HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$299+ Cheap flights from Greenville to Panama City, FL (GSP - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — ECP
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Greenville to Panama City

Cheapest flights from Greenville to Panama City
Explore the most affordable flight options available from Greenville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:12 amGSP - ECP
1 stop5h 25mAmerican Airlines
Mon 12/294:09 pmECP - GSP
1 stop4h 34mAmerican Airlines
Deal found 12/10$584
This Delta deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:36 pmGSP - ECP
1 stop4h 30mDelta
Sun 12/146:00 amECP - GSP
1 stop4h 15mDelta
Deal found 12/9$627
This Southwest deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:35 amGSP - ECP
1 stop9h 30mSouthwest
Sun 12/141:30 pmECP - GSP
2 stops7h 05mSouthwest
Deal found 12/9$703
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:20 pmGSP - ECP
1 stop6h 33mAmerican Airlines
Thu 1/17:15 amECP - GSP
1 stop5h 48mAmerican Airlines
Deal found 12/10$713
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:40 amGSP - ECP
2 stops24h 37mUnited Airlines
Mon 12/292:55 pmECP - GSP
1 stop6h 02mUnited Airlines
Deal found 12/10$726
This Southwest deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:40 amGSP - ECP
2 stops11h 15mSouthwest
Thu 1/17:15 amECP - GSP
1 stop7h 50mSouthwest
Deal found 12/10$727

Find flight deals from Greenville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$299
(Delta)

One-way from

$145
(American Airlines)

Popular in

October

Cheapest in

June

Average price

$423
Provider with most accurate pricing for Greenville-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Panama City NW Florida Beaches flights.
Search Deals
From Greenville to Panama City NW Florida Beaches
Search Deals
One-way flight from Greenville to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 28% potential increase in price ($161 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Greenville to Panama City that are best for you.

Fly from

Greenville

Fly to

Panama City

Route

Depart

Return

Price

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 1/13

6:50 am-9:12 am

1 stop3h 22m

Panama City NW Florida Beaches

Mon 1/19

6:09 pm-11:50 pm

1 stop4h 41m

$299

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 2/22

10:50 am-4:45 pm

1 stop6h 55m

Panama City NW Florida Beaches

Thu 2/26

12:35 pm-7:05 pm

1 stop5h 30m

$323

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 1/13

11:15 am-6:10 pm

1 stop7h 55m

Panama City NW Florida Beaches

Mon 1/19

10:10 am-6:00 pm

2 stops6h 50m

$389

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 2/21

6:50 am-12:04 pm

1 stop6h 14m

Panama City NW Florida Beaches

Wed 2/25

6:30 am-3:36 pm

1 stop8h 06m

$425

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 1/13

7:42 pm-11:33 am

2 stops16h 51m

Panama City NW Florida Beaches

Mon 1/19

1:34 pm-9:47 am

2 stops19h 13m

$529

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Thu 12/25

11:12 am-3:37 pm

1 stop5h 25m

Panama City NW Florida Beaches

Mon 12/29

4:09 pm-9:43 pm

1 stop4h 34m

$584

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 12/28

6:20 pm-11:53 pm

1 stop6h 33m

Panama City NW Florida Beaches

Thu 1/1

7:15 am-2:03 pm

1 stop5h 48m

$713

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Thu 12/25

9:40 am-9:17 am

2 stops24h 37m

Panama City NW Florida Beaches

Mon 12/29

2:55 pm-9:57 pm

1 stop6h 02m

$726

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 12/28

7:40 am-5:55 pm

2 stops11h 15m

Panama City NW Florida Beaches

Thu 1/1

7:15 am-4:05 pm

1 stop7h 50m

$727

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/11

Compare providers for flights from Greenville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to Panama City

What is the cheapest month to book a flight from Greenville to Panama City, Florida?

Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City, Florida (average of $65). Flying from Greenville to Panama City, Florida in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to ECP?

Find hourly flight availability from Greenville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s typically best to fly out from Greenville to Panama City, Florida in the evening. Doing so could potentially save you 21% on the flight price compared to flying in the morning, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta from Greenville to Panama City to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Greenville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to Panama City, Florida?

    There are many flights that can get you from Greenville to Panama City, Florida in 3h 22m. Fly via Delta, Southwest, or United Airlines to get the fastest option. Greenville and Panama City, Florida are separated by a distance of 376 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Greenville to Panama City, Florida round-trip?

    Our cheapest airline available from Greenville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $254 on this airline. Delta is currently priced 37% below the average price you’ll pay for this route.

  • Can I find deals for flights from Greenville to Panama City that include hotel bookings?

    Yes. In addition to deals on Greenville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to Panama City.

  • Can I find deals for business class flights from Greenville to Panama City?

    Yes. Cheapflights offers flight deals from Greenville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to Panama City, Florida?

    Currently, August is the cheapest month in which you can book a flight from Greenville to Panama City, Florida (average of $65). Flying from Greenville to Panama City, Florida in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Miami flights
Charlotte to Orlando flights
Charlotte to Fort Lauderdale flights
Charlotte to Tampa flights
Charleston to Miami flights
Charlotte to Fort Myers flights
Charleston to Fort Lauderdale flights
Greenville to Miami flights
Charlotte to Sarasota flights
Charlotte to West Palm Beach flights
Columbia to Orlando flights
Charlotte to Key West flights
Charleston to Tampa flights
Charlotte to Jacksonville flights
Myrtle Beach to Fort Lauderdale flights
Columbia to Miami flights
Savannah to Miami flights
Myrtle Beach to Miami flights
Charleston to Orlando flights
Myrtle Beach to Orlando flights
Charlotte to Pensacola flights
Greenville to Orlando flights
Charlotte to Panama City flights
Charleston to Key West flights
Columbia to Tampa flights
Savannah to Fort Lauderdale flights
Charleston to Fort Myers flights
Greenville to Fort Lauderdale flights
Savannah to Orlando flights
Columbia to West Palm Beach flights
Myrtle Beach to Fort Myers flights
Myrtle Beach to Key West flights
Charlotte to Melbourne flights
Savannah to Fort Myers flights
Greenville to Sarasota flights
Greenville to Tampa flights
Charleston to Sarasota flights
Charlotte to Valparaiso flights
Charlotte to Tallahassee flights
Columbia to Fort Lauderdale flights
Savannah to Pensacola flights
Myrtle Beach to West Palm Beach flights
Augusta to Fort Lauderdale flights
Greenville to Key West flights
Augusta to Miami flights
Charleston to West Palm Beach flights
Savannah to Tampa flights
Greenville to West Palm Beach flights
Myrtle Beach to Tampa flights
Charlotte to St Petersburg flights

Top airline flying from Greenville to Panama City

Discover the top airline that operate flights from Greenville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$266Average$372FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.