Panama City

$222+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Jan 26 — Feb 21
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Cheap flight deals from Missouri to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$469
(United)

One-way from

$222
(American Airlines)
From Missouri to Panama City Tocumen Intl
One-way flight from Missouri to Panama City Tocumen Intl

Find flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This United deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/126:15 amSTL - PTY
1 stop12h 23mUnited Airlines
Thu 3/203:40 pmPTY - STL
1 stop18h 11mUnited Airlines
Deal found 1/21$469
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/125:06 amSTL - PTY
2 stops9h 26mAmerican Airlines
Thu 3/201:05 pmPTY - STL
2 stops19h 04mAmerican Airlines
Deal found 1/20$473
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:30 amMCI - PTY
1 stop12h 07mUnited Airlines
Mon 10/63:40 pmPTY - MCI
1 stop18h 00mUnited Airlines
Deal found 1/19$501
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/196:15 amSGF - PTY
1 stop9h 52mUnited Airlines
Wed 2/264:40 pmPTY - SGF
2 stops22h 54mUnited Airlines
Deal found 1/21$546
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/204:28 pmSGF - PTY
2 stops20h 02mAmerican Airlines
Thu 2/274:40 pmPTY - SGF
2 stops19h 50mAmerican Airlines
Deal found 1/21$566
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/811:04 amSTL - PTY
1 stop7h 57mDelta
Wed 2/123:27 pmPTY - STL
1 stop9h 09mDelta
Deal found 1/20$569
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/205:40 pmSGF - PTY
1 stop25h 21mDelta
Wed 2/263:27 pmPTY - SGF
1 stop7h 55mDelta
Deal found 1/21$571
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/35:35 amMCI - PTY
1 stop7h 27mDelta
Sat 2/88:05 amPTY - MCI
1 stop8h 01mDelta
Deal found 1/20$601
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/207:01 amMCI - PTY
1 stop7h 49mAmerican Airlines
Mon 2/244:40 pmPTY - MCI
1 stop8h 52mAmerican Airlines
Deal found 1/20$611
This Mytrip deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1612:15 pmSTL - PTY
3 stops35h 05mMultiple Airlines
Sat 2/223:19 amPTY - STL
3 stops33h 11mMultiple Airlines
Deal found 1/19$735
This Avianca deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/28:15 amSTL - PTY
2 stops15h 05mAvianca
Sun 2/96:30 pmPTY - STL
2 stops16h 54mAvianca
Deal found 1/21$813
This Mytrip deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/154:17 pmMCI - PTY
3 stops31h 03mMultiple Airlines
Fri 2/213:19 amPTY - MCI
3 stops35h 49mMultiple Airlines
Deal found 1/21$859

Find flights from Missouri to Panama City within your budget

Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 3/12

6:15 am-6:38 pm

1 stop12h 23m

Panama City Tocumen Intl

Thu 3/20

3:40 pm-9:51 am

1 stop18h 11m

$469

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 4/21

6:00 am-12:51 pm

1 stop6h 51m

Panama City Tocumen Intl

Sat 4/26

8:05 am-4:27 pm

1 stop8h 22m

$489

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 5/25

6:36 pm-4:12 pm

2 stops21h 36m

Panama City Tocumen Intl

Thu 5/29

3:20 pm-2:25 pm

2 stops23h 05m

$506

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 2/26

5:37 pm-1:30 pm

2 stops18h 53m

Panama City Tocumen Intl

Thu 3/13

3:30 pm-1:00 pm

2 stops21h 30m

$514

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Wed 2/19

6:15 am-5:07 pm

1 stop9h 52m

Panama City Tocumen Intl

Wed 2/26

4:40 pm-2:34 pm

2 stops22h 54m

$546

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Thu 2/20

4:28 pm-1:30 pm

2 stops20h 02m

Panama City Tocumen Intl

Thu 2/27

4:40 pm-11:30 am

2 stops19h 50m

$566

SpringfieldPanama City

SGF - PTY

SGFPTY

Springfield-Branson

Thu 2/20

5:40 pm-8:01 pm

1 stop25h 21m

Panama City Tocumen Intl

Wed 2/26

3:27 pm-10:22 pm

1 stop7h 55m

$571

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sat 2/15

7:00 am-8:01 pm

1 stop12h 01m

Panama City Tocumen Intl

Sat 2/22

3:27 pm-11:54 pm

1 stop9h 27m

$601

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 2/20

6:37 pm-1:30 pm

2 stops17h 53m

Panama City Tocumen Intl

Mon 2/24

4:40 pm-11:58 am

2 stops20h 18m

$616

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 5/15

1:00 pm-12:10 am

3 stops35h 10m

Panama City Tocumen Intl

Sat 5/17

3:20 am-6:27 pm

2 stops15h 07m

$761

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Panama City

Get recent, data-driven insights about flights from Missouri to Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to PTY?

Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 21, 2025.
See what other customers who have flown with United Airlines, American Airlines and Delta from Missouri to Panama City have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good
8,521 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

8.0
Very good
8,521 reviews
8.0
Very good
8,521 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.4
Good
8,984 reviews
8.0
Very good
8,521 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.2
Good
10,000 reviews
8.0
Very good
8,521 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

6.9
Okay
2,579 reviews
8.0
Very good
8,521 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.6

Comfort

8.0

Food

7.3

Overall

8.0

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Panama City from Missouri?

    If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • What are the cheapest airlines to fly from Missouri to Panama City one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $222. Users have also found prices from $237 and $238 on United Airlines and Delta, respectively.

  • What are the most popular routes from Missouri to Panama City?

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Panama City (average of $478). Flying from Missouri to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Panama City

Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$397Average$548FlexibilityNo cancel feeOn-time69%
DeltaCheapest$437Average$601FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$440Average$581FlexibilityNo cancel feeOn-time71%
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