What are the cheapest airlines to fly from Des Moines to Mexico one-way?

For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $232. Users have also found prices from $247 and $280 on Delta and Air Canada, respectively.

What are the most popular routes from Des Moines to Mexico?

Most travelers choose Des Moines - Cancun, Des Moines - Cozumel or Des Moines - Mexico City Benito Juarez when deciding on the best route from Des Moines to Mexico.

What are the most popular airlines that fly from Des Moines to Mexico?

The most popular airlines flying from Des Moines to Mexico are American Airlines, Delta and United Airlines. Something to consider prior to booking your flight.

What is the cheapest month to fly from Des Moines to Mexico?

February can be a great time to fly to Mexico from Des Moines with a flight ticket averaging about $695. Cheapflights users have found deals in the month of February for as cheap as $535. The most expensive prices can be found in the month of December.

What airport do you fly from for flights from Des Moines to Mexico?

Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Mexico. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

Can I find deals for flights from Des Moines to Mexico that include hotel bookings?

Yes. In addition to deals on Des Moines to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Mexico?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mexico.

Can I find deals for business class flights from Des Moines to Mexico?

Yes. Cheapflights offers flight deals from Des Moines to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$449+ Flights from Des Moines to Mexico

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Cheap flight deals from Des Moines to Mexico

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$439 (American Airlines)
One-way from	$218 (Kiwi.com)
Popular in	December
Cheapest in	February
Average price	$639

Provider with most accurate pricing for Des Moines-Mexico City Benito Juarez flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Mexico City Benito Juarez flights.

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From Des Moines to Mexico

Search Deals

One-way flight from Des Moines to Mexico

Search Deals

Highest demand for flights based on searches. 4% potential increase in price ($34 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($17 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

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Find flight deals from Des Moines to Mexico

Cheapest flights from Des Moines to Mexico
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on avril 17, 2025.

lun. 5/122:20 pmDSM - CUN

1 stop23h 24mAmerican Airlines

sam. 5/177:50 amCUN - DSM

1 stop8h 47mAmerican Airlines

Deal found 4/15

$439

dim. 8/315:45 amDSM - SJD

1 stop7h 45mDelta

ven. 9/196:01 amSJD - DSM

2 stops14h 22mDelta

Deal found 4/16

$443

mer. 10/111:04 amDSM - CUN

1 stop8h 58mAeromexico

mer. 10/1512:23 pmCUN - DSM

1 stop8h 27mAeromexico

Deal found 4/16

$452

mar. 6/37:01 amDSM - CUN

2 stops13h 44mDelta

mar. 6/108:35 amCUN - DSM

2 stops14h 28mDelta

Deal found 4/16

$453

sam. 5/312:54 pmDSM - CUN

2 stops20h 19mMultiple Airlines

sam. 6/712:39 pmCUN - DSM

2 stops33h 58mMultiple Airlines

Deal found 4/16

$457

jeu. 5/85:45 amDSM - BJX

2 stops14h 46mUnited Airlines

mer. 5/1411:45 amBJX - DSM

1 stop10h 00mUnited Airlines

Deal found 4/16

$470

jeu. 5/15:00 amDSM - MEX

1 stop12h 15mAmerican Airlines

dim. 5/45:00 amMEX - DSM

1 stop16h 53mAmerican Airlines

Deal found 4/16

$474

sam. 5/312:44 pmDSM - PVR

1 stop22h 26mAmerican Airlines

sam. 6/710:48 amPVR - DSM

1 stop7h 16mAmerican Airlines

Deal found 4/16

$481

sam. 5/315:35 amDSM - MEX

2 stops10h 45mAeromexico

sam. 6/76:01 amMEX - DSM

2 stops10h 49mAeromexico

Deal found 4/16

$484

jeu. 5/88:00 amDSM - GDL

1 stop6h 34mUnited Airlines

sam. 5/172:30 pmGDL - DSM

1 stop7h 15mUnited Airlines

Deal found 4/16

$486

mar. 5/2011:26 amDSM - BJX

1 stop7h 57mAeromexico

dim. 6/19:41 amBJX - DSM

1 stop7h 09mAeromexico

Deal found 4/17

$487

sam. 5/312:54 pmDSM - MEX

2 stops32h 06mMultiple Airlines

sam. 6/76:20 amMEX - DSM

2 stops39h 17mMultiple Airlines

Deal found 4/15

$489

Best flights from Des Moines to Mexico
Discover carefully curated flight deals from Des Moines to Mexico that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated avril 17, 2025.

