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Florida Keys

$49+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated April 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$97
(Cheapflightsfares)

One-way from

$49
(Flightnetwork)

Popular in

March

Cheapest in

June

Average price

$376
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
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From South Carolina to Florida Keys
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One-way flight from South Carolina to Florida Keys
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Highest demand for flights based on searches. 20% potential increase in price ($81 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/219:32 pmCLT - MIA
Nonstop2h 10mSpirit Airlines
Sat 6/286:00 amMIA - CLT
Nonstop2h 09mSpirit Airlines
Deal found 4/23$97
This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/116:00 amCLT - MIA
Nonstop2h 04mMultiple Airlines
Fri 5/166:00 amMIA - CLT
Nonstop2h 14mMultiple Airlines
Deal found 4/23$99
This Cheapflightsfares deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/119:04 amCLT - MIA
Nonstop2h 07mFrontier
Fri 5/166:00 amMIA - CLT
Nonstop2h 14mFrontier
Deal found 4/23$104
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/165:40 amCAE - MIA
1 stop3h 43mDelta
Fri 8/226:00 amMIA - CAE
1 stop6h 32mDelta
Deal found 4/23$215
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/202:48 pmCHS - EYW
1 stop18h 34mBreeze Airways
Sun 8/241:47 pmEYW - CHS
1 stop20h 43mBreeze Airways
Deal found 4/22$216
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/117:30 amCHS - MIA
Nonstop1h 39mAmerican Airlines
Tue 5/138:09 amMIA - CHS
Nonstop1h 43mAmerican Airlines
Deal found 4/23$217
This Frontier deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/309:05 amCHS - MIA
1 stop11h 26mFrontier
Sun 6/89:42 pmMIA - CHS
1 stop10h 18mFrontier
Deal found 4/22$220
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/175:15 amCHS - MIA
1 stop5h 42mDelta
Tue 6/247:00 amMIA - CHS
1 stop6h 56mDelta
Deal found 4/23$223
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/126:46 amCAE - MIA
Nonstop1h 53mAmerican Airlines
Sat 7/199:54 pmMIA - CAE
Nonstop1h 59mAmerican Airlines
Deal found 4/23$231
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2811:24 amCLT - MIA
1 stop7h 01mDelta
Tue 6/32:26 pmMIA - CLT
1 stop3h 55mDelta
Deal found 4/23$239
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:00 amMYR - MIA
3 stops26h 00mSpirit Airlines
Mon 5/197:00 amMIA - MYR
1 stop9h 44mSpirit Airlines
Deal found 4/23$244
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/72:40 pmCHS - MIA
1 stop6h 15mSouthwest
Sat 5/105:05 amMIA - CHS
1 stop6h 00mSouthwest
Deal found 4/23$246

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from South Carolina to Florida Keys that are best for you.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sat 6/21

9:32 pm-11:42 pm

Nonstop2h 10m

Miami

Sat 6/28

6:00 am-8:09 am

Nonstop2h 09m

$97

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 5/11

6:00 am-8:04 am

Nonstop2h 04m

Miami

Fri 5/16

6:00 am-8:14 am

Nonstop2h 14m

$99

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Sun 5/11

9:04 am-11:11 am

Nonstop2h 07m

Miami

Fri 5/16

6:00 am-8:14 am

Nonstop2h 14m

$104

ColumbiaMiami

CAE - MIA

CAEMIA

Columbia Metropolitan

Sat 8/16

5:40 am-9:23 am

1 stop3h 43m

Miami

Fri 8/22

6:00 am-12:32 pm

1 stop6h 32m

$215

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 8/20

2:48 pm-9:22 am

1 stop18h 34m

Key West

Sun 8/24

1:47 pm-10:30 am

1 stop20h 43m

$216

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Sun 5/11

7:30 am-9:09 am

Nonstop1h 39m

Miami

Tue 5/13

8:09 am-9:52 am

Nonstop1h 43m

$217

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Fri 5/30

9:05 am-8:31 pm

1 stop11h 26m

Miami

Sun 6/8

9:42 pm-8:00 am

1 stop10h 18m

$220

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

Tue 6/17

5:15 am-10:57 am

1 stop5h 42m

Miami

Tue 6/24

7:00 am-1:56 pm

1 stop6h 56m

$223

ColumbiaMiami

CAE - MIA

CAEMIA

Columbia Metropolitan

Sat 7/12

6:46 am-8:39 am

Nonstop1h 53m

Miami

Sat 7/19

9:54 pm-11:53 pm

Nonstop1h 59m

$231

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

Wed 5/28

11:24 am-6:25 pm

1 stop7h 01m

Miami

Tue 6/3

2:26 pm-6:21 pm

1 stop3h 55m

$239

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Florida Keys

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EOA?

Find hourly flight availability from South Carolina to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 24, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Florida Keys as you normally would.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 24, 2025.
Peruse reviews from past customers who have flown with Alaska Airlines, Southwest and Delta from South Carolina to Florida Keys to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,918 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,286 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,920 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,685 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
JetBlue
7.3
Good
2,924 reviews
Alaska Airlines
8.0
Very good
9,918 reviews

Comfort

7.9

Food

7.1

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $49 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $53 and American Airlines from $109 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Florida Keys

Discover the top 2 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$428FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$483FlexibilityNo cancel feeOn-time71%

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