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$111+ Cheap flights from St. Louis to Knoxville (STL - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Apr 16 — Apr 231
Wed 4/16
Wed 4/23
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Knoxville McGhee Tyson are usually found in July or June, booked 42 days in advance, depart on a Thursday or Wednesday and return on a Wednesday

Cheap flight deals from St. Louis to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$217
(Delta)

One-way from

$111
(Mytrip)

Popular in

December

Cheapest in

July

Average price

$289
Provider with most accurate pricing for Lambert-St Louis-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Knoxville McGhee Tyson flights.
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From Lambert-St Louis to Knoxville McGhee Tyson
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One-way flight from Lambert-St Louis to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 11% potential increase in price ($44 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from St. Louis to Knoxville

Cheapest flights from St. Louis to Knoxville
Explore the most affordable flight options available from St. Louis to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/257:05 amSTL - TYS
1 stop3h 18mDelta
Fri 5/302:04 pmTYS - STL
1 stop3h 31mDelta
Deal found 4/8$217
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/207:10 amSTL - TYS
1 stop6h 14mAmerican Airlines
Sat 5/246:28 pmTYS - STL
1 stop5h 17mAmerican Airlines
Deal found 4/8$225
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/233:40 pmSTL - TYS
1 stop5h 42mUnited Airlines
Sat 4/267:00 amTYS - STL
1 stop6h 20mUnited Airlines
Deal found 4/9$239
This Mytrip deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2510:10 amSTL - TYS
2 stops23h 06mMultiple Airlines
Fri 5/309:03 pmTYS - STL
1 stop13h 12mMultiple Airlines
Deal found 4/9$288

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
Use the filters below to find and compare flights from St. Louis to Knoxville that are best for you.

Fly from

St. Louis

Fly to

Knoxville

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 5/25

7:05 am-11:23 am

1 stop3h 18m

Knoxville McGhee Tyson

Fri 5/30

2:04 pm-4:35 pm

1 stop3h 31m

$217

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 5/20

7:10 am-2:24 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 5/24

6:28 pm-10:45 pm

1 stop5h 17m

$225

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 4/23

3:40 pm-10:22 pm

1 stop5h 42m

Knoxville McGhee Tyson

Sat 4/26

7:00 am-12:20 pm

1 stop6h 20m

$239

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 5/25

10:10 am-10:16 am

2 stops23h 06m

Knoxville McGhee Tyson

Fri 5/30

9:03 pm-9:15 am

1 stop13h 12m

$288

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 5/17

10:10 am-2:21 pm

1 stop27h 11m

$111

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 4/16

6:51 pm-3:41 pm

1 stop19h 50m

$120

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 4/23

7:33 am-4:23 pm

1 stop7h 50m

$201

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 5/1

5:32 pm-11:48 pm

1 stop5h 16m

$230

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Tue 4/29

9:39 am-10:05 am

2 stops23h 26m

$371

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Compare providers for flights from St. Louis to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Knoxville

What is the cheapest month to book a flight from St. Louis to Knoxville?

Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $296). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to TYS?

Find hourly flight availability from St. Louis to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 11, 2025.

When flying from St. Louis to Knoxville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 28% versus a flight at noon.

What is the cheapest day to fly from St. Louis to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their St. Louis to Knoxville flight should consider departing on Thursday evenings when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 11, 2025.
Delta
8.0
Very good
7,910 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,910 reviews
Delta
8.0
Very good
7,910 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,636 reviews
Delta
8.0
Very good
7,910 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,910 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
6.0
Okay
3,277 reviews
Delta
8.0
Very good
7,910 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Knoxville round-trip?

    According to our current data, Delta ($217), American Airlines ($225), and United Airlines ($239) offers the cheapest pricing from St. Louis to Knoxville. Delta is priced at 36% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from St. Louis to Knoxville one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $120. Users have also found prices from $201 and $230 on American Airlines and Delta, respectively.

  • Can I find deals for flights from St. Louis to Knoxville that include hotel bookings?

    Yes. In addition to deals on St. Louis to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Knoxville.

  • Can I find deals for business class flights from St. Louis to Knoxville?

    Yes. Cheapflights offers flight deals from St. Louis to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from St. Louis to Knoxville (average of $296). Flying from St. Louis to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from St. Louis to Knoxville

Discover the top 3 airlines that operate flights from St. Louis to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$378FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$214Average$337FlexibilityNo cancel feeOn-time71%
DeltaCheapest$222Average$292FlexibilityNo cancel feeOn-timeN/A

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