How popular is this Santo Domingo to Panama City flight route?

This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 98 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $305. Other airlines that can offer you cheap pricing are Copa Airlines, from $415, and United Airlines, from $1,312. Avianca is 30% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?

To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $139. American Airlines flights start at $275 while deals on Copa Airlines start at $536 one-way.

What is the cheapest day to fly from Santo Domingo to Panama City?

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Friday afternoons when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most reliable airlines from Santo Domingo to Panama City?

Consider Air France (100%), Turkish Airlines (99%) or Copa Airlines (99%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

What is the cheapest day to fly round-trip from Santo Domingo to Panama City?

Flying to your destination on a Sunday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Panama City. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from Santo Domingo to Panama City?

To save on the cost of your flight from Santo Domingo to Panama City, book at least 28 days before your planned departure. Booking around this time can save you about 40% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $397 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $743.

What is the cheapest month to fly from Santo Domingo to Panama City?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, May can be a great choice for travel to Panama City. Flights to Panama City from Santo Domingo in May are about $441 on average during May, but can be found for as low as $306.

Most accurate provider : When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Santo Domingo to Panama City?

If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 8 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 33m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

Can I find deals for business class flights from Santo Domingo to Panama City?

Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$139+ Flights from Santo Domingo to Panama City

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 27 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$305 (Priceline)
One-way from	$139 (Kiwi.com)
Popular in	March
Cheapest in	May
Average price	$468
Good round-trip deal	$269 or less
Good one-way deal	$180 or less

Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.

Search Deals

From Santo Domingo Las Americas to Panama City Tocumen Intl

Search Deals

One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

Search Deals

Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

Search Deals

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Sat 5/316:10 pmSDQ - PTY

1 stop7h 00mAvianca

Fri 6/63:25 amPTY - SDQ

1 stop6h 25mAvianca

Deal found 4/15

$305

Tue 5/1311:45 amSDQ - PTY

1 stop10h 25mMultiple Airlines

Tue 5/2010:05 pmPTY - SDQ

2 stops24h 10mMultiple Airlines

Deal found 4/14

$412

Wed 4/235:20 amSDQ - PTY

Nonstop2h 38mCopa Airlines

Fri 5/211:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 4/15

$415

Fri 10/31:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Tue 10/710:00 amPTY - SDQ

2 stops14h 50mUnited Airlines

Deal found 4/15

$1,312

Fri 4/183:02 pmSDQ - PTY

2 stops22h 53mDelta

Tue 4/222:20 pmPTY - SDQ

2 stops27h 03mDelta

Deal found 4/15

$6,452

Best flights from Santo Domingo to Panama City
Discover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2025.

Sat 5/316:10 pmSDQ - PTY

1 stop7h 00mAvianca

Fri 6/63:25 amPTY - SDQ

1 stop6h 25mAvianca

Deal found 4/15

$305

Tue 5/1311:45 amSDQ - PTY

1 stop10h 25mMultiple Airlines

Tue 5/2010:05 pmPTY - SDQ

2 stops24h 10mMultiple Airlines

Deal found 4/14

$412

Thu 5/85:21 amSDQ - PTY

Nonstop2h 37mCopa Airlines

Sat 5/1711:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 4/15

$415

Fri 10/31:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Tue 10/710:00 amPTY - SDQ

2 stops14h 50mUnited Airlines

Deal found 4/15

$1,312

Mon 5/53:02 pmSDQ - PTY

2 stops22h 53mDelta

Sun 5/118:00 amPTY - SDQ

2 stops15h 19mDelta

Deal found 4/15

$6,452

Last-minute flights from Santo Domingo to Panama City
Discover last-minute flight deals from Santo Domingo to Panama City. Data last updated April 15, 2025 and is based on user searches.

Fri 4/183:02 pmSDQ - PTY

2 stops22h 53mDelta

Tue 4/222:20 pmPTY - SDQ

2 stops27h 03mDelta

Deal found 4/15

$6,452

Wed 4/235:20 amSDQ - PTY

Nonstop2h 38mCopa Airlines

Fri 5/211:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 4/15

$415

Wed 4/236:10 pmSDQ - PTY

1 stop7h 00mMultiple Airlines

Tue 4/296:34 pmPTY - SDQ

2 stops18h 45mMultiple Airlines

Deal found 4/15

$427

Thu 4/246:10 pmSDQ - PTY

1 stop7h 00mAvianca

Tue 4/299:50 amPTY - SDQ

1 stop6h 25mAvianca

Deal found 4/15

$305

Fri 4/251:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Thu 5/17:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Deal found 4/15

$1,506

Mon 5/121:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Fri 5/303:20 pmPTY - SDQ

2 stops33h 30mUnited Airlines

Deal found 4/15

$1,469

Tue 5/1311:45 amSDQ - PTY

1 stop10h 25mMultiple Airlines

Tue 5/2010:05 pmPTY - SDQ

2 stops24h 10mMultiple Airlines

Deal found 4/14

$412

Sat 5/316:10 pmSDQ - PTY

1 stop7h 00mAvianca

Fri 6/63:25 amPTY - SDQ

1 stop6h 25mAvianca

Deal found 4/15

$305

One-way flights from Santo Domingo to Panama City
Search for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated April 15, 2025.

