HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Mississippi

$100+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Mississippi with Cheapflights

1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”
2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.
3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(Delta)

One-way from

$106
(Mytrip)

Popular in

March

Cheapest in

April

Average price

$571
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
Search Deals
From Knoxville McGhee Tyson to Mississippi
Search Deals
One-way flight from Knoxville McGhee Tyson to Mississippi
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2025
Search Deals

Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/235:30 amTYS - MEM
1 stop3h 33mDelta
Wed 4/305:42 pmMEM - TYS
1 stop5h 06mDelta
Deal found 3/27$199
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/111:29 pmTYS - MEM
1 stop6h 13mMultiple Airlines
Sun 4/136:51 pmMEM - TYS
1 stop25h 24mMultiple Airlines
Deal found 3/27$213
This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/107:36 pmTYS - MEM
1 stop25h 09mAllegiant Air
Sun 4/138:46 pmMEM - TYS
1 stop14h 53mAllegiant Air
Deal found 3/26$225
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/47:25 pmTYS - GPT
1 stop3h 41mDelta
Mon 8/116:00 pmGPT - TYS
1 stop4h 47mDelta
Deal found 3/27$229
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1811:55 amTYS - BTR
1 stop6h 04mDelta
Tue 4/225:45 pmBTR - TYS
1 stop5h 03mDelta
Deal found 3/27$249
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/235:24 amTYS - BTR
1 stop5h 20mAmerican Airlines
Wed 4/306:22 amBTR - TYS
2 stops8h 28mAmerican Airlines
Deal found 3/26$254
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/114:59 pmTYS - BTR
1 stop5h 53mUnited Airlines
Mon 4/1412:01 pmBTR - TYS
1 stop7h 05mUnited Airlines
Deal found 3/26$259
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/285:45 amTYS - JAN
1 stop3h 54mDelta
Sun 3/307:15 amJAN - TYS
1 stop5h 35mDelta
Deal found 3/27$289
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/119:00 amTYS - MEM
1 stop8h 20mUnited Airlines
Tue 4/156:30 amMEM - TYS
1 stop6h 06mUnited Airlines
Deal found 3/27$299
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/278:02 pmTYS - JAN
1 stop4h 48mAmerican Airlines
Sun 3/305:05 amJAN - TYS
1 stop6h 19mAmerican Airlines
Deal found 3/27$314
This American Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/297:03 amTYS - MEM
1 stop3h 37mAmerican Airlines
Mon 9/15:37 amMEM - TYS
1 stop5h 41mAmerican Airlines
Deal found 3/26$324
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/45:45 amTYS - AEX
1 stop6h 25mDelta
Sun 6/86:09 amAEX - TYS
1 stop3h 57mDelta
Deal found 3/27$371

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Knoxville to Mississippi that are best for you.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Wed 4/23

5:30 am-8:03 am

1 stop3h 33m

Memphis

Wed 4/30

5:42 pm-11:48 pm

1 stop5h 06m

$199

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 4/11

1:29 pm-6:42 pm

1 stop6h 13m

Memphis

Sun 4/13

6:51 pm-9:15 pm

1 stop25h 24m

$213

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 4/10

7:36 pm-7:45 pm

1 stop25h 09m

Memphis

Sun 4/13

8:46 pm-12:39 pm

1 stop14h 53m

$225

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Mon 8/4

7:25 pm-10:06 pm

1 stop3h 41m

Gulfport Biloxi Regional

Mon 8/11

6:00 pm-11:47 pm

1 stop4h 47m

$229

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 4/18

11:55 am-4:59 pm

1 stop6h 04m

Baton Rouge Ryan

Tue 4/22

5:45 pm-11:48 pm

1 stop5h 03m

$249

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Wed 4/23

5:24 am-9:44 am

1 stop5h 20m

Baton Rouge Ryan

Wed 4/30

6:22 am-3:50 pm

2 stops8h 28m

$254

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Fri 4/11

4:59 pm-9:52 pm

1 stop5h 53m

Baton Rouge Ryan

Mon 4/14

12:01 pm-8:06 pm

1 stop7h 05m

$259

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 4/11

9:00 am-4:20 pm

1 stop8h 20m

Memphis

Tue 4/15

6:30 am-1:36 pm

1 stop6h 06m

$299

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 8/29

7:03 am-9:40 am

1 stop3h 37m

Memphis

Mon 9/1

5:37 am-12:18 pm

1 stop5h 41m

$324

KnoxvilleAlexandria

TYS - AEX

TYSAEX

Knoxville McGhee Tyson

Wed 6/4

5:45 am-11:10 am

1 stop6h 25m

Alexandria

Sun 6/8

6:09 am-11:06 am

1 stop3h 57m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/28

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Mississippi

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $454). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

When flying from Knoxville to Mississippi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated March 28, 2025.
To help decide which airline to fly from Knoxville to Mississippi, see what other customers have to say about Delta, United Airlines and Allegiant Air. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,896 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,603 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
731 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Comfort

8.0

Overall

8.0

Boarding

8.2

Food

7.3

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Mississippi one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $116. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Knoxville to Mississippi for a low price.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Memphis or Knoxville McGhee Tyson - Mobile, Knoxville McGhee Tyson - Baton Rouge Ryan is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $454). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Newark flights
Nashville to Seattle flights
Nashville to John F Kennedy Intl flights
Nashville to LaGuardia flights
Nashville to Los Angeles flights
Nashville to Fort Lauderdale flights
Nashville to Dallas/Fort Worth flights
Nashville to Las Vegas flights
Nashville to Orlando flights
Nashville to Denver flights
Memphis to LaGuardia flights
Nashville to O'Hare Intl flights
Nashville to Dulles Intl flights
Nashville to Miami flights
Memphis to Las Vegas flights
Nashville to Boston flights
Nashville to Sky Harbor Intl flights
Nashville to Reagan-National flights
Nashville to San Francisco flights
Memphis to Orlando flights
Memphis to John F Kennedy Intl flights
Memphis to Los Angeles flights
Nashville to Tampa flights
Memphis to Seattle flights
Nashville to Honolulu flights
Memphis to Miami flights
Memphis to O'Hare Intl flights
Nashville to Hobby flights
Memphis to Atlanta flights
Memphis to Newark flights
Nashville to Baltimore flights
Memphis to Dallas/Fort Worth flights
Knoxville to LaGuardia flights
Knoxville to O'Hare Intl flights
Memphis to Denver flights
Memphis to Hobby flights
Knoxville to Denver flights
Chattanooga to John F Kennedy Intl flights
Chattanooga to LaGuardia flights
Nashville to Salt Lake City flights
Knoxville to Dulles Intl flights
Memphis to Boston flights
Knoxville to John F Kennedy Intl flights
Nashville to Ontario flights
Nashville to George Bush Intcntl flights
Memphis to George Bush Intcntl flights
Nashville to Charlotte flights
Nashville to Philadelphia flights
Chattanooga to Dallas/Fort Worth flights
Chattanooga to O'Hare Intl flights

Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$217Average$291FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$346FlexibilityNo cancel feeOn-time71%
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.