What are the cheapest airlines to fly from South Carolina to Iowa one-way?

To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $91. Frontier flights start at $126 while deals on American Airlines start at $136 one-way.

Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Iowa?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

Can I find deals for business class flights from South Carolina to Iowa?

Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$91+ Flights from South Carolina to Iowa

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Cheap flight deals from South Carolina to Iowa

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$204 (Mytrip)
One-way from	$91 (Mytrip)

Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.

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From South Carolina to Iowa

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One-way flight from South Carolina to Iowa

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Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Fri 6/135:33 pmCLT - DSM

1 stop4h 51mMultiple Airlines

Sun 6/156:32 pmDSM - CLT

1 stop21h 05mMultiple Airlines

Deal found 4/22

$204

Sat 6/76:50 pmCHS - CID

1 stop4h 26mDelta

Wed 6/115:56 amCID - CHS

1 stop7h 00mDelta

Deal found 4/22

$249

Thu 6/58:15 amSAV - DSM

1 stop29h 31mAllegiant Air

Sun 6/88:30 amDSM - SAV

2 stops31h 29mAllegiant Air

Deal found 4/22

$272

Thu 7/178:38 pmCHS - CID

1 stop4h 07mAmerican Airlines

Mon 7/2112:34 pmCID - CHS

1 stop5h 24mAmerican Airlines

Deal found 4/22

$279

Wed 7/164:24 pmCHS - DSM

1 stop6h 42mAmerican Airlines

Sat 7/195:00 amDSM - CHS

1 stop7h 03mAmerican Airlines

Deal found 4/21

$297

Wed 6/412:58 pmSAV - DSM

1 stop7h 08mDelta

Mon 6/96:47 pmDSM - SAV

1 stop4h 24mDelta

Deal found 4/22

$300

Thu 8/76:39 pmGSP - DSM

1 stop3h 57mAmerican Airlines

Wed 8/133:45 pmDSM - GSP

1 stop6h 48mAmerican Airlines

Deal found 4/22

$300

Wed 6/47:20 amCHS - OMA

1 stop6h 20mSouthwest

Mon 6/94:50 pmOMA - CHS

1 stop7h 05mSouthwest

Deal found 4/21

$302

Thu 6/55:35 amCHS - DSM

1 stop6h 06mDelta

Mon 6/96:47 pmDSM - CHS

1 stop4h 12mDelta

Deal found 4/21

$303

Thu 6/267:59 pmGSP - OMA

1 stop5h 26mDelta

Mon 6/307:00 amOMA - GSP

1 stop5h 14mDelta

Deal found 4/22

$303

Sat 7/1212:45 pmCLT - OMA

1 stop4h 45mSouthwest

Tue 7/1510:50 amOMA - CLT

1 stop4h 15mSouthwest

Deal found 4/21

$316

Tue 7/88:13 pmSAV - OMA

1 stop5h 21mAmerican Airlines

Tue 7/151:50 pmOMA - SAV

1 stop4h 43mAmerican Airlines

Deal found 4/22

$317

Best flights from South Carolina to Iowa
Discover carefully curated flight deals from South Carolina to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 22, 2025.

