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$262+ Cheap flights from Florence, SC (FLO) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Mar 31 — Apr 71
Mon 3/31
Mon 4/7
1 adult, Economy
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Cheap flight deals from Florence to Missouri

Keep the following information in mind while searching for Florence to Missouri flight deals. Data was last updated March 26, 2025.

Round-trip from

$379
(American Airlines)
From Florence to Missouri
Search Deals

Find flight deals from Florence to Missouri

Cheapest flights from Florence to Missouri
Explore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2025.

This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/282:35 pmFLO - STL
2 stops9h 58mAmerican Airlines
Tue 5/136:00 amSTL - FLO
2 stops16h 58mAmerican Airlines
Deal found 3/24$404

Cheapflights Fare Finder

Customize your flight search to find flights from Florence to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2025.
Use the filters below to find and compare flights from Florence to Missouri that are best for you.

Fly from

Florence

Fly to

Missouri

Route

Depart

Return

Price

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Sun 4/20

5:00 am-8:30 am

1 stop4h 30m

Lambert-St Louis

Sun 4/27

7:19 am-2:10 pm

1 stop5h 51m

$379

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Mon 4/7

2:35 pm-7:23 pm

1 stop5h 48m

$262

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Best time to book a flight from Florence to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Missouri

What is the cheapest month to book a flight from Florence, South Carolina to Missouri?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to Missouri (average of $311). Flying from Florence, South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated March 26, 2025.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.5

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Boarding

7.5

Entertainment

6.9

Overall

7.2

Food

6.5

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from Florence to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Missouri?

    Located just 2.3 mi from the city center, Florence (FLO) is the airport most travelers will use when flying to Missouri from Florence.

  • What are the most popular routes from Florence, South Carolina to Missouri?

    While some choose either Florence - Lambert-St Louis or Florence - Joplin, Florence - Kansas City is the most popular route from Florence, South Carolina to Missouri.

  • Can I find deals for flights from Florence to Missouri that include hotel bookings?

    Yes. In addition to deals on Florence to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Missouri.

  • Can I find deals for business class flights from Florence to Missouri?

    Yes. Cheapflights offers flight deals from Florence to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to Missouri (average of $311). Flying from Florence, South Carolina to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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