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$100+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Feb 4 — Feb 111
Tue 2/4
Tue 2/11
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Missouri (USMO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 30, 2025.

Round-trip from

$199
(Delta)

One-way from

$100
(American Airlines)
From Knoxville McGhee Tyson to Missouri
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One-way flight from Knoxville McGhee Tyson to Missouri
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2025.

This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/15:45 amTYS - STL
1 stop4h 29mDelta
Tue 4/87:05 amSTL - TYS
1 stop5h 45mDelta
Deal found 1/30$199
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/265:28 amTYS - MCI
1 stop5h 18mAmerican Airlines
Wed 3/53:25 pmMCI - TYS
1 stop7h 24mAmerican Airlines
Deal found 1/29$199
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/28:00 amTYS - SGF
1 stop5h 06mAmerican Airlines
Sun 4/66:38 pmSGF - TYS
1 stop4h 08mAmerican Airlines
Deal found 1/30$224
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/212:43 pmTYS - STL
1 stop5h 47mAmerican Airlines
Sun 2/235:37 pmSTL - TYS
1 stop5h 12mAmerican Airlines
Deal found 1/30$229
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/77:17 pmTYS - MCI
1 stop5h 37mDelta
Tue 2/118:05 amMCI - TYS
1 stop4h 22mDelta
Deal found 1/29$268
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/212:38 pmTYS - MCI
1 stop6h 35mMultiple Airlines
Tue 3/42:06 pmMCI - TYS
2 stops20h 54mMultiple Airlines
Deal found 1/30$283
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2812:08 pmTYS - SGF
1 stop5h 41mDelta
Sun 3/26:10 amSGF - TYS
1 stop4h 13mDelta
Deal found 1/29$299
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/75:45 amTYS - MCI
2 stops7h 39mUnited Airlines
Mon 2/104:20 pmMCI - TYS
1 stop6h 26mUnited Airlines
Deal found 1/29$324
This Flightnetwork deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/24:19 pmTYS - STL
1 stop17h 57mFrontier
Wed 2/57:09 pmSTL - TYS
1 stop19h 10mFrontier
Deal found 1/29$375
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/279:16 pmTYS - STL
3 stops22h 25mMultiple Airlines
Thu 3/65:38 pmSTL - TYS
2 stops15h 47mMultiple Airlines
Deal found 1/29$381
This United deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/217:25 pmTYS - STL
2 stops20h 14mUnited Airlines
Sun 2/235:36 pmSTL - TYS
1 stop4h 24mUnited Airlines
Deal found 1/30$382
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/145:35 pmTYS - JLN
1 stop6h 54mUnited Airlines
Tue 2/187:50 amJLN - TYS
1 stop14h 10mUnited Airlines
Deal found 1/30$481

Find flights from Knoxville to Missouri within your budget

Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 4/1

5:45 am-9:14 am

1 stop4h 29m

Lambert-St Louis

Tue 4/8

7:05 am-1:50 pm

1 stop5h 45m

$199

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 2/26

5:28 am-9:46 am

1 stop5h 18m

Kansas City

Wed 3/5

3:25 pm-11:49 pm

1 stop7h 24m

$199

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 4/2

8:00 am-12:06 pm

1 stop5h 06m

Springfield-Branson

Sun 4/6

6:38 pm-11:46 pm

1 stop4h 08m

$224

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 2/21

2:43 pm-7:30 pm

1 stop5h 47m

Lambert-St Louis

Sun 2/23

5:37 pm-11:49 pm

1 stop5h 12m

$229

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sun 3/2

12:38 pm-6:13 pm

1 stop6h 35m

Kansas City

Tue 3/4

2:06 pm-12:00 pm

2 stops20h 54m

$283

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Fri 2/28

12:08 pm-4:49 pm

1 stop5h 41m

Springfield-Branson

Sun 3/2

6:10 am-11:23 am

1 stop4h 13m

$299

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 2/26

5:45 am-9:37 am

1 stop4h 52m

Kansas City

Thu 2/27

6:43 pm-11:47 pm

1 stop4h 04m

$328

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 2/27

9:16 pm-6:41 pm

3 stops22h 25m

Lambert-St Louis

Thu 3/6

5:38 pm-10:25 am

2 stops15h 47m

$381

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Fri 2/21

7:25 pm-2:39 pm

2 stops20h 14m

Lambert-St Louis

Sun 2/23

5:36 pm-11:00 pm

1 stop4h 24m

$382

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Sat 6/7

7:00 am-10:29 am

1 stop4h 29m

Kansas City

Mon 6/16

5:30 pm-11:59 pm

1 stop5h 29m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 19 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to Missouri

Get recent, data-driven insights about flights from Knoxville to Missouri including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated January 30, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to Missouri by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,454 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,913 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.3
Good
790 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,454 reviews

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Comfort

8.0

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $100 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Allegiant Air, with prices starting from $220 and $251, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$331FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$331FlexibilityNo cancel feeOn-time71%
DeltaCheapest$217Average$337FlexibilityNo cancel feeOn-timeN/A
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