HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$130+ Cheap flights from Florida Keys to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — TYS
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida Keys to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida Keys to Knoxville

Keep the following information in mind while searching for Florida Keys to Knoxville flight deals. Data was last updated April 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$160
(American Airlines)

One-way from

$130
(Frontier)

Popular in

May

Cheapest in

August

Average price

$273
Provider with most accurate pricing for Key West-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Knoxville McGhee Tyson flights.
Search Deals
From Florida Keys to Knoxville McGhee Tyson
Search Deals
One-way flight from Florida Keys to Knoxville McGhee Tyson
Search Deals
High demand for flights, 2% potential price rise
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Florida Keys to Knoxville

Cheapest flights from Florida Keys to Knoxville
Explore the most affordable flight options available from Florida Keys to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/265:30 amMIA - TYS
1 stop4h 23mDelta
Tue 7/15:45 amTYS - MIA
1 stop5h 12mDelta
Deal found 4/28$179
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/510:11 pmMIA - TYS
Nonstop2h 13mAmerican Airlines
Mon 6/95:57 pmTYS - MIA
1 stop4h 25mAmerican Airlines
Deal found 4/28$180
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/261:00 pmEYW - TYS
1 stop6h 01mAmerican Airlines
Mon 6/3011:08 amTYS - EYW
1 stop5h 03mAmerican Airlines
Deal found 4/28$249
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/52:21 pmMIA - TYS
2 stops26h 26mMultiple Airlines
Mon 6/97:15 amTYS - MIA
1 stop12h 43mMultiple Airlines
Deal found 4/28$250
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/107:10 amEYW - TYS
1 stop3h 58mDelta
Tue 6/175:45 amTYS - EYW
1 stop5h 08mDelta
Deal found 4/27$314
This Frontier deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/226:00 amMIA - TYS
1 stop10h 35mFrontier
Sun 5/255:30 pmTYS - MIA
1 stop13h 00mFrontier
Deal found 4/27$350
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/184:16 pmMIA - TYS
1 stop6h 21mUnited Airlines
Wed 7/235:45 amTYS - MIA
2 stops10h 56mUnited Airlines
Deal found 4/28$420
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/108:45 amEYW - TYS
2 stops13h 55mUnited Airlines
Tue 6/179:35 amTYS - EYW
2 stops32h 30mUnited Airlines
Deal found 4/27$444

Cheapflights Fare Finder

Customize your flight search to find flights from Florida Keys to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Florida Keys to Knoxville that are best for you.

Fly from

Florida Keys

Fly to

Knoxville

Route

Depart

Return

Price

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 6/26

5:30 am-9:53 am

1 stop4h 23m

Knoxville McGhee Tyson

Tue 7/1

5:45 am-10:57 am

1 stop5h 12m

$179

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 6/5

10:11 pm-12:24 am

Nonstop2h 13m

Knoxville McGhee Tyson

Mon 6/9

5:57 pm-10:22 pm

1 stop4h 25m

$180

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 6/26

1:00 pm-7:01 pm

1 stop6h 01m

Knoxville McGhee Tyson

Mon 6/30

11:08 am-4:11 pm

1 stop5h 03m

$249

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 6/5

2:21 pm-4:47 pm

2 stops26h 26m

Knoxville McGhee Tyson

Mon 6/9

7:15 am-7:58 pm

1 stop12h 43m

$250

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 6/10

7:10 am-11:08 am

1 stop3h 58m

Knoxville McGhee Tyson

Tue 6/17

5:45 am-10:53 am

1 stop5h 08m

$314

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Thu 5/22

6:00 am-4:35 pm

1 stop10h 35m

Knoxville McGhee Tyson

Sun 5/25

5:30 pm-6:30 am

1 stop13h 00m

$350

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Fri 7/18

4:16 pm-10:37 pm

1 stop6h 21m

Knoxville McGhee Tyson

Wed 7/23

5:45 am-4:41 pm

2 stops10h 56m

$420

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 6/10

8:45 am-10:40 pm

2 stops13h 55m

Knoxville McGhee Tyson

Tue 6/17

9:35 am-6:05 pm

2 stops32h 30m

$444

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 5/25

6:00 am-4:35 pm

1 stop10h 35m

$130

MiamiKnoxville

MIA - TYS

MIATYS

Miami

Sun 5/25

9:05 am-11:42 am

2 stops26h 37m

$149

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 14 results
1
2

Best time to book a flight from Florida Keys to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Florida Keys with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida Keys to Knoxville

What is the cheapest month to book a flight from Florida Keys to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from EOA to TYS?

Find hourly flight availability from Florida Keys to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida Keys to Knoxville as you normally would.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 29, 2025.
Read through reviews of airlines operating flights from Florida Keys to Knoxville, such as Alaska Airlines, Delta and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,949 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,929 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Frontier
6.0
Okay
3,285 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Florida Keys to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Florida Keys?

    Located just 11.3 mi from the city center, Knoxville McGhee Tyson (TYS) is the airport most travelers will use when flying to Knoxville from Florida Keys.

  • What are the cheapest airlines to fly from Florida Keys to Knoxville one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $130. Users have also found prices from $185 and $212 on Delta and American Airlines, respectively.

  • Can I find deals for flights from Florida Keys to Knoxville that include hotel bookings?

    Yes. In addition to deals on Florida Keys to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida Keys to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida Keys to Knoxville.

  • Can I find deals for business class flights from Florida Keys to Knoxville?

    Yes. Cheapflights offers flight deals from Florida Keys to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida Keys to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Florida Keys to Knoxville (average of $296). Flying from Florida Keys to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florida Keys?

Book flights to Florida Keys if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida Keys to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Miami to Nashville flights
Tampa to Nashville flights
West Palm Beach to Nashville flights
Jacksonville to Nashville flights
Fort Myers to Knoxville flights
Fort Myers to Nashville flights
Sarasota to Nashville flights
Tampa to Knoxville flights
Miami to Memphis flights
Orlando to Memphis flights
Miami to Knoxville flights
Fort Lauderdale to Knoxville flights
Pensacola to Nashville flights
Tampa to Memphis flights
West Palm Beach to Knoxville flights
Orlando to Knoxville flights
Jacksonville to Memphis flights
Orlando Sanford Intl to Knoxville flights
Orlando to Chattanooga flights
Tampa to Chattanooga flights
Gainesville to Nashville flights
Tallahassee to Nashville flights
Panama City to Nashville flights
West Palm Beach to Chattanooga flights
Sarasota to Knoxville flights
Daytona Beach to Nashville flights
St Petersburg to Knoxville flights
Melbourne to Nashville flights
Fort Lauderdale to Chattanooga flights
Fort Lauderdale to Memphis flights
Fort Myers to Memphis flights
Jacksonville to Knoxville flights
Key West to Nashville flights
Jacksonville to Chattanooga flights
Fort Myers to Chattanooga flights
West Palm Beach to Memphis flights
Miami to Chattanooga flights
Melbourne to Chattanooga flights
Sarasota to Memphis flights
Orlando to Blountville flights
Pensacola to Knoxville flights
Tampa to Blountville flights
Punta Gorda to Nashville flights
Valparaiso to Nashville flights
Tallahassee to Memphis flights
Gainesville to Memphis flights
Tallahassee to Knoxville flights
Pensacola to Memphis flights

Top airline flying from Florida Keys to Knoxville

Discover the top airline that operate flights from Florida Keys to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$258Average$398FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.