lun. 5/122:20 pmDSM - CUN

1 stop23h 24mAmerican Airlines

sam. 5/177:50 amCUN - DSM

1 stop8h 47mAmerican Airlines

Deal found 4/15

$439

dim. 8/315:45 amDSM - SJD

1 stop7h 45mDelta

ven. 9/196:01 amSJD - DSM

2 stops14h 22mDelta

Deal found 4/16

$443

mer. 10/111:04 amDSM - CUN

1 stop8h 58mAeromexico

mer. 10/1512:23 pmCUN - DSM

1 stop8h 27mAeromexico

Deal found 4/16

$452

sam. 5/312:54 pmDSM - CUN

2 stops20h 19mMultiple Airlines

sam. 6/712:39 pmCUN - DSM

2 stops33h 58mMultiple Airlines

Deal found 4/16

$457

jeu. 5/85:45 amDSM - BJX

2 stops14h 46mUnited Airlines

mer. 5/1411:45 amBJX - DSM

1 stop10h 00mUnited Airlines

Deal found 4/16

$470

lun. 7/215:25 amDSM - SJD

2 stops8h 55mSouthwest

ven. 7/2511:55 amSJD - DSM

1 stop9h 00mSouthwest

Deal found 4/17

$561

sam. 5/315:15 amDSM - CZM

1 stop10h 55mBritish Airways

sam. 6/74:23 pmCZM - DSM

1 stop6h 43mBritish Airways

Deal found 4/16

$624

mar. 6/36:30 amDSM - CUN

1 stop6h 20mDelta

mar. 6/109:30 amCUN - DSM

2 stops13h 33mDelta

Deal found 4/16

$453

jeu. 5/15:00 amDSM - MEX

1 stop12h 15mAmerican Airlines

dim. 5/45:00 amMEX - DSM

1 stop16h 53mAmerican Airlines

Deal found 4/16

$474

sam. 5/315:35 amDSM - MEX

2 stops10h 45mAeromexico

sam. 6/76:01 amMEX - DSM

2 stops10h 49mAeromexico

Deal found 4/16

$484

jeu. 5/88:00 amDSM - GDL

1 stop6h 34mUnited Airlines

sam. 5/172:30 pmGDL - DSM

1 stop7h 15mUnited Airlines

Deal found 4/16

$486

sam. 5/312:54 pmDSM - MEX

2 stops32h 06mMultiple Airlines

sam. 6/76:20 amMEX - DSM

2 stops39h 17mMultiple Airlines

Deal found 4/15

$489

Last-minute flights from Des Moines to Mexico
Discover last-minute flight deals from Des Moines to Mexico. Data last updated avril 17, 2025 and is based on user searches.

