HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$420+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Panama with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$420
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$497
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
Search Deals
From Knoxville McGhee Tyson to Panama
Search Deals
Highest demand for flights based on searches. 31% potential increase in price ($280 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($39 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2025
Search Deals

Find flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:02 pmTYS - PTY
2 stops20h 23mAmerican Airlines
Mon 10/271:50 pmPTY - TYS
1 stop8h 22mAmerican Airlines
Deal found 2/19$420
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/510:00 amTYS - PTY
1 stop11h 19mMultiple Airlines
Sat 4/1212:03 pmPTY - TYS
1 stop9h 18mMultiple Airlines
Deal found 2/18$480
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/277:05 amTYS - PTY
1 stop10h 02mUnited Airlines
Thu 4/1010:00 amPTY - TYS
1 stop12h 15mUnited Airlines
Deal found 2/18$508
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/117:20 pmTYS - PTY
3 stops18h 15mAvianca
Tue 4/88:10 pmPTY - TYS
2 stops12h 55mAvianca
Deal found 2/20$830

Find flights from Knoxville to Panama within your budget

Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Knoxville

Fly to

Panama

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 4/13

7:54 pm-12:15 pm

2 stops17h 21m

Panama City Tocumen Intl

Wed 4/16

1:10 pm-10:38 am

2 stops20h 28m

$420

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 4/5

10:00 am-8:19 pm

1 stop11h 19m

Panama City Tocumen Intl

Sat 4/12

12:03 pm-10:21 pm

1 stop9h 18m

$480

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 3/27

7:05 am-4:07 pm

1 stop10h 02m

Panama City Tocumen Intl

Thu 4/10

10:00 am-11:15 pm

1 stop12h 15m

$508

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 3/11

7:20 pm-12:35 pm

3 stops18h 15m

Panama City Tocumen Intl

Tue 4/8

8:10 pm-10:05 am

2 stops12h 55m

$830

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to Panama

Get recent, data-driven insights about flights from Knoxville to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama (average of $478). Flying from Knoxville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PA?

Find hourly flight availability from Knoxville to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 20, 2025.
United Airlines
7.4
Good
8,765 reviews

Food

6.7

Crew

8.1

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20

2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

United Airlines
7.4
Good
8,765 reviews
United Airlines
7.4
Good
8,765 reviews

Food

6.7

Crew

8.1

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20

2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,765 reviews

Food

6.7

Crew

8.1

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20

2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Avianca
6.8
Okay
2,435 reviews
United Airlines
7.4
Good
8,765 reviews

Food

6.7

Crew

8.1

Entertainment

7.1

Boarding

7.7

Comfort

7.3

Overall

7.4

Reviews

1 / 20

2.0
Mediocre

Deb,Jan 2025

MKE - ORD

It was terrible! So much to say, but in a nutshell we used vouchers from United because our last trip with them was awful with many mishaps and errors made. Unfortunately, this trip was even worse!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama?

    For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • Can I find deals for flights from Knoxville to Panama that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

  • Can I find deals for business class flights from Knoxville to Panama?

    Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama (average of $478). Flying from Knoxville to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to San José flights
Nashville to Panama City flights
Nashville to Liberia flights
Nashville to Philip S.W.Goldson flights
Nashville to Guatemala City flights
Nashville to San Salvador flights
Knoxville to Liberia flights
Nashville to San Pedro Sula flights
Knoxville to Philip S.W.Goldson flights
Memphis to San José flights
Nashville to Managua flights
Nashville to Coxen Hole flights
Knoxville to Panama City flights
Knoxville to San José flights
Memphis to Panama City flights
Memphis to San Salvador flights
Memphis to Philip S.W.Goldson flights
Memphis to Liberia flights
Knoxville to Managua flights
Memphis to Guatemala City flights
Memphis to San Pedro Sula flights
Knoxville to Coxen Hole flights
Knoxville to Guatemala City flights
Chattanooga to Philip S.W.Goldson flights
Blountville to San José flights
Chattanooga to San José flights
Blountville to San Pedro Sula flights
Knoxville to San Salvador flights
Chattanooga to San Salvador flights
Blountville to Panama City flights
Blountville to San Salvador flights
Blountville to Managua flights
Nashville to Tegucigalpa flights

Top 3 airlines flying from Knoxville to Panama

Discover the top 3 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$288Average$695FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$406Average$659FlexibilityNo cancel feeOn-time71%
DeltaCheapest$427Average$568FlexibilityNo cancel feeOn-timeN/A
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.