HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama

$188+ Cheap flights from Des Moines (DSM) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PTY
Feb 4 — Feb 111
Tue 2/4
Tue 2/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Panama with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Panama

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama (PA0). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$441
(United)

One-way from

$188
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$534
Provider with most accurate pricing for Des Moines-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City Tocumen Intl flights.
Search Deals
From Des Moines to Panama
Search Deals
One-way flight from Des Moines to Panama
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($71 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2025
Search Deals

Find flight deals from Des Moines to Panama

Cheapest flights from Des Moines to Panama
Explore the most affordable flight options available from Des Moines to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2025.

This United deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/248:00 amDSM - PTY
1 stop8h 07mUnited Airlines
Tue 3/48:55 amPTY - DSM
1 stop14h 35mUnited Airlines
Deal found 1/30$441
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/165:25 pmDSM - PTY
2 stops19h 34mDelta
Tue 8/262:12 pmPTY - DSM
2 stops19h 04mDelta
Deal found 1/29$446
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/115:29 pmDSM - PTY
2 stops18h 46mAmerican Airlines
Tue 3/183:30 pmPTY - DSM
2 stops22h 10mAmerican Airlines
Deal found 1/29$463
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/243:44 pmDSM - PTY
3 stops31h 36mMultiple Airlines
Tue 3/49:55 pmPTY - DSM
2 stops24h 43mMultiple Airlines
Deal found 1/29$812

Find flights from Des Moines to Panama within your budget

Customize your flight search to find flights from Des Moines to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/24

8:00 am-5:07 pm

1 stop8h 07m

Panama City Tocumen Intl

Tue 3/4

8:55 am-10:30 pm

1 stop14h 35m

$441

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Tue 3/11

5:29 pm-12:15 pm

2 stops18h 46m

Panama City Tocumen Intl

Tue 3/18

3:30 pm-1:40 pm

2 stops22h 10m

$463

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Fri 3/7

11:30 am-8:01 pm

1 stop7h 31m

Panama City Tocumen Intl

Fri 3/14

2:20 pm-10:56 pm

1 stop8h 36m

$481

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 2/24

3:44 pm-12:20 am

3 stops31h 36m

Panama City Tocumen Intl

Tue 3/4

9:55 pm-9:38 pm

2 stops24h 43m

$812

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 3/10

2:07 pm-12:15 pm

2 stops22h 08m

$188

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Mon 3/10

2:57 pm-4:07 pm

1 stop25h 10m

$203

Des MoinesPanama City

DSM - PTY

DSMPTY

Des Moines

Sat 3/15

5:45 am-12:55 pm

1 stop7h 10m

$1,242

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/30

Best time to book a flight from Des Moines to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to Panama

Get recent, data-driven insights about flights from Des Moines to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to Panama?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to PA?

Find hourly flight availability from Des Moines to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 30, 2025.
Delta
8.0
Very good
8,450 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,450 reviews
Delta
8.0
Very good
8,450 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,906 reviews
Delta
8.0
Very good
8,450 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,450 reviews

Boarding

8.2

Crew

8.5

Overall

8.0

Comfort

8.0

Food

7.3

Entertainment

7.9

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Panama?

    For a flight from Des Moines to Panama, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Des Moines to Panama one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $188. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Des Moines to Panama for a low price.

  • Can I find deals for flights from Des Moines to Panama that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama.

  • Can I find deals for business class flights from Des Moines to Panama?

    Yes. Cheapflights offers flight deals from Des Moines to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Panama (average of $478). Flying from Des Moines to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Panama

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Panama City flights
Cedar Rapids to Philip S.W.Goldson flights
Omaha to San José flights
Omaha to Guatemala City flights
Omaha to Liberia flights
Cedar Rapids to Liberia flights
Des Moines to Philip S.W.Goldson flights
Des Moines to San José flights
Des Moines to San Salvador flights
Des Moines to Liberia flights
Omaha to San Salvador flights
Omaha to Coxen Hole flights
Omaha to Philip S.W.Goldson flights
Omaha to Panama City flights
Cedar Rapids to San Salvador flights
Cedar Rapids to San José flights
Des Moines to Guatemala City flights
Moline to Philip S.W.Goldson flights
Cedar Rapids to Guatemala City flights
Cedar Rapids to Coxen Hole flights
Cedar Rapids to Panama City flights
Moline to San José flights
Des Moines to Managua flights
Omaha to San Pedro Sula flights
Moline to Guatemala City flights
Omaha to Managua flights
Moline to Liberia flights
Moline to San Salvador flights
La Crosse to Panama City flights
Des Moines to Tegucigalpa flights

Top 3 airlines flying from Des Moines to Panama

Discover the top 3 airlines that operate flights from Des Moines to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$329Average$539FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$337Average$453FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$354Average$595FlexibilityNo cancel feeOn-time71%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.