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Florida Keys

$88+ Cheap flights from Missouri to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheap flight deals from Missouri to Florida Keys

Keep the following information in mind while searching for Missouri to Florida Keys flight deals. Data was last updated April 17, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$209
(American Airlines)

One-way from

$88
(Cheapflightsfares)

Popular in

March

Cheapest in

September

Average price

$381
Provider with most accurate pricing for Kansas City-Miami flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Miami flights.
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From Missouri to Florida Keys
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One-way flight from Missouri to Florida Keys
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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Missouri to Florida Keys

Cheapest flights from Missouri to Florida Keys
Explore the most affordable flight options available from Missouri to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/165:00 amSGF - MIA
1 stop8h 09mAmerican Airlines
Sat 9/208:30 amMIA - SGF
1 stop6h 06mAmerican Airlines
Deal found 4/17$209
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/17:00 amMCI - EYW
1 stop8h 07mAmerican Airlines
Wed 7/21:24 pmEYW - MCI
2 stops10h 49mAmerican Airlines
Deal found 4/17$214
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/133:48 pmMCI - MIA
1 stop7h 49mDelta
Tue 5/208:09 amMIA - MCI
1 stop5h 01mDelta
Deal found 4/16$219
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/65:15 amMCI - MIA
Nonstop3h 05mAmerican Airlines
Tue 5/138:15 pmMIA - MCI
Nonstop3h 23mAmerican Airlines
Deal found 4/16$226
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/137:05 amSTL - MIA
1 stop5h 10mDelta
Wed 5/2810:37 amMIA - STL
1 stop6h 58mDelta
Deal found 4/17$240
This CheapOair deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/166:53 pmSTL - MIA
1 stop9h 29mFrontier
Sun 5/186:00 amMIA - STL
1 stop28h 09mFrontier
Deal found 4/17$241
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/115:13 amSTL - MIA
Nonstop2h 46mAmerican Airlines
Wed 5/143:30 pmMIA - STL
Nonstop2h 59mAmerican Airlines
Deal found 4/17$243
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:30 pmSGF - MIA
1 stop6h 14mDelta
Sat 11/88:05 amMIA - SGF
1 stop7h 45mDelta
Deal found 4/17$243
This Booking.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/98:51 pmMCI - MIA
1 stop7h 31mFrontier
Mon 5/126:00 amMIA - MCI
1 stop14h 51mFrontier
Deal found 4/17$250
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/146:00 amSTL - EYW
1 stop6h 39mAmerican Airlines
Wed 5/215:24 pmEYW - STL
1 stop5h 02mAmerican Airlines
Deal found 4/16$251
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2511:51 amSTL - EYW
1 stop6h 53mDelta
Tue 12/22:35 pmEYW - STL
1 stop4h 27mDelta
Deal found 4/16$259
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/208:40 amSGF - MIA
1 stop6h 11mUnited Airlines
Wed 7/234:53 pmMIA - SGF
1 stop6h 00mUnited Airlines
Deal found 4/17$267

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Missouri to Florida Keys that are best for you.

Fly from

Missouri

Fly to

Florida Keys

Route

Depart

Return

Price

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Tue 9/16

5:00 am-2:09 pm

1 stop8h 09m

Miami

Sat 9/20

8:30 am-1:36 pm

1 stop6h 06m

$209

Kansas CityKey West

MCI - EYW

MCIEYW

Kansas City

Tue 7/1

7:00 am-4:07 pm

1 stop8h 07m

Key West

Wed 7/2

1:24 pm-11:50 pm

2 stops11h 26m

$214

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Tue 5/13

3:48 pm-12:37 am

1 stop7h 49m

Miami

Tue 5/20

8:09 am-12:10 pm

1 stop5h 01m

$219

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Tue 5/6

5:15 am-9:20 am

Nonstop3h 05m

Miami

Tue 5/13

8:15 pm-10:38 pm

Nonstop3h 23m

$226

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Tue 5/13

7:05 am-1:15 pm

1 stop5h 10m

Miami

Wed 5/28

10:37 am-4:35 pm

1 stop6h 58m

$240

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Fri 5/16

6:53 pm-5:22 am

1 stop9h 29m

Miami

Sun 5/18

6:00 am-9:09 am

1 stop28h 09m

$241

St. LouisMiami

STL - MIA

STLMIA

Lambert-St Louis

Wed 5/14

10:36 am-6:41 pm

1 stop7h 05m

Miami

Tue 5/20

3:30 pm-5:29 pm

Nonstop2h 59m

$243

Kansas CityMiami

MCI - MIA

MCIMIA

Kansas City

Fri 5/9

8:51 pm-5:22 am

1 stop7h 31m

Miami

Sun 5/11

6:00 am-7:51 pm

1 stop14h 51m

$250

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 9/30

5:29 am-1:34 pm

1 stop7h 05m

Key West

Sat 10/4

7:31 pm-11:01 pm

1 stop4h 30m

$251

SpringfieldMiami

SGF - MIA

SGFMIA

Springfield-Branson

Sun 7/20

8:40 am-3:51 pm

1 stop6h 11m

Miami

Wed 7/23

4:53 pm-9:53 pm

1 stop6h 00m

$267

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 51 results
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Best time to book a flight from Missouri to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florida Keys

What is the cheapest month to book a flight from Missouri to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to EOA?

Find hourly flight availability from Missouri to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

When flying from Missouri to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 17, 2025.
See what other customers who have flown with Alaska Airlines, Southwest and Delta from Missouri to Florida Keys have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Alaska Airlines
8.0
Very good
9,882 reviews
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Southwest
8.0
Very good
4,280 reviews
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Delta
8.0
Very good
7,917 reviews
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
United Airlines
7.4
Good
8,667 reviews
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,882 reviews

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
4.0
Okay

Anonymous,Apr 2025

LAS - STS

flight was delayed both ways even tho the weather was clear >

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to Florida Keys one-way?

    One-way options have recently been found by users for as low as $88 on Frontier. Other airlines that offer cheap prices include American Airlines from $90 and Delta from $100 one-way.

  • Can I find deals for flights from Missouri to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Missouri to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florida Keys.

  • Can I find deals for business class flights from Missouri to Florida Keys?

    Yes. Cheapflights offers flight deals from Missouri to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Florida Keys (average of $328). Flying from Missouri to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Florida Keys

Discover the top 3 airlines that operate flights from Missouri to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$403FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$213Average$428FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$497FlexibilityNo cancel feeOn-time69%

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