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$89+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Apr 27 — May 41
Sun 4/27
Sun 5/4
1 adult, Economy
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Cheap flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated April 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$177
(Delta)

One-way from

$89
(Delta)

Popular in

January

Cheapest in

July

Average price

$368
Provider with most accurate pricing for Raleigh-Durham-Kansas City flight deals.
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Provider most trusted by Cheapflights users for Raleigh-Durham-Kansas City flights.
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From Durham to Missouri
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One-way flight from Durham to Missouri
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Highest demand for flights based on searches. 17% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/147:30 amRDU - MCI
Nonstop2h 46mDelta
Mon 6/167:32 pmMCI - RDU
Nonstop2h 27mDelta
Deal found 4/22$177
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/295:00 amRDU - MCI
1 stop7h 22mAmerican Airlines
Sun 6/16:33 pmMCI - RDU
1 stop4h 25mAmerican Airlines
Deal found 4/22$201
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/35:02 amRDU - SGF
1 stop6h 42mAmerican Airlines
Sat 6/76:29 pmSGF - RDU
1 stop5h 23mAmerican Airlines
Deal found 4/21$249
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1210:34 amRDU - MCI
1 stop5h 14mUnited Airlines
Tue 8/193:01 pmMCI - RDU
1 stop5h 51mUnited Airlines
Deal found 4/22$267
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/285:15 pmRDU - SGF
1 stop6h 01mDelta
Tue 5/66:00 amSGF - RDU
1 stop4h 53mDelta
Deal found 4/21$284
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/293:55 pmRDU - MCI
2 stops19h 53mMultiple Airlines
Sun 6/18:30 amMCI - RDU
1 stop6h 55mMultiple Airlines
Deal found 4/22$293
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/228:20 amRDU - STL
Nonstop2h 10mSouthwest
Sun 5/251:30 pmSTL - RDU
1 stop3h 45mSouthwest
Deal found 4/22$300
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/910:17 amRDU - MCI
1 stop25h 14mSpirit Airlines
Thu 5/1510:15 amMCI - RDU
1 stop7h 35mSpirit Airlines
Deal found 4/22$303
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/16:25 pmRDU - STL
1 stop18h 06mMultiple Airlines
Sat 5/1010:10 amSTL - RDU
2 stops20h 45mMultiple Airlines
Deal found 4/22$306
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/254:43 pmRDU - STL
1 stop8h 09mFrontier
Sun 6/225:47 pmSTL - RDU
1 stop5h 31mFrontier
Deal found 4/21$311
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/147:40 pmRDU - MCI
1 stop4h 30mSouthwest
Mon 6/168:30 amMCI - RDU
2 stops7h 00mSouthwest
Deal found 4/22$312
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:15 amRDU - SGF
1 stop5h 36mUnited Airlines
Tue 6/173:06 pmSGF - RDU
1 stop5h 26mUnited Airlines
Deal found 4/22$319

Cheapflights Fare Finder

Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
Use the filters below to find and compare flights from Durham to Missouri that are best for you.

Fly from

Durham

Fly to

Missouri

Route

Depart

Return

Price

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Thu 6/5

7:40 am-9:19 am

Nonstop2h 39m

Kansas City

Thu 6/12

7:32 pm-10:59 pm

Nonstop2h 27m

$177

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Thu 6/5

6:15 am-10:34 am

1 stop5h 19m

Kansas City

Thu 6/12

6:00 am-2:08 pm

2 stops7h 08m

$241

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Tue 6/3

5:02 am-10:44 am

1 stop6h 42m

Springfield-Branson

Sat 6/7

6:29 pm-12:52 am

1 stop5h 23m

$249

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Thu 7/10

8:18 pm-11:55 pm

1 stop4h 37m

Kansas City

Sun 7/13

5:00 am-10:28 am

1 stop4h 28m

$257

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Sun 5/4

11:29 am-4:04 pm

1 stop29h 35m

Kansas City

Thu 5/8

10:15 am-6:50 pm

1 stop7h 35m

$282

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Thu 5/15

6:05 am-9:10 am

1 stop4h 05m

Kansas City

Thu 6/19

6:30 pm-11:15 pm

1 stop3h 45m

$286

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Thu 5/22

8:20 am-9:30 am

Nonstop2h 10m

Lambert-St Louis

Sun 5/25

1:30 pm-6:15 pm

1 stop3h 45m

$300

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 5/9

10:17 am-10:31 am

1 stop25h 14m

Kansas City

Sun 5/11

7:30 am-4:29 pm

1 stop7h 59m

$303

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Thu 5/1

6:25 pm-11:31 am

1 stop18h 06m

Lambert-St Louis

Sat 5/10

10:10 am-7:55 am

2 stops20h 45m

$306

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Sun 5/25

4:43 pm-11:52 pm

1 stop8h 09m

Lambert-St Louis

Sun 6/22

5:47 pm-12:18 am

1 stop5h 31m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 37 results
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Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Missouri

What is the cheapest month to book a flight from Durham to Missouri?

Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

When flying from Durham to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated April 22, 2025.
To help decide which airline to fly from Durham to Missouri, see what other customers have to say about Alaska Airlines, Southwest and Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,911 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,287 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,683 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,911 reviews

Food

7.1

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.1

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Missouri flight route?

    Within the past month, 20 users have taken a look at flights from Durham to Missouri.

  • What are the cheapest airlines to fly from Durham to Missouri one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $89. Frontier flights start at $89 while deals on United Airlines start at $94 one-way.

  • What are the most popular routes from Durham to Missouri?

    When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Lambert-St Louis, Raleigh-Durham - Kansas City or Raleigh-Durham - Springfield-Branson as they are the most popular.

  • What are the cheapest flights from Durham to Missouri?

    Looking for the cheapest flight from Durham to Missouri? While on average our users pay $315, our data indicates the cheapest price to be $166. The most popular route (Raleigh-Durham - Lambert-St Louis), is priced around $239.

  • Can I find deals for flights from Durham to Missouri that include hotel bookings?

    Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

  • Can I find deals for business class flights from Durham to Missouri?

    Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Durham to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Durham to Missouri

Discover the top 6 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$45Average$258FlexibilityNo cancel feeOn-time65%
FrontierCheapest$85Average$208FlexibilityNo cancel feeOn-time62%
DeltaCheapest$158Average$337FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$176Average$380FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$194Average$410FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$196Average$368FlexibilityNo cancel feeOn-time69%

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