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$156+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Jan 26 — Feb 21
Sun 1/26
Sun 2/2
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$199
(United Airlines)

One-way from

$156
(Mytrip)
From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/43:11 pmSGF - TYS
1 stop7h 35mUnited Airlines
Sat 2/89:10 amTYS - SGF
1 stop5h 49mUnited Airlines
Deal found 1/20$199
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/185:35 amMCI - TYS
1 stop4h 39mAmerican Airlines
Sat 2/226:00 pmTYS - MCI
1 stop6h 29mAmerican Airlines
Deal found 1/20$199
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/194:40 pmSTL - TYS
1 stop6h 07mDelta
Wed 2/265:45 amTYS - STL
1 stop4h 35mDelta
Deal found 1/20$199
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/412:08 pmSGF - TYS
2 stops8h 19mAmerican Airlines
Sat 2/82:48 pmTYS - SGF
2 stops6h 41mAmerican Airlines
Deal found 1/20$209
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/69:55 amMCI - TYS
1 stop6h 04mUnited Airlines
Tue 2/112:35 pmTYS - MCI
1 stop6h 51mUnited Airlines
Deal found 1/20$229
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/215:37 pmSTL - TYS
1 stop5h 12mAmerican Airlines
Sun 2/233:54 pmTYS - STL
1 stop7h 49mAmerican Airlines
Deal found 1/20$229
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/304:15 pmMCI - TYS
1 stop6h 32mDelta
Sat 9/67:25 pmTYS - MCI
1 stop3h 52mDelta
Deal found 1/21$249
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/42:06 pmMCI - TYS
2 stops26h 54mMultiple Airlines
Thu 3/69:54 pmTYS - MCI
2 stops18h 50mMultiple Airlines
Deal found 1/20$281
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/295:33 pmSTL - TYS
1 stop4h 12mUnited Airlines
Sun 3/307:00 amTYS - STL
1 stop6h 20mUnited Airlines
Deal found 1/20$293
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/204:00 pmSTL - TYS
2 stops18h 30mMultiple Airlines
Wed 2/261:53 pmTYS - STL
3 stops31h 17mMultiple Airlines
Deal found 1/20$357
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/56:08 pmCOU - TYS
1 stop4h 41mAmerican Airlines
Sat 3/811:15 amTYS - COU
1 stop5h 33mAmerican Airlines
Deal found 1/21$380
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/311:03 pmSGF - TYS
3 stops26h 22mMultiple Airlines
Fri 2/147:30 amTYS - SGF
1 stop8h 09mMultiple Airlines
Deal found 1/20$666

Find flights from Missouri to Knoxville within your budget

Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Tue 2/4

3:11 pm-11:46 pm

1 stop7h 35m

Knoxville McGhee Tyson

Sat 2/8

9:10 am-1:59 pm

1 stop5h 49m

$199

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 2/18

5:35 am-11:14 am

1 stop4h 39m

Knoxville McGhee Tyson

Sat 2/22

6:00 pm-11:29 pm

1 stop6h 29m

$199

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 2/19

4:40 pm-11:47 pm

1 stop6h 07m

Knoxville McGhee Tyson

Wed 2/26

5:45 am-9:20 am

1 stop4h 35m

$199

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Tue 2/4

12:08 pm-9:27 pm

2 stops8h 19m

Knoxville McGhee Tyson

Sat 2/8

2:48 pm-8:29 pm

2 stops6h 41m

$209

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 2/6

9:55 am-4:59 pm

1 stop6h 04m

Knoxville McGhee Tyson

Tue 2/11

2:35 pm-8:26 pm

1 stop6h 51m

$229

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 2/21

5:37 pm-11:49 pm

1 stop5h 12m

Knoxville McGhee Tyson

Sun 2/23

3:54 pm-10:43 pm

1 stop7h 49m

$229

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 2/28

12:00 pm-8:29 pm

1 stop7h 29m

Knoxville McGhee Tyson

Sun 3/2

5:45 am-9:42 am

1 stop4h 57m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Tue 3/4

2:06 pm-6:00 pm

2 stops26h 54m

Knoxville McGhee Tyson

Thu 3/6

9:54 pm-3:44 pm

2 stops18h 50m

$281

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sat 3/29

5:33 pm-10:45 pm

1 stop4h 12m

Knoxville McGhee Tyson

Sun 3/30

7:00 am-12:20 pm

1 stop6h 20m

$293

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 2/20

4:00 pm-11:30 am

2 stops18h 30m

Knoxville McGhee Tyson

Wed 2/26

1:53 pm-8:10 pm

3 stops31h 17m

$357

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 21 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Knoxville

Get recent, data-driven insights about flights from Missouri to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $297). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 21, 2025.
To help decide which airline to fly from Missouri to Knoxville, see what other customers have to say about Delta, United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,521 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,521 reviews
Delta
8.0
Very good
8,521 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,984 reviews
Delta
8.0
Very good
8,521 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.4
Good
801 reviews
Delta
8.0
Very good
8,521 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,521 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $210. However, be on the lookout for offers from American Airlines and Allegiant Air, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $297). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$322FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$407FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$476FlexibilityNo cancel feeOn-time69%
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