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Knoxville

$100+ Cheap flights from Missouri to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — TYS
Apr 8 — Apr 151
Tue 4/8
Tue 4/15
1 adult, Economy
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Cheap flight deals from Missouri to Knoxville

Keep the following information in mind while searching for Missouri to Knoxville flight deals. Data was last updated April 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$189
(Booking.com)

One-way from

$100
(American Airlines)

Popular in

December

Cheapest in

January

Average price

$299
Provider with most accurate pricing for Kansas City-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Knoxville McGhee Tyson flights.
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From Missouri to Knoxville McGhee Tyson
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One-way flight from Missouri to Knoxville McGhee Tyson
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High demand for flights, 1% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Missouri to Knoxville

Cheapest flights from Missouri to Knoxville
Explore the most affordable flight options available from Missouri to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 3, 2025.

This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/196:00 amMCI - TYS
1 stop7h 44mUnited Airlines
Sat 4/267:00 amTYS - MCI
1 stop4h 32mUnited Airlines
Deal found 4/2$199
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/205:26 amSTL - TYS
1 stop5h 08mAmerican Airlines
Sat 4/266:21 pmTYS - STL
1 stop5h 07mAmerican Airlines
Deal found 4/2$199
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/257:01 pmSTL - TYS
1 stop3h 47mDelta
Tue 4/295:30 amTYS - STL
1 stop5h 06mDelta
Deal found 4/2$214
This Delta deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/148:00 amMCI - TYS
1 stop6h 05mDelta
Sat 9/206:10 pmTYS - MCI
1 stop5h 11mDelta
Deal found 4/2$233
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/25:36 pmMCI - TYS
1 stop4h 54mAmerican Airlines
Fri 5/95:58 pmTYS - MCI
1 stop7h 01mAmerican Airlines
Deal found 4/2$249
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/165:46 amMCI - TYS
1 stop5h 30mMultiple Airlines
Mon 5/198:00 amTYS - MCI
1 stop15h 41mMultiple Airlines
Deal found 4/2$256
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/16:14 pmMCI - TYS
1 stop25h 49mAllegiant Air
Sun 5/46:00 amTYS - MCI
1 stop12h 24mAllegiant Air
Deal found 4/2$281
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:54 pmSGF - TYS
1 stop3h 54mDelta
Mon 4/217:24 pmTYS - SGF
1 stop3h 52mDelta
Deal found 4/1$284
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/57:03 amSGF - TYS
1 stop4h 26mAmerican Airlines
Sat 4/125:15 amTYS - SGF
1 stop7h 30mAmerican Airlines
Deal found 4/2$324
This Mytrip deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/206:10 pmSTL - TYS
1 stop26h 05mMultiple Airlines
Sat 4/269:19 amTYS - STL
3 stops34h 22mMultiple Airlines
Deal found 4/2$353
This United deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/255:35 pmSTL - TYS
1 stop3h 47mUnited Airlines
Tue 4/295:45 amTYS - STL
2 stops11h 02mUnited Airlines
Deal found 4/2$402
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/195:15 pmCOU - TYS
1 stop5h 35mAmerican Airlines
Sat 7/262:57 pmTYS - COU
1 stop5h 23mAmerican Airlines
Deal found 4/2$410

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
Use the filters below to find and compare flights from Missouri to Knoxville that are best for you.

Fly from

Missouri

Fly to

Knoxville

Route

Depart

Return

Price

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sat 4/19

6:00 am-2:44 pm

1 stop7h 44m

Knoxville McGhee Tyson

Sat 4/26

7:00 am-10:32 am

1 stop4h 32m

$199

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 4/20

5:26 am-11:34 am

1 stop5h 08m

Knoxville McGhee Tyson

Sat 4/26

6:21 pm-10:28 pm

1 stop5h 07m

$199

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 4/25

7:01 pm-11:48 pm

1 stop3h 47m

Knoxville McGhee Tyson

Tue 4/29

5:30 am-9:36 am

1 stop5h 06m

$214

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Sun 9/14

8:00 am-3:05 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 9/20

6:10 pm-10:21 pm

1 stop5h 11m

$233

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 5/2

5:36 pm-11:30 pm

1 stop4h 54m

Knoxville McGhee Tyson

Fri 5/9

5:58 pm-11:59 pm

1 stop7h 01m

$249

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Fri 5/16

5:46 am-12:16 pm

1 stop5h 30m

Knoxville McGhee Tyson

Mon 5/19

8:00 am-10:41 pm

1 stop15h 41m

$256

Kansas CityKnoxville

MCI - TYS

MCITYS

Kansas City

Thu 5/1

6:14 pm-9:03 pm

1 stop25h 49m

Knoxville McGhee Tyson

Sun 5/4

6:00 am-5:24 pm

1 stop12h 24m

$281

SpringfieldKnoxville

SGF - TYS

SGFTYS

Springfield-Branson

Thu 4/17

6:54 pm-11:48 pm

1 stop3h 54m

Knoxville McGhee Tyson

Mon 4/21

7:24 pm-10:16 pm

1 stop3h 52m

$284

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Sun 4/20

6:10 pm-9:15 pm

1 stop26h 05m

Knoxville McGhee Tyson

Sat 4/26

9:19 am-6:41 pm

3 stops34h 22m

$353

St. LouisKnoxville

STL - TYS

STLTYS

Lambert-St Louis

Fri 4/25

5:35 pm-10:22 pm

1 stop3h 47m

Knoxville McGhee Tyson

Tue 4/29

5:45 am-3:47 pm

2 stops11h 02m

$402

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/2

Showing 1-10 of 22 results
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Best time to book a flight from Missouri to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Knoxville

What is the cheapest month to book a flight from Missouri to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to TYS?

Find hourly flight availability from Missouri to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 3, 2025.

When flying from Missouri to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 3, 2025.
To help decide which airline to fly from Missouri to Knoxville, see what other customers have to say about Delta, United Airlines and Allegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,897 reviews
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,619 reviews
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
732 reviews
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Frontier
6.0
Okay
3,276 reviews
Delta
8.0
Very good
7,897 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Comfort

7.9

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Missouri to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Missouri?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Missouri to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the cheapest airlines to fly from Missouri to Knoxville one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $100. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Missouri to Knoxville for a low price.

  • What are the most popular routes from Missouri to Knoxville?

    The most popular route from Missouri to Knoxville is Lambert-St Louis - Knoxville McGhee Tyson. You may also consider Kansas City - Knoxville McGhee Tyson or Columbia Regional - Knoxville McGhee Tyson.

  • Can I find deals for flights from Missouri to Knoxville that include hotel bookings?

    Yes. In addition to deals on Missouri to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Knoxville.

  • Can I find deals for business class flights from Missouri to Knoxville?

    Yes. Cheapflights offers flight deals from Missouri to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Knoxville (average of $296). Flying from Missouri to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Missouri to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Knoxville

Discover the top 3 airlines that operate flights from Missouri to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$213Average$391FlexibilityNo cancel feeOn-time69%
DeltaCheapest$217Average$306FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$217Average$409FlexibilityNo cancel feeOn-time71%

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