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$100+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
mar. 8 — mar. 151
sáb. 3/8
sáb. 3/15
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated marzo 3, 2025.

Round-trip from

$199
(Delta)

One-way from

$100
(American Airlines)
From Knoxville McGhee Tyson to Missouri
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One-way flight from Knoxville McGhee Tyson to Missouri
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 3, 2025.

This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/15:45 amTYS - STL
1 stop4h 29mDelta
mar. 4/86:00 amSTL - TYS
1 stop4h 12mDelta
Deal found 3/3$199
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/411:02 amTYS - MCI
1 stop4h 57mAmerican Airlines
sáb. 4/512:25 pmMCI - TYS
1 stop8h 23mAmerican Airlines
Deal found 3/2$224
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/2710:05 amTYS - SGF
1 stop5h 40mDelta
dom. 3/306:49 pmSGF - TYS
1 stop3h 48mDelta
Deal found 3/2$249
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/15:30 amTYS - MCI
1 stop5h 07mDelta
lun. 5/56:45 pmMCI - TYS
1 stop4h 03mDelta
Deal found 3/3$249
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/26:23 amTYS - STL
1 stop5h 20mAmerican Airlines
lun. 6/97:23 amSTL - TYS
1 stop4h 13mAmerican Airlines
Deal found 3/2$294
This Mytrip deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/269:19 amTYS - STL
3 stops34h 22mMultiple Airlines
mar. 4/296:10 pmSTL - TYS
1 stop18h 53mMultiple Airlines
Deal found 3/2$301
This United deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/47:00 amTYS - MCI
1 stop4h 32mUnited Airlines
sáb. 4/57:45 amMCI - TYS
2 stops10h 51mUnited Airlines
Deal found 3/1$334
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/265:45 amTYS - STL
2 stops11h 02mUnited Airlines
mar. 4/299:39 amSTL - TYS
1 stop6h 05mUnited Airlines
Deal found 3/2$342
This Mytrip deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/188:51 amTYS - SGF
1 stop11h 13mAllegiant Air
sáb. 3/228:28 pmSGF - TYS
1 stop23h 43mAllegiant Air
Deal found 3/2$404
This Mytrip deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/166:00 amTYS - MCI
2 stops35h 17mMultiple Airlines
lun. 3/245:12 pmMCI - TYS
2 stops29h 19mMultiple Airlines
Deal found 3/2$411
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/274:16 pmTYS - SGF
2 stops7h 11mAmerican Airlines
dom. 3/305:33 amSGF - TYS
1 stop4h 09mAmerican Airlines
Deal found 3/2$444
This Mytrip deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 3/168:36 amTYS - MCI
1 stop11h 39mAllegiant Air
jue. 3/206:50 pmMCI - TYS
1 stop16h 25mAllegiant Air
Deal found 3/2$528

Find flights from Knoxville to Missouri within your budget

Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 3, 2025.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

mar. 4/1

5:45 am-9:14 am

1 stop4h 29m

Lambert-St Louis

mar. 4/8

6:00 am-11:12 am

1 stop4h 12m

$199

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

vie. 4/4

11:02 am-2:59 pm

1 stop4h 57m

Kansas City

sáb. 4/5

12:25 pm-9:48 pm

1 stop8h 23m

$224

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

jue. 3/27

10:05 am-2:45 pm

1 stop5h 40m

Springfield-Branson

dom. 3/30

6:49 pm-11:37 pm

1 stop3h 48m

$249

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

jue. 5/1

5:30 am-9:37 am

1 stop5h 07m

Kansas City

lun. 5/5

6:45 pm-11:48 pm

1 stop4h 03m

$249

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

lun. 6/2

6:23 am-10:43 am

1 stop5h 20m

Lambert-St Louis

lun. 6/9

7:23 am-12:36 pm

1 stop4h 13m

$294

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

sáb. 4/26

9:19 am-6:41 pm

3 stops34h 22m

Lambert-St Louis

mar. 4/29

6:10 pm-2:03 pm

1 stop18h 53m

$301

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

vie. 4/4

7:00 am-10:32 am

1 stop4h 32m

Kansas City

sáb. 4/5

7:45 am-7:36 pm

2 stops10h 51m

$334

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

sáb. 4/26

5:45 am-3:47 pm

2 stops11h 02m

Lambert-St Louis

mar. 4/29

9:39 am-4:44 pm

1 stop6h 05m

$342

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

mar. 3/18

8:51 am-7:04 pm

1 stop11h 13m

Springfield-Branson

sáb. 3/22

8:28 pm-9:11 pm

1 stop23h 43m

$404

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

dom. 3/16

6:00 am-4:17 pm

2 stops35h 17m

Kansas City

lun. 3/24

5:12 pm-11:31 pm

2 stops29h 19m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 22 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to Missouri

Get recent, data-driven insights about flights from Knoxville to Missouri including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated marzo 3, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated marzo 3, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to Missouri by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,068 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,068 reviews
Delta
8.0
Very good
8,068 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,679 reviews
Delta
8.0
Very good
8,068 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.3
Good
752 reviews
Delta
8.0
Very good
8,068 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,068 reviews

Comfort

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $100 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Allegiant Air, with prices starting from $135 and $169, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$353FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$362FlexibilityNo cancel feeOn-time71%
DeltaCheapest$217Average$329FlexibilityNo cancel feeOn-timeN/A
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