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$243+ Cheap flights from Odessa, TX to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
MAF — TYS
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Odessa to Knoxville

Keep the following information in mind while searching for Odessa to Knoxville flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$243
(Delta)

Popular in

March

Cheapest in

February

Average price

$383
Provider with most accurate pricing for Midland Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Midland Intl-Knoxville McGhee Tyson flights.
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From Odessa to Knoxville McGhee Tyson
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Odessa to Knoxville

Cheapest flights from Odessa to Knoxville
Explore the most affordable flight options available from Odessa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/2512:39 pmMAF - TYS
2 stops10h 12mDelta
Sun 6/15:45 amTYS - MAF
2 stops7h 14mDelta
Deal found 4/16$243
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:55 amMAF - TYS
1 stop6h 10mAmerican Airlines
Wed 5/212:56 pmTYS - MAF
1 stop5h 58mAmerican Airlines
Deal found 4/16$354
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/16:00 amMAF - TYS
2 stops15h 45mUnited Airlines
Mon 5/54:14 pmTYS - MAF
1 stop8h 04mUnited Airlines
Deal found 4/16$533

Cheapflights Fare Finder

Customize your flight search to find flights from Odessa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Odessa to Knoxville that are best for you.

Fly from

Odessa

Fly to

Knoxville

Route

Depart

Return

Price

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Sun 5/25

12:39 pm-11:51 pm

2 stops10h 12m

Knoxville McGhee Tyson

Sun 6/1

5:45 am-11:59 am

2 stops7h 14m

$243

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Wed 5/14

6:55 am-2:05 pm

1 stop6h 10m

Knoxville McGhee Tyson

Wed 5/21

2:56 pm-7:54 pm

1 stop5h 58m

$354

MidlandKnoxville

MAF - TYS

MAFTYS

Midland Intl

Thu 5/1

6:00 am-10:45 pm

2 stops15h 45m

Knoxville McGhee Tyson

Mon 5/5

4:14 pm-11:18 pm

1 stop8h 04m

$533

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Best time to book a flight from Odessa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Odessa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Odessa to Knoxville

What is the cheapest month to book a flight from Odessa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $296). Flying from Odessa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 17, 2025.
Read through reviews of airlines operating flights from Odessa to Knoxville, such as Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,917 reviews

Comfort

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,917 reviews
Delta
8.0
Very good
7,917 reviews

Comfort

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,917 reviews

Comfort

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,917 reviews

Comfort

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Odessa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Odessa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Odessa. On average, McGhee Tyson has 0 inbound flights from Odessa per day from 3 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • Can I find deals for flights from Odessa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Odessa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Odessa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Odessa to Knoxville.

  • Can I find deals for business class flights from Odessa to Knoxville?

    Yes. Cheapflights offers flight deals from Odessa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Odessa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Odessa to Knoxville (average of $296). Flying from Odessa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Odessa?

Book flights to Odessa if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Odessa to Knoxville

Discover the top 3 airlines that operate flights from Odessa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$234Average$292FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$445FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$301Average$668FlexibilityNo cancel feeOn-time69%

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