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to PA?

Find hourly flight availability from Mexico City to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2025.

It’s typically best to fly out from Mexico City to Panama in the evening. Doing so could potentially save you 10% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Mexico City to Panama?

Use this chart to determine the cheapest time to fly round-trip from Mexico City to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mexico City to Panama flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Mexico City to Panama

Explore weekly flight availability from Mexico City to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 22, 2025.

The most flights from MEX to PA0 are scheduled on a Wednesday (9 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (2 on average).

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 22, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, Aeromexico and United Airlines from Mexico City to Panama to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Copa Airlines
7.6
Good
1,502 reviews
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Aeromexico
7.5
Good
1,769 reviews
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

United Airlines
7.4
Good
8,759 reviews
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Avianca
6.8
Okay
2,430 reviews
Copa Airlines
7.6
Good
1,502 reviews

Food

6.9

Crew

8.1

Comfort

7.4

Boarding

7.8

Overall

7.6

Entertainment

6.9

Reviews

1 / 20

4.0
Okay

Anonymous,Jan 2025

PTY - ORD

Our first flight was good. The return flight is a different story. I picked and paid for seat 11D and then checked in with that same seat assignment. When I boarded the plain I somehow had lost that seat and was stuck in a middle seat that I was not happy with for a 5 hour flight. The food was terrible - I could not even eat the chicken and "cheese" sandwich it was so bad. The difference in the two flights was amazing - the one from the Chicago to Panama City was great - seating and food. The return flight was very different.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Mexico City to Panama?

    If you book a flight to Panama from Mexico City, you will be flying from Benito Juarez, which is the city’s only airport. Mexico City Benito Juarez (MEX) is located 5.5 mi from the center of Mexico City.

  • How popular is this Mexico City to Panama flight route?

    The Mexico City Benito Juarez to Panama flight path was viewed by 14 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest flights from Mexico City to Panama?

    Looking at all options, your cheapest flight can be booked for $132. While the most popular route (Mexico City Benito Juarez - Panama City Tocumen Intl) can be booked for $386 on average our data indicates $478 when flying from Mexico City to Panama.

  • Can I find deals for flights from Mexico City to Panama that include hotel bookings?

    Yes. In addition to deals on Mexico City to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Panama.

  • Can I find deals for business class flights from Mexico City to Panama?

    Yes. Cheapflights offers flight deals from Mexico City to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Panama?

    Currently, October is the cheapest month in which you can book a flight from Mexico City to Panama (average of $478). Flying from Mexico City to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Mexico City to Panama

Discover the top 2 airlines that operate flights from Mexico City to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$275Average$465FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$426Average$539FlexibilityNo cancel feeOn-time70%
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