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Knoxville

$113+ Cheap flights from South Carolina to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — TYS
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from South Carolina to Knoxville

Keep the following information in mind while searching for South Carolina to Knoxville flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$219
(Mytrip)

One-way from

$113
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$346
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From South Carolina to Knoxville McGhee Tyson
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One-way flight from South Carolina to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 26% potential increase in price ($132 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from South Carolina to Knoxville

Cheapest flights from South Carolina to Knoxville
Explore the most affordable flight options available from South Carolina to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/15:26 pmSAV - TYS
1 stop22h 44mMultiple Airlines
Mon 5/55:15 pmTYS - SAV
1 stop5h 58mMultiple Airlines
Deal found 4/17$219
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/97:55 pmMYR - TYS
1 stop3h 56mDelta
Wed 5/145:45 amTYS - MYR
1 stop4h 23mDelta
Deal found 4/17$229
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/11:46 pmMYR - TYS
1 stop9h 47mMultiple Airlines
Sun 6/89:34 pmTYS - MYR
1 stop23h 31mMultiple Airlines
Deal found 4/17$232
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/25:43 pmCLT - TYS
1 stop22h 20mMultiple Airlines
Mon 5/510:00 amTYS - CLT
1 stop24h 12mMultiple Airlines
Deal found 4/16$268
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/35:50 amCHS - TYS
1 stop4h 37mUnited Airlines
Sat 6/75:45 amTYS - CHS
1 stop4h 29mUnited Airlines
Deal found 4/17$287
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/96:00 amCHS - TYS
1 stop6h 00mMultiple Airlines
Sun 5/1112:34 pmTYS - CHS
2 stops27h 45mMultiple Airlines
Deal found 4/16$288
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/13:02 pmSAV - TYS
2 stops30h 01mAllegiant Air
Mon 5/55:15 pmTYS - SAV
1 stop5h 58mAllegiant Air
Deal found 4/17$296
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2912:28 pmSAV - TYS
1 stop2h 49mDelta
Sun 6/15:45 amTYS - SAV
1 stop3h 31mDelta
Deal found 4/16$327
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/183:31 pmMYR - TYS
1 stop6h 51mUnited Airlines
Sun 4/207:00 amTYS - MYR
1 stop7h 43mUnited Airlines
Deal found 4/17$359
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1412:15 pmCHS - TYS
1 stop5h 58mDelta
Mon 11/176:10 pmTYS - CHS
1 stop5h 31mDelta
Deal found 4/16$367
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/99:25 amCLT - TYS
1 stop9h 49mAmerican Airlines
Mon 5/127:44 pmTYS - CLT
1 stop10h 44mAmerican Airlines
Deal found 4/16$367
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/131:26 pmSAV - TYS
1 stop4h 36mAmerican Airlines
Fri 5/167:54 pmTYS - SAV
1 stop4h 02mAmerican Airlines
Deal found 4/16$477

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from South Carolina to Knoxville that are best for you.

Fly from

South Carolina

Fly to

Knoxville

Route

Depart

Return

Price

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/1

5:26 pm-4:10 pm

1 stop22h 44m

Knoxville McGhee Tyson

Mon 5/5

5:15 pm-11:13 pm

1 stop5h 58m

$219

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 5/9

7:55 pm-11:51 pm

1 stop3h 56m

Knoxville McGhee Tyson

Wed 5/14

5:45 am-10:08 am

1 stop4h 23m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 6/1

1:46 pm-11:33 pm

1 stop9h 47m

Knoxville McGhee Tyson

Sun 6/8

9:34 pm-9:05 pm

1 stop23h 31m

$232

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Tue 6/3

5:50 am-10:27 am

1 stop4h 37m

Knoxville McGhee Tyson

Sat 6/7

5:45 am-10:14 am

1 stop4h 29m

$287

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sun 5/25

8:50 am-7:45 pm

1 stop10h 55m

Knoxville McGhee Tyson

Tue 5/27

7:00 am-10:00 pm

2 stops39h 00m

$287

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/9

6:00 am-12:00 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sun 5/11

12:34 pm-4:19 pm

2 stops27h 45m

$288

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/1

3:02 pm-9:03 pm

2 stops30h 01m

Knoxville McGhee Tyson

Mon 5/5

5:15 pm-11:13 pm

1 stop5h 58m

$296

SavannahKnoxville

SAV - TYS

SAVTYS

Savannah/Hilton Head

Thu 5/29

8:30 am-11:23 am

1 stop2h 53m

Knoxville McGhee Tyson

Sun 6/1

7:10 pm-12:01 am

1 stop4h 51m

$327

CharlestonKnoxville

CHS - TYS

CHSTYS

Charleston

Fri 5/9

10:53 am-7:14 pm

1 stop8h 21m

Knoxville McGhee Tyson

Sun 5/11

6:00 am-2:04 pm

1 stop8h 04m

$367

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 5/1

3:15 pm-10:45 pm

1 stop7h 30m

Knoxville McGhee Tyson

Mon 5/5

7:00 am-2:27 pm

1 stop7h 27m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 27 results
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Best time to book a flight from South Carolina to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Knoxville

What is the cheapest month to book a flight from South Carolina to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to TYS?

Find hourly flight availability from South Carolina to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from South Carolina to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 17, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from South Carolina to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,917 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,917 reviews

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Food

7.3

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South Carolina?

    For a flight from South Carolina to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Knoxville one-way?

    The cheapest airlines for a one-way flight from South Carolina to Knoxville are American Airlines ($144), Delta ($244), and United Airlines ($340).

  • What are the most popular routes from South Carolina to Knoxville?

    Most travelers choose Charlotte Douglas - Knoxville McGhee Tyson, Myrtle Beach Intl - Knoxville McGhee Tyson or Savannah/Hilton Head - Knoxville McGhee Tyson when deciding on the best route from South Carolina to Knoxville.

  • Can I find deals for flights from South Carolina to Knoxville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Knoxville.

  • Can I find deals for business class flights from South Carolina to Knoxville?

    Yes. Cheapflights offers flight deals from South Carolina to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South Carolina to Knoxville (average of $296). Flying from South Carolina to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South Carolina to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Knoxville

Discover the top 2 airlines that operate flights from South Carolina to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$473FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$479FlexibilityNo cancel feeOn-time71%

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