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$100+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Jan 26 — Feb 21
Sun 1/26
Sun 2/2
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Mississippi (USMS) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2025.

Round-trip from

$199
(American Airlines)

One-way from

$183
(Mytrip)
From Mississippi to Knoxville McGhee Tyson
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One-way flight from Mississippi to Knoxville McGhee Tyson
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Find flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2025.

This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1811:57 amJAN - TYS
1 stop7h 05mUnited Airlines
Tue 3/257:05 amTYS - JAN
1 stop5h 15mUnited Airlines
Deal found 1/21$199
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/116:05 pmMEM - TYS
1 stop4h 53mAmerican Airlines
Tue 2/186:00 pmTYS - MEM
1 stop6h 44mAmerican Airlines
Deal found 1/21$199
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/296:00 pmGPT - TYS
1 stop4h 46mDelta
Tue 5/65:30 amTYS - GPT
1 stop5h 07mDelta
Deal found 1/20$229
This American Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/17:05 amJAN - TYS
1 stop4h 11mAmerican Airlines
Tue 3/411:04 amTYS - JAN
1 stop5h 56mAmerican Airlines
Deal found 1/21$229
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/44:55 pmGPT - TYS
1 stop5h 51mUnited Airlines
Sat 2/89:10 amTYS - GPT
1 stop5h 16mUnited Airlines
Deal found 1/20$239
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/205:45 pmBTR - TYS
1 stop5h 02mDelta
Sun 2/235:45 amTYS - BTR
1 stop4h 55mDelta
Deal found 1/21$249
This American Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/133:31 pmBTR - TYS
1 stop7h 18mAmerican Airlines
Sun 2/165:28 amTYS - BTR
1 stop5h 03mAmerican Airlines
Deal found 1/19$254
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/316:45 pmGPT - TYS
1 stop4h 13mAmerican Airlines
Mon 2/34:08 pmTYS - GPT
1 stop6h 47mAmerican Airlines
Deal found 1/20$279
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2311:54 amMEM - TYS
1 stop7h 09mUnited Airlines
Sun 1/265:47 pmTYS - MEM
1 stop5h 25mUnited Airlines
Deal found 1/20$359
This Mytrip deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:41 pmMEM - TYS
2 stops22h 18mMultiple Airlines
Sun 4/206:00 amTYS - MEM
1 stop15h 01mMultiple Airlines
Deal found 1/20$403
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/156:00 amMEM - TYS
1 stop4h 07mDelta
Fri 9/197:25 pmTYS - MEM
1 stop3h 17mDelta
Deal found 1/20$419
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/135:07 amBTR - TYS
2 stops16h 53mUnited Airlines
Sun 2/167:00 amTYS - BTR
3 stops15h 29mUnited Airlines
Deal found 1/19$683

Find flights from Mississippi to Knoxville within your budget

Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Tue 3/18

11:57 am-8:02 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 3/25

7:05 am-11:20 am

1 stop5h 15m

$199

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Tue 2/11

6:05 pm-11:58 pm

1 stop4h 53m

Knoxville McGhee Tyson

Tue 2/18

6:00 pm-11:44 pm

1 stop6h 44m

$199

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Tue 4/29

6:00 pm-11:46 pm

1 stop4h 46m

Knoxville McGhee Tyson

Tue 5/6

5:30 am-9:37 am

1 stop5h 07m

$229

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Sat 3/1

7:05 am-12:16 pm

1 stop4h 11m

Knoxville McGhee Tyson

Tue 3/4

11:04 am-4:00 pm

1 stop5h 56m

$229

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Tue 2/4

4:55 pm-11:46 pm

1 stop5h 51m

Knoxville McGhee Tyson

Sat 2/8

9:10 am-1:26 pm

1 stop5h 16m

$239

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 2/20

5:45 pm-11:47 pm

1 stop5h 02m

Knoxville McGhee Tyson

Sun 2/23

5:45 am-9:40 am

1 stop4h 55m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 2/13

3:31 pm-11:49 pm

1 stop7h 18m

Knoxville McGhee Tyson

Sun 2/16

5:28 am-9:31 am

1 stop5h 03m

$254

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Fri 1/31

6:45 pm-11:58 pm

1 stop4h 13m

Knoxville McGhee Tyson

Mon 2/3

4:08 pm-9:55 pm

1 stop6h 47m

$279

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 4/17

6:41 pm-5:59 pm

2 stops22h 18m

Knoxville McGhee Tyson

Sun 4/20

6:00 am-8:01 pm

1 stop15h 01m

$403

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Tue 2/11

6:45 am-1:58 pm

1 stop6h 13m

Knoxville McGhee Tyson

Tue 2/18

5:35 pm-1:53 pm

2 stops21h 18m

$427

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 24 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Mississippi to Knoxville

Get recent, data-driven insights about flights from Mississippi to Knoxville including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $297). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Knoxville as you normally would.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 21, 2025.
See what other customers who have flown with American Airlines, Delta and United Airlines from Mississippi to Knoxville have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
8,521 reviews

Crew

8.6

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Delta
8.0
Very good
8,521 reviews
Delta
8.0
Very good
8,521 reviews

Crew

8.6

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

United Airlines
7.4
Good
8,984 reviews
Delta
8.0
Very good
8,521 reviews

Crew

8.6

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
8,521 reviews

Crew

8.6

Entertainment

7.9

Overall

8.0

Boarding

8.2

Food

7.3

Comfort

8.0

Reviews

1 / 10

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Mississippi to Knoxville one-way?

    $192 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $325 and $409, respectively.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Gulfport Biloxi Regional - Knoxville McGhee Tyson, Memphis - Knoxville McGhee Tyson or Baton Rouge Ryan - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $297). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mississippi?

Book flights to Mississippi if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$204Average$420FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$406FlexibilityNo cancel feeOn-timeN/A
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