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$92+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Mytrip)

One-way from

$92
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$308
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 18% potential increase in price ($86 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Mytrip deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/66:41 pmMYR - TYS
1 stop26h 40mMultiple Airlines
Mon 3/1012:24 pmTYS - MYR
1 stop9h 18mMultiple Airlines
Deal found 2/18$195
This Mytrip deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2911:14 amCHS - TYS
1 stop26h 49mMultiple Airlines
Fri 5/27:15 amTYS - CHS
1 stop9h 46mMultiple Airlines
Deal found 2/19$196
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/712:35 pmSAV - TYS
1 stop8h 46mAllegiant Air
Tue 3/118:51 amTYS - SAV
1 stop26h 46mAllegiant Air
Deal found 2/20$196
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/712:35 pmSAV - TYS
2 stops34h 17mMultiple Airlines
Tue 3/118:51 amTYS - SAV
1 stop26h 46mMultiple Airlines
Deal found 2/20$225
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/76:59 pmMYR - TYS
1 stop4h 48mDelta
Tue 3/117:23 pmTYS - MYR
1 stop4h 26mDelta
Deal found 2/20$239
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/711:45 amCLT - TYS
2 stops23h 46mMultiple Airlines
Tue 3/111:35 pmTYS - CLT
1 stop27h 32mMultiple Airlines
Deal found 2/20$250
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/287:48 pmMYR - TYS
1 stop3h 57mAmerican Airlines
Sat 5/37:54 pmTYS - MYR
1 stop3h 50mAmerican Airlines
Deal found 2/20$274
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/147:55 pmSAV - TYS
1 stop3h 47mDelta
Tue 3/1811:59 amTYS - SAV
1 stop3h 22mDelta
Deal found 2/20$387
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/142:25 pmCHS - TYS
1 stop3h 52mDelta
Mon 11/177:25 pmTYS - CHS
1 stop4h 19mDelta
Deal found 2/19$399
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:09 pmCHS - TYS
1 stop3h 09mAmerican Airlines
Sun 5/187:55 pmTYS - CHS
1 stop4h 20mAmerican Airlines
Deal found 2/19$429
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/128:14 amCLT - TYS
1 stop13h 34mAmerican Airlines
Thu 4/177:32 pmTYS - CLT
1 stop10h 53mAmerican Airlines
Deal found 2/20$432
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/61:24 pmSAV - TYS
1 stop4h 43mAmerican Airlines
Tue 5/206:51 amTYS - SAV
1 stop3h 37mAmerican Airlines
Deal found 2/20$449

Find flights from South Carolina to Knoxville within your budget

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 4/29

11:14 am-2:03 pm

1 stop26h 49m

Knoxville McGhee Tyson

Fri 5/2

7:15 am-5:01 pm

1 stop9h 46m

$196

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 3/29

3:43 pm-10:27 pm

1 stop6h 44m

Knoxville McGhee Tyson

Mon 3/31

1:05 pm-7:54 am

1 stop18h 49m

$206

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 3/7

6:59 pm-11:47 pm

1 stop4h 48m

Knoxville McGhee Tyson

Tue 3/11

7:23 pm-11:49 pm

1 stop4h 26m

$239

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 3/7

11:45 am-11:31 am

2 stops23h 46m

Knoxville McGhee Tyson

Tue 3/11

1:35 pm-5:07 pm

1 stop27h 32m

$250

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 3/6

12:46 pm-9:21 pm

2 stops32h 35m

Knoxville McGhee Tyson

Mon 3/10

12:24 pm-11:14 pm

1 stop10h 50m

$267

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 4/28

7:48 pm-11:45 pm

1 stop3h 57m

Knoxville McGhee Tyson

Sat 5/3

7:54 pm-11:44 pm

1 stop3h 50m

$274

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 3/6

12:46 pm-9:21 pm

2 stops32h 35m

Knoxville McGhee Tyson

Mon 3/10

1:05 pm-11:14 pm

2 stops10h 09m

$323

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/29

12:26 pm-3:06 pm

1 stop2h 40m

Knoxville McGhee Tyson

Sun 6/1

4:00 pm-6:48 pm

1 stop2h 48m

$399

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 5/15

6:09 pm-9:18 pm

1 stop3h 09m

Knoxville McGhee Tyson

Sun 5/18

7:55 pm-12:15 am

1 stop4h 20m

$429

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 4/12

8:14 am-9:48 pm

1 stop13h 34m

Knoxville McGhee Tyson

Thu 4/17

7:32 pm-6:25 am

1 stop10h 53m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Showing 1-10 of 27 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Knoxville

Get recent, data-driven insights about flights from South Carolina to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 20, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,220 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,766 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.3
Good
765 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,220 reviews

Crew

8.5

Comfort

8.0

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are American Airlines ($100), United Airlines ($244), and Delta ($259).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charlotte Douglas - Knoxville McGhee Tyson, Savannah/Hilton Head - Knoxville McGhee Tyson or Myrtle Beach Intl - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$473FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$489FlexibilityNo cancel feeOn-time71%
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