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$214+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Mar 31 — Apr 71
Mon 3/31
Mon 4/7
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in September or October, booked 33 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 26, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$297
(American Airlines)

One-way from

$214
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$656
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
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From Des Moines to Panama City NW Florida Beaches
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One-way flight from Des Moines to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 9% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/301:12 pmDSM - ECP
1 stop7h 22mAmerican Airlines
Sat 5/316:47 amECP - DSM
1 stop5h 18mAmerican Airlines
Deal found 3/25$297
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/132:14 pmDSM - ECP
1 stop5h 22mDelta
Sat 9/201:30 pmECP - DSM
1 stop4h 08mDelta
Deal found 3/25$367
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/178:30 amDSM - ECP
2 stops7h 25mSouthwest
Sat 5/248:45 amECP - DSM
2 stops7h 05mSouthwest
Deal found 3/25$413
This United deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/86:45 pmDSM - ECP
2 stops25h 34mUnited Airlines
Tue 5/138:50 amECP - DSM
2 stops11h 44mUnited Airlines
Deal found 3/25$482

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 5/30

1:12 pm-8:34 pm

1 stop7h 22m

Panama City NW Florida Beaches

Sat 5/31

6:47 am-12:05 pm

1 stop5h 18m

$297

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 4/12

5:45 am-9:58 am

1 stop4h 13m

Panama City NW Florida Beaches

Sat 4/19

6:00 am-4:38 pm

2 stops10h 38m

$412

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 5/17

8:30 am-3:55 pm

2 stops7h 25m

Panama City NW Florida Beaches

Sat 5/24

8:45 am-3:50 pm

2 stops7h 05m

$413

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 5/8

6:45 pm-8:19 pm

2 stops25h 34m

Panama City NW Florida Beaches

Tue 5/13

8:50 am-8:34 pm

2 stops11h 44m

$482

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 4/11

12:49 pm-8:37 pm

1 stop7h 48m

$214

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 5/23

6:35 pm-11:04 pm

1 stop4h 29m

$229

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 4/11

8:47 am-8:09 pm

2 stops11h 22m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on March 21, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 33 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to ECP?

Find hourly flight availability from Des Moines to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2025.

One of the essential ways to save on airfare from Des Moines to Panama City, Florida is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 6% on airfare.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 26, 2025.
To help decide which airline to fly from Des Moines to Panama City, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,273 reviews

Crew

8.6

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Comfort

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.1
Very good
4,273 reviews
Southwest
8.1
Very good
4,273 reviews

Crew

8.6

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Comfort

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,891 reviews
Southwest
8.1
Very good
4,273 reviews

Crew

8.6

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Comfort

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,608 reviews
Southwest
8.1
Very good
4,273 reviews

Crew

8.6

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Comfort

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,273 reviews

Crew

8.6

Overall

8.1

Boarding

8.2

Entertainment

7.6

Food

7.1

Comfort

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $297. Other airlines that can offer you cheap pricing are Delta, from $412, and Southwest, from $413. American Airlines is priced at 31% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?

    One-way options have recently been found by users for as low as $214 on American Airlines. Other airlines that offer cheap prices include Delta from $229 and United Airlines from $254 one-way.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $462). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

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Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$399FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$488FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$302Average$477FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$306Average$421FlexibilityNo cancel feeOn-time63%
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