HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$255+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$271
(Delta)

One-way from

$264
(Delta)

Popular in

November

Cheapest in

August

Average price

$410
Provider with most accurate pricing for Des Moines-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
Search Deals
From Des Moines to Greenville
Search Deals
One-way flight from Des Moines to Greenville
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2025
Search Deals

Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:30 amDSM - GSP
1 stop5h 46mAllegiant Air
Fri 5/233:50 pmGSP - DSM
1 stop25h 44mAllegiant Air
Deal found 4/22$255
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1412:48 pmDSM - GSP
1 stop4h 52mAmerican Airlines
Tue 5/207:00 amGSP - DSM
1 stop6h 18mAmerican Airlines
Deal found 4/23$271
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/83:41 pmDSM - GSP
1 stop7h 14mDelta
Tue 6/105:30 amGSP - DSM
1 stop6h 09mDelta
Deal found 4/23$342
This Mytrip deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:30 amDSM - GSP
1 stop5h 46mMultiple Airlines
Fri 5/236:16 pmGSP - DSM
2 stops25h 50mMultiple Airlines
Deal found 4/22$345
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:35 amDSM - GSP
2 stops10h 38mUnited Airlines
Wed 10/296:46 amGSP - DSM
1 stop4h 34mUnited Airlines
Deal found 4/23$372
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:00 amDSM - GSP
2 stops11h 35mSouthwest
Sat 5/2410:20 amGSP - DSM
2 stops12h 10mSouthwest
Deal found 4/23$489

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 5/16

7:30 am-2:16 pm

1 stop5h 46m

Greenville

Fri 5/23

3:50 pm-4:34 pm

1 stop25h 44m

$255

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 5/14

12:48 pm-6:40 pm

1 stop4h 52m

Greenville

Tue 5/20

7:00 am-12:18 pm

1 stop6h 18m

$271

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 6/8

3:41 pm-11:55 pm

1 stop7h 14m

Greenville

Tue 6/10

5:30 am-10:39 am

1 stop6h 09m

$342

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 5/16

7:30 am-2:16 pm

1 stop5h 46m

Greenville

Fri 5/23

6:16 pm-7:06 pm

2 stops25h 50m

$345

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 5/8

3:34 pm-11:00 pm

1 stop6h 26m

Greenville

Mon 5/12

6:45 am-10:30 am

1 stop4h 45m

$458

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 5/15

6:00 am-6:35 pm

2 stops11h 35m

Greenville

Sat 5/24

10:20 am-9:30 pm

2 stops12h 10m

$489

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/29

10:22 am-5:34 pm

1 stop6h 12m

$264

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/29

11:54 am-9:14 pm

2 stops8h 20m

$269

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/29

3:34 pm-9:55 am

3 stops17h 21m

$559

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Compare providers for flights from Des Moines to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Greenville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Greenville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Greenville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to GSP?

Find hourly flight availability from Des Moines to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

When flying from Des Moines to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight in the morning.

Rainfall in Greenville by month

Plan your trip to Greenville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Greenville ranges from 3.6 - 5.1 inches per month. March is typically the wettest month, when rainfall can reach 5.1 in. November is typically the driest time to visit Greenville when rainfall is around 3.6 in.

Temperature in Greenville by month

Plan your trip to Greenville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Greenville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated April 24, 2025.
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,286 reviews
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,685 reviews
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,286 reviews

Food

7.1

Comfort

8.0

Boarding

8.2

Entertainment

7.6

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $271, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Allegiant Air - these airlines can fly you to your destination from $276 and $299, respectively. These flights start at 34% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Greenville one-way?

    $264 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $269 and $559, respectively.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Simpsonville
Seneca
Duncan
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Charlotte flights
Omaha to Charlotte flights
Cedar Rapids to Charlotte flights
Omaha to Savannah flights
Moline to Charlotte flights
Cedar Rapids to Savannah flights
Cedar Rapids to Charleston flights
Des Moines to Charleston flights
Omaha to Myrtle Beach flights
Omaha to Charleston flights
Cedar Rapids to Myrtle Beach flights
Cedar Rapids to Greenville flights
Des Moines to Myrtle Beach flights
Des Moines to Savannah flights
Moline to Myrtle Beach flights
Omaha to Columbia flights
Cedar Rapids to Columbia flights
Moline to Charleston flights
Des Moines to Hilton Head Island flights
Moline to Savannah flights
Des Moines to Columbia flights
Cedar Rapids to Hilton Head Island flights
Moline to Greenville flights
Omaha to Greenville flights
Moline to Columbia flights
Moline to Augusta flights
La Crosse to Charlotte flights
Waterloo to Charlotte flights
Moline to Hilton Head Island flights
Omaha to Hilton Head Island flights
Sioux City to Columbia flights
Sioux City to Charleston flights
Waterloo to Myrtle Beach flights
La Crosse to Greenville flights
La Crosse to Savannah flights
La Crosse to Charleston flights
Dubuque to Savannah flights
Dubuque to Myrtle Beach flights
Waterloo to Greenville flights
Sioux City to Charlotte flights
Omaha to Florence flights
Moline to Florence flights
Dubuque to Greenville flights
Dubuque to Charlotte flights
Cedar Rapids to Florence flights

Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$424FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$306Average$421FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.