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$74+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/27. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Feb 26 — Mar 51
Wed 2/26
Wed 3/5
1 adult, Economy
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The best prices from Mesa to Knoxville McGhee Tyson are usually found in January or November, booked 38 days in advance, depart on a Monday or Thursday and return on a Thursday

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated February 21, 2025.

Round-trip from

$157
(Mytrip)

One-way from

$74
(Frontier)

Popular in

July

Cheapest in

January

Average price

$361
From Mesa to Knoxville McGhee Tyson
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One-way flight from Mesa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2025.

This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/104:06 pmPHX - TYS
Nonstop3h 22mAllegiant Air
Sun 4/201:55 pmTYS - PHX
Nonstop4h 21mAllegiant Air
Deal found 2/21$150
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/106:00 amPHX - TYS
1 stop6h 41mMultiple Airlines
Sun 4/201:55 pmTYS - PHX
Nonstop4h 21mMultiple Airlines
Deal found 2/21$165
This Trip.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/269:15 pmPHX - TYS
1 stop15h 08mFrontier
Sun 3/304:43 pmTYS - PHX
1 stop8h 17mFrontier
Deal found 2/20$262
This KAYAK deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1511:50 pmPHX - TYS
1 stop6h 31mDelta
Sat 4/195:30 amTYS - PHX
1 stop7h 17mDelta
Deal found 2/20$480
This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2812:50 amPHX - TYS
1 stop8h 34mAmerican Airlines
Tue 4/14:09 pmTYS - PHX
1 stop6h 10mAmerican Airlines
Deal found 2/21$489
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/292:27 pmPHX - TYS
1 stop6h 03mUnited Airlines
Tue 4/11:57 pmTYS - PHX
2 stops9h 33mUnited Airlines
Deal found 2/21$495

Find flights from Mesa to Knoxville within your budget

Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2025.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 4/10

4:06 pm-10:28 pm

Nonstop3h 22m

Knoxville McGhee Tyson

Sun 4/20

1:55 pm-3:16 pm

Nonstop4h 21m

$150

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 4/10

6:00 am-3:41 pm

1 stop6h 41m

Knoxville McGhee Tyson

Sun 4/20

1:55 pm-3:16 pm

Nonstop4h 21m

$165

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Wed 3/26

9:15 pm-3:23 pm

1 stop15h 08m

Knoxville McGhee Tyson

Sun 3/30

4:43 pm-10:00 pm

1 stop8h 17m

$262

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 4/15

11:50 pm-9:21 am

1 stop6h 31m

Knoxville McGhee Tyson

Sat 4/19

5:30 am-9:47 am

1 stop7h 17m

$480

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 3/28

12:50 am-12:24 pm

1 stop8h 34m

Knoxville McGhee Tyson

Tue 4/1

4:09 pm-7:19 pm

1 stop6h 10m

$489

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 3/29

2:27 pm-11:30 pm

1 stop6h 03m

Knoxville McGhee Tyson

Tue 4/1

1:57 pm-8:30 pm

2 stops9h 33m

$495

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 3/27

6:00 am-3:23 pm

1 stop6h 23m

$74

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 2/27

5:06 pm-10:30 pm

Nonstop3h 24m

$117

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 4/6

11:48 am-10:23 am

2 stops19h 35m

$182

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 3/24

9:45 pm-11:39 am

2 stops10h 54m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 12 results
1
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Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Mesa to Knoxville

Get recent, data-driven insights about flights from Mesa to Knoxville including ideal travel times, pricing trends, and more.

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on February 14, 2025.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 38 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $296). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 21, 2025.

When flying from Mesa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to Knoxville flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated February 21, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta and United Airlines from Mesa to Knoxville by reading reviews from past customers. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Alaska Airlines
8.0
Very good
9,697 reviews
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Delta
8.0
Very good
8,213 reviews
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

United Airlines
7.4
Good
8,759 reviews
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Allegiant Air
7.3
Good
765 reviews
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,697 reviews

Overall

8.0

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Reviews

1 / 20

10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • What are the cheapest airlines to fly from Mesa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Mesa to Knoxville are Frontier ($74), Allegiant Air ($117), and American Airlines ($229).

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $86. On average you can expect to pay $196. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $143.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $296). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mesa?

Book flights to Mesa if you plan to visit one of these locations
Morristown
Corbin
Cherokee
Maryville
Oak Ridge
Alcoa
Murphy

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$127Average$232FlexibilityNo cancel feeOn-time88%
FrontierCheapest$128Average$242FlexibilityNo cancel feeOn-time62%
DeltaCheapest$274Average$532FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$335Average$545FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$344Average$579FlexibilityNo cancel feeOn-time69%
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