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$100+ Cheap flights from Knoxville (TYS) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — JAN
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Knoxville to Mississippi

Keep the following information in mind while searching for Knoxville to Mississippi flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$229
(Delta)

One-way from

$100
(American Airlines)

Popular in

November

Cheapest in

May

Average price

$308
Provider with most accurate pricing for Knoxville McGhee Tyson-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Jackson-Evers Intl flights.
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From Knoxville McGhee Tyson to Mississippi
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One-way flight from Knoxville McGhee Tyson to Mississippi
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Highest demand for flights based on searches. 10% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($18 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Knoxville to Mississippi

Cheapest flights from Knoxville to Mississippi
Explore the most affordable flight options available from Knoxville to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Mytrip deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/37:13 pmTYS - MEM
1 stop25h 08mMultiple Airlines
Mon 4/78:24 pmMEM - TYS
1 stop23h 27mMultiple Airlines
Deal found 2/18$203
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/47:54 pmTYS - MEM
1 stop4h 51mAmerican Airlines
Sat 4/57:20 amMEM - TYS
1 stop4h 09mAmerican Airlines
Deal found 2/19$214
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/275:45 amTYS - MEM
1 stop3h 22mDelta
Sun 3/307:16 pmMEM - TYS
1 stop3h 21mDelta
Deal found 2/19$229
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/612:08 pmTYS - JAN
1 stop5h 12mDelta
Mon 3/107:26 pmJAN - TYS
1 stop3h 16mDelta
Deal found 2/19$239
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/239:00 amTYS - GPT
2 stops34h 08mMultiple Airlines
Sun 4/276:48 pmGPT - TYS
1 stop18h 42mMultiple Airlines
Deal found 2/20$278
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/77:05 amTYS - MEM
1 stop8h 22mUnited Airlines
Tue 3/113:15 pmMEM - TYS
1 stop6h 30mUnited Airlines
Deal found 2/20$300
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/77:05 amTYS - JAN
1 stop5h 15mUnited Airlines
Tue 3/115:11 pmJAN - TYS
1 stop5h 19mUnited Airlines
Deal found 2/20$300
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/236:05 pmTYS - GPT
1 stop4h 37mAmerican Airlines
Sun 4/276:42 pmGPT - TYS
1 stop4h 03mAmerican Airlines
Deal found 2/20$304
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/265:28 amTYS - BTR
1 stop5h 03mAmerican Airlines
Thu 3/64:58 pmBTR - TYS
1 stop5h 59mAmerican Airlines
Deal found 2/19$319
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/275:45 amTYS - MOB
1 stop3h 52mDelta
Sun 3/305:07 pmMOB - TYS
1 stop5h 30mDelta
Deal found 2/19$394
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/277:23 pmTYS - GPT
1 stop3h 40mDelta
Sun 3/306:02 pmGPT - TYS
1 stop4h 35mDelta
Deal found 2/19$459
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/77:05 amTYS - BTR
1 stop5h 10mUnited Airlines
Tue 3/112:00 pmBTR - TYS
1 stop5h 02mUnited Airlines
Deal found 2/20$485

Find flights from Knoxville to Mississippi within your budget

Customize your flight search to find flights from Knoxville to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Knoxville

Fly to

Mississippi

Route

Depart

Return

Price

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 4/3

7:13 pm-7:21 pm

1 stop25h 08m

Memphis

Mon 4/7

8:24 pm-8:51 pm

1 stop23h 27m

$203

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 4/4

7:54 pm-11:45 pm

1 stop4h 51m

Memphis

Sat 4/5

7:20 am-12:29 pm

1 stop4h 09m

$214

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Thu 3/27

5:45 am-8:07 am

1 stop3h 22m

Memphis

Sun 3/30

7:16 pm-11:37 pm

1 stop3h 21m

$229

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Thu 3/6

12:08 pm-4:20 pm

1 stop5h 12m

Jackson-Evers Intl

Mon 3/10

7:26 pm-11:42 pm

1 stop3h 16m

$239

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 4/23

9:00 am-6:08 pm

2 stops34h 08m

Gulfport Biloxi Regional

Sun 4/27

6:48 pm-2:30 pm

1 stop18h 42m

$278

KnoxvilleMemphis

TYS - MEM

TYSMEM

Knoxville McGhee Tyson

Fri 3/7

7:05 am-2:27 pm

1 stop8h 22m

Memphis

Tue 3/11

3:15 pm-10:45 pm

1 stop6h 30m

$300

KnoxvilleJackson

TYS - JAN

TYSJAN

Knoxville McGhee Tyson

Fri 3/7

7:05 am-11:20 am

1 stop5h 15m

Jackson-Evers Intl

Tue 3/11

5:11 pm-11:30 pm

1 stop5h 19m

$300

KnoxvilleGulfport

TYS - GPT

TYSGPT

Knoxville McGhee Tyson

Wed 4/23

6:05 pm-9:42 pm

1 stop4h 37m

Gulfport Biloxi Regional

Sun 4/27

6:42 pm-11:45 pm

1 stop4h 03m

$304

KnoxvilleBaton Rouge

TYS - BTR

TYSBTR

Knoxville McGhee Tyson

Wed 2/26

5:28 am-9:31 am

1 stop5h 03m

Baton Rouge Ryan

Thu 3/6

4:58 pm-11:57 pm

1 stop5h 59m

$319

KnoxvilleMobile

TYS - MOB

TYSMOB

Knoxville McGhee Tyson

Thu 3/27

5:45 am-8:37 am

1 stop3h 52m

Mobile

Sun 3/30

5:07 pm-11:37 pm

1 stop5h 30m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 20 results
1
2

Best time to book a flight from Knoxville to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Knoxville to Mississippi

Get recent, data-driven insights about flights from Knoxville to Mississippi including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Knoxville to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MS?

Find hourly flight availability from Knoxville to Mississippi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from Knoxville to Mississippi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated February 20, 2025.
To help decide which airline to fly from Knoxville to Mississippi, see what other customers have to say about Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,220 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,766 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

8.0

Entertainment

7.9

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Mississippi?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Mississippi. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the most popular routes from Knoxville to Mississippi?

    While some choose either Knoxville McGhee Tyson - Jackson-Evers Intl or Knoxville McGhee Tyson - Mobile, Knoxville McGhee Tyson - Gulfport Biloxi Regional is the most popular route from Knoxville to Mississippi.

  • Can I find deals for flights from Knoxville to Mississippi that include hotel bookings?

    Yes. In addition to deals on Knoxville to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Mississippi.

  • Can I find deals for business class flights from Knoxville to Mississippi?

    Yes. Cheapflights offers flight deals from Knoxville to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Mississippi (average of $371). Flying from Knoxville to Mississippi in March is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Mississippi

Discover the top 2 airlines that operate flights from Knoxville to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$217Average$293FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$233Average$334FlexibilityNo cancel feeOn-time71%
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