What are the cheapest airlines to fly from South Dakota to Knoxville one-way?

$230 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $300 and $667, respectively.

What are the most popular airlines that fly from South Dakota to Knoxville?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from South Dakota to Knoxville.

What is the cheapest month to fly from South Dakota to Knoxville?

Our data shows that August tends to be the cheapest month to fly to Knoxville from South Dakota. Users have commonly found prices around $422 for the month, but tickets can be as low as $197. Due to multiple factors, prepare for potentially higher prices in December.

What airport do you fly into for flights to Knoxville from South Dakota?

Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Dakota to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.

Can I find deals for business class flights from South Dakota to Knoxville?

Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$230+ Flights from South Dakota to Knoxville

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Cheap flight deals from South Dakota to Knoxville

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$329 (American Airlines)
One-way from	$230 (Mytrip)
Popular in	December
Cheapest in	August
Average price	$348

Provider with most accurate pricing for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flight deals.

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Provider most trusted by Cheapflights users for Sioux Falls Joe Foss Field-Knoxville McGhee Tyson flights.

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From South Dakota to Knoxville McGhee Tyson

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One-way flight from South Dakota to Knoxville McGhee Tyson

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Highest demand for flights based on searches. 22% potential increase in price ($118 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).

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Average for round-trip flights in April 2025

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Find flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

Thu 5/85:45 pmFSD - TYS

1 stop5h 13mAmerican Airlines

Tue 5/137:00 amTYS - FSD

1 stop7h 02mAmerican Airlines

Deal found 4/23

$329

Sat 5/1011:14 amFSD - TYS

1 stop4h 40mUnited Airlines

Mon 5/125:35 pmTYS - FSD

1 stop5h 37mUnited Airlines

Deal found 4/23

$454

Fri 5/95:27 amFSD - TYS

1 stop4h 56mDelta

Mon 5/127:10 pmTYS - FSD

1 stop5h 15mDelta

Deal found 4/23

$474

Best flights from South Dakota to Knoxville
Discover carefully curated flight deals from South Dakota to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2025.

Thu 5/85:45 pmFSD - TYS

1 stop5h 13mAmerican Airlines

Sun 5/117:00 amTYS - FSD

1 stop7h 02mAmerican Airlines

Deal found 4/23

$329

Sat 5/1011:14 amFSD - TYS

1 stop4h 40mUnited Airlines

Mon 5/125:35 pmTYS - FSD

1 stop5h 37mUnited Airlines

Deal found 4/23

$454

Fri 5/95:27 amFSD - TYS

1 stop4h 56mDelta

Mon 5/127:10 pmTYS - FSD

1 stop5h 15mDelta

Deal found 4/23

$474

Last-minute flights from South Dakota to Knoxville
Discover last-minute flight deals from South Dakota to Knoxville. Data last updated April 24, 2025 and is based on user searches.

Thu 5/85:45 pmFSD - TYS

1 stop5h 13mAmerican Airlines

Tue 5/137:00 amTYS - FSD

1 stop7h 02mAmerican Airlines

Deal found 4/23

$329

Fri 5/95:27 amFSD - TYS

1 stop4h 56mDelta

Mon 5/127:10 pmTYS - FSD

1 stop5h 15mDelta

Deal found 4/23

$474

Sat 5/1011:14 amFSD - TYS

1 stop4h 40mUnited Airlines

Mon 5/125:35 pmTYS - FSD

1 stop5h 37mUnited Airlines

Deal found 4/23

$454

One-way flights from South Dakota to Knoxville
Search for one-way flight options from South Dakota to Knoxville. Find affordable one-way fares based on user searches. Data last updated April 24, 2025.

Thu 5/811:20 amFSD - TYS

1 stop11h 19mAllegiant Air

Deal found 4/23

$230

Thu 5/85:27 amFSD - TYS

2 stops11h 09mDelta

Deal found 4/23

$300

Thu 5/86:00 amFSD - TYS

3 stops15h 45mUnited Airlines

Deal found 4/23

$667

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/8

5:45 pm-11:58 pm

1 stop5h 13m

Knoxville McGhee Tyson

Tue 5/13

7:00 am-1:02 pm

1 stop7h 02m

$329

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 5/10

11:14 am-4:54 pm

1 stop4h 40m

Knoxville McGhee Tyson

Mon 5/12

5:35 pm-10:12 pm

1 stop5h 37m

$454

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 5/9

5:27 am-11:23 am

1 stop4h 56m

Knoxville McGhee Tyson

Mon 5/12

7:10 pm-11:25 pm

1 stop5h 15m

$474

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/8

11:20 am-11:39 pm

1 stop11h 19m

$230

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/8

5:27 am-5:36 pm

2 stops11h 09m

$300

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 5/8

6:00 am-10:45 pm

3 stops15h 45m

$667

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $296). Flying from South Dakota to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SD to TYS?

When flying from South Dakota to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta

8.0

Very good

7,920 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines

7.4

Good

8,685 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air

7.3

Good

734 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,920 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

What airport do you fly into for flights to Knoxville from South Dakota?
Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from South Dakota.
What are the cheapest airlines to fly from South Dakota to Knoxville one-way?
$230 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $300 and $667, respectively.
Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?
Yes. In addition to deals on South Dakota to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Dakota to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Dakota to Knoxville.
Can I find deals for business class flights from South Dakota to Knoxville?
Yes. Cheapflights offers flight deals from South Dakota to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Dakota to Knoxville?
Currently, January is the cheapest month in which you can book a flight from South Dakota to Knoxville (average of $296). Flying from South Dakota to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Morristown

Cherokee

Corbin

Maryville

Oak Ridge

Alcoa

Murphy

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Top 3 airlines flying from South Dakota to Knoxville

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$208	Average$448	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$221	Average$343	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$248	Average$426	FlexibilityNo cancel fee	On-time71%

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$230+ Cheap flights from South Dakota to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Dakota to Knoxville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from South Dakota to Knoxville

Keep the following information in mind while searching for South Dakota to Knoxville flight deals. Data was last updated April 24, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from South Dakota to Knoxville

Cheapest flights from South Dakota to KnoxvilleExplore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Dakota to Knoxville that are best for you.

Best time to book a flight from South Dakota to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Dakota with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Dakota to Knoxville

What is the cheapest month to book a flight from South Dakota to Knoxville?

What is the cheapest time of day to fly from SD to TYS?

Find hourly flight availability from South Dakota to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

Reviews of airlines servicing Knoxville

Related info for your journey

Find useful and relevant information for your journey from South Dakota to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Knoxville from South Dakota?

What are the cheapest airlines to fly from South Dakota to Knoxville one-way?

Can I find deals for flights from South Dakota to Knoxville that include hotel bookings?

How can I find direct flights from South Dakota to Knoxville?

Can I find deals for business class flights from South Dakota to Knoxville?

What is the cheapest month to book a flight from South Dakota to Knoxville?

Traveling to a place near South Dakota?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Dakota to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from South Dakota to Knoxville

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Cheapest flights from South Dakota to Knoxville
Explore the most affordable flight options available from South Dakota to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.