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$260+ Cheap flights from South America to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
BOG — TYS
feb. 4 — feb. 111
mar. 2/4
mar. 2/11
1 adult, Economy
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Cheap flight deals from South America to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from South America (0SA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated enero 30, 2025.

Round-trip from

$639
(Mytrip)

One-way from

$260
(Kiwi.com)
From South America to Knoxville McGhee Tyson
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One-way flight from South America to Knoxville McGhee Tyson
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Find flight deals from South America to Knoxville

Cheapest flights from South America to Knoxville
Explore the most affordable flight options available from South America to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 30, 2025.

This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/1911:09 amGYE - TYS
2 stops36h 00mMultiple Airlines
dom. 5/116:00 amTYS - GYE
2 stops18h 20mMultiple Airlines
Deal found 1/29$639
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/152:45 pmGYE - TYS
2 stops50h 11mUnited Airlines
jue. 5/297:00 amTYS - GYE
2 stops20h 05mUnited Airlines
Deal found 1/29$650
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/76:00 amGYE - TYS
1 stop16h 28mAmerican Airlines
mié. 5/286:23 amTYS - GYE
2 stops15h 47mAmerican Airlines
Deal found 1/29$654
This Mytrip deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/235:00 pmUIO - TYS
3 stops28h 36mMultiple Airlines
jue. 5/810:59 amTYS - UIO
2 stops12h 26mMultiple Airlines
Deal found 1/30$664
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/231:35 amUIO - TYS
1 stop21h 55mUnited Airlines
lun. 5/127:00 amTYS - UIO
2 stops41h 25mUnited Airlines
Deal found 1/30$712
This Avianca deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/253:30 amGYE - TYS
2 stops13h 24mAvianca
mar. 5/137:00 amTYS - GYE
2 stops17h 20mAvianca
Deal found 1/29$739
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/216:29 amUIO - TYS
1 stop16h 36mAmerican Airlines
dom. 5/46:55 amTYS - UIO
1 stop15h 01mAmerican Airlines
Deal found 1/29$803
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/2311:59 pmUIO - TYS
1 stop9h 17mDelta
jue. 5/86:30 amTYS - UIO
2 stops13h 35mDelta
Deal found 1/30$858
This LATAM Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/227:13 amUIO - TYS
2 stops16h 34mLATAM Airlines
jue. 5/87:07 amTYS - UIO
2 stops17h 13mLATAM Airlines
Deal found 1/28$867
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/208:40 pmGYE - TYS
2 stops14h 43mDelta
lun. 4/285:30 amTYS - GYE
2 stops17h 53mDelta
Deal found 1/29$884
This Avianca deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/2411:25 amUIO - TYS
3 stops22h 34mAvianca
lun. 5/127:00 amTYS - UIO
2 stops35h 05mAvianca
Deal found 1/30$2,916

Find flights from South America to Knoxville within your budget

Customize your flight search to find flights from South America to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

mié. 2/19

11:09 am-11:09 pm

2 stops36h 00m

Knoxville McGhee Tyson

dom. 5/11

6:00 am-11:20 pm

2 stops18h 20m

$639

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

jue. 5/15

2:45 pm-5:56 pm

2 stops50h 11m

Knoxville McGhee Tyson

jue. 5/29

7:00 am-2:05 am

2 stops20h 05m

$650

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

mié. 5/7

6:00 am-11:28 pm

1 stop16h 28m

Knoxville McGhee Tyson

mié. 5/28

6:23 am-9:10 pm

2 stops15h 47m

$654

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

dom. 2/23

5:00 pm-9:36 pm

3 stops28h 36m

Knoxville McGhee Tyson

jue. 5/8

10:59 am-10:25 pm

2 stops12h 26m

$664

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

dom. 2/23

1:35 am-11:30 pm

1 stop21h 55m

Knoxville McGhee Tyson

lun. 5/12

7:00 am-11:25 pm

2 stops41h 25m

$712

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

mar. 2/25

3:30 am-4:54 pm

2 stops13h 24m

Knoxville McGhee Tyson

mar. 5/13

7:00 am-11:20 pm

2 stops17h 20m

$739

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

vie. 2/21

6:29 am-11:05 pm

1 stop16h 36m

Knoxville McGhee Tyson

dom. 5/4

6:55 am-8:56 pm

1 stop15h 01m

$803

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

dom. 2/23

11:59 pm-9:16 am

1 stop9h 17m

Knoxville McGhee Tyson

jue. 5/8

6:30 am-7:05 pm

2 stops13h 35m

$858

QuitoKnoxville

UIO - TYS

UIOTYS

Quito Mariscal Sucr

sáb. 2/22

7:13 am-11:47 pm

2 stops16h 34m

Knoxville McGhee Tyson

jue. 5/8

7:07 am-11:20 pm

2 stops17h 13m

$867

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

jue. 2/20

8:40 pm-11:23 am

2 stops14h 43m

Knoxville McGhee Tyson

lun. 4/28

5:30 am-10:23 pm

2 stops17h 53m

$884

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 21 results
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Best time to book a flight from South America to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from South America with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South America to Knoxville

Get recent, data-driven insights about flights from South America to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South America to Knoxville?

Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $296). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SA to TYS?

Find hourly flight availability from South America to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 30, 2025.

When flying from South America to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated enero 30, 2025.
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,454 reviews
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

LATAM Airlines
7.5
Good
1,838 reviews
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,913 reviews
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Avianca
6.9
Okay
2,534 reviews
Delta
8.0
Very good
8,454 reviews

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from South America to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from South America?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from South America to Knoxville.

  • What are the cheapest airlines to fly from South America to Knoxville one-way?

    $414 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and Avianca, with prices starting from $446 and $453, respectively.

  • What are the most popular routes from South America to Knoxville?

    When deciding which route to take from South America to Knoxville consider Guayaquil Jose Joaquin de Olmedo - Knoxville McGhee Tyson, Quito Mariscal Sucr - Knoxville McGhee Tyson or Santiago Arturo Merino Benitez - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from South America to Knoxville that include hotel bookings?

    Yes. In addition to deals on South America to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South America to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South America to Knoxville.

  • Can I find deals for business class flights from South America to Knoxville?

    Yes. Cheapflights offers flight deals from South America to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South America to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from South America to Knoxville (average of $296). Flying from South America to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South America?

Book flights to South America if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for South America to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South America to Knoxville

Discover the top 2 airlines that operate flights from South America to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$408Average$801FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$560Average$560FlexibilityNo cancel feeOn-time71%
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