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Panama City

$242+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated February 20, 2025.

Round-trip from

$455
(United)

One-way from

$242
(United Airlines)
From Missouri to Panama City Tocumen Intl
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One-way flight from Missouri to Panama City Tocumen Intl
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Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/278:25 amSTL - PTY
1 stop7h 47mUnited Airlines
Mon 6/1610:55 pmPTY - STL
1 stop11h 54mUnited Airlines
Deal found 2/19$452
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/316:00 amSTL - PTY
1 stop6h 55mDelta
Tue 4/82:23 pmPTY - STL
1 stop9h 07mDelta
Deal found 2/19$491
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:13 amSTL - PTY
1 stop7h 02mAmerican Airlines
Sun 5/111:20 pmPTY - STL
2 stops19h 36mAmerican Airlines
Deal found 2/18$494
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/126:15 amSGF - PTY
1 stop12h 22mUnited Airlines
Mon 5/197:55 amPTY - SGF
1 stop8h 20mUnited Airlines
Deal found 2/19$501
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/216:00 amMCI - PTY
1 stop6h 59mDelta
Mon 8/252:12 pmPTY - MCI
1 stop9h 41mDelta
Deal found 2/20$511
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/213:49 pmMCI - PTY
2 stops20h 26mAmerican Airlines
Mon 4/281:15 pmPTY - MCI
2 stops23h 14mAmerican Airlines
Deal found 2/19$516
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/158:45 amMCI - PTY
1 stop7h 27mUnited Airlines
Tue 5/207:55 amPTY - MCI
1 stop14h 25mUnited Airlines
Deal found 2/19$521
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/258:21 pmSGF - PTY
2 stops17h 54mAmerican Airlines
Tue 7/293:20 pmPTY - SGF
2 stops18h 14mAmerican Airlines
Deal found 2/19$566
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:43 pmMCI - PTY
3 stops22h 09mMultiple Airlines
Tue 5/207:55 amPTY - MCI
2 stops34h 32mMultiple Airlines
Deal found 2/20$673
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/512:15 pmSTL - PTY
3 stops35h 45mMultiple Airlines
Wed 3/128:05 pmPTY - STL
3 stops20h 37mMultiple Airlines
Deal found 2/19$799
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/288:25 amSTL - PTY
2 stops14h 55mAvianca
Fri 3/73:19 amPTY - STL
2 stops14h 52mAvianca
Deal found 2/20$1,837

Find flights from Missouri to Panama City within your budget

Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Missouri

Fly to

Panama City

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 4/5

4:56 pm-4:05 am

1 stop11h 09m

Panama City Tocumen Intl

Tue 4/8

10:00 am-10:09 pm

1 stop12h 09m

$455

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 3/22

6:45 pm-2:32 pm

2 stops19h 47m

Panama City Tocumen Intl

Thu 4/24

1:15 pm-9:01 am

2 stops19h 46m

$472

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 3/31

6:00 am-12:55 pm

1 stop6h 55m

Panama City Tocumen Intl

Tue 4/8

2:23 pm-11:30 pm

1 stop9h 07m

$491

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Mon 5/12

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 5/19

7:55 am-4:15 pm

1 stop8h 20m

$501

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 4/21

3:49 pm-12:15 pm

2 stops20h 26m

Panama City Tocumen Intl

Mon 4/28

1:15 pm-12:29 pm

2 stops23h 14m

$516

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 5/15

8:45 am-4:12 pm

1 stop7h 27m

Panama City Tocumen Intl

Tue 5/20

10:00 am-6:39 pm

1 stop8h 39m

$521

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Fri 7/25

8:21 pm-2:15 pm

2 stops17h 54m

Panama City Tocumen Intl

Tue 7/29

3:20 pm-9:34 am

2 stops18h 14m

$566

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 5/15

6:43 pm-4:52 pm

3 stops22h 09m

Panama City Tocumen Intl

Tue 5/20

7:55 am-6:27 pm

2 stops34h 32m

$673

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/5

12:15 pm-1:00 am

3 stops35h 45m

Panama City Tocumen Intl

Wed 3/12

8:05 pm-4:42 pm

3 stops20h 37m

$799

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Fri 2/28

8:25 am-12:20 am

2 stops14h 55m

Panama City Tocumen Intl

Fri 3/7

3:19 am-5:11 pm

2 stops14h 52m

$1,837

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 12 results
1
2

Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Panama City

Get recent, data-driven insights about flights from Missouri to Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated February 20, 2025.
See what other customers who have flown with Delta, United Airlines and American Airlines from Missouri to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta
8.0
Very good
8,220 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines
7.4
Good
8,766 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Avianca
6.8
Okay
2,435 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • What are the cheapest airlines to fly from Missouri to Panama City one-way?

    For one-way options, check prices for United Airlines. According to our data, you can fly for as low as $242. Users have also found prices from $291 and $336 on Delta and American Airlines, respectively.

  • What are the most popular routes from Missouri to Panama City?

    While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama City

Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$417Average$560FlexibilityNo cancel feeOn-time69%
DeltaCheapest$437Average$590FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$465Average$591FlexibilityNo cancel feeOn-time71%
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