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$110+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
Apr 9 — Apr 161
Wed 4/9
Wed 4/16
1 adult, Economy
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Cheap flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated April 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$189
(American Airlines)

One-way from

$110
(Frontier)

Popular in

May

Cheapest in

August

Average price

$298
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
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From Florida Keys to Knoxville McGhee Tyson
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One-way flight from Florida Keys to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 8% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/309:16 pmMIA - TYS
Nonstop2h 13mAmerican Airlines
Wed 5/77:10 amTYS - MIA
Nonstop2h 05mAmerican Airlines
Deal found 4/3$189
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/306:00 amMIA - TYS
1 stop5h 09mDelta
Wed 5/75:45 amTYS - MIA
1 stop5h 05mDelta
Deal found 4/3$209
This Frontier deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/176:25 amMIA - TYS
1 stop9h 16mFrontier
Sun 4/204:43 pmTYS - MIA
1 stop12h 38mFrontier
Deal found 4/3$220
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/39:20 pmMIA - TYS
1 stop15h 33mMultiple Airlines
Thu 5/81:43 pmTYS - MIA
2 stops18h 21mMultiple Airlines
Deal found 4/3$287
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1411:28 amEYW - TYS
2 stops9h 49mAmerican Airlines
Mon 5/197:10 amTYS - EYW
1 stop5h 41mAmerican Airlines
Deal found 4/3$329
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/67:00 amMIA - TYS
1 stop6h 22mUnited Airlines
Wed 4/309:55 amTYS - MIA
2 stops12h 01mUnited Airlines
Deal found 4/3$481
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/148:45 amEYW - TYS
2 stops9h 11mUnited Airlines
Mon 5/195:50 amTYS - EYW
3 stops12h 15mUnited Airlines
Deal found 4/3$689

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 4/30

9:16 pm-11:29 pm

Nonstop2h 13m

Knoxville McGhee Tyson

Wed 5/7

7:10 am-9:15 am

Nonstop2h 05m

$189

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Wed 4/30

6:00 am-11:09 am

1 stop5h 09m

Knoxville McGhee Tyson

Wed 5/7

5:45 am-10:50 am

1 stop5h 05m

$209

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 4/17

6:25 am-3:41 pm

1 stop9h 16m

Knoxville McGhee Tyson

Sun 4/20

4:43 pm-5:21 am

1 stop12h 38m

$220

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 5/3

9:20 pm-12:53 pm

1 stop15h 33m

Knoxville McGhee Tyson

Thu 5/8

1:43 pm-8:04 am

2 stops18h 21m

$287

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 5/14

11:28 am-9:17 pm

2 stops9h 49m

Knoxville McGhee Tyson

Mon 5/19

7:10 am-12:51 pm

1 stop5h 41m

$329

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sat 5/3

10:16 am-11:07 pm

2 stops12h 51m

Knoxville McGhee Tyson

Thu 5/8

7:05 am-3:54 pm

1 stop8h 49m

$490

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 5/14

8:45 am-5:56 pm

2 stops9h 11m

Knoxville McGhee Tyson

Mon 5/19

5:50 am-6:05 pm

3 stops12h 15m

$689

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 4/20

6:30 am-3:46 pm

1 stop9h 16m

$110

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 5/6

8:58 am-1:33 pm

2 stops28h 35m

$127

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Tue 5/6

10:15 am-11:48 pm

2 stops13h 33m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/3

Showing 1-10 of 15 results
1
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Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 4, 2025.
Read through reviews of airlines operating flights from Florida Keys to Knoxville, such as Delta, United Airlines and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
Delta
8.0
Very good
7,899 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
United Airlines
7.4
Good
8,618 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.
Frontier
6.0
Okay
3,276 reviews
Delta
8.0
Very good
7,899 reviews

Crew

8.5

Food

7.3

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Santiago,Apr 2024

MCO - ATL

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $110. Users have also found prices from $197 and $214 on Delta and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top airline flying from Florida Keys to Knoxville

Discover the top airline that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$398FlexibilityNo cancel feeOn-time71%

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