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$100+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(American Airlines)

One-way from

$100
(Mytrip)

Popular in

November

Cheapest in

August

Average price

$353
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Iowa
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One-way flight from Knoxville McGhee Tyson to Iowa
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Highest demand for flights based on searches. 12% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/47:00 amTYS - OMA
1 stop5h 53mAmerican Airlines
Tue 6/106:00 amOMA - TYS
1 stop6h 22mAmerican Airlines
Deal found 3/27$199
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/27:00 amTYS - DSM
1 stop4h 30mUnited Airlines
Mon 5/53:34 pmDSM - TYS
1 stop6h 11mUnited Airlines
Deal found 3/26$249
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/275:18 amTYS - DSM
2 stops6h 54mAmerican Airlines
Sat 8/307:20 amDSM - TYS
1 stop7h 25mAmerican Airlines
Deal found 3/27$254
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/116:45 amTYS - OMA
1 stop4h 29mDelta
Tue 4/156:32 pmOMA - TYS
1 stop4h 16mDelta
Deal found 3/27$259
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/114:59 pmTYS - OMA
1 stop6h 31mUnited Airlines
Tue 4/158:00 amOMA - TYS
2 stops10h 36mUnited Airlines
Deal found 3/27$264
This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/210:00 amTYS - DSM
2 stops14h 13mMultiple Airlines
Mon 5/56:00 amDSM - TYS
1 stop27h 36mMultiple Airlines
Deal found 3/26$281
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1512:01 pmTYS - OMA
1 stop25h 07mAllegiant Air
Sun 5/184:41 pmOMA - TYS
1 stop27h 58mAllegiant Air
Deal found 3/27$320
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/75:05 amTYS - LSE
1 stop7h 14mAmerican Airlines
Sun 5/114:36 pmLSE - TYS
1 stop4h 31mAmerican Airlines
Deal found 3/27$437
This Mytrip deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/153:11 pmTYS - OMA
2 stops20h 40mMultiple Airlines
Sun 5/184:41 pmOMA - TYS
1 stop27h 58mMultiple Airlines
Deal found 3/27$477
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/165:45 amTYS - DSM
2 stops7h 42mDelta
Sun 5/181:07 pmDSM - TYS
2 stops7h 10mDelta
Deal found 3/27$2,104

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 6/4

7:00 am-11:53 am

1 stop5h 53m

Omaha Eppley Airfield

Tue 6/10

6:00 am-1:22 pm

1 stop6h 22m

$199

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 5/2

7:00 am-10:30 am

1 stop4h 30m

Des Moines

Mon 5/5

3:34 pm-10:45 pm

1 stop6h 11m

$249

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Wed 8/27

5:18 am-11:12 am

2 stops6h 54m

Des Moines

Sat 8/30

7:20 am-3:45 pm

1 stop7h 25m

$254

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/11

6:45 am-10:14 am

1 stop4h 29m

Omaha Eppley Airfield

Tue 4/15

6:32 pm-11:48 pm

1 stop4h 16m

$259

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Fri 4/11

4:59 pm-10:30 pm

1 stop6h 31m

Omaha Eppley Airfield

Tue 4/15

8:00 am-7:36 pm

2 stops10h 36m

$264

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 5/2

10:00 am-11:13 pm

2 stops14h 13m

Des Moines

Mon 5/5

6:00 am-10:36 am

1 stop27h 36m

$281

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 5/15

12:01 pm-12:08 pm

1 stop25h 07m

Omaha Eppley Airfield

Sun 5/18

4:41 pm-9:39 pm

1 stop27h 58m

$320

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 5/7

5:05 am-11:19 am

1 stop7h 14m

La Crosse

Sun 5/11

4:36 pm-10:07 pm

1 stop4h 31m

$437

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Thu 5/15

3:11 pm-10:51 am

2 stops20h 40m

Omaha Eppley Airfield

Sun 5/18

4:41 pm-9:39 pm

1 stop27h 58m

$477

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 5/16

5:45 am-12:27 pm

2 stops7h 42m

Des Moines

Sun 5/18

1:07 pm-9:17 pm

2 stops7h 10m

$2,104

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/27

Showing 1-10 of 15 results
1
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

When flying from Knoxville to Iowa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Iowa by month

Plan your trip to Iowa by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Iowa ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Iowa when rainfall is around 1.0 in.

Temperature in Iowa by month

Plan your trip to Iowa by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Iowa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated March 28, 2025.
Read through reviews of airlines operating flights from Knoxville to Iowa, such as Delta, United Airlines and Allegiant Air. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,896 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,603 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
731 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,896 reviews

Entertainment

7.9

Overall

8.0

Food

7.3

Comfort

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $100 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on Delta and American Airlines, with prices starting from $201 and $220, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - La Crosse.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$208Average$330FlexibilityNo cancel feeOn-time71%
DeltaCheapest$212Average$272FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$393FlexibilityNo cancel feeOn-time69%
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