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$81+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Feb 25 — Mar 41
Tue 2/25
Tue 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated February 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$180
(Booking.com)

One-way from

$81
(Frontier)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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From South Carolina to Iowa
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One-way flight from South Carolina to Iowa
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Find flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 20, 2025.

This Booking.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/610:31 pmCLT - DSM
1 stop21h 48mFrontier
Fri 4/118:17 pmDSM - CLT
1 stop21h 40mFrontier
Deal found 2/19$180
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/35:06 pmCLT - OMA
1 stop27h 56mFrontier
Mon 5/59:02 pmOMA - CLT
1 stop18h 03mFrontier
Deal found 2/20$190
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2612:11 pmCLT - DSM
Nonstop2h 29mAmerican Airlines
Mon 3/312:07 pmDSM - CLT
Nonstop2h 23mAmerican Airlines
Deal found 2/20$243
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/46:08 pmCHS - MLI
1 stop4h 41mAmerican Airlines
Fri 4/1111:21 amMLI - CHS
2 stops7h 07mAmerican Airlines
Deal found 2/19$254
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/36:00 amCLT - DSM
1 stop5h 37mDelta
Tue 4/810:22 amDSM - CLT
1 stop4h 37mDelta
Deal found 2/20$263
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/46:09 pmCHS - MLI
1 stop5h 19mDelta
Fri 4/115:03 pmMLI - CHS
1 stop4h 33mDelta
Deal found 2/19$284
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/127:45 amGSP - OMA
1 stop6h 07mAmerican Airlines
Tue 4/151:50 pmOMA - GSP
1 stop6h 24mAmerican Airlines
Deal found 2/20$297
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/266:08 pmCHS - OMA
1 stop5h 39mAmerican Airlines
Wed 4/25:28 amOMA - CHS
1 stop4h 47mAmerican Airlines
Deal found 2/20$297
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/310:52 amGSP - DSM
1 stop7h 14mDelta
Sat 5/106:30 pmDSM - GSP
1 stop4h 13mDelta
Deal found 2/19$297
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/106:05 amSAV - OMA
1 stop4h 55mSouthwest
Tue 3/113:55 pmOMA - SAV
1 stop4h 50mSouthwest
Deal found 2/20$297
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/76:50 amGSP - OMA
1 stop4h 37mUnited Airlines
Sat 4/123:24 pmOMA - GSP
1 stop6h 13mUnited Airlines
Deal found 2/20$298
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/12:35 pmCLT - MLI
Nonstop2h 13mAmerican Airlines
Tue 4/85:12 amMLI - CLT
Nonstop2h 08mAmerican Airlines
Deal found 2/20$301

Find flights from South Carolina to Iowa within your budget

Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.

Fly from

South Carolina

Fly to

Iowa

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sun 4/6

10:31 pm-7:19 pm

1 stop21h 48m

Des Moines

Fri 4/11

8:17 pm-6:57 pm

1 stop21h 40m

$180

CharlotteOmaha

CLT - OMA

CLTOMA

Charlotte Douglas

Sat 5/3

5:06 pm-8:02 pm

1 stop27h 56m

Omaha Eppley Airfield

Mon 5/5

9:02 pm-4:05 pm

1 stop18h 03m

$190

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 3/26

12:11 pm-1:40 pm

Nonstop2h 29m

Des Moines

Mon 3/31

2:07 pm-5:30 pm

Nonstop2h 23m

$243

CharlestonMoline

CHS - MLI

CHSMLI

Charleston

Fri 4/4

6:08 pm-9:49 pm

1 stop4h 41m

Moline Quad-City

Fri 4/11

11:21 am-7:28 pm

2 stops7h 07m

$254

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 4/3

6:00 am-10:37 am

1 stop5h 37m

Des Moines

Tue 4/8

10:22 am-3:59 pm

1 stop4h 37m

$263

CharlestonMoline

CHS - MLI

CHSMLI

Charleston

Fri 4/4

6:09 pm-10:28 pm

1 stop5h 19m

Moline Quad-City

Fri 4/11

5:03 pm-10:36 pm

1 stop4h 33m

$284

SavannahOmaha

SAV - OMA

SAVOMA

Savannah/Hilton Head

Mon 3/10

6:05 am-10:00 am

1 stop4h 55m

Omaha Eppley Airfield

Tue 3/11

3:55 pm-9:45 pm

1 stop4h 50m

$297

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Sat 4/12

7:45 am-12:52 pm

1 stop6h 07m

Omaha Eppley Airfield

Tue 4/15

1:50 pm-9:14 pm

1 stop6h 24m

$297

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Sat 5/3

10:52 am-5:06 pm

1 stop7h 14m

Des Moines

Sat 5/10

6:30 pm-11:43 pm

1 stop4h 13m

$297

CharlestonOmaha

CHS - OMA

CHSOMA

Charleston

Wed 3/26

6:08 pm-10:47 pm

1 stop5h 39m

Omaha Eppley Airfield

Wed 4/2

5:28 am-11:15 am

1 stop4h 47m

$297

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 56 results
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Iowa

Get recent, data-driven insights about flights from South Carolina to Iowa including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $336). Flying from South Carolina to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Iowa as you normally would.

Rainfall in Iowa by month

Plan your trip to Iowa by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Iowa ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Iowa when rainfall is around 1.0 in.

Temperature in Iowa by month

Plan your trip to Iowa by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Iowa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated February 20, 2025.
Read through reviews of airlines operating flights from South Carolina to Iowa, such as Southwest, Alaska Airlines and Delta. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Alaska Airlines
8.0
Very good
9,692 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Entertainment

7.6

Food

7.1

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $81. American Airlines flights start at $127 while deals on Delta start at $132 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $336). Flying from South Carolina to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$188Average$406FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$372FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$418FlexibilityNo cancel feeOn-time69%
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