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$52+ Cheap flights from South Carolina to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — STL
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Missouri

Keep the following information in mind while searching for South Carolina to Missouri flight deals. Data was last updated February 20, 2025.

Round-trip from

$124
(CheapOair)

One-way from

$52
(Booking.com)

Good round-trip deal

$347 or less

Good one-way deal

$208 or less
From South Carolina to Missouri
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One-way flight from South Carolina to Missouri
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Price to beat on a round-trip flight from South Carolina to Missouri.
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Price to beat on a one-way flight from South Carolina to Missouri.
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Find flight deals from South Carolina to Missouri

Cheapest flights from South Carolina to Missouri
Explore the most affordable flight options available from South Carolina to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/57:58 amCLT - STL
1 stop16h 48mFrontier
Tue 4/84:57 pmSTL - CLT
1 stop23h 49mFrontier
Deal found 2/20$124
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/311:02 amCHS - STL
1 stop7h 50mSpirit Airlines
Sun 4/66:47 pmSTL - CHS
1 stop13h 46mSpirit Airlines
Deal found 2/19$150
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1010:30 amCLT - STL
1 stop7h 46mSpirit Airlines
Sun 4/136:11 pmSTL - CLT
1 stop14h 24mSpirit Airlines
Deal found 2/20$172
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/98:31 amCLT - STL
1 stop16h 15mMultiple Airlines
Sun 4/136:11 pmSTL - CLT
1 stop21h 05mMultiple Airlines
Deal found 2/20$174
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/87:54 pmCLT - MCI
1 stop23h 41mMultiple Airlines
Wed 3/1210:20 amMCI - CLT
1 stop5h 49mMultiple Airlines
Deal found 2/20$178
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/38:20 pmCLT - MCI
1 stop17h 35mSpirit Airlines
Fri 3/710:20 amMCI - CLT
1 stop5h 49mSpirit Airlines
Deal found 2/20$203
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2812:29 pmSAV - MCI
1 stop27h 34mMultiple Airlines
Mon 3/34:17 pmMCI - SAV
1 stop5h 46mMultiple Airlines
Deal found 2/20$214
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2911:14 amCHS - STL
1 stop7h 02mMultiple Airlines
Fri 5/29:50 amSTL - CHS
3 stops29h 10mMultiple Airlines
Deal found 2/19$220
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/56:32 pmCAE - STL
1 stop3h 52mAmerican Airlines
Sat 4/127:04 pmSTL - CAE
1 stop3h 37mAmerican Airlines
Deal found 2/19$248
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/249:08 pmGSP - MCI
3 stops42h 03mMultiple Airlines
Sun 3/306:50 pmMCI - GSP
1 stop25h 30mMultiple Airlines
Deal found 2/20$250
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/71:40 pmCLT - MCI
Nonstop2h 29mAmerican Airlines
Sun 3/96:42 pmMCI - CLT
Nonstop2h 13mAmerican Airlines
Deal found 2/20$253
This Mytrip deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/62:59 pmCHS - MCI
2 stops20h 36mSpirit Airlines
Mon 3/104:39 pmMCI - CHS
2 stops20h 25mSpirit Airlines
Deal found 2/18$255

Find flights from South Carolina to Missouri within your budget

Customize your flight search to find flights from South Carolina to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

South Carolina

Fly to

Missouri

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Sat 4/5

7:58 am-11:46 pm

1 stop16h 48m

Lambert-St Louis

Tue 4/8

4:57 pm-5:46 pm

1 stop23h 49m

$124

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Thu 4/3

11:02 am-5:52 pm

1 stop7h 50m

Lambert-St Louis

Sun 4/6

6:47 pm-9:33 am

1 stop13h 46m

$150

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 4/10

10:30 am-5:16 pm

1 stop7h 46m

Lambert-St Louis

Sun 4/13

6:11 pm-9:35 am

1 stop14h 24m

$172

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/9

8:31 am-11:46 pm

1 stop16h 15m

Lambert-St Louis

Sun 4/13

6:11 pm-4:16 pm

1 stop21h 05m

$174

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Sat 3/8

7:54 pm-6:35 pm

1 stop23h 41m

Kansas City

Wed 3/12

10:20 am-5:09 pm

1 stop5h 49m

$178

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Mon 3/3

8:20 pm-12:55 pm

1 stop17h 35m

Kansas City

Fri 3/7

10:20 am-5:09 pm

1 stop5h 49m

$203

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 4/29

11:14 am-5:16 pm

1 stop7h 02m

Lambert-St Louis

Fri 5/2

9:50 am-4:00 pm

3 stops29h 10m

$220

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Sat 4/5

6:32 pm-9:24 pm

1 stop3h 52m

Lambert-St Louis

Sat 4/12

7:04 pm-11:41 pm

1 stop3h 37m

$248

GreenvilleKansas City

GSP - MCI

GSPMCI

Greenville

Mon 3/24

9:08 pm-2:11 pm

3 stops42h 03m

Kansas City

Sun 3/30

6:50 pm-9:20 pm

1 stop25h 30m

$250

CharlotteKansas City

CLT - MCI

CLTMCI

Charlotte Douglas

Fri 3/7

10:25 pm-11:59 pm

Nonstop2h 34m

Kansas City

Tue 3/11

6:42 pm-9:55 pm

Nonstop2h 13m

$253

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Missouri

Get recent, data-driven insights about flights from South Carolina to Missouri including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Missouri?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to MO?

Find hourly flight availability from South Carolina to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Missouri as you normally would.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 20, 2025.
Peruse reviews from past customers who have flown with Southwest, Alaska Airlines and Delta from South Carolina to Missouri to help guide your decision. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,692 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Boarding

8.2

Food

7.1

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Missouri one-way?

    One-way options have recently been found by users for as low as $52 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $55 and Allegiant Air from $112 one-way.

  • Can I find deals for flights from South Carolina to Missouri that include hotel bookings?

    Yes. In addition to deals on South Carolina to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Missouri.

  • Can I find deals for business class flights from South Carolina to Missouri?

    Yes. Cheapflights offers flight deals from South Carolina to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Missouri?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Missouri (average of $311). Flying from South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to Missouri

Discover the top 4 airlines that operate flights from South Carolina to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$139Average$378FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$139Average$259FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$172Average$384FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$393FlexibilityNo cancel feeOn-time63%
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