ven. 4/255:29 pmDSM - CUN

1 stop16h 26mAmerican Airlines

mar. 4/292:40 pmCUN - DSM

1 stop7h 27mAmerican Airlines

Deal found 4/16

$562

ven. 4/256:47 pmDSM - CUN

2 stops24h 33mUnited Airlines

mar. 4/293:30 pmCUN - DSM

2 stops19h 10mUnited Airlines

Deal found 4/16

$569

ven. 4/255:00 amDSM - CZM

1 stop8h 55mAmerican Airlines

ven. 5/21:55 pmCZM - DSM

1 stop7h 58mAmerican Airlines

Deal found 4/17

$700

ven. 4/256:47 pmDSM - CZM

2 stops18h 45mUnited Airlines

ven. 5/21:21 pmCZM - DSM

1 stop8h 24mUnited Airlines

Deal found 4/16

$794

dim. 4/275:05 amDSM - SJD

1 stop8h 50mAmerican Airlines

ven. 5/22:29 pmSJD - DSM

1 stop6h 24mAmerican Airlines

Deal found 4/16

$512

mar. 4/295:45 amDSM - CUN

1 stop8h 16mDelta

mar. 5/68:31 amCUN - DSM

2 stops14h 07mDelta

Deal found 4/16

$475

jeu. 5/15:00 amDSM - MEX

1 stop12h 15mAmerican Airlines

dim. 5/45:00 amMEX - DSM

1 stop16h 53mAmerican Airlines

Deal found 4/16

$474

jeu. 5/110:22 amDSM - MEX

2 stops11h 43mDelta

mer. 5/76:55 amMEX - DSM

2 stops14h 35mDelta

Deal found 4/16

$492

jeu. 5/85:45 amDSM - BJX

2 stops14h 46mUnited Airlines

mer. 5/1411:45 amBJX - DSM

1 stop10h 00mUnited Airlines

Deal found 4/16

$470

jeu. 5/88:00 amDSM - GDL

1 stop6h 34mUnited Airlines

sam. 5/172:30 pmGDL - DSM

1 stop7h 15mUnited Airlines

Deal found 4/16

$486

lun. 5/122:20 pmDSM - CUN

1 stop23h 24mAmerican Airlines

sam. 5/177:50 amCUN - DSM

1 stop8h 47mAmerican Airlines

Deal found 4/15

$439

mar. 5/2011:26 amDSM - BJX

1 stop7h 57mAeromexico

dim. 6/19:41 amBJX - DSM

1 stop7h 09mAeromexico

Deal found 4/17

$487

One-way flights from Des Moines to Mexico
Search for one-way flight options from Des Moines to Mexico. Find affordable one-way fares based on user searches. Data last updated avril 17, 2025.

ven. 5/302:43 pmDSM - PVR

1 stop23h 49mMultiple Airlines

Deal found 4/16

$218

mer. 6/187:30 amDSM - GDL

1 stop10h 31mMultiple Airlines

Deal found 4/17

$223

sam. 5/3112:50 pmDSM - PVR

1 stop22h 25mAmerican Airlines

Deal found 4/16

$232

sam. 5/317:01 amDSM - PVR

2 stops11h 14mDelta

Deal found 4/16

$247

lun. 6/166:30 amDSM - BJX

3 stops33h 20mMultiple Airlines

Deal found 4/17

$250

lun. 6/166:30 amDSM - MLM

2 stops33h 54mMultiple Airlines

Deal found 4/17

$255

sam. 5/316:00 amDSM - MEX

2 stops17h 50mAir Canada

Deal found 4/16

$280

sam. 5/315:35 amDSM - MEX

2 stops10h 45mAeromexico

Deal found 4/15

$282

sam. 5/38:00 amDSM - MEX

1 stop6h 15mUnited Airlines

Deal found 4/16

$289

mar. 6/177:00 amDSM - GDL

2 stops11h 50mDelta

Deal found 4/17

$291

mar. 6/1711:24 amDSM - BJX

2 stops12h 55mDelta

Deal found 4/17

$301

mer. 6/185:00 amDSM - MLM

1 stop7h 54mAmerican Airlines

Deal found 4/17

$316

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

lun. 5/12

2:20 pm-1:44 pm

1 stop23h 24m

Cancun

sam. 5/17

7:50 am-4:37 pm

1 stop8h 47m

$439

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

mar. 6/3

7:01 am-8:45 pm

2 stops13h 44m

Cancun

mar. 6/10

8:35 am-11:03 pm

2 stops14h 28m

$453

Des MoinesCancún

DSM - CUN

DSMCUN

Des Moines

sam. 5/31

2:54 pm-11:13 am

2 stops20h 19m

Cancun

sam. 6/7

12:39 pm-10:37 pm

2 stops33h 58m

$457

Des MoinesLeón

DSM - BJX

DSMBJX

Des Moines

jeu. 5/8

5:45 am-7:31 pm

2 stops14h 46m

León Del Bajio

mer. 5/14

11:45 am-10:45 pm

1 stop10h 00m

$470

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

jeu. 5/1

5:00 am-4:15 pm

1 stop12h 15m

Mexico City Benito Juarez

dim. 5/4

5:00 am-10:53 pm

1 stop16h 53m

$474

Des MoinesPuerto Vallarta

DSM - PVR

DSMPVR

Des Moines

sam. 5/31

2:44 pm-12:10 pm

1 stop22h 26m

Puerto Vallarta Ordaz

sam. 6/7

10:48 am-7:04 pm

1 stop7h 16m

$481

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

sam. 5/31

5:35 am-3:20 pm

2 stops10h 45m

Mexico City Benito Juarez

sam. 6/7

6:01 am-5:50 pm

2 stops10h 49m

$484

Des MoinesGuadalajara

DSM - GDL

DSMGDL

Des Moines

jeu. 5/8

8:00 am-1:34 pm

1 stop6h 34m

Guadalajara Miguel Hidal

sam. 5/17

2:30 pm-10:45 pm

1 stop7h 15m

$486

Des MoinesLeón

DSM - BJX

DSMBJX

Des Moines

mar. 5/20

11:26 am-6:23 pm

1 stop7h 57m

León Del Bajio

dim. 6/1

9:41 am-5:50 pm

1 stop7h 09m

$487

Des MoinesMexico City

DSM - MEX

DSMMEX

Des Moines

sam. 5/31

2:54 pm-10:00 pm

2 stops32h 06m

Mexico City Benito Juarez

sam. 6/7

6:20 am-10:37 pm

2 stops39h 17m

$489

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 47 results

...

