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Knoxville

$91+ Cheap flights from Durham, NC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Durham to Knoxville

Cheapest flights from Durham to Knoxville
Explore the most affordable flight options available from Durham to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:06 amRDU - TYS
1 stop13h 36mMultiple Airlines
Mon 12/225:38 pmTYS - RDU
1 stop14h 36mMultiple Airlines
Deal found 12/10$255
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:37 amRDU - TYS
2 stops36h 19mMultiple Airlines
Mon 12/225:38 pmTYS - RDU
1 stop14h 36mMultiple Airlines
Deal found 12/11$265
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:14 pmRDU - TYS
1 stop21h 06mMultiple Airlines
Fri 12/195:38 pmTYS - RDU
1 stop15h 19mMultiple Airlines
Deal found 12/9$294
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:23 amRDU - TYS
1 stop5h 53mMultiple Airlines
Mon 12/296:00 amTYS - RDU
1 stop26h 14mMultiple Airlines
Deal found 12/10$305
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:23 amRDU - TYS
1 stop5h 53mMultiple Airlines
Wed 12/3112:01 pmTYS - RDU
2 stops12h 12mMultiple Airlines
Deal found 12/10$321
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amRDU - TYS
2 stops15h 56mMultiple Airlines
Sun 12/211:22 pmTYS - RDU
1 stop5h 50mMultiple Airlines
Deal found 12/11$323
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/259:23 amRDU - TYS
1 stop5h 53mMultiple Airlines
Tue 12/306:33 pmTYS - RDU
1 stop22h 22mMultiple Airlines
Deal found 12/10$325
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/289:49 pmRDU - TYS
1 stop12h 26mMultiple Airlines
Wed 12/3112:01 pmTYS - RDU
2 stops12h 12mMultiple Airlines
Deal found 12/10$341

Find flight deals from Durham to Knoxville

Keep the following information in mind while searching for Durham to Knoxville flight deals. Data was last updated December 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$231
(Kiwi.com)

One-way from

$91
(Kiwi.com)

Popular in

May

Cheapest in

August

Average price

$456
Provider with most accurate pricing for Raleigh-Durham-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Knoxville McGhee Tyson flights.
Search Deals
From Durham to Knoxville McGhee Tyson
Search Deals
One-way flight from Durham to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 4% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Durham to Knoxville that are best for you.

Fly from

Durham

Fly to

Knoxville

Route

Depart

Return

Price

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 12/18

9:06 am-10:42 pm

1 stop13h 36m

Knoxville McGhee Tyson

Mon 12/22

5:38 pm-8:14 am

1 stop14h 36m

$255

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sun 1/18

9:09 am-11:05 pm

1 stop13h 56m

Knoxville McGhee Tyson

Mon 1/19

7:15 am-6:01 pm

1 stop10h 46m

$261

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sun 1/11

9:09 am-11:05 pm

1 stop13h 56m

Knoxville McGhee Tyson

Tue 1/13

1:00 pm-2:18 pm

2 stops25h 18m

$272

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 1/17

7:47 pm-11:05 pm

2 stops27h 18m

Knoxville McGhee Tyson

Sat 3/14

5:12 pm-6:21 pm

1 stop25h 09m

$273

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 1/17

7:47 pm-11:05 pm

2 stops27h 18m

Knoxville McGhee Tyson

Sat 1/24

5:59 pm-2:13 pm

1 stop20h 14m

$273

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 1/17

3:39 pm-9:21 pm

1 stop5h 42m

Knoxville McGhee Tyson

Sat 1/24

8:09 am-1:23 pm

1 stop5h 14m

$302

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Thu 12/25

9:23 am-3:16 pm

1 stop5h 53m

Knoxville McGhee Tyson

Mon 12/29

6:00 am-8:14 am

1 stop26h 14m

$305

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Tue 3/10

4:40 pm-9:10 pm

1 stop4h 30m

Knoxville McGhee Tyson

Thu 3/12

7:50 am-1:20 pm

1 stop5h 30m

$312

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Sat 1/10

12:27 pm-4:49 pm

1 stop4h 22m

Knoxville McGhee Tyson

Mon 1/12

4:00 pm-8:43 pm

1 stop4h 43m

$317

RaleighKnoxville

RDU - TYS

RDUTYS

Raleigh-Durham

Mon 2/23

12:54 pm-11:38 pm

1 stop10h 44m

$91

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 17 results
1
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Best time to book a flight from Durham to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Knoxville

What is the cheapest month to book a flight from Durham to Knoxville?

Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $113). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to TYS?

Find hourly flight availability from Durham to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

A simple way to save on the total cost of your ticket is to fly from Durham to Knoxville in the afternoon. If you’re flexible enough to do this you can expect to save up to 30% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Durham to Knoxville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,008 reviews

Entertainment

7.9

Overall

7.9

Comfort

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Durham to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Durham?

    If you book a flight to Knoxville from Durham, you will be flying to McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 0 flights from Durham to McGhee Tyson per day from 3 different airlines.

  • Can I find deals for flights from Durham to Knoxville that include hotel bookings?

    Yes. In addition to deals on Durham to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Knoxville.

  • Can I find deals for business class flights from Durham to Knoxville?

    Yes. Cheapflights offers flight deals from Durham to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Knoxville?

    Currently, November is the cheapest month in which you can book a flight from Durham to Knoxville (average of $113). Flying from Durham to Knoxville in September is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Durham to Knoxville

Discover the top 3 airlines that operate flights from Durham to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$410FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$366FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$251Average$328FlexibilityNo cancel feeOn-time69%

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