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$125+ Cheap flights from San Francisco to Knoxville (SFO - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — TYS
Mar 26 — Apr 21
Wed 3/26
Wed 4/2
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Knoxville McGhee Tyson are usually found in August or February, booked 81 days in advance, depart on a Tuesday or Wednesday and return on a Tuesday

Cheap flight deals from San Francisco to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 21, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$339
(American Airlines)

One-way from

$125
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$473
Provider with most accurate pricing for San Francisco-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for San Francisco-Knoxville McGhee Tyson flights.
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From San Francisco to Knoxville McGhee Tyson
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One-way flight from San Francisco to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from San Francisco to Knoxville

Cheapest flights from San Francisco to Knoxville
Explore the most affordable flight options available from San Francisco to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 21, 2025.

This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/612:21 amSFO - TYS
1 stop8h 43mAmerican Airlines
Sat 4/125:15 amTYS - SFO
1 stop8h 53mAmerican Airlines
Deal found 3/20$339
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:00 amSFO - TYS
1 stop7h 14mDelta
Sun 5/45:00 pmTYS - SFO
1 stop9h 31mDelta
Deal found 3/21$399
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2612:08 amSFO - TYS
1 stop7h 07mUnited Airlines
Tue 5/67:00 amTYS - SFO
1 stop9h 33mUnited Airlines
Deal found 3/21$404
This Mytrip deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2211:59 pmSFO - TYS
1 stop13h 12mMultiple Airlines
Sat 6/288:10 amTYS - SFO
3 stops41h 43mMultiple Airlines
Deal found 3/19$440

Cheapflights Fare Finder

Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

San Francisco

Fly to

Knoxville

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/6

12:21 am-12:04 pm

1 stop8h 43m

Knoxville McGhee Tyson

Sat 4/12

5:15 am-11:08 am

1 stop8h 53m

$339

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 4/30

6:00 am-4:14 pm

1 stop7h 14m

Knoxville McGhee Tyson

Sun 5/4

5:00 pm-11:31 pm

1 stop9h 31m

$399

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 4/26

12:08 am-10:15 am

1 stop7h 07m

Knoxville McGhee Tyson

Sat 5/3

7:00 am-1:33 pm

1 stop9h 33m

$404

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 4/18

6:20 pm-10:21 pm

2 stops25h 01m

Knoxville McGhee Tyson

Wed 4/23

9:00 am-9:27 am

3 stops27h 27m

$451

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 4/19

1:07 pm-11:30 pm

1 stop7h 23m

$125

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 4/19

8:18 pm-3:46 pm

2 stops16h 28m

$204

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/14

11:05 pm-10:22 pm

2 stops20h 17m

$234

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 5/15

9:35 pm-9:40 am

1 stop9h 05m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Compare providers for flights from San Francisco to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Knoxville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Knoxville

How far ahead should I book a flight from San Francisco to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Knoxville. Price data was last updated on March 14, 2025.

Booking 81 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Knoxville?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $295). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to TYS?

Find hourly flight availability from San Francisco to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 21, 2025.

It’s optimal to fly from San Francisco to Knoxville in the afternoon. By choosing this option you can save up to 12% on the cost of your flight, compared to a flight at noon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 21, 2025.
Read through reviews of airlines operating flights from San Francisco to Knoxville, such as Delta, United Airlines and American Airlines. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,895 reviews

Overall

8.0

Comfort

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Delta
8.0
Very good
7,895 reviews
Delta
8.0
Very good
7,895 reviews

Overall

8.0

Comfort

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
United Airlines
7.4
Good
8,605 reviews
Delta
8.0
Very good
7,895 reviews

Overall

8.0

Comfort

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,895 reviews

Overall

8.0

Comfort

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin
Frontier
6.0
Okay
3,272 reviews
Delta
8.0
Very good
7,895 reviews

Overall

8.0

Comfort

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Michael,Sep 2023

SMF - ATL

Not sufficient leg room and three seats are very tigh.t on 737 in economy main cabin

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from San Francisco to Knoxville round-trip?

    Flying on American Airlines is currently your cheapest option to Knoxville, with prices starting at $339. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $399 and $404, respectively. Users have found that American Airlines is 30% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from San Francisco to Knoxville one-way?

    One-way options have recently been found by users for as low as $125 on American Airlines. Other airlines that offer cheap prices include Frontier from $204 and United Airlines from $234 one-way.

  • Where are the most common layover locations when flying from San Francisco to Knoxville?

    San Francisco to Knoxville flights have a layover in Dallas most often.

  • What are some popular things to do or see while on a layover in Dallas?

    Most Dallas visitors opt to spend their time experiencing American Airlines Center, Dos Equis Pavilion, and Dallas World Aquarium. Those on a layover in Dallas interested in visiting American Airlines Center, Dos Equis Pavilion, or Dallas World Aquarium can do so by traveling 15.0 mi, 18.3 mi, and 15.5 mi, respectively from Dallas/Fort Worth. Those looking to explore during their layover in Dallas can rent a car from Dallas/Fort Worth for about $55 per day.

  • Where are the least popular layover locations for San Francisco to Knoxville flights?

    Flights departing from San Francisco and landing in Knoxville layover in Charlotte least frequently.

  • Can I find deals for flights from San Francisco to Knoxville that include hotel bookings?

    Yes. In addition to deals on San Francisco to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Knoxville.

  • Can I find deals for business class flights from San Francisco to Knoxville?

    Yes. Cheapflights offers flight deals from San Francisco to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Knoxville (average of $295). Flying from San Francisco to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 4 airlines flying from San Francisco to Knoxville

Discover the top 4 airlines that operate flights from San Francisco to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$170Average$223FlexibilityNo cancel feeOn-time62%
DeltaCheapest$283Average$490FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$308Average$481FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$326Average$570FlexibilityNo cancel feeOn-time69%
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