Best time to book a flight from Des Moines to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mexico

What is the cheapest month to book a flight from Des Moines to Mexico?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $400). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MX?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Mexico as you normally would.

Rainfall in Mexico by month

In terms of precipitation, rainfall in Mexico ranges from 0.0 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. January is typically the driest time to visit Mexico when rainfall is around 0.0 in.

Temperature in Mexico by month

If weather is an important factor for your trip to Mexico, use this chart to help with planning. For those seeking warmer temperatures, May is the ideal time of year to visit, when temperatures reach an average of 66.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

Reviews of airlines servicing Mexico

Peruse reviews from past customers who have flown with Southwest, Delta and LATAM Airlines from Des Moines to Mexico to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Southwest

8.0

Very good

4,280 reviews

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Delta

8.0

Very good

7,917 reviews

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

LATAM Airlines

7.5

Good

1,761 reviews

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Aeromexico

7.5

Good

1,699 reviews

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

United Airlines

7.4

Good

8,667 reviews

Southwest

8.0

Very good

4,280 reviews

Reviews

1 / 20

8.0

Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

What airport do you fly from for flights from Des Moines to Mexico?
Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Mexico. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.
What are the cheapest airlines to fly from Des Moines to Mexico one-way?
For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $232. Users have also found prices from $247 and $280 on Delta and Air Canada, respectively.
What are the most popular routes from Des Moines to Mexico?
Most travelers choose Des Moines - Cancun, Des Moines - Cozumel or Des Moines - Mexico City Benito Juarez when deciding on the best route from Des Moines to Mexico.
Can I find deals for flights from Des Moines to Mexico that include hotel bookings?
Yes. In addition to deals on Des Moines to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Mexico?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Mexico.
Can I find deals for business class flights from Des Moines to Mexico?
Yes. Cheapflights offers flight deals from Des Moines to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Mexico?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Mexico (average of $400). Flying from Des Moines to Mexico in December is currently the most expensive (average of $615). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Des Moines to Mexico

Airline	Cheapest	Average	Flexibility	On-time
Aeromexico	Cheapest$350	Average$498	FlexibilityNo cancel fee	On-timeN/A
Delta	Cheapest$409	Average$576	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$421	Average$685	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$441	Average$624	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$460	Average$646	FlexibilityNo cancel fee	On-time63%

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$218+ Cheap flights from Des Moines (DSM) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Mexico with Cheapflights

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Cheap flight deals from Des Moines to Mexico

Keep the following information in mind while searching for Des Moines to Mexico flight deals. Data was last updated avril 17, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Mexico

Cheapest flights from Des Moines to MexicoExplore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on avril 17, 2025.

Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on avril 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Mexico that are best for you.

Best time to book a flight from Des Moines to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Mexico

What is the cheapest month to book a flight from Des Moines to Mexico?

What is the cheapest time of day to fly from DSM to MX?

Find hourly flight availability from Des Moines to Mexico. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated avril 17, 2025.

Rainfall in Mexico by month

Plan your trip to Mexico by taking into account the average rainfall totals by month.

Temperature in Mexico by month

Plan your trip to Mexico by taking into account the average temperature totals by month.

Reviews of airlines servicing Mexico

Peruse reviews from past customers who have flown with Southwest, Delta and LATAM Airlines from Des Moines to Mexico to help guide your decision. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Des Moines to Mexico?

What are the cheapest airlines to fly from Des Moines to Mexico one-way?

What are the most popular routes from Des Moines to Mexico?

Can I find deals for flights from Des Moines to Mexico that include hotel bookings?

How can I find direct flights from Des Moines to Mexico?

Can I find deals for business class flights from Des Moines to Mexico?

What is the cheapest month to book a flight from Des Moines to Mexico?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Mexico

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Des Moines to Mexico

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Cheapest flights from Des Moines to Mexico
Explore the most affordable flight options available from Des Moines to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on avril 17, 2025.