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$109+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Nov 25 — Dec 21
Mon 11/25
Mon 12/2
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 20, 2024.

Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2024.

This Delta deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/56:00 amMYR - TYS
1 stop3h 29mDelta
Mon 12/97:59 pmTYS - MYR
1 stop3h 59mDelta
Deal found 11/19$238
This eDestinos deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/39:22 pmCLT - TYS
2 stops41h 54mMultiple Airlines
Fri 12/612:50 pmTYS - CLT
1 stop7h 48mMultiple Airlines
Deal found 11/19$265
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1911:03 amMYR - TYS
1 stop4h 44mAmerican Airlines
Mon 12/28:08 pmTYS - MYR
1 stop3h 50mAmerican Airlines
Deal found 11/19$278
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/196:30 amSAV - TYS
1 stop14h 23mAllegiant Air
Sat 1/412:00 pmTYS - SAV
1 stop10h 09mAllegiant Air
Deal found 11/19$289
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/54:41 pmMYR - TYS
2 stops19h 19mMultiple Airlines
Mon 12/912:50 pmTYS - MYR
1 stop7h 14mMultiple Airlines
Deal found 11/19$316
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/208:46 pmCHS - TYS
2 stops24h 30mMultiple Airlines
Sun 12/2212:27 pmTYS - CHS
1 stop7h 24mMultiple Airlines
Deal found 11/19$332
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/147:30 amCLT - TYS
1 stop11h 13mAmerican Airlines
Mon 12/167:19 pmTYS - CLT
1 stop11h 21mAmerican Airlines
Deal found 11/19$345
This Mytrip deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/196:30 amSAV - TYS
1 stop14h 23mMultiple Airlines
Sat 1/47:15 amTYS - SAV
3 stops15h 26mMultiple Airlines
Deal found 11/19$372
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/177:40 amSAV - TYS
1 stop11h 02mAmerican Airlines
Mon 1/65:53 amTYS - SAV
1 stop13h 14mAmerican Airlines
Deal found 11/19$417
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/187:45 pmCLT - TYS
1 stop18h 58mUnited Airlines
Wed 12/255:35 pmTYS - CLT
2 stops16h 28mUnited Airlines
Deal found 11/20$446
This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/149:35 amSAV - TYS
1 stop9h 55mUnited Airlines
Tue 12/175:45 amTYS - SAV
1 stop8h 58mUnited Airlines
Deal found 11/19$487
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/265:15 amCHS - TYS
1 stop3h 23mAmerican Airlines
Fri 11/292:56 pmTYS - CHS
1 stop4h 40mAmerican Airlines
Deal found 11/19$493

Find flights from South Carolina to Knoxville within your budget

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,629,791 searches. Data last updated November 20, 2024.

Fly from

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Fly to

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Route

Depart

Return

Price

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 1/3

8:00 am-5:30 pm

1 stop9h 30m

Knoxville McGhee Tyson

Fri 1/10

12:00 pm-10:32 pm

1 stop10h 32m

$222

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 1/9

8:07 pm-11:58 pm

1 stop3h 51m

Knoxville McGhee Tyson

Mon 1/13

8:05 pm-11:51 pm

1 stop3h 46m

$228

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 12/5

6:00 am-9:29 am

1 stop3h 29m

Knoxville McGhee Tyson

Mon 12/9

7:59 pm-11:58 pm

1 stop3h 59m

$238

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 12/3

9:22 pm-3:16 pm

2 stops41h 54m

Knoxville McGhee Tyson

Fri 12/6

12:50 pm-8:38 pm

1 stop7h 48m

$265

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 2/7

7:10 am-9:56 pm

1 stop14h 46m

Knoxville McGhee Tyson

Sun 2/9

6:00 am-6:42 am

1 stop24h 42m

$275

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Fri 1/3

8:00 am-5:30 pm

1 stop9h 30m

Knoxville McGhee Tyson

Fri 1/10

10:00 am-10:32 pm

2 stops12h 32m

$282

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 1/9

6:47 pm-6:53 pm

3 stops24h 06m

Knoxville McGhee Tyson

Mon 1/13

9:15 am-3:01 pm

1 stop5h 46m

$288

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 12/20

8:46 pm-9:16 pm

2 stops24h 30m

Knoxville McGhee Tyson

Sun 12/22

12:27 pm-7:51 pm

1 stop7h 24m

$332

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 1/9

11:10 am-9:56 pm

1 stop10h 46m

Knoxville McGhee Tyson

Sun 1/12

10:40 am-9:44 pm

1 stop11h 04m

$394

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 12/18

7:45 pm-2:43 pm

1 stop18h 58m

Knoxville McGhee Tyson

Wed 12/25

5:35 pm-10:03 am

2 stops16h 28m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/20

Showing 1-10 of 30 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Knoxville

Get recent, data-driven insights about flights from South Carolina to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $301). Flying from South Carolina to Knoxville in April is currently the most expensive (average of $372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2024.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated November 20, 2024.
Get a feel of what it's like to fly with American Airlines, Delta and United Airlines from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,756 reviews
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
9,171 reviews
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.4
Good
850 reviews
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

WestJet
7.3
Good
2,811 reviews
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,756 reviews

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Overall

8.0

Food

7.3

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are Allegiant Air ($124), American Airlines ($184), and Delta ($194).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charlotte Douglas - Knoxville McGhee Tyson, Charleston - Knoxville McGhee Tyson or Savannah/Hilton Head - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $301). Flying from South Carolina to Knoxville in April is currently the most expensive (average of $372). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,629,791 searches. Data last updated November 20, 2024.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$518FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$254Average$496FlexibilityNo cancel feeOn-time71%
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