How popular is this Santo Domingo to Panama City flight route?

This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 104 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $415. Other airlines that can offer you cheap pricing are Avianca, from $433, and United Airlines, from $1,527. Copa Airlines is 5% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?

To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $205. Copa Airlines flights start at $536 while deals on American Airlines start at $1,105 one-way.

What is the cheapest day to fly from Santo Domingo to Panama City?

Travelers seeking maximum savings on their Santo Domingo to Panama City flight should consider departing on Friday afternoons when fares are most often at their lowest. Tuesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most reliable airlines from Santo Domingo to Panama City?

Consider Air France (100%), Copa Airlines (97%) or Turkish Airlines (97%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.

What is the cheapest day to fly round-trip from Santo Domingo to Panama City?

Flying to your destination on a Sunday can be more expensive, but this shouldn’t discourage you from finding affordable options to get to Panama City. Check prices with Cheapflights to find a great deal for your trip.

How far in advance should I book a flight from Santo Domingo to Panama City?

To save on the cost of your flight from Santo Domingo to Panama City, book at least 21 days before your planned departure. Booking around this time can save you about 23% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $395 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $743.

What is the cheapest month to fly from Santo Domingo to Panama City?

Due to multiple factors, expect to potentially pay more when booking in March. For low rates, May can be a great choice for travel to Panama City. Flights to Panama City from Santo Domingo in May are about $441 on average during May, but can be found for as low as $305.

Most accurate provider : When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

What airports do I use to fly from Santo Domingo to Panama City?

If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 7 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 33m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santo Domingo to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.

Can I find deals for business class flights from Santo Domingo to Panama City?

Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$205+ Save on Flights from Santo Domingo to Panama City

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 85 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$415 (Copa Airlines)
One-way from	$205 (Avianca)
Popular in	March
Cheapest in	May
Average price	$498
Good round-trip deal	$274 or less
Good one-way deal	$194 or less

Provider with most accurate pricing for Santo Domingo Las Americas-Panama City Tocumen Intl flight deals.

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Provider most trusted by Cheapflights users for Santo Domingo Las Americas-Panama City Tocumen Intl flights.

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From Santo Domingo Las Americas to Panama City Tocumen Intl

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One-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl

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Highest demand for flights based on searches. 9% potential increase in price ($47 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

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Average for round-trip flights in March 2025

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Price to beat on a round-trip flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

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Price to beat on a one-way flight from Santo Domingo Las Americas to Panama City Tocumen Intl.

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Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Tue 4/15:14 amSDQ - PTY

Nonstop2h 44mCopa Airlines

Mon 5/1211:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 3/24

$415

Thu 3/276:15 pmSDQ - PTY

1 stop7h 45mAvianca

Sat 4/53:20 amPTY - SDQ

1 stop12h 55mAvianca

Deal found 3/24

$433

Wed 3/261:25 amSDQ - PTY

2 stops20h 35mMultiple Airlines

Sun 4/65:25 pmPTY - SDQ

1 stop16h 25mMultiple Airlines

Deal found 3/24

$624

Thu 9/251:10 pmSDQ - PTY

2 stops26h 09mUnited Airlines

Tue 9/3010:00 amPTY - SDQ

2 stops14h 50mUnited Airlines

Deal found 3/23

$1,418

Wed 9/102:09 pmSDQ - PTY

2 stops23h 40mDelta

Thu 9/182:14 pmPTY - SDQ

2 stops26h 37mDelta

Deal found 3/24

$6,498

Best flights from Santo Domingo to Panama City
Discover carefully curated flight deals from Santo Domingo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 25, 2025.

Tue 4/155:20 amSDQ - PTY

Nonstop2h 38mCopa Airlines

Tue 4/2211:13 pmPTY - SDQ

Nonstop2h 27mCopa Airlines

Deal found 3/24

$415

Fri 6/66:10 pmSDQ - PTY

1 stop7h 35mAvianca

Sat 6/73:20 amPTY - SDQ

1 stop12h 55mAvianca

Deal found 3/24

$433

Fri 4/1811:00 amSDQ - PTY

3 stops22h 55mMultiple Airlines

Mon 4/2110:05 pmPTY - SDQ

1 stop11h 45mMultiple Airlines

Deal found 3/24

$625

Tue 4/151:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Tue 4/297:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Deal found 3/23

$1,527

Wed 9/102:09 pmSDQ - PTY

2 stops23h 40mDelta

Thu 9/182:14 pmPTY - SDQ

2 stops26h 37mDelta

Deal found 3/24

$6,498

Last-minute flights from Santo Domingo to Panama City
Discover last-minute flight deals from Santo Domingo to Panama City. Data last updated March 25, 2025 and is based on user searches.

