Florida Keys

$61+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Dec 28 — Jan 41
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Cheap flight deals from Missouri to Florida Keys

Discover tips and strategies to find the most affordable flight options for your journey from Missouri (USMO) to Florida Keys (zzEOA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2024.

Round-trip from

$258
(American Airlines)

One-way from

$61
(Mytrip)
From Missouri to Florida Keys
One-way flight from Missouri to Florida Keys

Find flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2024.

This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/236:00 amSTL - EYW
1 stop5h 07mDelta
Mon 12/306:02 pmEYW - STL
1 stop6h 38mDelta
Deal found 12/22$378
This American Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/245:16 amSGF - MIA
1 stop6h 05mAmerican Airlines
Tue 12/3111:21 amMIA - SGF
1 stop5h 39mAmerican Airlines
Deal found 12/23$378
This FlightHub deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/306:49 pmSTL - MIA
1 stop9h 11mFrontier
Sun 1/126:00 amMIA - STL
1 stop28h 06mFrontier
Deal found 12/22$380
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/239:30 amSTL - EYW
2 stops8h 59mAmerican Airlines
Mon 12/303:57 pmEYW - STL
1 stop7h 51mAmerican Airlines
Deal found 12/22$383
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/315:53 pmMCI - MIA
Nonstop3h 08mAmerican Airlines
Sun 1/59:43 pmMIA - MCI
Nonstop3h 35mAmerican Airlines
Deal found 12/22$401
This United Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/248:25 amMCI - MIA
1 stop8h 28mUnited Airlines
Tue 12/316:05 amMIA - MCI
1 stop6h 45mUnited Airlines
Deal found 12/23$418
This eDestinos deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/302:38 pmMCI - MIA
1 stop13h 22mFrontier
Sun 1/56:00 amMIA - MCI
1 stop14h 38mFrontier
Deal found 12/22$523
This United Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2411:25 amSGF - MIA
2 stops11h 34mUnited Airlines
Tue 12/317:00 amMIA - SGF
1 stop8h 37mUnited Airlines
Deal found 12/23$524
This Southwest deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/241:25 pmMCI - MIA
2 stops7h 35mSouthwest
Tue 12/3112:00 pmMIA - MCI
2 stops10h 25mSouthwest
Deal found 12/22$534
This Delta deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/254:50 pmMCI - MIA
1 stop6h 31mDelta
Mon 12/306:25 amMIA - MCI
1 stop9h 41mDelta
Deal found 12/23$537
This Mytrip deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/312:20 pmMCI - MIA
1 stop16h 09mSpirit Airlines
Sun 1/56:10 pmMIA - MCI
2 stops24h 55mSpirit Airlines
Deal found 12/23$582
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/296:00 amSTL - MIA
Nonstop3h 01mAmerican Airlines
Tue 12/319:40 pmMIA - STL
Nonstop3h 11mAmerican Airlines
Deal found 12/22$606

Find flights from Missouri to Florida Keys within your budget

Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2024.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 1/24

6:00 am-2:04 pm

1 stop7h 04m

Key West

Thu 1/30

4:00 pm-10:28 pm

1 stop7h 28m

$258

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Tue 1/14

6:00 am-1:46 pm

1 stop6h 46m

Miami

Tue 1/21

6:00 am-11:34 am

1 stop6h 34m

$258

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Tue 1/21

6:30 am-3:47 pm

1 stop8h 17m

Miami

Tue 1/28

1:30 pm-10:14 pm

2 stops9h 44m

$263

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 4/1

2:27 pm-8:30 pm

1 stop5h 03m

Key West

Wed 4/9

6:13 pm-11:57 pm

1 stop6h 44m

$268

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 4/1

7:00 am-6:49 pm

2 stops10h 49m

Key West

Tue 4/8

8:00 am-2:59 pm

1 stop7h 59m

$273

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 1/8

2:00 pm-8:11 pm

1 stop5h 11m

Key West

Wed 1/29

7:00 am-11:47 am

1 stop5h 47m

$273

SpringfieldKey West

SGF - EYW

SGFEYW

Springfield-Branson

Thu 1/9

11:40 am-7:07 pm

1 stop6h 27m

Key West

Wed 1/15

2:44 pm-8:21 pm

1 stop6h 37m

$273

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 1/25

5:05 pm-2:20 pm

1 stop20h 15m

Key West

Sat 2/1

3:05 pm-11:31 pm

1 stop9h 26m

$274

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Fri 1/31

6:22 am-1:12 pm

1 stop5h 50m

Miami

Wed 2/5

7:00 am-12:56 pm

1 stop6h 56m

$288

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Thu 1/9

7:27 pm-12:22 am

1 stop27h 55m

Miami

Wed 1/15

1:55 pm-6:32 pm

1 stop29h 37m

$290

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 52 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Missouri to Florida Keys

Get recent, data-driven insights about flights from Missouri to Florida Keys including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EOA?

Find hourly flight availability from Missouri to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2024.

When flying from Missouri to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated December 23, 2024.
See what other customers who have flown with Frontier, American Airlines and Alaska Airlines from Missouri to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

8.1
Very good
4,780 reviews
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

8.0
Very good
9,549 reviews
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

8.0
Very good
8,588 reviews
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

7.4
Good
9,022 reviews
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

7.2
Good
10,000 reviews
8.1
Very good
4,780 reviews

Food

7.2

Crew

8.7

Overall

8.1

Comfort

8.1

Boarding

8.2

Entertainment

7.7

Reviews

1 / 10

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What are the cheapest airlines to fly from Missouri to Florida Keys one-way?

    One-way options have recently been found by users for as low as $61 on Frontier. Other airlines that offer cheap prices include Delta from $103 and Spirit Airlines from $112 one-way.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2024.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$478FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$224Average$430FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$287Average$554FlexibilityNo cancel feeOn-time69%
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