HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$139+ Cheap flights from Santa Ana to Knoxville (SNA - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel.
SNA — TYS
Apr 16 — Apr 231
Wed 4/16
Wed 4/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Santa Ana to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson are usually found in January or March, booked 18 days in advance, depart on a Saturday or Wednesday and return on a Saturday

Cheap flight deals from Santa Ana to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santa Ana (SNA) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$251
(American Airlines)

One-way from

$139
(Delta)

Popular in

June

Cheapest in

January

Average price

$433
Provider with most accurate pricing for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santa Ana J. Wayne/Orange Cnty-Knoxville McGhee Tyson flights.
Search Deals
From Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
One-way flight from Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($121 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Santa Ana to Knoxville

Cheapest flights from Santa Ana to Knoxville
Explore the most affordable flight options available from Santa Ana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1310:48 amSNA - TYS
1 stop7h 49mAmerican Airlines
Sat 8/167:57 amTYS - SNA
1 stop6h 15mAmerican Airlines
Deal found 4/10$251
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/76:45 amSNA - TYS
2 stops10h 21mUnited Airlines
Tue 5/135:35 pmTYS - SNA
1 stop7h 42mUnited Airlines
Deal found 4/10$256
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/152:29 pmSNA - TYS
1 stop6h 18mDelta
Sat 7/265:30 amTYS - SNA
1 stop8h 33mDelta
Deal found 4/10$277
This Mytrip deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:45 amSNA - TYS
1 stop27h 39mMultiple Airlines
Mon 5/192:34 pmTYS - SNA
1 stop23h 18mMultiple Airlines
Deal found 4/10$323
This CheapOair deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/2512:01 pmSNA - TYS
1 stop25h 28mFrontier
Sun 6/295:25 pmTYS - SNA
1 stop20h 51mFrontier
Deal found 4/11$482
This Alaska Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/137:09 pmSNA - TYS
2 stops23h 39mAlaska Airlines
Fri 4/183:09 pmTYS - SNA
2 stops20h 38mAlaska Airlines
Deal found 4/11$664

Cheapflights Fare Finder

Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Santa Ana

Fly to

Knoxville

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/13

10:48 am-9:37 pm

1 stop7h 49m

Knoxville McGhee Tyson

Sat 8/16

7:57 am-11:12 am

1 stop6h 15m

$251

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 5/7

6:45 am-8:06 pm

2 stops10h 21m

Knoxville McGhee Tyson

Tue 5/13

5:35 pm-10:17 pm

1 stop7h 42m

$256

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 7/15

2:29 pm-11:47 pm

1 stop6h 18m

Knoxville McGhee Tyson

Sat 7/26

5:30 am-11:03 am

1 stop8h 33m

$277

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 5/15

6:45 am-1:24 pm

1 stop27h 39m

Knoxville McGhee Tyson

Mon 5/19

2:34 pm-10:52 am

1 stop23h 18m

$323

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 6/25

12:01 pm-4:29 pm

1 stop25h 28m

Knoxville McGhee Tyson

Sun 6/29

5:25 pm-11:16 am

1 stop20h 51m

$482

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 5/8

6:45 am-11:58 pm

2 stops14h 13m

Knoxville McGhee Tyson

Sun 5/11

5:20 am-2:19 pm

2 stops11h 59m

$744

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 6/25

2:35 pm-11:59 pm

1 stop6h 24m

$139

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 6/24

7:30 am-7:01 pm

1 stop8h 31m

$215

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 6/24

6:38 pm-10:27 am

2 stops12h 49m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/10

Compare providers for flights from Santa Ana to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Ana to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
CheapOairPrice Accuracy1 starTrust Score*3 stars
CheapfaremartPrice Accuracy-Trust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santa Ana-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Ana-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Ana-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Ana-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Ana-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Ana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santa Ana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Ana to Knoxville

How far ahead should I book a flight from Santa Ana to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Santa Ana to Knoxville. Price data was last updated on April 4, 2025.

The price you pay for your flight from Santa Ana to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 18 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santa Ana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SNA to TYS?

Find hourly flight availability from Santa Ana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 11, 2025.

It’s optimal to fly from Santa Ana to Knoxville at noon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight in the morning.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 11, 2025.
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Alaska Airlines
8.0
Very good
9,851 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Delta
8.0
Very good
7,910 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
United Airlines
7.4
Good
8,636 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Frontier
6.0
Okay
3,277 reviews
Alaska Airlines
8.0
Very good
9,851 reviews

Entertainment

7.1

Comfort

7.9

Crew

8.5

Food

7.1

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

Find useful and relevant information for your journey from Santa Ana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Santa Ana to Knoxville round-trip?

    Cheapflights users have booked flights from Santa Ana to Knoxville round-trip from $251. Other airlines that can offer you cheap pricing are United Airlines, from $256, and Delta, from $277. Users have found that American Airlines is 46% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Santa Ana to Knoxville one-way?

    $139 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $215 and $280, respectively.

  • Can I find deals for flights from Santa Ana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santa Ana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Ana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Ana to Knoxville.

  • Can I find deals for business class flights from Santa Ana to Knoxville?

    Yes. Cheapflights offers flight deals from Santa Ana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Ana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Santa Ana to Knoxville (average of $296). Flying from Santa Ana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Santa Ana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Nashville flights
San Francisco to Nashville flights
Ontario to Nashville flights
Burbank to Nashville flights
Los Angeles to Memphis flights
San Diego to Nashville flights
Sacramento to Nashville flights
Santa Ana to Nashville flights
Las Vegas to Nashville flights
Oakland to Nashville flights
Long Beach to Nashville flights
San Jose to Nashville flights
Ontario to Memphis flights
Fresno to Nashville flights
San Francisco to Knoxville flights
Los Angeles to Knoxville flights
San Diego to Knoxville flights
Ontario to Knoxville flights
San Francisco to Memphis flights
Palm Springs to Nashville flights
Burbank to Memphis flights
Santa Ana to Memphis flights
Fresno to Knoxville flights
Long Beach to Memphis flights
Las Vegas to Memphis flights
San Luis Obispo to Nashville flights
Oakland to Memphis flights
Ontario to Chattanooga flights
Monterey to Memphis flights
Sacramento to Knoxville flights
Santa Barbara to Nashville flights
San Jose to Memphis flights
Reno to Nashville flights
Palm Springs to Knoxville flights
Las Vegas to Knoxville flights
Los Angeles to Chattanooga flights
Fresno to Memphis flights
Sacramento to Memphis flights
San Jose to Knoxville flights
San Diego to Memphis flights
Reno to Knoxville flights
Bakersfield to Nashville flights
Medford to Nashville flights
Los Angeles to Blountville flights
San Francisco to Chattanooga flights
Santa Rosa to Nashville flights
Burbank to Knoxville flights
San Luis Obispo to Knoxville flights
Palm Springs to Memphis flights

Top 3 airlines flying from Santa Ana to Knoxville

Discover the top 3 airlines that operate flights from Santa Ana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$239Average$487FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$268Average$426FlexibilityNo cancel feeOn-time71%
DeltaCheapest$287Average$418FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.