Wed 3/261:25 amSDQ - PTY

2 stops20h 35mMultiple Airlines

Sun 4/65:25 pmPTY - SDQ

1 stop16h 25mMultiple Airlines

Deal found 3/24

$624

Thu 3/276:15 pmSDQ - PTY

1 stop16h 25mAvianca

Sun 4/610:05 pmPTY - SDQ

1 stop11h 45mAvianca

Deal found 3/24

$433

Sun 3/306:10 pmSDQ - PTY

1 stop7h 00mAvianca

Fri 4/43:25 amPTY - SDQ

1 stop12h 50mAvianca

Deal found 3/23

$451

Sun 3/306:10 pmSDQ - PTY

1 stop7h 00mMultiple Airlines

Sat 4/511:13 pmPTY - SDQ

Nonstop2h 27mMultiple Airlines

Deal found 3/23

$1,007

Sun 3/302:10 pmSDQ - PTY

2 stops23h 45mDelta

Sun 4/62:23 pmPTY - SDQ

2 stops27h 07mDelta

Deal found 3/24

$6,688

Tue 4/15:14 amSDQ - PTY

Nonstop2h 44mCopa Airlines

Mon 5/1211:13 pmPTY - SDQ

Nonstop2h 32mCopa Airlines

Deal found 3/24

$415

Tue 4/151:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Tue 4/297:55 amPTY - SDQ

2 stops16h 55mUnited Airlines

Deal found 3/23

$1,527

One-way flights from Santo Domingo to Panama City
Search for one-way flight options from Santo Domingo to Panama City. Find affordable one-way fares based on user searches. Data last updated March 25, 2025.

Tue 4/16:10 pmSDQ - PTY

1 stop7h 00mAvianca

Deal found 3/24

$205

Tue 4/111:00 amSDQ - PTY

3 stops28h 40mMultiple Airlines

Deal found 3/23

$370

Tue 4/15:14 amSDQ - PTY

Nonstop2h 44mCopa Airlines

Deal found 3/23

$536

Tue 4/13:58 pmSDQ - PTY

1 stop45h 17mAmerican Airlines

Deal found 3/23

$1,105

Tue 4/11:10 pmSDQ - PTY

2 stops26h 04mUnited Airlines

Deal found 3/23

$1,703

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/15

5:20 am-6:58 am

Nonstop2h 38m

Panama City Tocumen Intl

Tue 4/22

11:13 pm-2:40 am

Nonstop2h 27m

$415

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 6/6

6:10 pm-12:45 am

1 stop7h 35m

Panama City Tocumen Intl

Sat 6/7

3:20 am-5:15 pm

1 stop12h 55m

$433

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Fri 4/18

11:00 am-8:55 am

3 stops22h 55m

Panama City Tocumen Intl

Mon 4/21

10:05 pm-10:50 am

1 stop11h 45m

$625

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/15

1:10 pm-2:14 pm

2 stops26h 04m

Panama City Tocumen Intl

Tue 4/29

7:55 am-1:50 am

2 stops16h 55m

$1,527

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Wed 9/10

2:09 pm-12:49 pm

2 stops23h 40m

Panama City Tocumen Intl

Thu 9/18

2:14 pm-5:51 pm

2 stops26h 37m

$6,498

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/1

6:10 pm-12:10 am

1 stop7h 00m

$205

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/1

11:00 am-2:40 pm

3 stops28h 40m

$370

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/1

5:14 am-6:58 am

Nonstop2h 44m

$536

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/1

3:58 pm-12:15 pm

1 stop45h 17m

$1,105

Santo DomingoPanama City

SDQ - PTY

SDQPTY

Santo Domingo Las Americas

Tue 4/1

1:10 pm-2:14 pm

2 stops26h 04m

$1,703

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Compare providers for flights from Santo Domingo to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in March.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Jetabroad	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santo Domingo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santo Domingo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santo Domingo-Panama City flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santo Domingo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santo Domingo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

The best time to book flights from Santo Domingo to Panama City is 20 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDQ to PTY?

One of the essential ways to save on airfare from Santo Domingo to Panama City is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 12% on airfare.

Weekly flight availability from Santo Domingo to Panama City

The most flights from SDQ to PTY are scheduled on a Monday (9 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (5 on average).

