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Panama City

$243+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$429
(United)

Popular in

December

Cheapest in

April

Average price

$599
Provider with most accurate pricing for Kansas City-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Panama City Tocumen Intl flights.
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From Missouri to Panama City Tocumen Intl
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Highest demand for flights based on searches. 11% potential increase in price ($80 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This United deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/208:30 amSTL - PTY
1 stop7h 42mUnited Airlines
Tue 6/37:55 amPTY - STL
1 stop14h 20mUnited Airlines
Deal found 3/29$429
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/76:00 amSTL - PTY
1 stop6h 48mDelta
Sun 5/112:13 pmPTY - STL
1 stop9h 25mDelta
Deal found 3/30$455
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:13 amSTL - PTY
1 stop7h 06mAmerican Airlines
Tue 7/221:50 pmPTY - STL
2 stops19h 01mAmerican Airlines
Deal found 3/30$458
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/148:45 amMCI - PTY
1 stop7h 27mUnited Airlines
Wed 5/2110:00 amPTY - MCI
1 stop12h 20mUnited Airlines
Deal found 3/31$475
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/264:09 pmSGF - PTY
2 stops20h 10mAmerican Airlines
Sun 6/11:20 pmPTY - SGF
2 stops21h 24mAmerican Airlines
Deal found 3/30$488
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/275:45 amMCI - PTY
1 stop7h 10mDelta
Tue 5/62:20 pmPTY - MCI
1 stop9h 39mDelta
Deal found 3/30$493
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1312:59 pmMCI - PTY
2 stops23h 16mAmerican Airlines
Thu 4/171:15 pmPTY - MCI
2 stops19h 36mAmerican Airlines
Deal found 3/30$497
This Avianca Connect deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:35 amMCI - PTY
2 stops18h 35mMultiple Airlines
Tue 5/203:20 amPTY - MCI
2 stops19h 21mMultiple Airlines
Deal found 3/30$529
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/265:40 amSGF - PTY
1 stop7h 08mDelta
Sun 6/18:00 amPTY - SGF
1 stop10h 16mDelta
Deal found 3/30$553
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/268:35 amSGF - PTY
1 stop7h 37mUnited Airlines
Sun 6/13:20 pmPTY - SGF
2 stops19h 31mUnited Airlines
Deal found 3/30$725
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1510:10 amSTL - PTY
3 stops24h 00mMultiple Airlines
Sun 5/183:20 amPTY - STL
3 stops32h 50mMultiple Airlines
Deal found 3/30$768
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2612:09 pmSGF - PTY
3 stops26h 36mMultiple Airlines
Sat 5/313:20 amPTY - SGF
3 stops31h 59mMultiple Airlines
Deal found 3/30$1,027

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 5/20

8:30 am-4:12 pm

1 stop7h 42m

Panama City Tocumen Intl

Tue 6/3

7:55 am-10:15 pm

1 stop14h 20m

$429

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 5/7

6:00 am-12:48 pm

1 stop6h 48m

Panama City Tocumen Intl

Sun 5/11

2:13 pm-11:38 pm

1 stop9h 25m

$455

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 5/13

5:13 am-12:19 pm

1 stop7h 06m

Panama City Tocumen Intl

Tue 7/22

1:50 pm-8:51 am

2 stops19h 01m

$458

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 5/14

8:45 am-4:12 pm

1 stop7h 27m

Panama City Tocumen Intl

Wed 5/21

10:00 am-10:20 pm

1 stop12h 20m

$475

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Mon 5/26

4:09 pm-12:19 pm

2 stops20h 10m

Panama City Tocumen Intl

Sun 6/1

1:20 pm-10:44 am

2 stops21h 24m

$488

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 4/27

5:45 am-12:55 pm

1 stop7h 10m

Panama City Tocumen Intl

Tue 5/6

2:20 pm-11:59 pm

1 stop9h 39m

$493

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 4/13

12:59 pm-12:15 pm

2 stops23h 16m

Panama City Tocumen Intl

Thu 4/17

1:15 pm-8:51 am

2 stops19h 36m

$497

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Wed 5/14

5:35 am-12:10 am

2 stops18h 35m

Panama City Tocumen Intl

Tue 5/20

3:20 am-10:41 pm

2 stops19h 21m

$529

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Mon 5/26

5:40 am-12:48 pm

1 stop7h 08m

Panama City Tocumen Intl

Sun 6/1

8:00 am-6:16 pm

1 stop10h 16m

$553

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Mon 5/26

8:35 am-4:12 pm

1 stop7h 37m

Panama City Tocumen Intl

Sun 6/1

3:20 pm-10:51 am

2 stops19h 31m

$725

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 15 results
1
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 31, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Overall

8.0

Comfort

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Overall

8.0

Comfort

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Overall

8.0

Comfort

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Overall

8.0

Comfort

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,301 reviews
Delta
8.0
Very good
7,899 reviews

Overall

8.0

Comfort

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • What are the most popular routes from Missouri to Panama City?

    While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama City

Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$417Average$565FlexibilityNo cancel feeOn-time69%
DeltaCheapest$437Average$584FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$440Average$583FlexibilityNo cancel feeOn-time71%
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