Fri 6/135:33 pmCLT - DSM

1 stop4h 51mMultiple Airlines

Sun 6/156:32 pmDSM - CLT

1 stop21h 05mMultiple Airlines

Deal found 4/22

$204

Sat 6/76:50 pmCHS - CID

1 stop4h 26mDelta

Wed 6/115:56 amCID - CHS

1 stop7h 00mDelta

Deal found 4/22

$249

Thu 6/58:15 amSAV - DSM

1 stop29h 31mAllegiant Air

Sun 6/88:30 amDSM - SAV

2 stops31h 29mAllegiant Air

Deal found 4/22

$272

Thu 7/178:38 pmCHS - CID

1 stop4h 07mAmerican Airlines

Mon 7/2112:34 pmCID - CHS

1 stop5h 24mAmerican Airlines

Deal found 4/22

$279

Wed 6/47:20 amCHS - OMA

1 stop6h 20mSouthwest

Mon 6/94:50 pmOMA - CHS

1 stop7h 05mSouthwest

Deal found 4/21

$302

Thu 10/1610:18 amCHS - CID

2 stops9h 51mUnited Airlines

Tue 10/216:35 amCID - CHS

2 stops11h 28mUnited Airlines

Deal found 4/22

$329

Wed 7/164:24 pmCHS - DSM

1 stop6h 42mAmerican Airlines

Sat 7/195:00 amDSM - CHS

1 stop7h 03mAmerican Airlines

Deal found 4/21

$297

Wed 6/412:58 pmSAV - DSM

1 stop7h 08mDelta

Mon 6/96:47 pmDSM - SAV

1 stop4h 24mDelta

Deal found 4/22

$300

Sat 7/1212:45 pmCLT - OMA

1 stop4h 45mSouthwest

Tue 7/1510:50 amOMA - CLT

1 stop4h 15mSouthwest

Deal found 4/21

$316

Thu 6/58:15 amSAV - DSM

2 stops38h 09mMultiple Airlines

Sun 6/88:30 amDSM - SAV

2 stops31h 29mMultiple Airlines

Deal found 4/22

$329

Thu 8/76:39 pmGSP - DSM

1 stop3h 57mAmerican Airlines

Wed 8/133:45 pmDSM - GSP

1 stop6h 48mAmerican Airlines

Deal found 4/22

$300

Thu 6/55:35 amCHS - DSM

1 stop6h 06mDelta

Mon 6/96:47 pmDSM - CHS

1 stop4h 12mDelta

Deal found 4/21

$303

Last-minute flights from South Carolina to Iowa
Discover last-minute flight deals from South Carolina to Iowa. Data last updated April 22, 2025 and is based on user searches.

Wed 4/236:08 pmCHS - CID

1 stop4h 51mAmerican Airlines

Tue 4/291:37 pmCID - CHS

1 stop8h 03mAmerican Airlines

Deal found 4/21

$324

Wed 4/235:35 amCHS - CID

2 stops6h 50mDelta

Tue 4/295:30 amCID - CHS

1 stop4h 57mDelta

Deal found 4/21

$329

Sun 4/2711:59 amCLT - DSM

Nonstop2h 14mAmerican Airlines

Sun 5/47:00 amDSM - CLT

Nonstop2h 20mAmerican Airlines

Deal found 4/22

$561

Sun 4/276:04 amCLT - DSM

1 stop4h 33mDelta

Sun 5/45:45 amDSM - CLT

1 stop6h 55mDelta

Deal found 4/22

$581

Sun 4/276:36 amCLT - DSM

1 stop5h 08mUnited Airlines

Sun 5/45:45 amDSM - CLT

2 stops10h 51mUnited Airlines

Deal found 4/22

$586

Sun 4/271:40 pmCHS - DSM

2 stops34h 33mMultiple Airlines

Thu 5/13:59 pmDSM - CHS

2 stops29h 12mMultiple Airlines

Deal found 4/21

$633

Mon 4/2810:57 amCLT - DSM

2 stops13h 16mMultiple Airlines

Thu 5/17:30 amDSM - CLT

3 stops27h 42mMultiple Airlines

Deal found 4/21

$497

Tue 4/293:46 pmCLT - OMA

Nonstop2h 53mAmerican Airlines

Tue 5/66:11 amOMA - CLT

Nonstop2h 37mAmerican Airlines

Deal found 4/22

$455

Tue 4/297:00 amCLT - OMA

2 stops8h 25mUnited Airlines

Tue 5/61:08 pmOMA - CLT

1 stop7h 13mUnited Airlines

Deal found 4/22

$550

Wed 4/306:25 amCLT - OMA

1 stop4h 45mSouthwest

Sat 5/32:35 pmOMA - CLT

1 stop7h 50mSouthwest

Deal found 4/21

$349

Wed 4/301:14 pmCLT - OMA

1 stop4h 54mDelta

Tue 5/67:06 amOMA - CLT

1 stop5h 34mDelta

Deal found 4/22

$475

Fri 5/27:00 amSAV - DSM

1 stop4h 41mDelta

Mon 5/55:45 amDSM - SAV

1 stop4h 46mDelta

Deal found 4/21

$537

One-way flights from South Carolina to Iowa
Search for one-way flight options from South Carolina to Iowa. Find affordable one-way fares based on user searches. Data last updated April 22, 2025.