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, Copa Airlines and United Airlines from Santo Domingo to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Bad experience with the staff boarding the gate. I couldn’t board with my carry on, personal item and a funny bag. I had to put my passport inside my pockets and put the funny bag inside the personal item. Then after passing the staff pull out everything again.

Delta

8.0

Very good

7,890 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Copa Airlines

7.6

Good

1,393 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

United Airlines

7.4

Good

8,605 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Avianca

6.7

Okay

2,294 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Santiago,Apr 2024

ATL - JNB

Related info for your journey

What airports do I use to fly from Santo Domingo to Panama City?
If you wish to fly to Panama City from Santo Domingo, then you need to book flights from Santo Domingo Las Americas to Panama City Tocumen Intl. There are 7 flights from Las Americas (SDQ) to Tocumen Intl (PTY) per day to choose from. Flights to Panama City from Las Americas are available from 2 different airlines, which means you should have some options if you want to compare airfare deals. 2h 33m is how long a nonstop flight from Santo Domingo to Panama City Tocumen Intl typically takes.
How popular is this Santo Domingo to Panama City flight route?
This flight path from Santo Domingo Las Americas to Panama City Tocumen Intl was viewed by 104 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?
Cheapflights users have booked flights from Santo Domingo to Panama City round-trip from $415. Other airlines that can offer you cheap pricing are Avianca, from $433, and United Airlines, from $1,527. Copa Airlines is 5% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?
To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $205. Copa Airlines flights start at $536 while deals on American Airlines start at $1,105 one-way.
What are the most reliable airlines from Santo Domingo to Panama City?
Consider Air France (100%), Copa Airlines (97%) or Turkish Airlines (97%) when booking your flight. These represent the most reliable airlines when flying from Santo Domingo to Panama City.
What are the cheapest flights from Santo Domingo to Panama City?
Looking at all options, your cheapest flight can be booked for $162. While the most popular route (Santo Domingo Las Americas - Panama City Tocumen Intl) can be booked for $415 on average our data indicates $358 when flying from Santo Domingo to Panama City.
Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?
Yes. In addition to deals on Santo Domingo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santo Domingo to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santo Domingo to Panama City.
Can I find deals for business class flights from Santo Domingo to Panama City?
Yes. Cheapflights offers flight deals from Santo Domingo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santo Domingo to Panama City?
Currently, October is the cheapest month in which you can book a flight from Santo Domingo to Panama City (average of $478). Flying from Santo Domingo to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Other flights to Panama City

Top 2 airlines flying from Santo Domingo to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$304	Average$350	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$370	Average$479	FlexibilityNo cancel fee	On-time70%

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$205+ Cheap flights from Santo Domingo (SDQ) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santo Domingo to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Santo Domingo Las Americas to Panama City Tocumen Intl are usually found in May or June, booked 85 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from Santo Domingo to Panama City

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Santo Domingo to Panama City

Cheapest flights from Santo Domingo to Panama CityExplore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santo Domingo to Panama City that are best for you.

Compare providers for flights from Santo Domingo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santo Domingo to Panama City in March.

Best time to book a flight from Santo Domingo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Santo Domingo with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santo Domingo to Panama City

How far ahead should I book a flight from Santo Domingo to Panama City?

Use this chart to determine the optimal time to book a round-trip flight from Santo Domingo to Panama City. Price data was last updated on March 21, 2025.

What is the cheapest month to book a flight from Santo Domingo to Panama City?

What is the cheapest time of day to fly from SDQ to PTY?

Find hourly flight availability from Santo Domingo to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 25, 2025.

Weekly flight availability from Santo Domingo to Panama City

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, Copa Airlines and United Airlines from Santo Domingo to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santo Domingo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Santo Domingo to Panama City?

How popular is this Santo Domingo to Panama City flight route?

What are the cheapest airlines flying from Santo Domingo to Panama City round-trip?

What are the cheapest airlines to fly from Santo Domingo to Panama City one-way?

What are the most reliable airlines from Santo Domingo to Panama City?

What are the cheapest flights from Santo Domingo to Panama City?

Can I find deals for flights from Santo Domingo to Panama City that include hotel bookings?

How can I find direct flights from Santo Domingo to Panama City?

Can I find deals for business class flights from Santo Domingo to Panama City?

What is the cheapest month to book a flight from Santo Domingo to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santo Domingo to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Santo Domingo to Panama City

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Cheapest flights from Santo Domingo to Panama City
Explore the most affordable flight options available from Santo Domingo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.