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$88+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Jan 22 — Jan 291
Wed 1/22
Wed 1/29
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 17, 2025.

Round-trip from

$216
(Mytrip)

One-way from

$103
(Mytrip)
From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 17, 2025.

This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/137:16 pmCLT - TYS
1 stop15h 00mMultiple Airlines
Thu 2/2012:40 pmTYS - CLT
1 stop11h 19mMultiple Airlines
Deal found 1/16$216
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/279:31 pmCHS - TYS
1 stop14h 44mMultiple Airlines
Mon 3/316:30 pmTYS - CHS
2 stops15h 43mMultiple Airlines
Deal found 1/16$229
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/76:59 pmMYR - TYS
1 stop4h 48mDelta
Sun 2/95:45 amTYS - MYR
1 stop4h 31mDelta
Deal found 1/16$254
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/38:00 amSAV - TYS
1 stop11h 11mAllegiant Air
Fri 2/72:50 pmTYS - SAV
1 stop7h 58mAllegiant Air
Deal found 1/16$284
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/137:43 pmMYR - TYS
1 stop4h 14mAmerican Airlines
Sun 2/169:09 amTYS - MYR
1 stop3h 08mAmerican Airlines
Deal found 1/16$294
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/56:40 amCHS - TYS
1 stop4h 43mDelta
Wed 2/1212:08 pmTYS - CHS
1 stop5h 52mDelta
Deal found 1/15$309
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1211:04 amCHS - TYS
1 stop4h 34mAmerican Airlines
Sun 2/166:00 pmTYS - CHS
1 stop4h 02mAmerican Airlines
Deal found 1/16$359
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/157:10 amCLT - TYS
1 stop9h 26mAmerican Airlines
Sat 2/2211:03 amTYS - CLT
1 stop8h 04mAmerican Airlines
Deal found 1/16$367
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/135:45 amMYR - TYS
2 stops17h 24mMultiple Airlines
Sun 2/167:00 amTYS - MYR
1 stop13h 36mMultiple Airlines
Deal found 1/16$367
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/58:14 amSAV - TYS
1 stop3h 09mDelta
Mon 3/107:23 pmTYS - SAV
1 stop4h 34mDelta
Deal found 1/16$389
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/127:46 amSAV - TYS
1 stop10h 54mAmerican Airlines
Wed 2/1911:03 amTYS - SAV
1 stop10h 37mAmerican Airlines
Deal found 1/15$397
This Mytrip deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/33:40 pmSAV - TYS
2 stops16h 29mMultiple Airlines
Fri 2/79:15 amTYS - SAV
2 stops13h 17mMultiple Airlines
Deal found 1/16$478

Find flights from South Carolina to Knoxville within your budget

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 2/13

7:16 pm-10:16 am

1 stop15h 00m

Knoxville McGhee Tyson

Thu 2/20

12:40 pm-11:59 pm

1 stop11h 19m

$216

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Thu 3/27

9:31 pm-12:15 pm

1 stop14h 44m

Knoxville McGhee Tyson

Mon 3/31

6:30 pm-10:13 am

2 stops15h 43m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 2/7

6:59 pm-11:47 pm

1 stop4h 48m

Knoxville McGhee Tyson

Sun 2/9

5:45 am-10:16 am

1 stop4h 31m

$254

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Mon 2/3

8:00 am-7:11 pm

1 stop11h 11m

Knoxville McGhee Tyson

Fri 2/7

2:50 pm-10:48 pm

1 stop7h 58m

$283

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 2/13

7:43 pm-11:57 pm

1 stop4h 14m

Knoxville McGhee Tyson

Sun 2/16

9:09 am-12:17 pm

1 stop3h 08m

$294

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 2/5

6:40 am-11:23 am

1 stop4h 43m

Knoxville McGhee Tyson

Wed 2/12

12:08 pm-6:00 pm

1 stop5h 52m

$309

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Wed 2/12

11:04 am-3:38 pm

1 stop4h 34m

Knoxville McGhee Tyson

Sun 2/16

6:00 pm-10:02 pm

1 stop4h 02m

$359

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 2/15

7:10 am-4:36 pm

1 stop9h 26m

Knoxville McGhee Tyson

Sat 2/22

11:03 am-7:07 pm

1 stop8h 04m

$367

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 2/13

5:45 am-11:09 pm

2 stops17h 24m

Knoxville McGhee Tyson

Sun 2/16

7:00 am-8:36 pm

1 stop13h 36m

$367

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Tue 2/11

7:46 am-6:40 pm

1 stop10h 54m

Knoxville McGhee Tyson

Tue 2/18

7:35 am-7:08 pm

1 stop11h 33m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 30 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Knoxville

Get recent, data-driven insights about flights from South Carolina to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $297). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 17, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 17, 2025.
Get a feel of what it's like to fly with American Airlines, United Airlines and Delta from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,511 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,511 reviews
Delta
8.0
Very good
8,511 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,964 reviews
Delta
8.0
Very good
8,511 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.4
Good
801 reviews
Delta
8.0
Very good
8,511 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,511 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.2

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are Delta ($184), American Airlines ($230), and United Airlines ($250).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charleston - Knoxville McGhee Tyson, Savannah/Hilton Head - Knoxville McGhee Tyson or Charlotte Douglas - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $297). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$508FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$254Average$502FlexibilityNo cancel feeOn-time71%
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