What are the cheapest airlines flying from Des Moines to Key West round-trip?

Delta, at $237, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and Allegiant Air. Users have found that Delta is 45% cheaper than the other options available to this destination.

What is the cheapest day to fly from Des Moines to Key West?

Travelers seeking maximum savings on their Des Moines to Key West flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Des Moines to Key West?

The most popular airlines flying from Des Moines to Key West are American Airlines, Delta and Allegiant Air. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Des Moines to Key West?

Users have found that leaving on a Tuesday can be a cost-effective option. It’s possible to save up to 68% on your flight compared to booking on days when demand is much higher.

How far in advance should I book a flight from Des Moines to Key West?

Find a great deal and save up to 96% by booking at least 28 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Key West within the next two weeks, with the cheapest ticket starting at $363.

What is the cheapest month to fly from Des Moines to Key West?

The best pricing can be found in the month of April. Prices to Key West from Des Moines average $438. You can even find prices in April for less than $438, as users have found deals to Key West from as low as $244. The month of May appears to be one of the more expensive times to travel to Key West from Des Moines. Flying in the targeted month can save you up to 35%.

What is the cheapest time of day to fly from DSM to EYW?

It’s optimal to fly from Des Moines to Key West at noon. By choosing this option you can save up to 8% on the cost of your flight, compared to a flight in the morning.

Most accurate provider : When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Key West that include hotel bookings?

Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Key West?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.

Can I find deals for business class flights from Des Moines to Key West?

Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$237+ Flights from Des Moines to Key West

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Cheap flight deals from Des Moines to Key West

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$237 (Delta)
Popular in	May
Cheapest in	April
Average price	$319

Provider with most accurate pricing for Des Moines-Key West flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Key West flights.

Search Deals

From Des Moines to Key West

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($61 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Sun 5/252:15 pmDSM - EYW

1 stop4h 52mDelta

Fri 5/306:25 pmEYW - DSM

1 stop5h 05mDelta

Deal found 4/14

$237

Tue 7/17:00 amDSM - EYW

1 stop8h 11mAmerican Airlines

Wed 7/94:46 pmEYW - DSM

1 stop7h 15mAmerican Airlines

Deal found 4/15

$239

Sun 4/278:30 amDSM - EYW

1 stop23h 31mAllegiant Air

Wed 4/304:23 pmEYW - DSM

1 stop23h 35mAllegiant Air

Deal found 4/14

$275

Tue 6/33:01 pmDSM - EYW

2 stops15h 59mUnited Airlines

Fri 6/62:45 pmEYW - DSM

2 stops25h 04mUnited Airlines

Deal found 4/14

$478

Best flights from Des Moines to Key West
Discover carefully curated flight deals from Des Moines to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 15, 2025.

Sun 5/252:15 pmDSM - EYW

1 stop4h 52mDelta

Fri 5/306:25 pmEYW - DSM

1 stop5h 05mDelta

Deal found 4/14

$237

Tue 7/17:00 amDSM - EYW

1 stop8h 11mAmerican Airlines

Wed 7/94:46 pmEYW - DSM

1 stop7h 15mAmerican Airlines

Deal found 4/15

$239

Sun 4/278:30 amDSM - EYW

1 stop23h 31mAllegiant Air

Wed 4/304:23 pmEYW - DSM

1 stop23h 35mAllegiant Air

Deal found 4/14

$275

Tue 6/33:01 pmDSM - EYW

2 stops15h 59mUnited Airlines

Fri 6/62:45 pmEYW - DSM

2 stops25h 04mUnited Airlines

Deal found 4/14

$478

Last-minute flights from Des Moines to Key West
Discover last-minute flight deals from Des Moines to Key West. Data last updated April 15, 2025 and is based on user searches.

