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$126+ Cheap flights from Knoxville (TYS) to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — DSM
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Knoxville to Iowa

Keep the following information in mind while searching for Knoxville to Iowa flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$224
(American Airlines)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

August

Average price

$338
Provider with most accurate pricing for Knoxville McGhee Tyson-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Des Moines flights.
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From Knoxville McGhee Tyson to Iowa
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One-way flight from Knoxville McGhee Tyson to Iowa
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Highest demand for flights based on searches. 16% potential increase in price ($75 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($32 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Iowa

Cheapest flights from Knoxville to Iowa
Explore the most affordable flight options available from Knoxville to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2411:43 amTYS - DSM
1 stop4h 43mAmerican Airlines
Sun 5/257:20 amDSM - TYS
1 stop9h 01mAmerican Airlines
Deal found 4/16$224
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/46:50 amTYS - OMA
1 stop4h 21mDelta
Tue 6/105:16 amOMA - TYS
1 stop4h 52mDelta
Deal found 4/17$249
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/74:10 pmTYS - OMA
1 stop7h 29mAmerican Airlines
Wed 5/145:00 amOMA - TYS
1 stop5h 41mAmerican Airlines
Deal found 4/17$254
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/14:14 pmTYS - DSM
1 stop8h 25mUnited Airlines
Mon 5/53:20 pmDSM - TYS
1 stop7h 26mUnited Airlines
Deal found 4/16$259
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2711:26 amTYS - DSM
1 stop8h 49mDelta
Mon 6/306:10 amDSM - TYS
1 stop4h 56mDelta
Deal found 4/17$279
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/45:45 amTYS - OMA
2 stops9h 39mUnited Airlines
Tue 6/103:23 pmOMA - TYS
1 stop6h 17mUnited Airlines
Deal found 4/17$359
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/711:43 amTYS - LSE
1 stop5h 22mAmerican Airlines
Sun 5/1111:50 amLSE - TYS
1 stop6h 35mAmerican Airlines
Deal found 4/16$469
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/277:00 amTYS - MLI
1 stop4h 12mUnited Airlines
Sat 5/33:56 pmMLI - TYS
1 stop6h 11mUnited Airlines
Deal found 4/16$474
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/279:05 amTYS - MLI
2 stops9h 53mAmerican Airlines
Sat 5/31:08 pmMLI - TYS
2 stops9h 37mAmerican Airlines
Deal found 4/16$780

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Knoxville to Iowa that are best for you.

Fly from

Knoxville

Fly to

Iowa

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sat 5/24

11:43 am-3:26 pm

1 stop4h 43m

Des Moines

Sun 5/25

7:20 am-5:21 pm

1 stop9h 01m

$224

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 6/4

6:50 am-10:11 am

1 stop4h 21m

Omaha Eppley Airfield

Tue 6/10

5:16 am-11:08 am

1 stop4h 52m

$249

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 5/7

4:10 pm-10:39 pm

1 stop7h 29m

Omaha Eppley Airfield

Wed 5/14

5:00 am-11:41 am

1 stop5h 41m

$254

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Thu 5/1

4:14 pm-11:39 pm

1 stop8h 25m

Des Moines

Mon 5/5

3:20 pm-11:46 pm

1 stop7h 26m

$259

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 6/27

11:26 am-7:15 pm

1 stop8h 49m

Des Moines

Mon 6/30

6:10 am-12:06 pm

1 stop4h 56m

$279

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 6/4

5:45 am-2:24 pm

2 stops9h 39m

Omaha Eppley Airfield

Tue 6/10

3:23 pm-10:40 pm

1 stop6h 17m

$359

KnoxvilleLa Crosse

TYS - LSE

TYSLSE

Knoxville McGhee Tyson

Wed 5/7

11:43 am-4:05 pm

1 stop5h 22m

La Crosse

Sun 5/11

11:50 am-7:25 pm

1 stop6h 35m

$469

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sun 4/27

7:00 am-10:12 am

1 stop4h 12m

Moline Quad-City

Sat 5/3

3:56 pm-11:07 pm

1 stop6h 11m

$474

KnoxvilleMoline

TYS - MLI

TYSMLI

Knoxville McGhee Tyson

Sun 4/27

9:05 am-5:58 pm

2 stops9h 53m

Moline Quad-City

Sat 5/3

1:08 pm-11:45 pm

2 stops9h 37m

$780

KnoxvilleOmaha

TYS - OMA

TYSOMA

Knoxville McGhee Tyson

Wed 5/14

6:50 am-12:40 pm

1 stop6h 50m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 18 results
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Best time to book a flight from Knoxville to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Iowa

What is the cheapest month to book a flight from Knoxville to Iowa?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to IA?

Find hourly flight availability from Knoxville to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from Knoxville to Iowa, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Iowa by month

Plan your trip to Iowa by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Iowa ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Iowa when rainfall is around 1.0 in.

Temperature in Iowa by month

Plan your trip to Iowa by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Iowa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated April 17, 2025.
Read through reviews of airlines operating flights from Knoxville to Iowa, such as Delta, United Airlines and Allegiant Air. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,916 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
8.0
Very good
7,916 reviews
Delta
8.0
Very good
7,916 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
United Airlines
7.4
Good
8,667 reviews
Delta
8.0
Very good
7,916 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Allegiant Air
7.3
Good
734 reviews
Delta
8.0
Very good
7,916 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,916 reviews

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Iowa?

    If you book a flight to Iowa from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the cheapest airlines to fly from Knoxville to Iowa one-way?

    $126 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on Allegiant Air and United Airlines, with prices starting from $157 and $195, respectively.

  • What are the most popular routes from Knoxville to Iowa?

    The most popular route from Knoxville to Iowa is Knoxville McGhee Tyson - Omaha Eppley Airfield. You may also consider Knoxville McGhee Tyson - Des Moines or Knoxville McGhee Tyson - La Crosse.

  • Can I find deals for flights from Knoxville to Iowa that include hotel bookings?

    Yes. In addition to deals on Knoxville to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Iowa.

  • Can I find deals for business class flights from Knoxville to Iowa?

    Yes. Cheapflights offers flight deals from Knoxville to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Iowa?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Iowa (average of $336). Flying from Knoxville to Iowa in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Iowa

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Top 3 airlines flying from Knoxville to Iowa

Discover the top 3 airlines that operate flights from Knoxville to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$208Average$331FlexibilityNo cancel feeOn-time71%
DeltaCheapest$212Average$253FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$393FlexibilityNo cancel feeOn-time69%

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