What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $357 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $407 and $550 round-trip. You may be able to fly from Knoxville to Panama City, Florida for 36% less than the average price by searching for these airlines.

What is the cheapest day to fly from Knoxville to Panama City, Florida?

Travelers seeking maximum savings on their Knoxville to Panama City, Florida flight should consider departing on Saturday afternoons when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Knoxville to Panama City, Florida?

Friday flights are found to be more expensive to fly from Knoxville to Panama City, Florida. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City, Florida.

How far in advance should I book a flight from Knoxville to Panama City, Florida?

Users have found that booking a flight from Knoxville to Panama City, Florida at least 40 days early can save you up to 149% on average compared to booking a flight this week. If booking 40 days before your flight isn’t an option for you, users have found flights from Knoxville to Panama City, Florida for as little as $614 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $723 for flights departing within the next 3 days.

What is the cheapest month to fly from Knoxville to Panama City, Florida?

Flights from Knoxville to Panama City, Florida lean towards being more expensive in March. Prices are generally better when you fly from Knoxville to Panama City, Florida in August, with the cheapest ticket starting at $358.

Most accurate provider : When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

Can I find deals for business class flights from Knoxville to Panama City?

Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$357+ Flights from Knoxville to Panama City, FL

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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3. Compare prices and book

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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Panama City NW Florida Beaches are usually found in August or September, booked 40 days in advance, depart on a Tuesday or Friday and return on a Tuesday

Cheap flight deals from Knoxville to Panama City

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$357 (Delta)
Popular in	March
Cheapest in	August
Average price	$977

Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.

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From Knoxville McGhee Tyson to Panama City NW Florida Beaches

Search Deals

Highest demand for flights based on searches. 20% potential increase in price ($148 potential increase over avg. RT price).

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Cheapest flight prices on average. 7% potential price decrease ($38 potential savings vs. average RT price).

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Average for round-trip flights in March 2025

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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Fri 5/27:24 pmTYS - ECP

1 stop4h 39mDelta

Tue 5/66:00 amECP - TYS

1 stop4h 09mDelta

Deal found 3/24

$357

Sat 6/148:13 pmTYS - ECP

1 stop4h 36mAmerican Airlines

Sat 6/215:30 amECP - TYS

1 stop4h 03mAmerican Airlines

Deal found 3/24

$407

Fri 5/167:00 amTYS - ECP

2 stops14h 19mUnited Airlines

Tue 5/202:15 pmECP - TYS

1 stop22h 07mUnited Airlines

Deal found 3/25

$550

Best flights from Knoxville to Panama City
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 25, 2025.

Fri 5/27:24 pmTYS - ECP

1 stop4h 39mDelta

Tue 5/66:00 amECP - TYS

1 stop4h 09mDelta

Deal found 3/24

$357

Sat 6/148:13 pmTYS - ECP

1 stop4h 36mAmerican Airlines

Sat 6/215:30 amECP - TYS

1 stop4h 03mAmerican Airlines

Deal found 3/24

$407

Fri 5/167:00 amTYS - ECP

2 stops14h 19mUnited Airlines

Tue 5/202:15 pmECP - TYS

1 stop22h 07mUnited Airlines

Deal found 3/25

$550

Last-minute flights from Knoxville to Panama City
Discover last-minute flight deals from Knoxville to Panama City. Data last updated March 25, 2025 and is based on user searches.

Fri 3/2811:07 amTYS - ECP

1 stop5h 46mAmerican Airlines

Sun 3/302:41 pmECP - TYS

1 stop5h 46mAmerican Airlines

Deal found 3/24

$587

Mon 3/315:45 amTYS - ECP

1 stop5h 32mDelta

Sun 4/137:23 amECP - TYS

1 stop5h 27mDelta

Deal found 3/24

$477

Mon 3/315:25 pmTYS - ECP

1 stop21h 00mUnited Airlines

Sun 4/134:58 pmECP - TYS

2 stops22h 46mUnited Airlines

Deal found 3/24

$657

Thu 4/105:25 pmTYS - ECP

2 stops20h 15mUnited Airlines

Sun 4/134:58 pmECP - TYS

2 stops22h 46mUnited Airlines

Deal found 3/24

$578

Thu 4/247:24 pmTYS - ECP

1 stop4h 39mDelta

Wed 4/307:30 amECP - TYS

1 stop5h 18mDelta

Deal found 3/24

$357

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 5/2

7:24 pm-11:03 pm

1 stop4h 39m

Panama City NW Florida Beaches

Tue 5/6

6:00 am-11:09 am

1 stop4h 09m

$357

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 6/14

8:13 pm-11:49 pm

1 stop4h 36m

Panama City NW Florida Beaches

Sat 6/21

5:30 am-10:33 am

1 stop4h 03m

$407

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 5/16

7:00 am-8:19 pm

2 stops14h 19m

Panama City NW Florida Beaches

Tue 5/20

2:15 pm-1:22 pm

1 stop22h 07m

$550

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/24

Compare providers for flights from Knoxville to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in March.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

How far ahead should I book a flight from Knoxville to Panama City, Florida?

The price you pay for your flight from Knoxville to Panama City, Florida may vary depending on when you book. For the best chance of a lower fare, look to book 39 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ECP?

It’s typically best to fly out from Knoxville to Panama City, Florida in the morning. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

To help decide which airline to fly from Knoxville to Panama City, see what other customers have to say about Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Delta

8.0

Very good

7,890 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

United Airlines

7.4

Good

8,605 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,890 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Related info for your journey

What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?
Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $357 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $407 and $550 round-trip. You may be able to fly from Knoxville to Panama City, Florida for 36% less than the average price by searching for these airlines.
Can I find deals for flights from Knoxville to Panama City that include hotel bookings?
Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.
Can I find deals for business class flights from Knoxville to Panama City?
Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 2 airlines flying from Knoxville to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$358	Average$497	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$378	Average$536	FlexibilityNo cancel fee	On-time71%

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$357+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Panama City NW Florida Beaches are usually found in August or September, booked 40 days in advance, depart on a Tuesday or Friday and return on a Tuesday

Cheap flight deals from Knoxville to Panama City

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in March.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

How far ahead should I book a flight from Knoxville to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Panama City. Price data was last updated on March 21, 2025.

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

What is the cheapest time of day to fly from TYS to ECP?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 25, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

To help decide which airline to fly from Knoxville to Panama City, see what other customers have to say about Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

How can I find direct flights from Knoxville to Panama City?

Can I find deals for business class flights from Knoxville to Panama City?

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

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Alternative routes for Knoxville to Panama City

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Top 2 airlines flying from Knoxville to Panama City

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Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2025.