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Knoxville

$112+ Cheap flights from Mississippi to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/20. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — TYS
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from Mississippi to Knoxville

Keep the following information in mind while searching for Mississippi to Knoxville flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$214
(Delta)

One-way from

$112
(Mytrip)

Popular in

August

Cheapest in

September

Average price

$298
Provider with most accurate pricing for Jackson-Evers Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Knoxville McGhee Tyson flights.
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From Mississippi to Knoxville McGhee Tyson
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One-way flight from Mississippi to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 16% potential increase in price ($90 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Mississippi to Knoxville

Cheapest flights from Mississippi to Knoxville
Explore the most affordable flight options available from Mississippi to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/299:05 amMEM - TYS
1 stop5h 12mDelta
Mon 6/27:10 pmTYS - MEM
1 stop5h 06mDelta
Deal found 4/23$214
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/301:14 pmMEM - TYS
2 stops32h 26mMultiple Airlines
Tue 6/39:00 amTYS - MEM
1 stop23h 30mMultiple Airlines
Deal found 4/23$220
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/302:08 pmMEM - TYS
1 stop17h 12mAllegiant Air
Sun 6/18:00 amTYS - MEM
1 stop24h 41mAllegiant Air
Deal found 4/22$231
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:54 pmJAN - TYS
1 stop4h 19mAmerican Airlines
Mon 9/158:45 pmTYS - JAN
1 stop3h 48mAmerican Airlines
Deal found 4/22$249
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1412:56 pmBTR - TYS
1 stop5h 18mAmerican Airlines
Wed 5/214:10 pmTYS - BTR
1 stop6h 42mAmerican Airlines
Deal found 4/23$249
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/221:40 pmBTR - TYS
1 stop3h 33mDelta
Sat 10/257:15 pmTYS - BTR
1 stop3h 45mDelta
Deal found 4/23$279
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/252:40 pmMEM - TYS
1 stop3h 26mAmerican Airlines
Mon 4/284:20 pmTYS - MEM
1 stop4h 49mAmerican Airlines
Deal found 4/23$289
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/175:03 pmGPT - TYS
1 stop5h 48mDelta
Wed 5/215:45 amTYS - GPT
1 stop3h 44mDelta
Deal found 4/23$294
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:18 pmJAN - TYS
1 stop3h 33mDelta
Tue 5/205:45 amTYS - JAN
1 stop5h 34mDelta
Deal found 4/22$294
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/88:00 amMEM - TYS
1 stop4h 22mUnited Airlines
Mon 5/125:35 pmTYS - MEM
1 stop5h 34mUnited Airlines
Deal found 4/23$404
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/37:00 amGPT - TYS
1 stop6h 20mAmerican Airlines
Sun 7/68:22 pmTYS - GPT
1 stop4h 43mAmerican Airlines
Deal found 4/23$477
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/811:59 amJAN - TYS
1 stop4h 57mUnited Airlines
Tue 5/135:35 pmTYS - JAN
2 stops18h 49mUnited Airlines
Deal found 4/22$486

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Mississippi to Knoxville that are best for you.

Fly from

Mississippi

Fly to

Knoxville

Route

Depart

Return

Price

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 5/29

9:05 am-3:17 pm

1 stop5h 12m

Knoxville McGhee Tyson

Mon 6/2

7:10 pm-11:16 pm

1 stop5h 06m

$214

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 5/30

1:14 pm-10:40 pm

2 stops32h 26m

Knoxville McGhee Tyson

Tue 6/3

9:00 am-7:30 am

1 stop23h 30m

$220

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Fri 5/30

2:08 pm-8:20 am

1 stop17h 12m

Knoxville McGhee Tyson

Sun 6/1

8:00 am-7:41 am

1 stop24h 41m

$231

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Fri 9/12

6:54 pm-12:13 am

1 stop4h 19m

Knoxville McGhee Tyson

Mon 9/15

8:45 pm-11:33 pm

1 stop3h 48m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Wed 5/14

12:56 pm-7:14 pm

1 stop5h 18m

Knoxville McGhee Tyson

Wed 5/21

4:10 pm-9:52 pm

1 stop6h 42m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Thu 9/11

1:40 pm-6:13 pm

1 stop3h 33m

Knoxville McGhee Tyson

Mon 9/15

6:10 pm-10:00 pm

1 stop4h 50m

$279

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Sat 5/17

5:03 pm-11:51 pm

1 stop5h 48m

Knoxville McGhee Tyson

Wed 5/21

5:45 am-8:29 am

1 stop3h 44m

$294

JacksonKnoxville

JAN - TYS

JANTYS

Jackson-Evers Intl

Fri 5/16

7:18 pm-11:51 pm

1 stop3h 33m

Knoxville McGhee Tyson

Tue 5/20

5:45 am-10:19 am

1 stop5h 34m

$294

MemphisKnoxville

MEM - TYS

MEMTYS

Memphis

Thu 5/8

8:00 am-1:22 pm

1 stop4h 22m

Knoxville McGhee Tyson

Mon 5/12

5:35 pm-10:09 pm

1 stop5h 34m

$404

GulfportKnoxville

GPT - TYS

GPTTYS

Gulfport Biloxi Regional

Thu 7/3

7:00 am-2:20 pm

1 stop6h 20m

Knoxville McGhee Tyson

Sun 7/6

8:22 pm-12:05 am

1 stop4h 43m

$477

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 22 results
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Best time to book a flight from Mississippi to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Knoxville

What is the cheapest month to book a flight from Mississippi to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $296). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to TYS?

Find hourly flight availability from Mississippi to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to Knoxville as you normally would.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 24, 2025.
See what other customers who have flown with Delta, United Airlines and Allegiant Air from Mississippi to Knoxville have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,685 reviews
Delta
8.0
Very good
7,920 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,920 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Boarding

8.2

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mississippi?

    For a flight from Mississippi to Knoxville, you will be flying into McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • What are the cheapest airlines to fly from Mississippi to Knoxville one-way?

    $210 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $279 and $449, respectively.

  • What are the most popular routes from Mississippi to Knoxville?

    When deciding which route to take from Mississippi to Knoxville consider Baton Rouge Ryan - Knoxville McGhee Tyson, Memphis - Knoxville McGhee Tyson or Jackson-Evers Intl - Knoxville McGhee Tyson as they are the most popular.

  • Can I find deals for flights from Mississippi to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mississippi to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Knoxville.

  • Can I find deals for business class flights from Mississippi to Knoxville?

    Yes. Cheapflights offers flight deals from Mississippi to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Knoxville (average of $296). Flying from Mississippi to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mississippi?

Book flights to Mississippi if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Mississippi to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to Knoxville

Discover the top 2 airlines that operate flights from Mississippi to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$360FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$229Average$416FlexibilityNo cancel feeOn-time71%

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