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$118+ Cheap flights from Des Moines to Knoxville (DSM - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — TYS
Apr 16 — Apr 231
Wed 4/16
Wed 4/23
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Knoxville McGhee Tyson are usually found in January or September, booked 21 days in advance, depart on a Saturday or Tuesday and return on a Thursday

Cheap flight deals from Des Moines to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 11, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$229
(Mytrip)

One-way from

$118
(Mytrip)

Popular in

March

Cheapest in

January

Average price

$376
Provider with most accurate pricing for Des Moines-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Knoxville McGhee Tyson flights.
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From Des Moines to Knoxville McGhee Tyson
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One-way flight from Des Moines to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 13% potential increase in price ($57 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Knoxville

Cheapest flights from Des Moines to Knoxville
Explore the most affordable flight options available from Des Moines to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 11, 2025.

This Mytrip deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/181:44 pmDSM - TYS
1 stop7h 33mAllegiant Air
Fri 5/236:39 pmTYS - DSM
1 stop20h 25mAllegiant Air
Deal found 4/10$229
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:15 pmDSM - TYS
1 stop4h 43mUnited Airlines
Sat 12/62:00 pmTYS - DSM
1 stop4h 33mUnited Airlines
Deal found 4/10$249
This American Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/237:25 amDSM - TYS
1 stop7h 58mAmerican Airlines
Tue 5/205:20 amTYS - DSM
1 stop8h 01mAmerican Airlines
Deal found 4/9$254
This Mytrip deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/153:45 pmDSM - TYS
2 stops19h 31mMultiple Airlines
Tue 5/203:13 pmTYS - DSM
1 stop23h 23mMultiple Airlines
Deal found 4/9$290
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/115:59 pmDSM - TYS
1 stop4h 07mDelta
Sun 4/136:45 amTYS - DSM
1 stop5h 28mDelta
Deal found 4/10$339

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
Use the filters below to find and compare flights from Des Moines to Knoxville that are best for you.

Fly from

Des Moines

Fly to

Knoxville

Route

Depart

Return

Price

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 5/18

1:44 pm-10:17 pm

1 stop7h 33m

Knoxville McGhee Tyson

Fri 5/23

6:39 pm-2:04 pm

1 stop20h 25m

$229

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 5/14

2:01 pm-7:14 pm

1 stop4h 13m

Knoxville McGhee Tyson

Mon 5/19

7:54 pm-11:58 pm

1 stop5h 04m

$249

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 5/15

3:45 pm-12:16 pm

2 stops19h 31m

Knoxville McGhee Tyson

Tue 5/20

3:13 pm-1:36 pm

1 stop23h 23m

$290

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/23

11:38 am-11:15 pm

2 stops10h 37m

Knoxville McGhee Tyson

Tue 5/20

5:50 am-2:38 pm

2 stops9h 48m

$413

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 5/14

10:17 am-5:36 pm

1 stop6h 19m

Knoxville McGhee Tyson

Sun 5/18

6:50 am-10:19 am

1 stop4h 29m

$509

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 5/16

7:30 am-6:12 pm

1 stop9h 42m

$118

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 5/16

4:43 pm-2:32 pm

2 stops20h 49m

$216

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/23

11:38 am-4:44 pm

1 stop4h 06m

$295

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/9

Compare providers for flights from Des Moines to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Knoxville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Knoxville

How far ahead should I book a flight from Des Moines to Knoxville?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Knoxville. Price data was last updated on April 4, 2025.

Booking 21 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Knoxville. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $296). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated April 11, 2025.
Delta
8.0
Very good
7,910 reviews

Overall

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,910 reviews
Delta
8.0
Very good
7,910 reviews

Overall

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,636 reviews
Delta
8.0
Very good
7,910 reviews

Overall

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,910 reviews

Overall

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,910 reviews

Overall

8.0

Food

7.3

Crew

8.5

Entertainment

7.9

Boarding

8.2

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Knoxville round-trip?

    According to our current data, Allegiant Air ($229), American Airlines ($249), and United Airlines ($413) offers the cheapest pricing from Des Moines to Knoxville. These flights start at 36% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Knoxville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Knoxville.

  • Can I find deals for business class flights from Des Moines to Knoxville?

    Yes. Cheapflights offers flight deals from Des Moines to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Knoxville (average of $296). Flying from Des Moines to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

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Top 3 airlines flying from Des Moines to Knoxville

Discover the top 3 airlines that operate flights from Des Moines to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$219Average$342FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$243Average$344FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$502FlexibilityNo cancel feeOn-time69%

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