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$55+ Cheap flights from Durham, NC to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — STL
Feb 28 — Mar 71
Fri 2/28
Fri 3/7
1 adult, Economy
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Cheap flight deals from Durham to Missouri

Keep the following information in mind while searching for Durham to Missouri flight deals. Data was last updated February 23, 2025.

Round-trip from

$133
(Mytrip)

One-way from

$55
(Frontier)
From Durham to Missouri
Search Deals
One-way flight from Durham to Missouri
Search Deals

Find flight deals from Durham to Missouri

Cheapest flights from Durham to Missouri
Explore the most affordable flight options available from Durham to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 23, 2025.

This Mytrip deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/82:05 pmRDU - STL
1 stop10h 41mFrontier
Tue 4/154:57 pmSTL - RDU
1 stop27h 25mFrontier
Deal found 2/22$133
This CheapOair deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/92:36 pmRDU - STL
1 stop10h 10mMultiple Airlines
Sun 4/136:11 pmSTL - RDU
1 stop25h 42mMultiple Airlines
Deal found 2/22$179
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1911:19 amRDU - SGF
1 stop4h 34mAmerican Airlines
Wed 3/262:15 pmSGF - RDU
1 stop6h 53mAmerican Airlines
Deal found 2/22$199
This Mytrip deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/810:58 amRDU - STL
1 stop7h 54mSpirit Airlines
Tue 4/156:11 pmSTL - RDU
3 stops23h 27mSpirit Airlines
Deal found 2/22$203
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/85:02 pmRDU - SGF
1 stop6h 13mUnited Airlines
Tue 4/153:13 pmSGF - RDU
2 stops7h 44mUnited Airlines
Deal found 2/22$204
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/712:17 pmRDU - MCI
3 stops28h 27mMultiple Airlines
Mon 3/104:39 pmMCI - RDU
1 stop26h 50mMultiple Airlines
Deal found 2/21$209
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/59:34 pmRDU - MCI
2 stops19h 43mSpirit Airlines
Wed 3/124:39 pmMCI - RDU
1 stop26h 50mSpirit Airlines
Deal found 2/21$212
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/248:35 pmRDU - STL
Nonstop2h 15mSouthwest
Mon 3/317:45 amSTL - RDU
Nonstop1h 50mSouthwest
Deal found 2/20$257
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/127:55 amRDU - MCI
Nonstop2h 46mDelta
Wed 5/146:55 pmMCI - RDU
Nonstop2h 24mDelta
Deal found 2/21$285
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/812:41 pmRDU - STL
1 stop3h 53mDelta
Wed 3/126:50 amSTL - RDU
1 stop4h 06mDelta
Deal found 2/22$297
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/15:30 pmRDU - MCI
1 stop5h 30mUnited Airlines
Tue 4/81:55 pmMCI - RDU
1 stop8h 16mUnited Airlines
Deal found 2/22$300
This Booking.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/45:24 pmRDU - MCI
1 stop27h 13mFrontier
Sun 4/68:35 pmMCI - RDU
1 stop19h 00mFrontier
Deal found 2/21$320

Find flights from Durham to Missouri within your budget

Customize your flight search to find flights from Durham to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2025.

