Panama City

$159+ Cheap flights from South Carolina to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
ene. 25 — feb. 11
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Cheap flight deals from South Carolina to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 20, 2025.

Round-trip from

$379
(Mytrip)

One-way from

$159
(Delta)
From South Carolina to Panama City Tocumen Intl
One-way flight from South Carolina to Panama City Tocumen Intl

Find flight deals from South Carolina to Panama City

Cheapest flights from South Carolina to Panama City
Explore the most affordable flight options available from South Carolina to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 20, 2025.

This Mytrip deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/186:52 amCLT - PTY
2 stops27h 48mMultiple Airlines
lun. 3/246:30 pmPTY - CLT
2 stops29h 02mMultiple Airlines
Deal found 1/18$379
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/187:04 amGSP - PTY
1 stop7h 41mUnited Airlines
mar. 3/259:30 amPTY - GSP
1 stop10h 40mUnited Airlines
Deal found 1/19$383
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 1/206:18 pmGSP - PTY
2 stops19h 11mAmerican Airlines
lun. 1/274:40 pmPTY - GSP
1 stop7h 34mAmerican Airlines
Deal found 1/19$388
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/45:55 amCHS - PTY
1 stop7h 34mAmerican Airlines
mar. 2/114:40 pmPTY - CHS
1 stop7h 19mAmerican Airlines
Deal found 1/19$403
This Avianca Connect deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/119:11 amMYR - PTY
2 stops11h 49mMultiple Airlines
lun. 2/173:19 amPTY - MYR
2 stops18h 13mMultiple Airlines
Deal found 1/19$408
This United Airlines deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/1111:15 amCHS - PTY
1 stop8h 47mUnited Airlines
jue. 2/204:40 pmPTY - CHS
1 stop30h 38mUnited Airlines
Deal found 1/18$412
This Delta deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/2112:30 pmCHS - PTY
1 stop7h 31mDelta
mié. 2/263:27 pmPTY - CHS
1 stop17h 56mDelta
Deal found 1/18$430
This Kiwi.com deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/227:15 amCHS - PTY
1 stop13h 04mMultiple Airlines
lun. 2/2412:03 pmPTY - CHS
1 stop9h 16mMultiple Airlines
Deal found 1/18$435
This United deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/206:25 amCLT - PTY
1 stop13h 13mUnited Airlines
lun. 3/2410:55 pmPTY - CLT
1 stop9h 34mUnited Airlines
Deal found 1/20$437
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/239:44 amCLT - PTY
1 stop28h 11mDelta
mié. 3/262:20 pmPTY - CLT
1 stop17h 35mDelta
Deal found 1/19$444
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/237:24 pmGSP - PTY
1 stop18h 31mDelta
jue. 3/272:20 pmPTY - GSP
1 stop8h 13mDelta
Deal found 1/19$456
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/2210:28 pmCLT - PTY
2 stops14h 57mAmerican Airlines
vie. 9/261:50 pmPTY - CLT
2 stops16h 15mAmerican Airlines
Deal found 1/19$462

Find flights from South Carolina to Panama City within your budget

Customize your flight search to find flights from South Carolina to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 20, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

mar. 3/18

6:52 am-9:40 am

2 stops27h 48m

Panama City Tocumen Intl

lun. 3/24

6:30 pm-12:32 am

2 stops29h 02m

$379

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mar. 3/18

7:04 am-1:45 pm

1 stop7h 41m

Panama City Tocumen Intl

mar. 3/25

9:30 am-9:10 pm

1 stop10h 40m

$383

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

mar. 2/25

6:43 pm-1:30 pm

2 stops18h 47m

Panama City Tocumen Intl

mar. 3/11

1:05 pm-9:56 am

2 stops19h 51m

$388

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 2/4

5:55 am-1:29 pm

1 stop7h 34m

Panama City Tocumen Intl

mar. 2/11

4:40 pm-11:59 pm

1 stop7h 19m

$403

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

mar. 2/11

9:11 am-9:00 pm

2 stops11h 49m

Panama City Tocumen Intl

lun. 2/17

3:19 am-9:32 pm

2 stops18h 13m

$408

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

mar. 2/11

11:15 am-8:02 pm

1 stop8h 47m

Panama City Tocumen Intl

jue. 2/20

4:40 pm-11:18 pm

1 stop30h 38m

$412

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

vie. 2/21

12:30 pm-8:01 pm

1 stop7h 31m

Panama City Tocumen Intl

mié. 2/26

3:27 pm-9:23 am

1 stop17h 56m

$430

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

sáb. 2/22

7:15 am-8:19 pm

1 stop13h 04m

Panama City Tocumen Intl

lun. 2/24

12:03 pm-9:19 pm

1 stop9h 16m

$435

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

jue. 3/20

6:25 am-6:38 pm

1 stop13h 13m

Panama City Tocumen Intl

lun. 3/24

10:55 pm-9:29 am

1 stop9h 34m

$437

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

dom. 3/23

9:44 am-12:55 pm

1 stop28h 11m

Panama City Tocumen Intl

mié. 3/26

2:20 pm-8:55 am

1 stop17h 35m

$444

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 36 results
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Best time to book a flight from South Carolina to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Panama City

Get recent, data-driven insights about flights from South Carolina to Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Panama City?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PTY?

Find hourly flight availability from South Carolina to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 20, 2025.

When flying from South Carolina to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated enero 20, 2025.
See what other customers who have flown with United Airlines, American Airlines and Delta from South Carolina to Panama City have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

8.0
Very good
8,521 reviews
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.4
Good
8,982 reviews
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.2
Good
10,000 reviews
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

6.9
Okay
2,579 reviews
8.0
Very good
8,521 reviews

Comfort

8.0

Crew

8.6

Boarding

8.2

Food

7.3

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Panama City from South Carolina?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Panama City from South Carolina.

  • What are the cheapest airlines to fly from South Carolina to Panama City one-way?

    The cheapest airlines for a one-way flight from South Carolina to Panama City are Delta ($159), American Airlines ($169), and United Airlines ($206).

  • What are the most popular routes from South Carolina to Panama City?

  • Can I find deals for flights from South Carolina to Panama City that include hotel bookings?

    Yes. In addition to deals on South Carolina to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Panama City.

  • Can I find deals for business class flights from South Carolina to Panama City?

    Yes. Cheapflights offers flight deals from South Carolina to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Panama City?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama City (average of $478). Flying from South Carolina to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from South Carolina to Panama City

Discover the top 3 airlines that operate flights from South Carolina to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$268Average$393FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$284Average$539FlexibilityNo cancel feeOn-time71%
DeltaCheapest$331Average$598FlexibilityNo cancel feeOn-timeN/A
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