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$149+ Cheap flights from Iowa to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Apr 5 — Apr 121
Sat 4/5
Sat 4/12
1 adult, Economy
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Cheap flight deals from Iowa to Knoxville

Keep the following information in mind while searching for Iowa to Knoxville flight deals. Data was last updated March 31, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(American Airlines)

One-way from

$149
(Mytrip)

Popular in

November

Cheapest in

January

Average price

$438
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Iowa to Knoxville McGhee Tyson
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One-way flight from Iowa to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 3% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Iowa to Knoxville

Cheapest flights from Iowa to Knoxville
Explore the most affordable flight options available from Iowa to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 31, 2025.

This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2412:50 pmDSM - TYS
1 stop6h 10mAmerican Airlines
Fri 5/3012:02 pmTYS - DSM
1 stop7h 57mAmerican Airlines
Deal found 3/31$199
This American Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/295:12 amMLI - TYS
1 stop5h 52mAmerican Airlines
Wed 5/75:58 pmTYS - MLI
1 stop5h 16mAmerican Airlines
Deal found 3/29$199
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/231:50 pmOMA - TYS
1 stop7h 17mAmerican Airlines
Wed 7/307:24 amTYS - OMA
1 stop6h 33mAmerican Airlines
Deal found 3/31$199
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/226:30 pmOMA - TYS
1 stop4h 17mDelta
Wed 7/305:30 amTYS - OMA
1 stop5h 26mDelta
Deal found 3/30$217
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:56 amCID - TYS
1 stop4h 10mDelta
Fri 7/117:25 pmTYS - CID
1 stop4h 30mDelta
Deal found 3/30$233
This Mytrip deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/148:00 amDSM - TYS
1 stop11h 39mAllegiant Air
Fri 4/189:29 pmTYS - DSM
1 stop25h 22mAllegiant Air
Deal found 3/29$234
This Mytrip deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/145:47 pmCID - TYS
1 stop23h 45mAllegiant Air
Fri 4/189:29 pmTYS - CID
1 stop21h 18mAllegiant Air
Deal found 3/30$244
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1110:16 amOMA - TYS
1 stop28h 48mAllegiant Air
Fri 5/162:01 pmTYS - OMA
1 stop26h 55mAllegiant Air
Deal found 3/31$251
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/36:29 pmOMA - TYS
1 stop4h 24mUnited Airlines
Wed 10/85:50 amTYS - OMA
2 stops9h 36mUnited Airlines
Deal found 3/30$264
This American Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/111:18 amCID - TYS
1 stop4h 15mAmerican Airlines
Tue 7/86:34 amTYS - CID
1 stop6h 30mAmerican Airlines
Deal found 3/30$269
This Mytrip deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/146:30 amDSM - TYS
2 stops30h 08mMultiple Airlines
Fri 4/189:29 pmTYS - DSM
1 stop25h 22mMultiple Airlines
Deal found 3/29$293
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/255:26 pmCID - TYS
1 stop4h 09mUnited Airlines
Wed 7/307:00 amTYS - CID
1 stop4h 40mUnited Airlines
Deal found 3/31$313

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Iowa

Fly to

Knoxville

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/24

12:50 pm-8:00 pm

1 stop6h 10m

Knoxville McGhee Tyson

Fri 5/30

12:02 pm-6:59 pm

1 stop7h 57m

$199

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Tue 4/29

5:12 am-12:04 pm

1 stop5h 52m

Knoxville McGhee Tyson

Wed 5/7

5:58 pm-10:14 pm

1 stop5h 16m

$199

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 7/23

1:50 pm-10:07 pm

1 stop7h 17m

Knoxville McGhee Tyson

Wed 7/30

7:24 am-12:57 pm

1 stop6h 33m

$199

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 7/22

6:30 pm-11:47 pm

1 stop4h 17m

Knoxville McGhee Tyson

Wed 7/30

5:30 am-9:56 am

1 stop5h 26m

$217

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 7/1

5:56 am-11:06 am

1 stop4h 10m

Knoxville McGhee Tyson

Fri 7/11

7:25 pm-10:55 pm

1 stop4h 30m

$233

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 4/14

8:00 am-8:39 pm

1 stop11h 39m

Knoxville McGhee Tyson

Fri 4/18

9:29 pm-9:51 pm

1 stop25h 22m

$234

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Mon 4/14

5:47 pm-6:32 pm

1 stop23h 45m

Knoxville McGhee Tyson

Fri 4/18

9:29 pm-5:47 pm

1 stop21h 18m

$244

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Sun 5/11

10:16 am-4:04 pm

1 stop28h 48m

Knoxville McGhee Tyson

Fri 5/16

2:01 pm-3:56 pm

1 stop26h 55m

$251

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 7/1

11:18 am-4:33 pm

1 stop4h 15m

Knoxville McGhee Tyson

Tue 7/8

6:34 am-12:04 pm

1 stop6h 30m

$269

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 7/23

11:28 am-5:05 pm

1 stop4h 37m

Knoxville McGhee Tyson

Tue 7/29

5:45 am-2:22 pm

2 stops9h 37m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 21 results
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Best time to book a flight from Iowa to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Knoxville

What is the cheapest month to book a flight from Iowa to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $296). Flying from Iowa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to TYS?

Find hourly flight availability from Iowa to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 31, 2025.

When flying from Iowa to Knoxville, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 31, 2025.
Read reviews from past customers who have flown Delta, United Airlines and Allegiant Air from Iowa to Knoxville. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Comfort

8.0

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Comfort

8.0

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,614 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Comfort

8.0

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
731 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Comfort

8.0

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Boarding

8.2

Comfort

8.0

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Iowa to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Iowa?

    Most people fly into Knoxville McGhee Tyson (TYS) if they book a flight to Knoxville from Iowa. McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Iowa to Knoxville one-way?

    The cheapest airlines for a one-way flight from Iowa to Knoxville are Allegiant Air ($149), American Airlines ($206), and Delta ($220).

  • What are the most popular routes from Iowa to Knoxville?

    The most popular flight routes from Iowa to Knoxville are Omaha Eppley Airfield - Knoxville McGhee Tyson, Des Moines - Knoxville McGhee Tyson and Cedar Rapids - Knoxville McGhee Tyson.

  • Can I find deals for flights from Iowa to Knoxville that include hotel bookings?

    Yes. In addition to deals on Iowa to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Knoxville.

  • Can I find deals for business class flights from Iowa to Knoxville?

    Yes. Cheapflights offers flight deals from Iowa to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Iowa to Knoxville (average of $296). Flying from Iowa to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Iowa?

Book flights to Iowa if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Alternative routes for Iowa to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Knoxville

Discover the top 3 airlines that operate flights from Iowa to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$226Average$356FlexibilityNo cancel feeOn-time71%
DeltaCheapest$232Average$323FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$465FlexibilityNo cancel feeOn-time69%
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