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Knoxville

$140+ Cheap flights from Louisiana to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
MSY — TYS
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Louisiana to Knoxville

Keep the following information in mind while searching for Louisiana to Knoxville flight deals. Data was last updated April 17, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$224
(American Airlines)

One-way from

$140
(Mytrip)

Popular in

December

Cheapest in

January

Average price

$323
Provider with most accurate pricing for New Orleans Louis Armstrong-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for New Orleans Louis Armstrong-Knoxville McGhee Tyson flights.
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From Louisiana to Knoxville McGhee Tyson
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One-way flight from Louisiana to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 5% potential increase in price ($18 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Louisiana to Knoxville

Cheapest flights from Louisiana to Knoxville
Explore the most affordable flight options available from Louisiana to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/244:21 pmMSY - TYS
1 stop3h 56mAmerican Airlines
Mon 5/267:54 pmTYS - MSY
1 stop4h 56mAmerican Airlines
Deal found 4/16$224
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/315:32 pmMSY - TYS
1 stop5h 19mDelta
Fri 6/67:10 pmTYS - MSY
1 stop5h 21mDelta
Deal found 4/16$243
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/205:27 pmBTR - TYS
1 stop5h 24mDelta
Sun 5/255:45 amTYS - BTR
1 stop4h 49mDelta
Deal found 4/17$243
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/109:29 amMSY - TYS
2 stops32h 50mMultiple Airlines
Sun 6/159:34 pmTYS - MSY
1 stop11h 44mMultiple Airlines
Deal found 4/17$246
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2512:45 pmSHV - TYS
1 stop4h 32mDelta
Tue 7/296:10 pmTYS - SHV
1 stop6h 12mDelta
Deal found 4/17$249
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/266:22 pmBTR - TYS
1 stop4h 33mAmerican Airlines
Mon 4/287:54 pmTYS - BTR
1 stop5h 08mAmerican Airlines
Deal found 4/17$309
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/251:42 pmSHV - TYS
1 stop4h 24mAmerican Airlines
Wed 4/306:59 amTYS - SHV
2 stops9h 54mAmerican Airlines
Deal found 4/17$314
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/235:40 pmLFT - TYS
1 stop5h 11mDelta
Tue 5/274:22 pmTYS - LFT
1 stop6h 44mDelta
Deal found 4/17$344
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/236:17 pmLFT - TYS
1 stop4h 41mAmerican Airlines
Sun 5/255:20 amTYS - LFT
1 stop5h 40mAmerican Airlines
Deal found 4/17$413
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/255:58 pmSHV - TYS
2 stops27h 37mUnited Airlines
Tue 7/299:35 amTYS - SHV
1 stop6h 55mUnited Airlines
Deal found 4/17$448
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/197:20 pmMSY - TYS
2 stops26h 20mUnited Airlines
Mon 6/235:45 amTYS - MSY
1 stop5h 28mUnited Airlines
Deal found 4/17$565
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/99:30 pmBTR - TYS
2 stops18h 24mUnited Airlines
Mon 5/125:35 pmTYS - BTR
2 stops18h 43mUnited Airlines
Deal found 4/17$613

Cheapflights Fare Finder

Customize your flight search to find flights from Louisiana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Louisiana to Knoxville that are best for you.

Fly from

Louisiana

Fly to

Knoxville

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 5/24

4:21 pm-9:17 pm

1 stop3h 56m

Knoxville McGhee Tyson

Mon 5/26

7:54 pm-11:50 pm

1 stop4h 56m

$224

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 5/31

5:32 pm-11:51 pm

1 stop5h 19m

Knoxville McGhee Tyson

Fri 6/6

7:10 pm-11:31 pm

1 stop5h 21m

$243

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 5/20

5:27 pm-11:51 pm

1 stop5h 24m

Knoxville McGhee Tyson

Sun 5/25

5:45 am-9:34 am

1 stop4h 49m

$243

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 6/10

9:29 am-7:19 pm

2 stops32h 50m

Knoxville McGhee Tyson

Sun 6/15

9:34 pm-8:18 am

1 stop11h 44m

$246

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Fri 7/25

12:45 pm-6:17 pm

1 stop4h 32m

Knoxville McGhee Tyson

Tue 7/29

6:10 pm-11:22 pm

1 stop6h 12m

$249

Baton RougeKnoxville

BTR - TYS

BTRTYS

Baton Rouge Ryan

Tue 5/20

5:30 am-2:24 pm

2 stops7h 54m

Knoxville McGhee Tyson

Sun 5/25

5:20 am-10:01 am

1 stop5h 41m

$324

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Fri 5/23

5:40 pm-11:51 pm

1 stop5h 11m

Knoxville McGhee Tyson

Tue 5/27

4:22 pm-10:06 pm

1 stop6h 44m

$344

LafayetteKnoxville

LFT - TYS

LFTTYS

Lafayette Regional

Fri 5/23

6:17 pm-11:58 pm

1 stop4h 41m

Knoxville McGhee Tyson

Sun 5/25

5:20 am-10:00 am

1 stop5h 40m

$413

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Fri 7/25

5:58 pm-10:35 pm

2 stops27h 37m

Knoxville McGhee Tyson

Tue 7/29

9:35 am-3:30 pm

1 stop6h 55m

$448

ShreveportKnoxville

SHV - TYS

SHVTYS

Shreveport

Fri 5/2

10:02 am-7:00 pm

2 stops7h 58m

Knoxville McGhee Tyson

Tue 5/6

2:56 pm-8:17 pm

1 stop6h 21m

$464

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Louisiana to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Louisiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisiana to Knoxville

What is the cheapest month to book a flight from Louisiana to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $296). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from LA to TYS?

Find hourly flight availability from Louisiana to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from Louisiana to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 17, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines and American Airlines from Louisiana to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,917 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,917 reviews
Delta
8.0
Very good
7,917 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,917 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,917 reviews

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Louisiana to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Louisiana?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Louisiana to Knoxville. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • What are the most popular routes from Louisiana to Knoxville?

    The most popular route from Louisiana to Knoxville is New Orleans Louis Armstrong - Knoxville McGhee Tyson. You may also consider Baton Rouge Ryan - Knoxville McGhee Tyson or Shreveport - Knoxville McGhee Tyson.

  • Can I find deals for flights from Louisiana to Knoxville that include hotel bookings?

    Yes. In addition to deals on Louisiana to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisiana to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisiana to Knoxville.

  • Can I find deals for business class flights from Louisiana to Knoxville?

    Yes. Cheapflights offers flight deals from Louisiana to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisiana to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Louisiana to Knoxville (average of $296). Flying from Louisiana to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisiana?

Book flights to Louisiana if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Louisiana to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Louisiana to Knoxville

Discover the top 3 airlines that operate flights from Louisiana to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$104Average$359FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$382FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$216Average$389FlexibilityNo cancel feeOn-time71%

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