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$173+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Apr 9 — Apr 161
Wed 4/9
Wed 4/16
1 adult, Economy
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Cheap flight deals from Des Moines to Panama

Keep the following information in mind while searching for Des Moines to Panama flight deals. Data was last updated April 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$441
(United Airlines)

One-way from

$173
(Delta)

Popular in

March

Cheapest in

August

Average price

$460
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
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From Des Moines to Panama
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One-way flight from Des Moines to Panama
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Highest demand for flights based on searches. 16% potential increase in price ($93 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/128:00 amDSM - PTY
1 stop10h 37mUnited Airlines
Sun 4/207:55 amPTY - DSM
1 stop14h 50mUnited Airlines
Deal found 4/3$411
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/242:20 pmDSM - PTY
2 stops21h 59mAmerican Airlines
Sat 5/311:20 pmPTY - DSM
2 stops22h 58mAmerican Airlines
Deal found 4/3$481
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/246:30 amDSM - PTY
2 stops13h 23mDelta
Sat 5/318:00 amPTY - DSM
1 stop9h 50mDelta
Deal found 4/3$486
This CheapTickets.ch deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapTickets.ch is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/186:45 amDSM - PTY
2 stops29h 34mBritish Airways
Sun 5/251:20 pmPTY - DSM
2 stops23h 01mBritish Airways
Deal found 4/2$548
This CheapTickets.ch deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapTickets.ch is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/188:00 amDSM - PTY
1 stop8h 12mLufthansa
Sun 5/2510:00 amPTY - DSM
1 stop12h 22mLufthansa
Deal found 4/2$664
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1812:32 pmDSM - PTY
3 stops31h 18mMultiple Airlines
Sun 5/2511:05 amPTY - DSM
3 stops26h 48mMultiple Airlines
Deal found 4/2$681
This KAYAK deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/128:00 amDSM - PTY
2 stops37h 10mAvianca
Sat 4/193:20 amPTY - DSM
2 stops18h 32mAvianca
Deal found 4/3$985

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
Use the filters below to find and compare flights from Des Moines to Panama that are best for you.

Fly from

Des Moines

Fly to

Panama

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 7/1

6:02 am-2:14 pm

1 stop8h 12m

Panama City Tocumen Intl

Sat 7/5

10:00 am-10:17 pm

1 stop12h 17m

$441

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/24

2:20 pm-12:19 pm

2 stops21h 59m

Panama City Tocumen Intl

Sat 5/31

1:20 pm-12:18 pm

2 stops22h 58m

$481

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/24

6:30 am-7:53 pm

2 stops13h 23m

Panama City Tocumen Intl

Sat 5/31

8:00 am-5:50 pm

1 stop9h 50m

$486

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 5/18

6:45 am-12:19 pm

2 stops29h 34m

Panama City Tocumen Intl

Sun 5/25

1:20 pm-12:21 pm

2 stops23h 01m

$548

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 5/18

8:00 am-4:12 pm

1 stop8h 12m

Panama City Tocumen Intl

Sun 5/25

10:00 am-10:22 pm

1 stop12h 22m

$664

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sun 5/18

12:32 pm-7:50 pm

3 stops31h 18m

Panama City Tocumen Intl

Sun 5/25

11:05 am-1:53 pm

3 stops26h 48m

$681

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 7/1

8:00 am-4:30 pm

2 stops32h 30m

Panama City Tocumen Intl

Fri 7/4

3:25 am-9:47 pm

2 stops18h 22m

$1,146

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/24

6:30 am-7:53 pm

2 stops13h 23m

$173

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 5/24

2:20 pm-12:19 pm

2 stops21h 59m

$238

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/2

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to PA?

Find hourly flight availability from Des Moines to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated April 4, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Des Moines to Panama to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,901 reviews
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,618 reviews
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,304 reviews
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Lufthansa
6.7
Okay
6,970 reviews
Delta
8.0
Very good
7,901 reviews

Entertainment

7.9

Comfort

8.0

Crew

8.5

Boarding

8.2

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Panama

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Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$349Average$697FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$349Average$451FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$354Average$544FlexibilityNo cancel feeOn-time71%

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