Sat 4/268:00 amDSM - EYW

2 stops9h 05mUnited Airlines

Tue 4/296:45 pmEYW - DSM

3 stops24h 21mUnited Airlines

Deal found 4/14

$712

Sun 4/278:30 amDSM - EYW

1 stop23h 31mAllegiant Air

Wed 4/304:23 pmEYW - DSM

1 stop23h 35mAllegiant Air

Deal found 4/14

$275

Sun 4/273:44 pmDSM - EYW

3 stops23h 32mMultiple Airlines

Wed 4/304:23 pmEYW - DSM

1 stop23h 35mMultiple Airlines

Deal found 4/14

$521

Sun 5/252:15 pmDSM - EYW

1 stop4h 52mDelta

Fri 5/306:25 pmEYW - DSM

1 stop5h 05mDelta

Deal found 4/14

$237

Sun 5/257:20 amDSM - EYW

2 stops8h 32mAmerican Airlines

Fri 5/305:24 pmEYW - DSM

1 stop7h 34mAmerican Airlines

Deal found 4/14

$269

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 5/25

2:15 pm-8:07 pm

1 stop4h 52m

Key West

Fri 5/30

6:25 pm-10:30 pm

1 stop5h 05m

$237

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

7:00 am-4:11 pm

1 stop8h 11m

Key West

Wed 7/9

4:46 pm-11:01 pm

1 stop7h 15m

$239

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 4/27

8:30 am-9:01 am

1 stop23h 31m

Key West

Wed 4/30

4:23 pm-2:58 pm

1 stop23h 35m

$275

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 6/3

3:01 pm-8:00 am

2 stops15h 59m

Key West

Fri 6/6

2:45 pm-2:49 pm

2 stops25h 04m

$478

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/14

Compare providers for flights from Des Moines to Key West

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Key West flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Key West flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

The price you pay for your flight from Des Moines to Key West may vary depending on when you book. For the best chance of a lower fare, look to book 79 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Key West?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Key West (average of $328). Flying from Des Moines to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Key West by month

In terms of precipitation, rainfall in Key West ranges from 1.5 - 6.7 inches per month. September is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Key West when rainfall is around 1.5 in.

Temperature in Key West by month

If weather is an important factor for your trip to Key West, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 69.8 F).

Reviews of airlines servicing Key West

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Delta

8.0

Very good

7,916 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

United Airlines

7.4

Good

8,656 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Allegiant Air

7.3

Good

734 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,916 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Related info for your journey

What are the cheapest airlines flying from Des Moines to Key West round-trip?
Delta, at $237, was found to be the cheapest airline from Des Moines to Key West.Alternate airlines to your destination round-trip include American Airlines and Allegiant Air. Users have found that Delta is 45% cheaper than the other options available to this destination.
Can I find deals for flights from Des Moines to Key West that include hotel bookings?
Yes. In addition to deals on Des Moines to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Key West?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Key West.
Can I find deals for business class flights from Des Moines to Key West?
Yes. Cheapflights offers flight deals from Des Moines to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Key West?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Key West (average of $328). Flying from Des Moines to Key West in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Other flights to Key West

Top 4 airlines flying from Des Moines to Key West

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$96	Average$254	FlexibilityNo cancel fee	On-time88%
American Airlines	Cheapest$257	Average$409	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$268	Average$505	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$281	Average$508	FlexibilityNo cancel fee	On-time69%

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$237+ Cheap flights from Des Moines to Key West (DSM - EYW)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Key West with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Key West

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Key West

Cheapest flights from Des Moines to Key WestExplore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Key West that are best for you.

Compare providers for flights from Des Moines to Key West

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Key West in April.

Best time to book a flight from Des Moines to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Key West

How far ahead should I book a flight from Des Moines to Key West?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Key West. Price data was last updated on April 11, 2025.

What is the cheapest month to book a flight from Des Moines to Key West?

Rainfall in Key West by month

Plan your trip to Key West by taking into account the average rainfall totals by month.

Temperature in Key West by month

Plan your trip to Key West by taking into account the average temperature totals by month.

Reviews of airlines servicing Key West

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Key West round-trip?

Can I find deals for flights from Des Moines to Key West that include hotel bookings?

How can I find direct flights from Des Moines to Key West?

Can I find deals for business class flights from Des Moines to Key West?

What is the cheapest month to book a flight from Des Moines to Key West?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Key West

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Key West

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Cheapest flights from Des Moines to Key West
Explore the most affordable flight options available from Des Moines to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2025.