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$120+ Cheap flights from Iowa to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from Iowa to Key West

Keep the following information in mind while searching for Iowa to Key West flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$234
(Delta)

One-way from

$120
(Mytrip)

Popular in

June

Cheapest in

April

Average price

$319
Provider with most accurate pricing for Des Moines-Key West flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Key West flights.
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From Iowa to Key West
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One-way flight from Iowa to Key West
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Highest demand for flights based on searches. 12% potential increase in price ($60 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Iowa to Key West

Cheapest flights from Iowa to Key West
Explore the most affordable flight options available from Iowa to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/315:55 amMLI - EYW
1 stop6h 14mDelta
Sat 9/611:45 amEYW - MLI
1 stop5h 37mDelta
Deal found 4/22$234
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/317:19 amMLI - EYW
1 stop5h 14mAmerican Airlines
Sat 9/64:01 pmEYW - MLI
2 stops8h 21mAmerican Airlines
Deal found 4/22$235
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/17:05 amDSM - EYW
1 stop8h 06mAmerican Airlines
Wed 7/94:46 pmEYW - DSM
1 stop7h 15mAmerican Airlines
Deal found 4/23$239
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:45 amCID - EYW
1 stop6h 23mDelta
Tue 10/76:00 pmEYW - CID
1 stop4h 51mDelta
Deal found 4/22$251
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/206:44 amCID - EYW
2 stops11h 05mAmerican Airlines
Tue 5/2712:49 pmEYW - CID
1 stop6h 02mAmerican Airlines
Deal found 4/21$256
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:05 amOMA - EYW
1 stop7h 39mDelta
Wed 11/126:00 pmEYW - OMA
1 stop6h 56mDelta
Deal found 4/24$269
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/156:00 amOMA - EYW
2 stops9h 16mAmerican Airlines
Sat 7/191:22 pmEYW - OMA
2 stops11h 37mAmerican Airlines
Deal found 4/22$295
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:45 amDSM - EYW
1 stop6h 24mDelta
Wed 7/96:00 pmEYW - DSM
1 stop5h 22mDelta
Deal found 4/23$349
This Trip.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/168:30 amDSM - EYW
1 stop8h 35mMultiple Airlines
Mon 5/198:45 amEYW - DSM
1 stop8h 08mMultiple Airlines
Deal found 4/23$398
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/149:53 amCID - EYW
2 stops28h 23mAllegiant Air
Sun 5/184:06 pmEYW - CID
2 stops27h 02mAllegiant Air
Deal found 4/22$407
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:15 amCID - EYW
1 stop5h 51mUnited Airlines
Tue 11/116:45 pmEYW - CID
2 stops27h 29mUnited Airlines
Deal found 4/22$432
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/316:30 amMLI - EYW
2 stops30h 30mUnited Airlines
Sat 9/62:45 pmEYW - MLI
3 stops29h 42mUnited Airlines
Deal found 4/22$441

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Iowa to Key West that are best for you.

Fly from

Iowa

Fly to

Key West

Route

Depart

Return

Price

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Sun 8/31

5:55 am-1:09 pm

1 stop6h 14m

Key West

Sat 9/6

11:45 am-4:22 pm

1 stop5h 37m

$234

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Sun 8/31

7:19 am-1:33 pm

1 stop5h 14m

Key West

Sat 9/6

4:01 pm-11:22 pm

2 stops8h 21m

$235

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

7:05 am-4:11 pm

1 stop8h 06m

Key West

Wed 7/9

4:46 pm-11:01 pm

1 stop7h 15m

$239

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 5/20

6:44 am-6:49 pm

2 stops11h 05m

Key West

Tue 5/27

12:49 pm-5:51 pm

1 stop6h 02m

$256

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 7/22

5:45 am-1:09 pm

1 stop6h 24m

Key West

Tue 7/29

6:00 pm-10:55 pm

1 stop5h 55m

$294

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Tue 7/15

6:00 am-4:16 pm

2 stops9h 16m

Key West

Sat 7/19

1:22 pm-11:59 pm

2 stops11h 37m

$295

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Thu 5/8

2:17 pm-8:07 pm

1 stop4h 50m

Key West

Mon 5/12

6:25 pm-11:58 pm

1 stop6h 33m

$319

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

5:45 am-1:09 pm

1 stop6h 24m

Key West

Wed 7/9

6:00 pm-10:22 pm

1 stop5h 22m

$349

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 5/16

8:30 am-6:05 pm

1 stop8h 35m

Key West

Mon 5/19

8:45 am-3:53 pm

1 stop8h 08m

$398

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Wed 5/14

9:53 am-3:16 pm

2 stops28h 23m

Key West

Sun 5/18

4:06 pm-6:08 pm

2 stops27h 02m

$407

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 23 results
1
2
3

Best time to book a flight from Iowa to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Key West

What is the cheapest month to book a flight from Iowa to Key West?

Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to EYW?

Find hourly flight availability from Iowa to Key West. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

When flying from Iowa to Key West, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Key West by month

Plan your trip to Key West by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

Temperature in Key West by month

Plan your trip to Key West by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated April 24, 2025.
Get a feel of what it's like to fly with Delta, United Airlines and Allegiant Air from Iowa to Key West by reading reviews from past customers. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,920 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,920 reviews
Delta
8.0
Very good
7,920 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
United Airlines
7.4
Good
8,685 reviews
Delta
8.0
Very good
7,920 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,920 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,920 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from Iowa?

    Located just 2.6 mi from the city center, Key West (EYW) is the airport most travelers will use when flying to Key West from Iowa.

  • What are the cheapest airlines to fly from Iowa to Key West one-way?

    $120 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $126 and $131, respectively.

  • What are the most popular routes from Iowa to Key West?

    While some choose either Des Moines - Key West or Omaha Eppley Airfield - Key West, Moline Quad-City - Key West is the most popular route from Iowa to Key West.

  • Can I find deals for flights from Iowa to Key West that include hotel bookings?

    Yes. In addition to deals on Iowa to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Key West.

  • Can I find deals for business class flights from Iowa to Key West?

    Yes. Cheapflights offers flight deals from Iowa to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Key West?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Key West (average of $328). Flying from Iowa to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Iowa to Key West

Discover the top 3 airlines that operate flights from Iowa to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$239Average$409FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$453FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$548FlexibilityNo cancel feeOn-time69%

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