HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Missouri

$126+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Missouri with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$199
(American Airlines)

One-way from

$126
(American Airlines)

Popular in

January

Cheapest in

September

Average price

$308
Provider with most accurate pricing for Knoxville McGhee Tyson-Kansas City flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Kansas City flights.
Search Deals
From Knoxville McGhee Tyson to Missouri
Search Deals
One-way flight from Knoxville McGhee Tyson to Missouri
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:27 pmTYS - MCI
1 stop4h 32mAmerican Airlines
Wed 5/286:15 amMCI - TYS
1 stop7h 09mAmerican Airlines
Deal found 4/23$199
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/215:45 amTYS - STL
1 stop4h 15mDelta
Wed 5/285:40 pmSTL - TYS
1 stop5h 11mDelta
Deal found 4/22$214
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:45 amTYS - MCI
1 stop6h 22mDelta
Sat 5/105:26 pmMCI - TYS
1 stop5h 25mDelta
Deal found 4/23$259
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:30 amTYS - MCI
1 stop12h 57mAllegiant Air
Sat 5/319:17 pmMCI - TYS
2 stops25h 16mAllegiant Air
Deal found 4/23$278
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/311:02 amTYS - SGF
1 stop5h 49mAmerican Airlines
Wed 5/78:20 amSGF - TYS
1 stop4h 45mAmerican Airlines
Deal found 4/23$284
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:28 pmTYS - STL
1 stop5h 17mAmerican Airlines
Sat 5/245:19 amSTL - TYS
1 stop5h 25mAmerican Airlines
Deal found 4/23$289
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2412:52 pmTYS - MCI
2 stops31h 11mMultiple Airlines
Sat 5/319:17 pmMCI - TYS
2 stops25h 16mMultiple Airlines
Deal found 4/23$302
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/299:55 amTYS - MCI
1 stop6h 09mUnited Airlines
Tue 5/136:00 amMCI - TYS
2 stops7h 35mUnited Airlines
Deal found 4/23$304
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/610:59 amTYS - STL
1 stop25h 26mMultiple Airlines
Fri 6/1311:28 amSTL - TYS
1 stop20h 06mMultiple Airlines
Deal found 4/23$309
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/109:55 amTYS - STL
2 stops13h 50mUnited Airlines
Sat 6/145:27 pmSTL - TYS
1 stop4h 38mUnited Airlines
Deal found 4/22$337
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/35:35 pmTYS - SGF
1 stop5h 26mUnited Airlines
Wed 5/75:45 amSGF - TYS
2 stops13h 21mUnited Airlines
Deal found 4/23$384
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/15:30 amTYS - SGF
1 stop6h 32mDelta
Sun 8/36:00 amSGF - TYS
1 stop4h 07mDelta
Deal found 4/22$409

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 5/24

8:27 pm-11:59 pm

1 stop4h 32m

Kansas City

Wed 5/28

6:15 am-2:24 pm

1 stop7h 09m

$199

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 5/21

5:45 am-9:00 am

1 stop4h 15m

Lambert-St Louis

Wed 5/28

5:40 pm-11:51 pm

1 stop5h 11m

$214

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/7

5:45 am-11:07 am

1 stop6h 22m

Kansas City

Sat 5/10

5:26 pm-11:51 pm

1 stop5h 25m

$259

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 5/24

8:30 am-8:27 pm

1 stop12h 57m

Kansas City

Sat 5/31

9:17 pm-11:33 pm

2 stops25h 16m

$278

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 5/23

6:28 pm-10:45 pm

1 stop5h 17m

Lambert-St Louis

Sat 5/24

5:19 am-11:44 am

1 stop5h 25m

$289

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 5/24

12:52 pm-7:03 pm

2 stops31h 11m

Kansas City

Sat 5/31

9:17 pm-11:33 pm

2 stops25h 16m

$302

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Tue 4/29

9:55 am-3:04 pm

1 stop6h 09m

Kansas City

Tue 5/13

6:00 am-2:35 pm

2 stops7h 35m

$304

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 6/6

10:59 am-11:25 am

1 stop25h 26m

Lambert-St Louis

Fri 6/13

11:28 am-8:34 am

1 stop20h 06m

$309

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 6/10

9:55 am-10:45 pm

2 stops13h 50m

Lambert-St Louis

Sat 6/14

5:27 pm-11:05 pm

1 stop4h 38m

$337

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 8/1

5:30 am-11:02 am

1 stop6h 32m

Springfield-Branson

Sun 8/3

6:00 am-11:07 am

1 stop4h 07m

$409

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 22 results
1
2
3

Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 24, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to Missouri by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,685 reviews
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
6.0
Okay
3,283 reviews
Delta
8.0
Very good
7,920 reviews

Overall

8.0

Food

7.3

Comfort

7.9

Entertainment

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $126 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Allegiant Air and Frontier, with prices starting from $156 and $182, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Seattle flights
Nashville to John F Kennedy Intl flights
Nashville to Denver flights
Nashville to LaGuardia flights
Nashville to Newark flights
Nashville to Las Vegas flights
Nashville to Los Angeles flights
Memphis to Los Angeles flights
Nashville to Orlando flights
Memphis to Las Vegas flights
Nashville to Dallas/Fort Worth flights
Nashville to Fort Lauderdale flights
Memphis to Newark flights
Nashville to Boston flights
Memphis to Miami flights
Nashville to O'Hare Intl flights
Memphis to Hobby flights
Nashville to Sky Harbor Intl flights
Nashville to Dulles Intl flights
Memphis to LaGuardia flights
Memphis to Denver flights
Nashville to Reagan-National flights
Nashville to San Francisco flights
Knoxville to Denver flights
Nashville to Miami flights
Nashville to Hobby flights
Nashville to Baltimore flights
Nashville to Portland flights
Memphis to John F Kennedy Intl flights
Memphis to Seattle flights
Memphis to Orlando flights
Memphis to O'Hare Intl flights
Nashville to Ontario flights
Nashville to Honolulu flights
Chattanooga to Dallas/Fort Worth flights
Chattanooga to O'Hare Intl flights
Knoxville to LaGuardia flights
Memphis to Baltimore flights
Memphis to George Bush Intcntl flights
Chattanooga to LaGuardia flights
Memphis to Boston flights
Knoxville to John F Kennedy Intl flights
Memphis to Atlanta flights
Nashville to Salt Lake City flights
Memphis to Reagan-National flights
Memphis to Dulles Intl flights
Nashville to George Bush Intcntl flights
Chattanooga to John F Kennedy Intl flights
Knoxville to O'Hare Intl flights
Nashville to Santa Ana flights

Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$343FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$366FlexibilityNo cancel feeOn-time71%
DeltaCheapest$227Average$334FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.