HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$154+ Cheap flights from Florida Keys to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — ECP
Mar 19 — Mar 261
Wed 3/19
Wed 3/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to Panama City with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to Panama City

Keep the following information in mind while searching for Florida Keys to Panama City flight deals. Data was last updated March 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$272
(Delta)

One-way from

$154
(American Airlines)
Provider with most accurate pricing for Key West-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Panama City NW Florida Beaches flights.
Search Deals
From Florida Keys to Panama City NW Florida Beaches
Search Deals
One-way flight from Florida Keys to Panama City NW Florida Beaches
Search Deals

Find flight deals from Florida Keys to Panama City

Cheapest flights from Florida Keys to Panama City
Explore the most affordable flight options available from Florida Keys to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 14, 2025.

This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/225:35 amMIA - ECP
1 stop3h 51mDelta
Sat 5/245:10 pmECP - MIA
1 stop6h 27mDelta
Deal found 3/13$272
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1510:15 amMIA - ECP
1 stop4h 15mAmerican Airlines
Wed 4/232:27 pmECP - MIA
1 stop6h 56mAmerican Airlines
Deal found 3/13$297
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/207:00 amEYW - ECP
1 stop3h 49mDelta
Wed 5/286:00 amECP - EYW
1 stop3h 51mDelta
Deal found 3/12$317
This Southwest deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/153:30 pmMIA - ECP
1 stop6h 45mSouthwest
Wed 4/2311:25 amECP - MIA
2 stops9h 30mSouthwest
Deal found 3/13$322
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/247:29 pmEYW - ECP
2 stops17h 26mAmerican Airlines
Fri 5/3010:22 amECP - EYW
1 stop5h 18mAmerican Airlines
Deal found 3/12$551
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/236:22 amMIA - ECP
1 stop14h 47mUnited Airlines
Fri 4/253:00 pmECP - MIA
2 stops19h 48mUnited Airlines
Deal found 3/12$570

Find flights from Florida Keys to Panama City within your budget

Customize your flight search to find flights from Florida Keys to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 14, 2025.

Fly from

Florida Keys

Fly to

Panama City

Route

Depart

Return

Price

MiamiPanama City

MIA - ECP

MIAECP

Miami

Thu 5/22

5:35 am-8:26 am

1 stop3h 51m

Panama City NW Florida Beaches

Sat 5/24

5:10 pm-12:37 am

1 stop6h 27m

$272

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 4/15

10:15 am-1:30 pm

1 stop4h 15m

Panama City NW Florida Beaches

Wed 4/23

2:27 pm-10:23 pm

1 stop6h 56m

$297

Key WestPanama City

EYW - ECP

EYWECP

Key West

Tue 5/20

7:00 am-9:49 am

1 stop3h 49m

Panama City NW Florida Beaches

Wed 5/28

6:00 am-10:51 am

1 stop3h 51m

$317

MiamiPanama City

MIA - ECP

MIAECP

Miami

Tue 4/15

3:30 pm-9:15 pm

1 stop6h 45m

Panama City NW Florida Beaches

Wed 4/23

11:25 am-9:55 pm

2 stops9h 30m

$322

Key WestPanama City

EYW - ECP

EYWECP

Key West

Sat 5/24

7:29 pm-11:55 am

2 stops17h 26m

Panama City NW Florida Beaches

Fri 5/30

10:22 am-4:40 pm

1 stop5h 18m

$551

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 4/23

6:22 am-8:09 pm

1 stop14h 47m

Panama City NW Florida Beaches

Fri 4/25

3:00 pm-11:48 am

2 stops19h 48m

$570

MiamiPanama City

MIA - ECP

MIAECP

Miami

Sun 5/4

6:00 am-9:28 am

1 stop4h 28m

$154

MiamiPanama City

MIA - ECP

MIAECP

Miami

Wed 4/9

8:10 am-12:48 pm

1 stop5h 38m

$159

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 4/11

8:15 am-2:25 pm

1 stop7h 10m

$206

MiamiPanama City

MIA - ECP

MIAECP

Miami

Fri 4/11

4:07 pm-8:09 pm

2 stops29h 02m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Showing 1-10 of 13 results
1
2

Best time to book a flight from Florida Keys to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Florida Keys to Panama City

Get recent, data-driven insights about flights from Florida Keys to Panama City including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Florida Keys to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to Panama City, Florida (average of $346). Flying from Florida Keys to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 14, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Florida Keys to Panama City. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,292 reviews

Comfort

8.1

Boarding

8.2

Food

7.1

Crew

8.7

Overall

8.1

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,292 reviews
Southwest
8.1
Very good
4,292 reviews

Comfort

8.1

Boarding

8.2

Food

7.1

Crew

8.7

Overall

8.1

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
7,944 reviews
Southwest
8.1
Very good
4,292 reviews

Comfort

8.1

Boarding

8.2

Food

7.1

Crew

8.7

Overall

8.1

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,623 reviews
Southwest
8.1
Very good
4,292 reviews

Comfort

8.1

Boarding

8.2

Food

7.1

Crew

8.7

Overall

8.1

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,292 reviews

Comfort

8.1

Boarding

8.2

Food

7.1

Crew

8.7

Overall

8.1

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Florida Keys?

    Most people fly into Panama City NW Florida Beaches (ECP) if they book a flight to Panama City from Florida Keys. NW Florida Beaches is conveniently located just 16.0 mi from Panama City’s city center.

  • What are the cheapest airlines to fly from Florida Keys to Panama City, Florida one-way?

    $154 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and Southwest, with prices starting from $159 and $206, respectively.

  • Can I find deals for flights from Florida Keys to Panama City that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Panama City.

  • Can I find deals for business class flights from Florida Keys to Panama City?

    Yes. Cheapflights offers flight deals from Florida Keys to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Panama City, Florida (average of $346). Flying from Florida Keys to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Tampa to Miami flights
Tampa to Fort Lauderdale flights
Fort Lauderdale to Tampa flights
Miami to Tampa flights
Orlando to Miami flights
Tampa to Key West flights
Miami to Orlando flights
Fort Lauderdale to Orlando flights
Jacksonville to Miami flights
Fort Lauderdale to Jacksonville flights
Orlando to Key West flights
Fort Lauderdale to Pensacola flights
Miami to Jacksonville flights
Jacksonville to Fort Lauderdale flights
Pensacola to Orlando flights
Orlando to Fort Lauderdale flights
Pensacola to Fort Lauderdale flights
Pensacola to Tampa flights
Fort Lauderdale to Tallahassee flights
Tampa to Pensacola flights
Pensacola to Miami flights
Orlando to Pensacola flights
Miami to Pensacola flights
Miami to Tallahassee flights
Tallahassee to Fort Lauderdale flights
Tallahassee to Miami flights
Jacksonville to Key West flights
Fort Lauderdale to Key West flights
Tampa to West Palm Beach flights
West Palm Beach to Pensacola flights
Miami to Key West flights
West Palm Beach to Tampa flights
Tampa to Panama City flights
Miami to Panama City flights
West Palm Beach to Jacksonville flights
Pensacola to Key West flights
Fort Lauderdale to Panama City flights
Tampa to Tallahassee flights
West Palm Beach to Tallahassee flights
Orlando to Panama City flights
Fort Myers to Jacksonville flights
Fort Myers to Orlando flights
Orlando to Valparaiso flights
Sarasota to Key West flights
Pensacola to Fort Myers flights
Jacksonville to West Palm Beach flights
Gainesville to Miami flights
Key West to Orlando flights
Fort Myers to Key West flights
Sarasota to Miami flights
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.