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$100+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
abr. 20 — abr. 271
dom. 4/20
dom. 4/27
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated abril 15, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$191
(Booking.com)

One-way from

$100
(United Airlines)

Popular in

May

Cheapest in

December
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
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From Des Moines to Mississippi
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One-way flight from Des Moines to Mississippi
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Highest demand for flights based on searches. 8% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Find flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 15, 2025.

This Booking.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/307:27 pmDSM - MEM
1 stop18h 39mFrontier
dom. 5/43:05 pmMEM - DSM
1 stop27h 25mFrontier
Deal found 4/15$191
This Mytrip deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/118:30 amDSM - MEM
1 stop11h 09mMultiple Airlines
mar. 5/209:08 pmMEM - DSM
1 stop17h 24mMultiple Airlines
Deal found 4/15$226
This Southwest deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/117:35 amDSM - MEM
1 stop6h 25mSouthwest
mar. 5/202:40 pmMEM - DSM
2 stops7h 25mSouthwest
Deal found 4/15$234
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/56:25 pmDSM - MEM
1 stop4h 52mDelta
mié. 5/76:00 amMEM - DSM
1 stop6h 27mDelta
Deal found 4/14$242
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/32:20 pmDSM - MOB
1 stop4h 27mDelta
mar. 6/105:59 pmMOB - DSM
1 stop5h 04mDelta
Deal found 4/14$244
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/35:32 amDSM - MOB
2 stops12h 54mAmerican Airlines
mar. 6/105:00 pmMOB - DSM
1 stop5h 59mAmerican Airlines
Deal found 4/14$254
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/312:49 pmDSM - BTR
1 stop5h 03mAmerican Airlines
sáb. 5/104:32 pmBTR - DSM
1 stop7h 26mAmerican Airlines
Deal found 4/14$254
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/25:29 pmDSM - GPT
1 stop5h 31mAmerican Airlines
vie. 5/96:21 pmGPT - DSM
1 stop5h 37mAmerican Airlines
Deal found 4/13$254
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/295:45 amDSM - GPT
1 stop6h 27mDelta
sáb. 5/34:40 pmGPT - DSM
1 stop5h 58mDelta
Deal found 4/14$259
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 6/295:00 amDSM - MEM
1 stop4h 32mAmerican Airlines
mar. 7/15:05 pmMEM - DSM
1 stop5h 13mAmerican Airlines
Deal found 4/14$268
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/33:01 pmDSM - GPT
1 stop4h 53mUnited Airlines
mar. 6/105:15 pmGPT - DSM
2 stops17h 05mUnited Airlines
Deal found 4/14$433
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/232:15 pmDSM - AEX
1 stop6h 58mDelta
lun. 5/266:05 amAEX - DSM
1 stop4h 36mDelta
Deal found 4/13$436

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 15, 2025.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

mié. 4/30

7:27 pm-2:06 pm

1 stop18h 39m

Memphis

dom. 5/4

3:05 pm-6:30 pm

1 stop27h 25m

$191

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

dom. 5/11

8:30 am-7:39 pm

1 stop11h 09m

Memphis

mar. 5/20

9:08 pm-2:32 pm

1 stop17h 24m

$226

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

dom. 5/11

7:35 am-2:00 pm

1 stop6h 25m

Memphis

mar. 5/20

2:40 pm-10:05 pm

2 stops7h 25m

$234

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

lun. 5/5

6:25 pm-11:17 pm

1 stop4h 52m

Memphis

mié. 5/7

6:00 am-12:27 pm

1 stop6h 27m

$242

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

mar. 6/3

2:20 pm-6:47 pm

1 stop4h 27m

Mobile

mar. 6/10

5:59 pm-11:03 pm

1 stop5h 04m

$244

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

mar. 6/3

5:32 am-6:26 pm

2 stops12h 54m

Mobile

mar. 6/10

5:00 pm-10:59 pm

1 stop5h 59m

$254

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

sáb. 5/3

12:49 pm-5:52 pm

1 stop5h 03m

Baton Rouge Ryan

sáb. 5/10

4:32 pm-11:58 pm

1 stop7h 26m

$254

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

vie. 5/2

5:29 pm-11:00 pm

1 stop5h 31m

Gulfport Biloxi Regional

vie. 5/9

6:21 pm-11:58 pm

1 stop5h 37m

$254

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

mar. 4/29

5:45 am-12:12 pm

1 stop6h 27m

Gulfport Biloxi Regional

sáb. 5/3

4:40 pm-10:38 pm

1 stop5h 58m

$259

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

dom. 6/29

5:00 am-9:32 am

1 stop4h 32m

Memphis

mar. 7/1

5:05 pm-10:18 pm

1 stop5h 13m

$268

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/15

Showing 1-10 of 30 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mississippi

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $451). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated abril 15, 2025.
To help decide which airline to fly from Des Moines to Mississippi, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,279 reviews
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,918 reviews
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,658 reviews
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,279 reviews

Comfort

8.0

Crew

8.6

Entertainment

7.6

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • What are the cheapest airlines to fly from Des Moines to Mississippi one-way?

    The cheapest airlines for a one-way flight from Des Moines to Mississippi are United Airlines ($100), American Airlines ($105), and Delta ($128).

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Mobile, Des Moines - Gulfport Biloxi Regional or Des Moines - Memphis as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $451). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Omaha to Reagan-National flights
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Cedar Rapids to Reagan-National flights

Top 2 airlines flying from Des Moines to Mississippi

Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$362FlexibilityNo cancel feeOn-time71%
DeltaCheapest$263Average$323FlexibilityNo cancel feeOn-timeN/A

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