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$140+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Dec 24 — Dec 311
Tue 12/24
Tue 12/31
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 19, 2024.

Round-trip from

$180
(FlightHub)

One-way from

$140
(Mytrip)
From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 19, 2024.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/205:32 amMCI - TYS
1 stop4h 37mAmerican Airlines
Sun 12/226:10 pmTYS - MCI
1 stop5h 45mAmerican Airlines
Deal found 12/16$338
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/255:03 amSTL - TYS
1 stop3h 56mAmerican Airlines
Wed 1/17:48 amTYS - STL
1 stop6h 02mAmerican Airlines
Deal found 12/17$353
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/265:00 amSTL - TYS
1 stop4h 05mUnited Airlines
Sun 12/296:55 amTYS - STL
1 stop6h 31mUnited Airlines
Deal found 12/17$624
This Mytrip deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/219:50 amSTL - TYS
3 stops12h 44mMultiple Airlines
Tue 12/246:20 amTYS - STL
3 stops13h 21mMultiple Airlines
Deal found 12/17$638
This Mytrip deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/237:30 pmMCI - TYS
1 stop15h 34mMultiple Airlines
Thu 12/269:13 pmTYS - MCI
2 stops21h 52mMultiple Airlines
Deal found 12/18$797
This United deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/215:20 amMCI - TYS
2 stops13h 40mUnited Airlines
Thu 12/265:35 pmTYS - MCI
1 stop5h 21mUnited Airlines
Deal found 12/18$819
This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2610:27 amSGF - TYS
1 stop5h 53mAmerican Airlines
Fri 12/276:10 pmTYS - SGF
1 stop5h 11mAmerican Airlines
Deal found 12/18$823
This Mytrip deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/269:02 amSGF - TYS
1 stop8h 04mMultiple Airlines
Fri 12/275:58 pmTYS - SGF
3 stops27h 13mMultiple Airlines
Deal found 12/18$1,298

Find flights from Missouri to Knoxville within your budget

Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 19, 2024.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/29

6:00 am-11:23 am

1 stop4h 23m

Knoxville McGhee Tyson

Tue 2/4

5:45 am-9:21 am

1 stop4h 36m

$228

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Wed 1/8

9:36 am-2:18 pm

1 stop3h 42m

Knoxville McGhee Tyson

Tue 1/14

11:02 am-4:20 pm

2 stops6h 18m

$233

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 1/9

9:11 am-5:27 pm

1 stop7h 16m

Knoxville McGhee Tyson

Sun 1/12

5:23 am-11:38 am

1 stop7h 15m

$248

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Wed 1/8

7:04 am-3:25 pm

1 stop7h 21m

Knoxville McGhee Tyson

Sat 1/11

11:43 am-2:56 pm

1 stop4h 13m

$248

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 1/3

6:40 pm-11:55 pm

1 stop4h 15m

Knoxville McGhee Tyson

Thu 1/9

11:52 am-8:23 pm

1 stop9h 31m

$253

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 1/3

10:00 am-4:54 pm

1 stop5h 54m

Knoxville McGhee Tyson

Thu 1/9

5:45 am-2:29 pm

2 stops9h 44m

$258

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 1/31

6:15 am-1:58 pm

1 stop6h 43m

Knoxville McGhee Tyson

Sun 2/2

4:55 pm-10:20 pm

1 stop6h 25m

$288

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Thu 2/20

3:48 pm-11:09 pm

1 stop6h 21m

Knoxville McGhee Tyson

Sun 2/23

9:24 pm-11:45 am

3 stops39h 21m

$331

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 1/3

7:11 pm-11:41 am

1 stop15h 30m

Knoxville McGhee Tyson

Thu 1/9

12:33 pm-6:54 pm

3 stops31h 21m

$378

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Tue 1/7

7:45 am-1:18 pm

1 stop4h 33m

Knoxville McGhee Tyson

Fri 1/10

5:47 pm-2:36 pm

1 stop21h 49m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/18

Showing 1-10 of 18 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Knoxville

Get recent, data-driven insights about flights from Missouri to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $304). Flying from Missouri to Knoxville in April is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 19, 2024.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 19, 2024.
To help decide which airline to fly from Missouri to Knoxville, see what other customers have to say about United Airlines, Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,600 reviews
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
9,048 reviews
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Allegiant Air
7.4
Good
829 reviews
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Frontier
6.1
Okay
3,478 reviews
Delta
8.0
Very good
8,600 reviews

Food

7.3

Entertainment

7.9

Crew

8.6

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $163. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Kansas City - Knoxville McGhee Tyson. You may also consider Lambert-St Louis - Knoxville McGhee Tyson or Springfield-Branson - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $304). Flying from Missouri to Knoxville in April is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 19, 2024.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$208Average$320FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$208Average$410FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$278Average$483FlexibilityNo cancel feeOn-time69%
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