What are the most popular routes from Missouri to Panama City?

While some choose either Lambert-St Louis - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Kansas City - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

What are the most popular airlines that fly from Missouri to Panama City?

When booking a flight from Missouri to Panama City, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

How far in advance should I book a flight from Missouri to Panama City?

Users have found that booking a flight from Missouri to Panama City at least 40 days early can save you up to 8% on average compared to booking a flight this week. If booking 40 days before your flight isn’t an option for you, users have found flights from Missouri to Panama City for as little as $493 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $667 for flights departing within the next 3 days.

What is the cheapest month to fly from Missouri to Panama City?

Due to multiple factors, expect to potentially pay more when booking in December. For low rates, April can be a great choice for travel to Panama City. Flights to Panama City from Missouri in April are about $636 on average during April, but can be found for as low as $482.

What airport do you fly into for flights to Panama City from Missouri?

If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

Can I find deals for business class flights from Missouri to Panama City?

Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$176+ Flights from Missouri to Panama City

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Cheap flight deals from Missouri to Panama City

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$390 (United Airlines)
One-way from	$176 (Delta)
Popular in	December
Cheapest in	April
Average price	$531

Provider with most accurate pricing for Kansas City-Panama City Tocumen Intl flight deals.

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Provider most trusted by Cheapflights users for Kansas City-Panama City Tocumen Intl flights.

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From Missouri to Panama City Tocumen Intl

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One-way flight from Missouri to Panama City Tocumen Intl

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Highest demand for flights based on searches. 13% potential increase in price ($102 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($32 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Sat 7/511:15 amSTL - PTY

1 stop7h 22mUnited Airlines

Tue 7/87:55 amPTY - STL

1 stop10h 58mUnited Airlines

Deal found 4/16

$390

Sat 7/265:14 pmSTL - PTY

2 stops19h 40mAmerican Airlines

Sat 8/23:05 pmPTY - STL

2 stops20h 55mAmerican Airlines

Deal found 4/16

$412

Sun 8/247:05 pmSTL - PTY

1 stop17h 49mDelta

Mon 9/82:14 pmPTY - STL

1 stop17h 56mDelta

Deal found 4/17

$421

Sat 6/215:49 pmMCI - PTY

2 stops20h 36mAmerican Airlines

Sat 6/283:20 pmPTY - MCI

2 stops18h 36mAmerican Airlines

Deal found 4/17

$433

Wed 5/288:25 amMCI - PTY

1 stop10h 12mUnited Airlines

Sat 6/283:20 pmPTY - MCI

2 stops19h 15mUnited Airlines

Deal found 4/17

$470

Wed 5/75:45 amMCI - PTY

1 stop7h 03mDelta

Wed 5/282:13 pmPTY - MCI

1 stop9h 46mDelta

Deal found 4/16

$501

Tue 5/202:45 pmMCI - PTY

3 stops42h 10mMultiple Airlines

Tue 5/273:40 pmPTY - MCI

3 stops28h 32mMultiple Airlines

Deal found 4/15

$567

Fri 6/1311:28 amSTL - PTY

3 stops46h 42mMultiple Airlines

Sat 6/213:20 amPTY - STL

3 stops31h 13mMultiple Airlines

Deal found 4/17

$713

Mon 8/259:17 amSTL - PTY

2 stops15h 28mAvianca

Fri 9/53:40 pmPTY - STL

2 stops18h 08mAvianca

Deal found 4/17

$1,440

Best flights from Missouri to Panama City
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 17, 2025.

Sat 7/511:15 amSTL - PTY

1 stop7h 22mUnited Airlines

Tue 7/87:55 amPTY - STL

1 stop10h 58mUnited Airlines

Deal found 4/16

$390

Sat 7/265:14 pmSTL - PTY

2 stops19h 40mAmerican Airlines

Sat 8/23:05 pmPTY - STL

2 stops20h 55mAmerican Airlines

Deal found 4/16

$412

Sun 8/247:05 pmSTL - PTY

1 stop17h 49mDelta

Thu 9/112:14 pmPTY - STL

1 stop9h 25mDelta

Deal found 4/17

$421

Tue 5/202:45 pmMCI - PTY

3 stops42h 10mMultiple Airlines

Tue 5/273:40 pmPTY - MCI

3 stops28h 32mMultiple Airlines

Deal found 4/15

$567

Wed 5/288:25 amMCI - PTY

1 stop10h 12mUnited Airlines

Sat 6/283:20 pmPTY - MCI

2 stops19h 15mUnited Airlines

Deal found 4/17

$470

Wed 5/75:45 amMCI - PTY

1 stop7h 03mDelta

Wed 5/282:13 pmPTY - MCI

1 stop9h 46mDelta

Deal found 4/16

$501

Tue 5/206:33 pmMCI - PTY

2 stops17h 46mAmerican Airlines

Tue 5/271:20 pmPTY - MCI

2 stops21h 03mAmerican Airlines

Deal found 4/15

$581

Fri 6/1311:28 amSTL - PTY

3 stops46h 42mMultiple Airlines

Sat 6/213:20 amPTY - STL

3 stops31h 13mMultiple Airlines

Deal found 4/17

$713

Mon 8/259:17 amSTL - PTY

2 stops15h 28mAvianca

Fri 9/53:40 pmPTY - STL

2 stops18h 08mAvianca

Deal found 4/17

$1,440

Last-minute flights from Missouri to Panama City
Discover last-minute flight deals from Missouri to Panama City. Data last updated April 17, 2025 and is based on user searches.

