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$124+ Cheap flights from Des Moines (DSM) to Mississippi

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Mar 10 — Mar 171
Mon 3/10
Mon 3/17
1 adult, Economy
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Cheap flight deals from Des Moines to Mississippi

Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated March 5, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$244
(United Airlines)

One-way from

$124
(American Airlines)

Popular in

March

Cheapest in

December

Average price

$623
Provider with most accurate pricing for Des Moines-Jackson-Evers Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Jackson-Evers Intl flights.
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From Des Moines to Mississippi
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One-way flight from Des Moines to Mississippi
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Highest demand for flights based on searches. 15% potential increase in price ($78 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Des Moines to Mississippi

Cheapest flights from Des Moines to Mississippi
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2025.

This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/96:30 pmDSM - MOB
1 stop4h 26mDelta
Sun 7/135:55 amMOB - DSM
1 stop4h 19mDelta
Deal found 3/4$244
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:25 pmDSM - MEM
1 stop4h 52mDelta
Thu 4/246:00 amMEM - DSM
1 stop4h 41mDelta
Deal found 3/4$247
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/51:45 pmDSM - MOB
2 stops7h 57mUnited Airlines
Fri 4/115:20 pmMOB - DSM
1 stop5h 25mUnited Airlines
Deal found 3/5$254
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1511:54 amDSM - MEM
2 stops8h 15mAmerican Airlines
Fri 4/185:26 pmMEM - DSM
1 stop5h 27mAmerican Airlines
Deal found 3/4$267
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/154:45 pmDSM - MEM
2 stops5h 55mSouthwest
Fri 4/184:00 pmMEM - DSM
2 stops7h 05mSouthwest
Deal found 3/5$272
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/86:30 amDSM - BTR
2 stops8h 14mDelta
Sat 5/106:00 amBTR - DSM
1 stop7h 29mDelta
Deal found 3/4$295
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/58:00 amDSM - JAN
1 stop5h 25mUnited Airlines
Fri 4/115:15 pmJAN - DSM
1 stop5h 30mUnited Airlines
Deal found 3/5$317
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/81:12 pmDSM - BTR
1 stop4h 40mAmerican Airlines
Sat 5/107:00 amBTR - DSM
1 stop5h 05mAmerican Airlines
Deal found 3/4$324
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/85:00 amDSM - MOB
1 stop6h 41mAmerican Airlines
Wed 3/1212:54 pmMOB - DSM
2 stops9h 56mAmerican Airlines
Deal found 3/4$329
This Mytrip deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/194:43 pmDSM - MEM
2 stops23h 22mMultiple Airlines
Thu 5/225:00 pmMEM - DSM
1 stop20h 53mMultiple Airlines
Deal found 3/5$329
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/512:49 pmDSM - JAN
2 stops11h 04mAmerican Airlines
Fri 4/115:18 amJAN - DSM
1 stop6h 44mAmerican Airlines
Deal found 3/5$332
This United deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/155:45 amDSM - MEM
2 stops8h 37mUnited Airlines
Fri 4/183:14 pmMEM - DSM
2 stops8h 28mUnited Airlines
Deal found 3/5$392

Find flights from Des Moines to Mississippi within your budget

Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2025.

Fly from

Des Moines

Fly to

Mississippi

Route

Depart

Return

Price

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Wed 7/9

6:30 pm-10:56 pm

1 stop4h 26m

Mobile

Sun 7/13

5:55 am-10:14 am

1 stop4h 19m

$244

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 4/17

6:25 pm-11:17 pm

1 stop4h 52m

Memphis

Thu 4/24

6:00 am-10:41 am

1 stop4h 41m

$247

Des MoinesMobile

DSM - MOB

DSMMOB

Des Moines

Sat 4/5

1:45 pm-9:42 pm

2 stops7h 57m

Mobile

Fri 4/11

5:20 pm-10:45 pm

1 stop5h 25m

$254

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 4/15

11:54 am-8:09 pm

2 stops8h 15m

Memphis

Fri 4/18

5:26 pm-10:53 pm

1 stop5h 27m

$267

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 4/15

4:45 pm-10:40 pm

2 stops5h 55m

Memphis

Fri 4/18

4:00 pm-11:05 pm

2 stops7h 05m

$272

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 5/8

6:30 am-2:44 pm

2 stops8h 14m

Baton Rouge Ryan

Sat 5/10

6:00 am-1:29 pm

1 stop7h 29m

$295

Des MoinesJackson

DSM - JAN

DSMJAN

Des Moines

Sat 4/5

8:00 am-1:25 pm

1 stop5h 25m

Jackson-Evers Intl

Fri 4/11

5:15 pm-10:45 pm

1 stop5h 30m

$317

Des MoinesBaton Rouge

DSM - BTR

DSMBTR

Des Moines

Thu 5/8

1:12 pm-5:52 pm

1 stop4h 40m

Baton Rouge Ryan

Sat 5/10

7:00 am-12:05 pm

1 stop5h 05m

$324

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 5/19

4:43 pm-4:05 pm

2 stops23h 22m

Memphis

Thu 5/22

5:00 pm-1:53 pm

1 stop20h 53m

$329

Des MoinesJackson

DSM - JAN

DSMJAN

Des Moines

Sat 4/5

12:49 pm-11:53 pm

2 stops11h 04m

Jackson-Evers Intl

Fri 4/11

5:18 am-12:02 pm

1 stop6h 44m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/4

Showing 1-10 of 29 results
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Best time to book a flight from Des Moines to Mississippi

Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to Mississippi

Get recent, data-driven insights about flights from Des Moines to Mississippi including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to Mississippi?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Mississippi by month

Plan your trip to Mississippi by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Mississippi ranges from 2.2 - 5.6 inches per month. December is typically the wettest month, when rainfall can reach 5.6 in. October is typically the driest time to visit Mississippi when rainfall is around 2.2 in.

Temperature in Mississippi by month

Plan your trip to Mississippi by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Mississippi, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Mississippi

Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated March 5, 2025.
To help decide which airline to fly from Des Moines to Mississippi, see what other customers have to say about Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest
8.1
Very good
4,321 reviews
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta
8.0
Very good
8,044 reviews
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines
7.4
Good
8,655 reviews
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Allegiant Air
7.3
Good
751 reviews
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,321 reviews

Boarding

8.2

Food

7.1

Entertainment

7.6

Comfort

8.1

Overall

8.1

Crew

8.7

Reviews

1 / 20

8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Mississippi?

    If you book a flight to Mississippi from Des Moines, you will be flying from Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • What are the cheapest airlines to fly from Des Moines to Mississippi one-way?

    The cheapest airlines for a one-way flight from Des Moines to Mississippi are American Airlines ($124), Southwest ($214), and Delta ($321).

  • What are the most popular routes from Des Moines to Mississippi?

    When deciding which route to take from Des Moines to Mississippi consider Des Moines - Memphis, Des Moines - Mobile or Des Moines - Baton Rouge Ryan as they are the most popular.

  • Can I find deals for flights from Des Moines to Mississippi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Mississippi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Mississippi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mississippi.

  • Can I find deals for business class flights from Des Moines to Mississippi?

    Yes. Cheapflights offers flight deals from Des Moines to Mississippi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Mississippi?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Mississippi (average of $371). Flying from Des Moines to Mississippi in March is currently the most expensive (average of $471). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Mississippi

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Des Moines to Mississippi

Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$362FlexibilityNo cancel feeOn-time71%
DeltaCheapest$282Average$323FlexibilityNo cancel feeOn-timeN/A
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