Wed 4/236:10 pmSDQ - PTY

1 stop7h 00mAvianca

Deal found 4/15

$139

Tue 4/225:00 amSDQ - PTY

1 stop8h 15mAmerican Airlines

Deal found 4/15

$275

Tue 4/227:40 amSDQ - PTY

2 stops12h 35mMultiple Airlines

Deal found 4/14

$342

Tue 4/2211:51 amSDQ - PTY

Nonstop2h 38mCopa Airlines

Deal found 4/15

$536

Mon 4/211:10 pmSDQ - PTY

2 stops28h 02mUnited Airlines

Deal found 4/14

$1,192

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Sat 5/31

6:10 pm-12:10 am

1 stop7h 00m

Panama City Tocumen Intl

Fri 6/6

3:25 am-10:50 am

1 stop6h 25m

$305

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 5/13

11:45 am-9:10 pm

1 stop10h 25m

Panama City Tocumen Intl

Tue 5/20

10:05 pm-11:15 pm

2 stops24h 10m

$412

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Thu 5/8

5:21 am-6:58 am

Nonstop2h 37m

Panama City Tocumen Intl

Sat 5/17

11:13 pm-2:45 am

Nonstop2h 32m

$415

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 10/3

1:10 pm-2:14 pm

2 stops26h 04m

Panama City Tocumen Intl

Tue 10/7

10:00 am-1:50 am

2 stops14h 50m

$1,312

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 5/5

3:02 pm-12:55 pm

2 stops22h 53m

Panama City Tocumen Intl

Sun 5/11

8:00 am-12:19 am

2 stops15h 19m

$6,452

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 4/23

6:10 pm-12:10 am

1 stop7h 00m

$139

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/22

5:00 am-12:15 pm

1 stop8h 15m

$275

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/22

7:40 am-7:15 pm

2 stops12h 35m

$342

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/22

11:51 am-1:29 pm

Nonstop2h 38m

$536

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Mon 4/21

1:10 pm-4:12 pm

2 stops28h 02m

$1,192

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Compare providers for flights from Santo Domingo to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in April.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Jetabroad	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 27 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 15% on airfare.

Weekly flight availability from Santo Domingo to Panama City

The most flights from SDQ to PTY are scheduled on a Friday (10 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (6 on average).

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Bad experience with the staff boarding the gate. I couldn’t board with my carry on, personal item and a funny bag. I had to put my passport inside my pockets and put the funny bag inside the personal item. Then after passing the staff pull out everything again.

Delta

8.0

Very good

7,918 reviews

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Copa Airlines

7.6

Good

1,408 reviews

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

United Airlines

7.4

Good

8,658 reviews

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Avianca

6.7

Okay

2,313 reviews

Delta

8.0

Very good

7,918 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Related info for your journey

What airports do I use to fly from Santo Domingo to Panama City?
If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 8 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 33m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.
How popular is this Santo Domingo to Panama City flight route?
This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 98 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?
Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $305. Other airlines that can offer you cheap pricing are Copa Airlines, from $415, and United Airlines, from $1,312. Avianca is 30% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?
To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $139. American Airlines flights start at $275 while deals on Copa Airlines start at $536 one-way.
What are the most reliable airlines from Santo Domingo to Panama City?
Consider Air France (100%), Turkish Airlines (99%) or Copa Airlines (99%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.
What are the cheapest flights from Santo Domingo to Panama City?
Looking at all options, your cheapest flight can be booked for $134. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $322 on average our data indicates $318 when flying from Santo Domingo to Panama City.
Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.
Can I find deals for business class flights from Santo Domingo to Panama City?
Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to Panama City?
Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Other flights to Panama City

Top 2 airlines flying from Santo Domingo to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$281	Average$350	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$370	Average$485	FlexibilityNo cancel fee	On-time70%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$139+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 27 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama CityExplore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Compare providers for flights from Santo Domingo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in April.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on April 11, 2025.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 15, 2025.

Weekly flight availability from Santo Domingo to Panama City

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Santo Domingo to Panama City?

How popular is this Santo Domingo to Panama City flight route?

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?

What are the most reliable airlines from Santo Domingo to Panama City?

What are the cheapest flights from Santo Domingo to Panama City?

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

How can I find direct flights from Santo Domingo to Panama City?

Can I find deals for business class flights from Santo Domingo to Panama City?

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santo Domingo to Panama City

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.