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$100+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Apr 5 — Apr 121
Sa 4/5
Sa 4/12
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated März 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$194
(Mytrip)

One-way from

$100
(Mytrip)

Popular in

June

Cheapest in

May

Average price

$603
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
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From Spartanburg to Knoxville McGhee Tyson
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One-way flight from Spartanburg to Knoxville McGhee Tyson
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High demand for flights, 4% potential price rise
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on März 31, 2025.

This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 5/56:58 amCLT - TYS
1 stop15h 20mMultiple Airlines
Mi 5/78:30 amTYS - CLT
1 stop13h 30mMultiple Airlines
Deal found 3/31$228
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 4/2911:16 amCLT - TYS
1 stop22h 49mAmerican Airlines
Di 5/67:44 pmTYS - CLT
1 stop10h 44mAmerican Airlines
Deal found 3/31$357
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 4/295:32 pmCLT - TYS
1 stop16h 43mUnited Airlines
Di 5/65:35 pmTYS - CLT
2 stops20h 36mUnited Airlines
Deal found 3/31$464
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/37:00 amCLT - TYS
1 stop9h 42mDelta
So 5/411:55 amTYS - CLT
1 stop2h 59mDelta
Deal found 3/31$490

Cheapflights Fare Finder

Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 31, 2025.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Spartanburg

Fly to

Knoxville

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mi 5/7

6:17 pm-8:55 pm

1 stop26h 38m

Knoxville McGhee Tyson

Mi 5/14

5:02 pm-1:58 pm

1 stop20h 56m

$220

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Di 4/29

11:16 am-10:05 am

1 stop22h 49m

Knoxville McGhee Tyson

Di 5/6

7:44 pm-6:28 am

1 stop10h 44m

$357

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Di 4/29

5:32 pm-10:15 am

1 stop16h 43m

Knoxville McGhee Tyson

Di 5/6

5:35 pm-2:11 pm

2 stops20h 36m

$464

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sa 5/3

7:00 am-4:42 pm

1 stop9h 42m

Knoxville McGhee Tyson

So 5/4

11:55 am-2:54 pm

1 stop2h 59m

$490

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sa 4/26

6:58 am-8:22 pm

1 stop13h 24m

$100

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sa 5/31

8:06 am-5:11 pm

1 stop9h 05m

$184

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fr 5/30

7:59 pm-10:34 am

1 stop14h 35m

$238

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Di 7/1

11:16 am-11:59 pm

2 stops12h 43m

$250

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest month to book a flight from Spartanburg to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $296). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated März 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Spartanburg to Knoxville as you normally would.

What is the cheapest day to fly from Spartanburg to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Spartanburg to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Spartanburg to Knoxville flight should consider departing on Saturday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated März 31, 2025.

The most flights from SB1 to TYS are scheduled on a Tuesday (8 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated März 31, 2025.
Delta
8.0
Very good
7,899 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Boarding

8.2

Overall

8.0

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 2 airlines have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 6 inbound flights from Spartanburg per day.

  • What are the cheapest airlines to fly from Spartanburg to Knoxville one-way?

    One-way options have recently been found by users for as low as $184 on American Airlines. Other airlines that offer cheap prices include Delta from $238 and United Airlines from $254 one-way.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Piedmont Airlines (85%), Envoy Air (81%) and American Airlines (76%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $320 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $320 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $194.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Spartanburg to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Spartanburg to Knoxville (average of $296). Flying from Spartanburg to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Spartanburg?

Book flights to Spartanburg if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 2 airlines flying from Spartanburg to Knoxville

Discover the top 2 airlines that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated März 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$308Average$378FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$447Average$584FlexibilityNo cancel feeOn-time71%
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