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Panama City

$390+ Cheap flights from St. Louis (STL) to Panama City (PTY)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Panama City Tocumen Intl are usually found in April or May, booked 39 days in advance, depart on a Tuesday or Wednesday and return on a Thursday

Cheap flight deals from St. Louis to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 17, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$390
(United Airlines)

Popular in

July

Cheapest in

April

Average price

$441
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
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From Lambert-St Louis to Panama City Tocumen Intl
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Highest demand for flights based on searches. 1% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from St. Louis to Panama City

Cheapest flights from St. Louis to Panama City
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/511:15 amSTL - PTY
1 stop7h 22mUnited Airlines
Tue 7/87:55 amPTY - STL
1 stop10h 58mUnited Airlines
Deal found 4/16$390
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/265:14 pmSTL - PTY
2 stops19h 40mAmerican Airlines
Sat 8/23:05 pmPTY - STL
2 stops20h 55mAmerican Airlines
Deal found 4/16$412
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/247:05 pmSTL - PTY
1 stop17h 49mDelta
Mon 9/82:14 pmPTY - STL
1 stop17h 56mDelta
Deal found 4/17$421
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1311:28 amSTL - PTY
3 stops46h 42mMultiple Airlines
Sat 6/213:20 amPTY - STL
3 stops31h 13mMultiple Airlines
Deal found 4/17$713
This Avianca deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/259:17 amSTL - PTY
2 stops15h 28mAvianca
Fri 9/53:40 pmPTY - STL
2 stops18h 08mAvianca
Deal found 4/17$1,440

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.

Fly from

St. Louis

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 7/5

11:15 am-6:37 pm

1 stop7h 22m

Panama City Tocumen Intl

Tue 7/8

7:55 am-6:53 pm

1 stop10h 58m

$390

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 7/26

5:14 pm-12:54 pm

2 stops19h 40m

Panama City Tocumen Intl

Sat 8/2

3:05 pm-12:00 pm

2 stops20h 55m

$412

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/24

7:05 pm-12:54 pm

1 stop17h 49m

Panama City Tocumen Intl

Thu 9/11

2:14 pm-11:39 pm

1 stop9h 25m

$421

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 6/13

11:28 am-10:10 am

3 stops46h 42m

Panama City Tocumen Intl

Sat 6/21

3:20 am-10:33 am

3 stops31h 13m

$713

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

9:17 am-12:45 am

2 stops15h 28m

Panama City Tocumen Intl

Fri 9/5

3:40 pm-9:48 am

2 stops18h 08m

$1,440

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Compare providers for flights from St. Louis to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Panama City flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Panama City

How far ahead should I book a flight from St. Louis to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Panama City. Price data was last updated on April 11, 2025.

The best time to book flights from St. Louis to Panama City is 39 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from St. Louis to Panama City?

Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to PTY?

Find hourly flight availability from St. Louis to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from St. Louis to Panama City, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 26% versus a flight in the afternoon.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 17, 2025.
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,916 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,316 reviews
Delta
8.0
Very good
7,916 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Panama City round-trip?

    Cheapflights users have booked flights from St. Louis to Panama City round-trip from $390. Other airlines that can offer you cheap pricing are American Airlines, from $412, and Delta, from $421. United Airlines is 29% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from St. Louis to Panama City that include hotel bookings?

    Yes. In addition to deals on St. Louis to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Panama City.

  • Can I find deals for business class flights from St. Louis to Panama City?

    Yes. Cheapflights offers flight deals from St. Louis to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Panama City?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $478). Flying from St. Louis to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Panama City flights
Springfield to Panama City flights

Top 3 airlines flying from St. Louis to Panama City

Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$437Average$563FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$440Average$550FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$448Average$541FlexibilityNo cancel feeOn-time69%

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