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$79+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$161
(CheapOair)

One-way from

$79
(Cheapflightsfares)

Popular in

December

Cheapest in

February

Average price

$386

Good round-trip deal

$336 or less

Good one-way deal

$158 or less
Provider with most accurate pricing for Myrtle Beach Intl-Kansas City flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Kansas City flights.
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From South Carolina to Missouri
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One-way flight from South Carolina to Missouri
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Highest demand for flights based on searches. 1% potential increase in price ($3 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Price to beat on a round-trip flight from South Carolina to Missouri.
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Price to beat on a one-way flight from South Carolina to Missouri.
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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This CheapOair deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/164:21 pmCLT - STL
1 stop8h 53mFrontier
Sun 5/185:45 pmSTL - CLT
1 stop14h 12mFrontier
Deal found 4/22$161
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:40 pmCLT - MCI
1 stop4h 30mSouthwest
Tue 5/2012:45 pmMCI - CLT
1 stop7h 35mSouthwest
Deal found 4/22$193
This Priceline deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:42 pmCLT - STL
1 stop6h 24mMultiple Airlines
Tue 5/66:10 pmSTL - CLT
1 stop5h 17mMultiple Airlines
Deal found 4/21$208
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/315:10 amCAE - STL
1 stop4h 08mAmerican Airlines
Sun 6/16:47 pmSTL - CAE
1 stop4h 07mAmerican Airlines
Deal found 4/23$224
This Booking.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2211:23 amCLT - MCI
1 stop12h 18mSpirit Airlines
Tue 5/275:46 amMCI - CLT
1 stop9h 05mSpirit Airlines
Deal found 4/23$227
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/67:59 pmCAE - STL
1 stop4h 39mDelta
Thu 6/126:00 amSTL - CAE
1 stop5h 58mDelta
Deal found 4/24$249
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/133:43 pmCAE - MCI
1 stop5h 44mDelta
Tue 5/205:45 amMCI - CAE
1 stop6h 18mDelta
Deal found 4/23$249
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/218:30 pmCLT - STL
Nonstop1h 56mAmerican Airlines
Wed 5/285:12 amSTL - CLT
Nonstop1h 58mAmerican Airlines
Deal found 4/23$255
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2410:20 amGSP - STL
1 stop4h 50mSouthwest
Wed 5/282:55 pmSTL - GSP
1 stop4h 15mSouthwest
Deal found 4/23$257
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:10 amCAE - MCI
2 stops7h 30mAmerican Airlines
Sat 5/177:11 amMCI - CAE
1 stop7h 33mAmerican Airlines
Deal found 4/23$259
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/245:18 pmGSP - STL
1 stop6h 09mUnited Airlines
Wed 5/285:00 amSTL - GSP
2 stops8h 17mUnited Airlines
Deal found 4/23$262
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/244:15 pmCLT - MCI
Nonstop2h 20mAmerican Airlines
Sat 6/285:06 amMCI - CLT
Nonstop2h 19mAmerican Airlines
Deal found 4/23$263

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from South Carolina to Missouri that are best for you.

Fly from

South Carolina

Fly to

Missouri

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Fri 5/16

4:21 pm-12:14 am

1 stop8h 53m

Lambert-St Louis

Sun 5/18

5:45 pm-8:57 am

1 stop14h 12m

$161

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Wed 5/14

6:40 pm-10:10 pm

1 stop4h 30m

Kansas City

Tue 5/20

12:45 pm-9:20 pm

1 stop7h 35m

$193

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 5/3

6:42 pm-12:06 am

1 stop6h 24m

Lambert-St Louis

Tue 5/6

6:10 pm-12:27 am

1 stop5h 17m

$208

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 5/31

5:10 am-8:18 am

1 stop4h 08m

Lambert-St Louis

Sun 6/1

6:47 pm-11:54 pm

1 stop4h 07m

$224

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Thu 5/22

11:23 am-10:41 pm

1 stop12h 18m

Kansas City

Tue 5/27

5:46 am-3:51 pm

1 stop9h 05m

$227

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Fri 6/6

7:59 pm-11:38 pm

1 stop4h 39m

Lambert-St Louis

Thu 6/12

6:00 am-12:58 pm

1 stop5h 58m

$249

ColumbiaKansas City

CAE - MCI

CAEMCI

Columbia Metropolitan

Tue 5/13

3:43 pm-8:27 pm

1 stop5h 44m

Kansas City

Tue 5/20

5:45 am-1:03 pm

1 stop6h 18m

$249

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 5/21

8:30 pm-9:26 pm

Nonstop1h 56m

Lambert-St Louis

Wed 5/28

5:12 am-8:10 am

Nonstop1h 58m

$255

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Sat 5/24

5:18 pm-10:27 pm

1 stop6h 09m

Lambert-St Louis

Wed 5/28

8:15 am-2:17 pm

1 stop5h 02m

$257

ColumbiaKansas City

CAE - MCI

CAEMCI

Columbia Metropolitan

Tue 5/13

5:10 am-11:40 am

2 stops7h 30m

Kansas City

Sat 5/17

7:11 am-3:44 pm

1 stop7h 33m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Missouri

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Missouri as you normally would.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 24, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from South Carolina to Missouri to help guide your decision. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,685 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Sun Country Air
6.9
Okay
349 reviews
Southwest
8.0
Very good
4,287 reviews

Food

7.1

Crew

8.6

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this South Carolina to Missouri flight route?

    The South Carolina to Missouri flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from South Carolina to Missouri one-way?

    One-way options have recently been found by users for as low as $79 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $112 and Sun Country Air from $123 one-way.

  • Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

    Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

  • Can I find deals for business class flights from South Carolina to Missouri?

    Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Missouri?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to Missouri

Discover the top 5 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$139Average$360FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$139Average$243FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$170Average$383FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$174Average$366FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$286Average$389FlexibilityNo cancel feeOn-time63%

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