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$113+ Cheap flights from Mesa, AZ to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
PHX — TYS
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheapflights Tip: The best prices from Mesa to Knoxville McGhee Tyson are usually found in January or November, booked 47 days in advance, depart on a Monday or Thursday and return on a Thursday

Cheap flight deals from Mesa to Knoxville

Keep the following information in mind while searching for Mesa to Knoxville flight deals. Data was last updated April 24, 2025.

Round-trip from

$153
(Mytrip)

One-way from

$113
(Mytrip)

Popular in

December

Cheapest in

January

Average price

$313
From Mesa to Knoxville McGhee Tyson
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One-way flight from Mesa to Knoxville McGhee Tyson
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High demand for flights, 12% potential price rise
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Mesa to Knoxville

Cheapest flights from Mesa to Knoxville
Explore the most affordable flight options available from Mesa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/197:40 amPHX - TYS
Nonstop3h 27mAllegiant Air
Thu 6/266:00 amTYS - PHX
Nonstop3h 50mAllegiant Air
Deal found 4/23$153
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1912:54 pmPHX - TYS
2 stops16h 10mMultiple Airlines
Thu 6/266:00 amTYS - PHX
Nonstop3h 50mMultiple Airlines
Deal found 4/23$226
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2012:45 amPHX - TYS
1 stop6h 43mAmerican Airlines
Wed 5/282:56 pmTYS - PHX
1 stop6h 40mAmerican Airlines
Deal found 4/23$240
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1711:55 pmPHX - TYS
1 stop6h 18mDelta
Tue 7/228:47 amTYS - PHX
1 stop8h 48mDelta
Deal found 4/23$273
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1311:20 pmPHX - TYS
1 stop7h 49mUnited Airlines
Mon 6/165:45 amTYS - PHX
1 stop7h 35mUnited Airlines
Deal found 4/23$306
This Alaska Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/36:16 pmPHX - TYS
2 stops14h 18mAlaska Airlines
Sat 5/107:50 pmTYS - PHX
2 stops20h 04mAlaska Airlines
Deal found 4/23$570

Cheapflights Fare Finder

Customize your flight search to find flights from Mesa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Mesa to Knoxville that are best for you.

Fly from

Mesa

Fly to

Knoxville

Route

Depart

Return

Price

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 6/19

7:40 am-2:07 pm

Nonstop3h 27m

Knoxville McGhee Tyson

Thu 6/26

6:00 am-6:50 am

Nonstop3h 50m

$153

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 6/19

12:54 pm-8:04 am

2 stops16h 10m

Knoxville McGhee Tyson

Thu 6/26

6:00 am-6:50 am

Nonstop3h 50m

$226

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Tue 5/20

12:45 am-10:28 am

1 stop6h 43m

Knoxville McGhee Tyson

Wed 5/28

2:56 pm-6:36 pm

1 stop6h 40m

$240

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 7/17

11:55 pm-9:13 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 7/22

8:47 am-2:35 pm

1 stop8h 48m

$273

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Fri 6/13

11:20 pm-10:09 am

1 stop7h 49m

Knoxville McGhee Tyson

Mon 6/16

5:45 am-10:20 am

1 stop7h 35m

$306

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sat 5/3

6:16 pm-11:34 am

2 stops14h 18m

Knoxville McGhee Tyson

Sat 5/10

7:50 pm-12:54 pm

2 stops20h 04m

$570

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 5/22

8:05 am-2:32 pm

Nonstop3h 27m

$113

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Thu 5/29

7:18 am-4:35 pm

1 stop6h 17m

$118

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Sun 5/18

9:19 am-1:44 pm

1 stop25h 25m

$134

PhoenixKnoxville

PHX - TYS

PHXTYS

Phoenix Sky Harbor Intl

Mon 5/12

12:45 am-10:28 am

1 stop6h 43m

$201

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 12 results
1
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Best time to book a flight from Mesa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Mesa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mesa to Knoxville

How far ahead should I book a flight from Mesa to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Mesa to Knoxville. Price data was last updated on April 18, 2025.

The price you pay for your flight from Mesa to Knoxville may vary depending on when you book. For the best chance of a lower fare, look to book 47 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Mesa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $296). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS9 to TYS?

Find hourly flight availability from Mesa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

When flying from Mesa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Mesa to Knoxville?

Use this chart to determine the cheapest time to fly round-trip from Mesa to Knoxville. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Mesa to Knoxville flight should consider departing on Friday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 24, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Delta and United Airlines from Mesa to Knoxville by reading reviews from past customers. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,918 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,685 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Crew

8.5

Comfort

7.9

Boarding

8.2

Food

7.1

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Mesa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Mesa?

    If you book a flight to Knoxville from Mesa, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Mesa to McGhee Tyson per day from 5 different airlines.

  • What are the cheapest airlines to fly from Mesa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Mesa to Knoxville are Allegiant Air ($113), Frontier ($118), and American Airlines ($201).

  • What are the cheapest flights from Mesa to Knoxville?

    The cheapest flight price from Mesa to Knoxville is $88. On average you can expect to pay $184. The most popular route, (Phoenix Sky Harbor Intl - Knoxville McGhee Tyson), can usually be booked for $109.

  • Can I find deals for flights from Mesa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Mesa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mesa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mesa to Knoxville.

  • Can I find deals for business class flights from Mesa to Knoxville?

    Yes. Cheapflights offers flight deals from Mesa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mesa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Mesa to Knoxville (average of $296). Flying from Mesa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mesa?

Book flights to Mesa if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 5 airlines flying from Mesa to Knoxville

Discover the top 5 airlines that operate flights from Mesa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$108Average$210FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$127Average$227FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$288Average$528FlexibilityNo cancel feeOn-time71%
DeltaCheapest$288Average$501FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$344Average$522FlexibilityNo cancel feeOn-time69%

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