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$126+ Cheap flights from Columbus to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — TYS
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from Columbus to Knoxville

Cheapest flights from Columbus to Knoxville
Explore the most affordable flight options available from Columbus to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:45 pmCMH - TYS
1 stop4h 54mUnited Airlines
Mon 12/295:45 amTYS - CMH
1 stop4h 04mUnited Airlines
Deal found 12/10$345
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:14 amCMH - TYS
1 stop23h 28mMultiple Airlines
Thu 1/159:29 amTYS - CMH
1 stop13h 58mMultiple Airlines
Deal found 12/11$354
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:14 amCMH - TYS
1 stop23h 28mMultiple Airlines
Fri 1/166:18 pmTYS - CMH
1 stop29h 01mMultiple Airlines
Deal found 12/11$390
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:05 amCMH - TYS
1 stop4h 51mUnited Airlines
Tue 12/307:23 pmTYS - CMH
1 stop4h 21mUnited Airlines
Deal found 12/11$407
This Kiwi.com deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1611:14 amCMH - TYS
1 stop23h 28mMultiple Airlines
Sat 12/206:13 pmTYS - CMH
1 stop26h 05mMultiple Airlines
Deal found 12/11$424
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:34 amCMH - TYS
2 stops8h 04mAmerican Airlines
Mon 12/293:01 pmTYS - CMH
1 stop7h 01mAmerican Airlines
Deal found 12/10$461
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:49 amCMH - TYS
1 stop4h 01mAmerican Airlines
Mon 12/295:08 pmTYS - CMH
1 stop4h 54mAmerican Airlines
Deal found 12/11$482

Find flight deals from Columbus to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Columbus (C01) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 12, 2025.

Round-trip from

$268
(Kiwi.com)

One-way from

$126
(Delta)

Popular in

November

Cheapest in

January

Average price

$309
From Columbus to Knoxville McGhee Tyson
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One-way flight from Columbus to Knoxville McGhee Tyson
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Highest demand for flights based on searches. 7% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbus to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from Columbus to Knoxville that are best for you.

Fly from

Columbus

Fly to

Knoxville

Route

Depart

Return

Price

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Fri 1/9

10:40 am-11:09 am

1 stop24h 29m

Knoxville McGhee Tyson

Fri 1/16

6:18 pm-11:19 pm

1 stop29h 01m

$261

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 1/8

6:06 am-10:10 am

1 stop28h 04m

Knoxville McGhee Tyson

Thu 1/15

9:29 am-11:27 pm

1 stop13h 58m

$274

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 3/7

11:29 am-3:15 pm

1 stop3h 46m

Knoxville McGhee Tyson

Sat 3/14

7:40 am-11:19 am

1 stop3h 39m

$317

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Sat 3/7

5:45 am-1:10 pm

2 stops7h 25m

Knoxville McGhee Tyson

Sat 3/14

7:50 am-11:55 am

1 stop4h 05m

$337

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Mon 1/19

6:00 am-10:57 am

1 stop4h 57m

Knoxville McGhee Tyson

Wed 1/21

9:30 am-2:17 pm

1 stop4h 47m

$344

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 12/25

5:45 pm-10:39 pm

1 stop4h 54m

Knoxville McGhee Tyson

Mon 12/29

5:45 am-9:49 am

1 stop4h 04m

$345

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 12/16

11:14 am-10:42 am

1 stop23h 28m

Knoxville McGhee Tyson

Thu 1/15

9:29 am-11:27 pm

1 stop13h 58m

$354

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 2/24

7:00 am-11:08 am

1 stop4h 08m

$126

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Tue 2/24

10:40 am-12:09 pm

2 stops49h 29m

$159

ColumbusKnoxville

CMH - TYS

CMHTYS

Columbus

Thu 1/22

3:13 pm-9:44 pm

1 stop6h 31m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 15 results
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Best time to book a flight from Columbus to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Columbus with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to Knoxville

What is the cheapest month to book a flight from Columbus to Knoxville?

Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $193). Flying from Columbus to Knoxville in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to TYS?

Find hourly flight availability from Columbus to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

One of the essential ways to save on airfare from Columbus to Knoxville is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 28% on airfare.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated December 12, 2025.
See what other customers who have flown with Delta and American Airlines from Columbus to Knoxville have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,050 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Columbus to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Columbus?

    Knoxville McGhee Tyson (TYS) is the airport you will fly into if you book a flight from Columbus to Knoxville. You should not have trouble finding flights to McGhee Tyson from Columbus; the airport handles an average of 0 inbound flights from Columbus per day. You should also have plenty of airline options to choose from since 3 airlines have flights to the Knoxville airport from Columbus. It is only a 11.3 mi journey from McGhee Tyson (TYS) to Knoxville’s city center.

  • How long is the flight from Columbus to Knoxville?

    A quick flight from Columbus to Knoxville can take about 3h 46m. Delta provides one of the quickest options available for as low as $317. Airlines will cover a distance of 296 mi.

  • What are the cheapest airlines flying from Columbus to Knoxville round-trip?

    Currently priced at $218, American Airlines will fly you from Columbus to Knoxville and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Delta for as low as $218. American Airlines is currently priced 29% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbus to Knoxville that include hotel bookings?

    Yes. In addition to deals on Columbus to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbus to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to Knoxville.

  • Can I find deals for business class flights from Columbus to Knoxville?

    Yes. Cheapflights offers flight deals from Columbus to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Columbus to Knoxville?

    Currently, April is the cheapest month in which you can book a flight from Columbus to Knoxville (average of $193). Flying from Columbus to Knoxville in November is currently the most expensive (average of $252). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top 3 airlines flying from Columbus to Knoxville

Discover the top 3 airlines that operate flights from Columbus to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$218Average$322FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$316FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$243Average$294FlexibilityNo cancel feeOn-time69%

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