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$100+ Cheap flights from Knoxville (TYS) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — STL
Apr 8 — Apr 151
Tue 4/8
Tue 4/15
1 adult, Economy
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Cheap flight deals from Knoxville to Missouri

Keep the following information in mind while searching for Knoxville to Missouri flight deals. Data was last updated April 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(American Airlines)

One-way from

$100
(American Airlines)

Popular in

January

Cheapest in

September

Average price

$299
Provider with most accurate pricing for Knoxville McGhee Tyson-Kansas City flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Kansas City flights.
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From Knoxville McGhee Tyson to Missouri
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One-way flight from Knoxville McGhee Tyson to Missouri
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Highest demand for flights based on searches. 13% potential increase in price ($57 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Missouri

Cheapest flights from Knoxville to Missouri
Explore the most affordable flight options available from Knoxville to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2025.

This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:58 pmTYS - MCI
1 stop7h 01mAmerican Airlines
Sat 5/104:06 pmMCI - TYS
1 stop5h 01mAmerican Airlines
Deal found 4/2$199
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2410:05 amTYS - STL
1 stop3h 19mDelta
Sat 7/266:00 amSTL - TYS
1 stop3h 40mDelta
Deal found 4/2$229
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/175:30 amTYS - MCI
1 stop4h 57mDelta
Wed 7/238:00 amMCI - TYS
1 stop6h 08mDelta
Deal found 4/2$233
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/166:17 amTYS - STL
1 stop6h 15mAmerican Airlines
Sun 4/205:00 amSTL - TYS
1 stop4h 38mAmerican Airlines
Deal found 4/2$239
This United deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/79:55 amTYS - MCI
1 stop6h 14mUnited Airlines
Sat 5/106:00 amMCI - TYS
2 stops7h 35mUnited Airlines
Deal found 4/1$274
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/202:04 pmTYS - SGF
1 stop5h 12mDelta
Mon 5/265:40 amSGF - TYS
1 stop6h 39mDelta
Deal found 4/2$279
This Mytrip deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/227:30 amTYS - MCI
1 stop11h 11mMultiple Airlines
Sun 5/252:45 pmMCI - TYS
1 stop18h 31mMultiple Airlines
Deal found 4/1$305
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/47:10 amTYS - STL
2 stops27h 05mMultiple Airlines
Mon 6/97:00 amSTL - TYS
1 stop8h 11mMultiple Airlines
Deal found 4/2$377
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/215:20 amTYS - SGF
1 stop6h 24mAmerican Airlines
Mon 5/264:09 pmSGF - TYS
1 stop4h 08mAmerican Airlines
Deal found 4/2$383
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/208:30 amTYS - SGF
3 stops37h 07mMultiple Airlines
Mon 5/268:18 pmSGF - TYS
1 stop17h 13mMultiple Airlines
Deal found 4/2$434
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/185:45 amTYS - STL
2 stops15h 19mUnited Airlines
Mon 4/215:35 pmSTL - TYS
1 stop3h 47mUnited Airlines
Deal found 4/2$489
This United deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/137:25 pmTYS - SGF
2 stops20h 07mUnited Airlines
Sun 6/158:00 amSGF - TYS
1 stop13h 40mUnited Airlines
Deal found 4/2$659

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
Use the filters below to find and compare flights from Knoxville to Missouri that are best for you.

Fly from

Knoxville

Fly to

Missouri

Route

Depart

Return

Price

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/7

5:58 pm-11:59 pm

1 stop7h 01m

Kansas City

Sat 5/10

4:06 pm-10:07 pm

1 stop5h 01m

$199

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/24

10:05 am-12:24 pm

1 stop3h 19m

Lambert-St Louis

Sat 7/26

6:00 am-10:40 am

1 stop3h 40m

$229

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Thu 7/17

5:30 am-9:27 am

1 stop4h 57m

Kansas City

Wed 7/23

8:00 am-3:08 pm

1 stop6h 08m

$233

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 4/16

6:17 am-11:32 am

1 stop6h 15m

Lambert-St Louis

Sun 4/20

5:00 am-10:38 am

1 stop4h 38m

$239

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Wed 5/7

9:55 am-3:09 pm

1 stop6h 14m

Kansas City

Sat 5/10

6:00 am-2:35 pm

2 stops7h 35m

$274

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Tue 5/20

2:04 pm-6:16 pm

1 stop5h 12m

Springfield-Branson

Mon 5/26

5:40 am-1:19 pm

1 stop6h 39m

$279

KnoxvilleKansas City

TYS - MCI

TYSMCI

Knoxville McGhee Tyson

Thu 5/22

7:30 am-5:41 pm

1 stop11h 11m

Kansas City

Sun 5/25

2:45 pm-10:16 am

1 stop18h 31m

$305

KnoxvilleSt. Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 6/4

7:10 am-9:15 am

2 stops27h 05m

Lambert-St Louis

Mon 6/9

7:00 am-4:11 pm

1 stop8h 11m

$377

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Wed 5/21

5:20 am-10:44 am

1 stop6h 24m

Springfield-Branson

Mon 5/26

4:09 pm-9:17 pm

1 stop4h 08m

$383

KnoxvilleSpringfield

TYS - SGF

TYSSGF

Knoxville McGhee Tyson

Tue 5/20

8:30 am-8:37 pm

3 stops37h 07m

Springfield-Branson

Mon 5/26

8:18 pm-2:31 pm

1 stop17h 13m

$434

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/2

Showing 1-10 of 21 results
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Best time to book a flight from Knoxville to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Missouri

What is the cheapest month to book a flight from Knoxville to Missouri?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MO?

Find hourly flight availability from Knoxville to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2025.

When flying from Knoxville to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 3, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Knoxville to Missouri by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,897 reviews
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,619 reviews
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
731 reviews
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
6.0
Okay
3,277 reviews
Delta
8.0
Very good
7,897 reviews

Crew

8.5

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Missouri?

    For a flight from Knoxville to Missouri, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Knoxville to Missouri one-way?

    $100 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on United Airlines and Allegiant Air, with prices starting from $131 and $167, respectively.

  • What are the most popular routes from Knoxville to Missouri?

    While some choose either Knoxville McGhee Tyson - Lambert-St Louis or Knoxville McGhee Tyson - Springfield-Branson, Knoxville McGhee Tyson - Kansas City is the most popular route from Knoxville to Missouri.

  • Can I find deals for flights from Knoxville to Missouri that include hotel bookings?

    Yes. In addition to deals on Knoxville to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Missouri.

  • Can I find deals for business class flights from Knoxville to Missouri?

    Yes. Cheapflights offers flight deals from Knoxville to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Missouri (average of $311). Flying from Knoxville to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Missouri

Discover the top 3 airlines that operate flights from Knoxville to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$198Average$344FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$368FlexibilityNo cancel feeOn-time71%
DeltaCheapest$227Average$356FlexibilityNo cancel feeOn-timeN/A

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