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$149+ Cheap flights from Panama City, FL (ECP) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/23. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — EYW
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Panama City to Florida Keys

Keep the following information in mind while searching for Panama City to Florida Keys flight deals. Data was last updated April 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$267
(Delta)

One-way from

$149
(Delta)

Popular in

December

Cheapest in

January

Average price

$410
Provider with most accurate pricing for Panama City NW Florida Beaches-Miami flight deals.
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Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Miami flights.
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From Panama City NW Florida Beaches to Florida Keys
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One-way flight from Panama City NW Florida Beaches to Florida Keys
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High demand for flights, 2% potential price rise
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Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Panama City to Florida Keys

Cheapest flights from Panama City to Florida Keys
Explore the most affordable flight options available from Panama City to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:59 pmECP - MIA
1 stop4h 38mDelta
Wed 6/412:05 pmMIA - ECP
1 stop4h 31mDelta
Deal found 4/16$267
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/222:29 pmECP - MIA
1 stop5h 16mAmerican Airlines
Tue 5/276:00 amMIA - ECP
1 stop4h 48mAmerican Airlines
Deal found 4/16$302
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/211:30 amECP - MIA
2 stops9h 05mSouthwest
Wed 6/43:30 pmMIA - ECP
1 stop6h 45mSouthwest
Deal found 4/16$326
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/71:30 pmECP - EYW
1 stop5h 14mDelta
Tue 10/147:00 amEYW - ECP
1 stop6h 40mDelta
Deal found 4/16$347
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/295:30 amECP - EYW
1 stop7h 03mAmerican Airlines
Sun 8/314:00 pmEYW - ECP
2 stops8h 40mAmerican Airlines
Deal found 4/16$559
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/135:01 pmECP - MIA
2 stops20h 55mUnited Airlines
Tue 5/209:00 amMIA - ECP
1 stop10h 26mUnited Airlines
Deal found 4/16$560
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/194:58 pmECP - EYW
2 stops21h 06mUnited Airlines
Mon 4/216:45 pmEYW - ECP
3 stops43h 40mUnited Airlines
Deal found 4/16$1,254

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Panama City to Florida Keys that are best for you.

Fly from

Panama City

Fly to

Florida Keys

Route

Depart

Return

Price

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Fri 5/30

6:59 pm-12:37 am

1 stop4h 38m

Miami

Wed 6/4

12:05 pm-3:36 pm

1 stop4h 31m

$267

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Thu 5/22

2:29 pm-8:45 pm

1 stop5h 16m

Miami

Tue 5/27

6:00 am-9:48 am

1 stop4h 48m

$302

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Mon 6/2

11:30 am-9:35 pm

2 stops9h 05m

Miami

Wed 6/4

3:30 pm-9:15 pm

1 stop6h 45m

$326

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Tue 10/7

1:30 pm-7:44 pm

1 stop5h 14m

Key West

Tue 10/14

7:00 am-12:40 pm

1 stop6h 40m

$347

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 8/29

5:30 am-1:33 pm

1 stop7h 03m

Key West

Sun 8/31

4:00 pm-11:40 pm

2 stops8h 40m

$559

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 5/13

5:01 pm-2:56 pm

2 stops20h 55m

Miami

Tue 5/20

9:00 am-6:26 pm

1 stop10h 26m

$560

Panama CityKey West

ECP - EYW

ECPEYW

Panama City NW Florida Beaches

Fri 5/9

2:15 pm-6:05 pm

2 stops26h 50m

Key West

Sun 5/11

8:45 am-12:25 pm

2 stops52h 40m

$748

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Wed 7/23

9:23 am-3:48 pm

1 stop5h 25m

$149

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Tue 5/13

11:25 am-8:55 pm

2 stops8h 30m

$157

Panama CityMiami

ECP - MIA

ECPMIA

Panama City NW Florida Beaches

Thu 5/8

4:29 pm-10:20 pm

1 stop4h 51m

$170

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Panama City to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Florida Keys

What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $328). Flying from Panama City, Florida to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 17, 2025.
To help decide which airline to fly from Panama City to Florida Keys, see what other customers have to say about Southwest, Delta and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
Delta
8.0
Very good
7,916 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Comfort

8.0

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Anonymous,Feb 2025

MCO - STL

Cancelled at last minute, SWA unable to assist in formulating alternate plans. Wound up renting a car and driving 13 hours to beat bad weather forecast at home. Not SWA’s fault that there was significant bad weather across the country.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Florida Keys?

    If you book a flight to Florida Keys from Panama City, you will be flying from NW Florida Beaches, which is the city’s only airport. Panama City NW Florida Beaches (ECP) is located 16.0 mi from the center of Panama City.

  • What are the cheapest airlines to fly from Panama City, Florida to Florida Keys one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $149. Southwest flights start at $157 while deals on American Airlines start at $170 one-way.

  • Can I find deals for flights from Panama City to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Panama City to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Florida Keys.

  • Can I find deals for business class flights from Panama City to Florida Keys?

    Yes. Cheapflights offers flight deals from Panama City to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Panama City, Florida to Florida Keys (average of $328). Flying from Panama City, Florida to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Panama City to Florida Keys

Discover the top 2 airlines that operate flights from Panama City to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$298Average$523FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$358Average$495FlexibilityNo cancel feeOn-time71%

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