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$38+ Cheap flights from South Carolina to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
feb. 25 — mar. 41
mar. 2/25
mar. 3/4
1 adult, Economy
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Cheap flight deals from South Carolina to Florida Keys

Keep the following information in mind while searching for South Carolina to Florida Keys flight deals. Data was last updated febrero 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$71
(CheapOair)

One-way from

$38
(Frontier)

Popular in

February

Cheapest in

April

Average price

$396
Provider with most accurate pricing for Myrtle Beach Intl-Miami flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Miami flights.
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From South Carolina to Florida Keys
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One-way flight from South Carolina to Florida Keys
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Highest demand for flights based on searches. 17% potential increase in price ($61 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in February 2025
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Find flight deals from South Carolina to Florida Keys

Cheapest flights from South Carolina to Florida Keys
Explore the most affordable flight options available from South Carolina to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on febrero 20, 2025.

This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/2710:20 pmCLT - MIA
Nonstop2h 15mMultiple Airlines
mié. 4/29:55 amMIA - CLT
Nonstop2h 15mMultiple Airlines
Deal found 2/20$71
This FlightHub deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/107:24 pmCLT - MIA
Nonstop2h 06mSpirit Airlines
mar. 3/189:24 amMIA - CLT
Nonstop2h 15mSpirit Airlines
Deal found 2/20$74
This Cheapflightsfares deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/108:53 amCLT - MIA
Nonstop2h 10mFrontier
lun. 4/144:55 pmMIA - CLT
Nonstop2h 18mFrontier
Deal found 2/19$79
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/206:00 amMYR - MIA
1 stop11h 05mSpirit Airlines
mié. 3/2611:32 amMIA - MYR
1 stop10h 24mSpirit Airlines
Deal found 2/20$157
This Priceline deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/210:47 pmMYR - MIA
1 stop10h 58mMultiple Airlines
dom. 5/116:00 amMIA - MYR
1 stop8h 09mMultiple Airlines
Deal found 2/19$178
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/68:19 amCAE - MIA
1 stop5h 31mDelta
mar. 5/137:00 amMIA - CAE
1 stop4h 16mDelta
Deal found 2/19$199
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/105:20 pmCHS - MIA
1 stop27h 40mMultiple Airlines
lun. 4/148:00 amMIA - CHS
1 stop6h 09mMultiple Airlines
Deal found 2/20$205
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/31:03 pmCHS - MIA
1 stop19h 50mSpirit Airlines
mié. 3/59:35 pmMIA - CHS
1 stop16h 29mSpirit Airlines
Deal found 2/20$207
This Mytrip deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/48:05 amSAV - MIA
1 stop26h 08mMultiple Airlines
lun. 4/711:08 amMIA - SAV
2 stops12h 05mMultiple Airlines
Deal found 2/20$209
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/107:50 pmCHS - MIA
Nonstop1h 49mAmerican Airlines
mié. 3/129:57 pmMIA - CHS
Nonstop1h 49mAmerican Airlines
Deal found 2/20$217
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/84:27 pmSAV - MIA
1 stop5h 11mDelta
mar. 4/1512:00 pmMIA - SAV
1 stop7h 06mDelta
Deal found 2/19$217
This Southwest deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/131:55 pmSAV - MIA
1 stop9h 00mSouthwest
mar. 3/183:00 pmMIA - SAV
1 stop5h 50mSouthwest
Deal found 2/19$222

Find flights from South Carolina to Florida Keys within your budget

Customize your flight search to find flights from South Carolina to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 20, 2025.

Fly from

South Carolina

Fly to

Florida Keys

Route

Depart

Return

Price

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

jue. 3/27

10:20 pm-12:35 am

Nonstop2h 15m

Miami

mié. 4/2

9:55 am-12:10 pm

Nonstop2h 15m

$71

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

lun. 3/10

7:24 pm-9:30 pm

Nonstop2h 06m

Miami

mar. 3/18

9:24 am-11:39 am

Nonstop2h 15m

$74

CharlotteMiami

CLT - MIA

CLTMIA

Charlotte Douglas

jue. 4/10

8:53 am-11:03 am

Nonstop2h 10m

Miami

lun. 4/14

4:55 pm-7:13 pm

Nonstop2h 18m

$79

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

jue. 3/20

6:00 am-5:05 pm

1 stop11h 05m

Miami

mié. 3/26

11:32 am-9:56 pm

1 stop10h 24m

$157

Myrtle BeachMiami

MYR - MIA

MYRMIA

Myrtle Beach Intl

vie. 5/2

10:47 pm-9:45 am

1 stop10h 58m

Miami

dom. 5/11

6:00 am-2:09 pm

1 stop8h 09m

$178

ColumbiaMiami

CAE - MIA

CAEMIA

Columbia Metropolitan

mar. 5/6

8:19 am-1:50 pm

1 stop5h 31m

Miami

mar. 5/13

7:00 am-11:16 am

1 stop4h 16m

$199

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

jue. 4/10

5:20 pm-9:00 pm

1 stop27h 40m

Miami

lun. 4/14

8:00 am-2:09 pm

1 stop6h 09m

$205

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

lun. 3/3

1:03 pm-8:53 am

1 stop19h 50m

Miami

mié. 3/5

9:35 pm-2:04 pm

1 stop16h 29m

$207

SavannahMiami

SAV - MIA

SAVMIA

Savannah/Hilton Head

vie. 4/4

8:05 am-10:13 am

1 stop26h 08m

Miami

lun. 4/7

11:08 am-11:13 pm

2 stops12h 05m

$209

CharlestonMiami

CHS - MIA

CHSMIA

Charleston

lun. 3/10

7:50 pm-9:39 pm

Nonstop1h 49m

Miami

mié. 3/12

9:57 pm-11:46 pm

Nonstop1h 49m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/20

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Florida Keys

Get recent, data-driven insights about flights from South Carolina to Florida Keys including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to EOA?

Find hourly flight availability from South Carolina to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated febrero 20, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Florida Keys as you normally would.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated febrero 20, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta and JetBlue from South Carolina to Florida Keys to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Southwest
8.1
Very good
4,411 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Delta
8.0
Very good
8,220 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

JetBlue
7.4
Good
3,070 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

United Airlines
7.4
Good
8,766 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Allegiant Air
7.3
Good
765 reviews
Southwest
8.1
Very good
4,411 reviews

Crew

8.7

Overall

8.1

Boarding

8.2

Comfort

8.1

Entertainment

7.6

Food

7.1

Reviews

1 / 20

2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to Florida Keys one-way?

    One-way options have recently been found by users for as low as $38 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $42 and American Airlines from $99 one-way.

  • Can I find deals for flights from South Carolina to Florida Keys that include hotel bookings?

    Yes. In addition to deals on South Carolina to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Florida Keys.

  • Can I find deals for business class flights from South Carolina to Florida Keys?

    Yes. Cheapflights offers flight deals from South Carolina to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Florida Keys (average of $328). Flying from South Carolina to Florida Keys in March is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from South Carolina to Florida Keys

Discover the top 2 airlines that operate flights from South Carolina to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated febrero 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$198Average$443FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$247Average$502FlexibilityNo cancel feeOn-time71%
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