Tue 4/228:45 amMCI - PTY

1 stop9h 52mUnited Airlines

Thu 5/17:55 amPTY - MCI

1 stop14h 25mUnited Airlines

Deal found 4/17

$584

Wed 5/75:45 amMCI - PTY

1 stop7h 03mDelta

Wed 5/282:13 pmPTY - MCI

1 stop9h 46mDelta

Deal found 4/16

$501

Thu 5/86:00 amSTL - PTY

1 stop6h 48mDelta

Thu 5/152:13 pmPTY - STL

1 stop9h 25mDelta

Deal found 4/17

$529

Tue 5/202:45 pmMCI - PTY

3 stops42h 10mMultiple Airlines

Tue 5/273:40 pmPTY - MCI

3 stops28h 32mMultiple Airlines

Deal found 4/15

$567

Tue 5/206:33 pmMCI - PTY

2 stops17h 46mAmerican Airlines

Tue 5/271:20 pmPTY - MCI

2 stops21h 03mAmerican Airlines

Deal found 4/15

$581

Tue 5/276:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Tue 7/2210:00 amPTY - STL

1 stop8h 53mUnited Airlines

Deal found 4/17

$441

Tue 5/276:00 pmSTL - PTY

2 stops18h 19mAmerican Airlines

Tue 7/221:50 pmPTY - STL

2 stops18h 51mAmerican Airlines

Deal found 4/17

$494

Tue 5/278:15 amSTL - PTY

2 stops32h 15mAvianca

Mon 7/213:25 amPTY - STL

2 stops30h 34mAvianca

Deal found 4/17

$4,156

Wed 5/288:25 amMCI - PTY

1 stop10h 12mUnited Airlines

Sat 6/283:20 pmPTY - MCI

2 stops19h 15mUnited Airlines

Deal found 4/17

$470

One-way flights from Missouri to Panama City
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated April 17, 2025.

Wed 6/115:45 amMCI - PTY

1 stop7h 23mDelta

Deal found 4/17

$176

Wed 6/115:46 amMCI - PTY

3 stops34h 53mMultiple Airlines

Deal found 4/17

$293

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 7/5

11:15 am-6:37 pm

1 stop7h 22m

Panama City Tocumen Intl

Tue 7/8

7:55 am-6:53 pm

1 stop10h 58m

$390

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 7/26

5:14 pm-12:54 pm

2 stops19h 40m

Panama City Tocumen Intl

Sat 8/2

3:05 pm-12:00 pm

2 stops20h 55m

$412

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sun 8/24

7:05 pm-12:54 pm

1 stop17h 49m

Panama City Tocumen Intl

Thu 9/11

2:14 pm-11:39 pm

1 stop9h 25m

$421

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sat 6/21

5:49 pm-2:25 pm

2 stops20h 36m

Panama City Tocumen Intl

Sat 6/28

3:20 pm-9:56 am

2 stops18h 36m

$433

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 5/28

8:25 am-6:37 pm

1 stop10h 12m

Panama City Tocumen Intl

Sat 6/28

3:20 pm-10:35 am

2 stops19h 15m

$470

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 5/7

5:45 am-12:48 pm

1 stop7h 03m

Panama City Tocumen Intl

Wed 5/28

2:13 pm-11:59 pm

1 stop9h 46m

$501

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Tue 5/20

2:45 pm-8:55 am

3 stops42h 10m

Panama City Tocumen Intl

Tue 5/27

3:40 pm-8:12 pm

3 stops28h 32m

$567

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 6/13

11:28 am-10:10 am

3 stops46h 42m

Panama City Tocumen Intl

Sat 6/21

3:20 am-10:33 am

3 stops31h 13m

$713

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

9:17 am-12:45 am

2 stops15h 28m

Panama City Tocumen Intl

Fri 9/5

3:40 pm-9:48 am

2 stops18h 08m

$1,440

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 6/11

5:45 am-1:08 pm

1 stop7h 23m

$176

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 12 results

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,916 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,667 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Avianca

6.7

Okay

2,316 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What airport do you fly into for flights to Panama City from Missouri?
If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.
What are the most popular routes from Missouri to Panama City?
While some choose either Lambert-St Louis - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Kansas City - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.
Can I find deals for flights from Missouri to Panama City that include hotel bookings?
Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.
Can I find deals for business class flights from Missouri to Panama City?
Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Panama City?
Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Missouri to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$397	Average$560	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$437	Average$583	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$440	Average$576	FlexibilityNo cancel fee	On-time71%

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$176+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/11. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to Panama City with Cheapflights

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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated April 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

See what other customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Missouri?

What are the most popular routes from Missouri to Panama City?

Can I find deals for flights from Missouri to Panama City that include hotel bookings?

How can I find direct flights from Missouri to Panama City?

Can I find deals for business class flights from Missouri to Panama City?

What is the cheapest month to book a flight from Missouri to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Panama City

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Travel Smart

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.