Thu 5/298:15 amSAV - DSM

1 stop29h 31mAllegiant Air

Deal found 4/22

$91

Fri 5/164:32 pmCLT - DSM

1 stop5h 23mMultiple Airlines

Deal found 4/22

$118

Thu 5/15:06 pmCLT - DSM

1 stop26h 24mFrontier

Deal found 4/20

$126

Sun 8/3111:19 amGSP - DSM

1 stop4h 59mAmerican Airlines

Deal found 4/22

$136

Fri 5/26:58 amCLT - CID

1 stop10h 59mMultiple Airlines

Deal found 4/21

$137

Tue 5/201:26 pmSAV - OMA

1 stop5h 18mAmerican Airlines

Deal found 4/21

$143

Thu 5/2912:58 pmSAV - DSM

1 stop7h 08mDelta

Deal found 4/22

$149

Tue 7/2912:53 pmGSP - OMA

1 stop5h 43mAmerican Airlines

Deal found 4/22

$149

Thu 5/224:20 pmCLT - DSM

1 stop7h 45mSouthwest

Deal found 4/22

$149

Wed 6/181:59 pmGSP - DSM

1 stop5h 03mDelta

Deal found 4/22

$149

Mon 6/28:43 pmCHS - DSM

1 stop4h 15mAmerican Airlines

Deal found 4/21

$152

Thu 5/295:00 amSAV - DSM

2 stops9h 48mAmerican Airlines

Deal found 4/22

$154

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Fri 6/13

5:33 pm-9:24 pm

1 stop4h 51m

Des Moines

Sun 6/15

6:32 pm-4:37 pm

1 stop21h 05m

$204

CharlestonCedar Rapids

CHS - CID

CHSCID

Charleston

Sat 6/7

6:50 pm-10:16 pm

1 stop4h 26m

Cedar Rapids

Wed 6/11

5:56 am-1:56 pm

1 stop7h 00m

$249

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Thu 6/5

8:15 am-12:46 pm

1 stop29h 31m

Des Moines

Sun 6/8

8:30 am-4:59 pm

2 stops31h 29m

$272

CharlestonCedar Rapids

CHS - CID

CHSCID

Charleston

Thu 7/17

8:38 pm-11:45 pm

1 stop4h 07m

Cedar Rapids

Mon 7/21

12:34 pm-6:58 pm

1 stop5h 24m

$279

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 7/16

4:24 pm-10:06 pm

1 stop6h 42m

Des Moines

Sat 7/19

5:00 am-1:03 pm

1 stop7h 03m

$297

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Wed 6/4

12:58 pm-7:06 pm

1 stop7h 08m

Des Moines

Mon 6/9

6:47 pm-12:11 am

1 stop4h 24m

$300

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Thu 8/7

6:39 pm-9:36 pm

1 stop3h 57m

Des Moines

Wed 8/13

3:45 pm-11:33 pm

1 stop6h 48m

$300

CharlestonOmaha

CHS - OMA

CHSOMA

Charleston

Wed 6/4

7:20 am-12:40 pm

1 stop6h 20m

Omaha Eppley Airfield

Mon 6/9

4:50 pm-12:55 am

1 stop7h 05m

$302

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Thu 6/5

5:35 am-10:41 am

1 stop6h 06m

Des Moines

Mon 6/9

6:47 pm-11:59 pm

1 stop4h 12m

$303

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Thu 6/26

7:59 pm-12:25 am

1 stop5h 26m

Omaha Eppley Airfield

Mon 6/30

7:00 am-1:14 pm

1 stop5h 14m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $336). Flying from South Carolina to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Iowa as you normally would.

Rainfall in Iowa by month

In terms of precipitation, rainfall in Iowa ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Iowa when rainfall is around 1.0 in.

Temperature in Iowa by month

If weather is an important factor for your trip to Iowa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Iowa

Read through reviews of airlines operating flights from South Carolina to Iowa, such as Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Delta

8.0

Very good

7,920 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

United Airlines

7.4

Good

8,683 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Allegiant Air

7.3

Good

734 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

What are the cheapest airlines to fly from South Carolina to Iowa one-way?
To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $91. Frontier flights start at $126 while deals on American Airlines start at $136 one-way.
Can I find deals for flights from South Carolina to Iowa that include hotel bookings?
Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Iowa?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.
Can I find deals for business class flights from South Carolina to Iowa?
Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Iowa?
Currently, August is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $336). Flying from South Carolina to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from South Carolina to Iowa

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$188	Average$404	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$198	Average$358	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$248	Average$418	FlexibilityNo cancel fee	On-time69%

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$91+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Iowa with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated April 22, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Find flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to IowaExplore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 22, 2025.

Rainfall in Iowa by month

Plan your trip to Iowa by taking into account the average rainfall totals by month.

Temperature in Iowa by month

Plan your trip to Iowa by taking into account the average temperature totals by month.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated April 22, 2025.

Read through reviews of airlines operating flights from South Carolina to Iowa, such as Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines to fly from South Carolina to Iowa one-way?

Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

How can I find direct flights from South Carolina to Iowa?

Can I find deals for business class flights from South Carolina to Iowa?

What is the cheapest month to book a flight from South Carolina to Iowa?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from South Carolina to Iowa

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Travel Smart

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2025.