Fly from

Durham

Fly to

Missouri

Route

Depart

Return

Price

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Tue 4/8

2:05 pm-11:46 pm

1 stop10h 41m

Lambert-St Louis

Tue 4/15

4:57 pm-9:22 pm

1 stop27h 25m

$133

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Wed 4/9

2:36 pm-11:46 pm

1 stop10h 10m

Lambert-St Louis

Sun 4/13

6:11 pm-8:53 pm

1 stop25h 42m

$179

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Wed 3/19

11:19 am-2:53 pm

1 stop4h 34m

Springfield-Branson

Wed 3/26

2:15 pm-10:08 pm

1 stop6h 53m

$199

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Tue 4/8

10:58 am-5:52 pm

1 stop7h 54m

Lambert-St Louis

Tue 4/15

6:11 pm-6:38 pm

3 stops23h 27m

$203

RaleighSpringfield

RDU - SGF

RDUSGF

Raleigh-Durham

Tue 4/8

5:02 pm-10:15 pm

1 stop6h 13m

Springfield-Branson

Tue 4/15

3:13 pm-11:57 pm

2 stops7h 44m

$204

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Fri 3/7

12:17 pm-3:44 pm

3 stops28h 27m

Kansas City

Mon 3/10

4:39 pm-8:29 pm

1 stop26h 50m

$209

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Wed 3/5

9:34 pm-4:17 pm

2 stops19h 43m

Kansas City

Wed 3/12

4:39 pm-8:29 pm

1 stop26h 50m

$212

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Mon 3/24

8:35 pm-9:50 pm

Nonstop2h 15m

Lambert-St Louis

Mon 3/31

7:45 am-10:35 am

Nonstop1h 50m

$257

RaleighKansas City

RDU - MCI

RDUMCI

Raleigh-Durham

Mon 5/12

7:55 am-9:41 am

Nonstop2h 46m

Kansas City

Wed 5/14

6:55 pm-10:19 pm

Nonstop2h 24m

$285

RaleighSt. Louis

RDU - STL

RDUSTL

Raleigh-Durham

Sat 3/8

12:41 pm-3:34 pm

1 stop3h 53m

Lambert-St Louis

Wed 3/12

6:50 am-11:56 am

1 stop4h 06m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 35 results
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Best time to book a flight from Durham to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Durham to Missouri

Get recent, data-driven insights about flights from Durham to Missouri including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Durham to Missouri?

Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to MO?

Find hourly flight availability from Durham to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 23, 2025.

When flying from Durham to Missouri, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Weekly flight availability from Durham to Missouri

Explore weekly flight availability from Durham to Missouri. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated February 23, 2025.

The most flights from DU8 to USMO are scheduled on a Thursday (3 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

Rainfall in Missouri by month

Plan your trip to Missouri by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Missouri ranges from 1.1 - 5.2 inches per month. May is typically the wettest month, when rainfall can reach 5.2 in. January is typically the driest time to visit Missouri when rainfall is around 1.1 in.

Temperature in Missouri by month

Plan your trip to Missouri by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Missouri, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated February 23, 2025.
To help decide which airline to fly from Durham to Missouri, see what other customers have to say about Southwest, Alaska Airlines and Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,396 reviews
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,702 reviews
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,203 reviews
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,754 reviews
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,396 reviews

Comfort

8.1

Food

7.1

Crew

8.7

Overall

8.1

Boarding

8.2

Entertainment

7.6

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Durham to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Durham to Missouri flight route?

    Within the past month, 11 users have taken a look at flights from Durham to Missouri.

  • What are the cheapest airlines to fly from Durham to Missouri one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $55. Spirit Airlines flights start at $84 while deals on Southwest start at $129 one-way.

  • What are the most popular routes from Durham to Missouri?

    When deciding which route to take from Durham to Missouri consider Raleigh-Durham - Kansas City, Raleigh-Durham - Lambert-St Louis or Raleigh-Durham - Springfield-Branson as they are the most popular.

  • What are the cheapest flights from Durham to Missouri?

    Looking for the cheapest flight from Durham to Missouri? While on average our users pay $327, our data indicates the cheapest price to be $148. The most popular route (Raleigh-Durham - Kansas City), is priced around $209.

  • Can I find deals for flights from Durham to Missouri that include hotel bookings?

    Yes. In addition to deals on Durham to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Missouri.

  • Can I find deals for business class flights from Durham to Missouri?

    Yes. Cheapflights offers flight deals from Durham to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Durham to Missouri (average of $311). Flying from Durham to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Durham to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Durham to Missouri

Discover the top 6 airlines that operate flights from Durham to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$85Average$208FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$176Average$369FlexibilityNo cancel feeOn-time63%
Spirit AirlinesCheapest$191Average$222FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$198Average$433FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$414FlexibilityNo cancel feeOn-time71%
DeltaCheapest$219Average$378FlexibilityNo cancel feeOn-timeN/A
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