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$92+ Cheap flights from Myrtle Beach to Knoxville (MYR - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — TYS
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$206
(Mytrip)

One-way from

$92
(Mytrip)

Popular in

December

Cheapest in

June

Average price

$308
Provider with most accurate pricing for Myrtle Beach Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Knoxville McGhee Tyson flights.
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From Myrtle Beach Intl to Knoxville McGhee Tyson
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One-way flight from Myrtle Beach Intl to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 18% potential increase in price ($86 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Myrtle Beach to Knoxville

Cheapest flights from Myrtle Beach to Knoxville
Explore the most affordable flight options available from Myrtle Beach to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Mytrip deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/66:41 pmMYR - TYS
1 stop26h 40mMultiple Airlines
Mon 3/1012:24 pmTYS - MYR
1 stop9h 18mMultiple Airlines
Deal found 2/18$195
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/76:59 pmMYR - TYS
1 stop4h 48mDelta
Tue 3/117:23 pmTYS - MYR
1 stop4h 26mDelta
Deal found 2/20$239
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/287:48 pmMYR - TYS
1 stop3h 57mAmerican Airlines
Sat 5/37:54 pmTYS - MYR
1 stop3h 50mAmerican Airlines
Deal found 2/20$274
This United deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:09 pmMYR - TYS
2 stops15h 36mUnited Airlines
Sun 9/217:00 amTYS - MYR
1 stop7h 15mUnited Airlines
Deal found 2/20$608

Find flights from Myrtle Beach to Knoxville within your budget

Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

Myrtle Beach

Fly to

Knoxville

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 3/29

3:43 pm-10:27 pm

1 stop6h 44m

Knoxville McGhee Tyson

Mon 3/31

1:05 pm-7:54 am

1 stop18h 49m

$206

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 3/7

6:59 pm-11:47 pm

1 stop4h 48m

Knoxville McGhee Tyson

Tue 3/11

7:23 pm-11:49 pm

1 stop4h 26m

$239

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 4/28

7:48 pm-11:45 pm

1 stop3h 57m

Knoxville McGhee Tyson

Sat 5/3

7:54 pm-11:44 pm

1 stop3h 50m

$274

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 4/29

11:54 am-10:05 am

2 stops22h 11m

Knoxville McGhee Tyson

Thu 5/1

5:50 am-2:27 pm

2 stops8h 37m

$903

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 3/29

3:43 pm-10:27 pm

1 stop6h 44m

$92

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/25

6:01 pm-9:27 pm

1 stop3h 26m

$100

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/25

2:32 pm-10:00 am

2 stops19h 28m

$406

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/19

Compare providers for flights from Myrtle Beach to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Knoxville in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Myrtle Beach to Knoxville

Get recent, data-driven insights about flights from Myrtle Beach to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $296). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to TYS?

Find hourly flight availability from Myrtle Beach to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 30% on flights from Myrtle Beach to Knoxville by exploring options for tickets in the afternoon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 20, 2025.
Delta
8.0
Very good
8,220 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,220 reviews
Delta
8.0
Very good
8,220 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,766 reviews
Delta
8.0
Very good
8,220 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,220 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Crew

8.5

Boarding

8.2

Comfort

8.0

Reviews

1 / 20

10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Myrtle Beach to Knoxville round-trip?

    According to our current data, Delta ($239), American Airlines ($274), and United Airlines ($903) offers the cheapest pricing from Myrtle Beach to Knoxville. Delta is priced at 37% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Myrtle Beach to Knoxville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Knoxville.

  • Can I find deals for business class flights from Myrtle Beach to Knoxville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Knoxville (average of $296). Flying from Myrtle Beach to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Maryville
Oak Ridge
Alcoa
Murphy

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Top 2 airlines flying from Myrtle Beach to Knoxville

Discover the top 2 airlines that operate flights from Myrtle Beach to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$358FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$360FlexibilityNo cancel feeOn-time71%
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