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$116+ Cheap flights from Knoxville (TYS) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — EYW
Apr 9 — Apr 161
Wed 4/9
Wed 4/16
1 adult, Economy
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Cheap flight deals from Knoxville to Florida Keys

Keep the following information in mind while searching for Knoxville to Florida Keys flight deals. Data was last updated April 4, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$218
(Mytrip)

One-way from

$116
(Frontier)

Popular in

March

Cheapest in

August

Average price

$376
Provider with most accurate pricing for Knoxville McGhee Tyson-Miami flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Miami flights.
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From Knoxville McGhee Tyson to Florida Keys
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One-way flight from Knoxville McGhee Tyson to Florida Keys
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Highest demand for flights based on searches. 4% potential increase in price ($19 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Florida Keys

Cheapest flights from Knoxville to Florida Keys
Explore the most affordable flight options available from Knoxville to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2025.

This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/254:54 pmTYS - EYW
1 stop22h 02mAllegiant Air
Wed 4/304:23 pmEYW - TYS
1 stop17h 46mAllegiant Air
Deal found 4/3$218
This Mytrip deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1812:46 pmTYS - MIA
1 stop16h 35mFrontier
Sun 4/206:30 amMIA - TYS
1 stop9h 16mFrontier
Deal found 4/3$230
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:30 amTYS - EYW
1 stop5h 26mDelta
Wed 8/272:35 pmEYW - TYS
1 stop3h 42mDelta
Deal found 4/4$249
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/17:15 amTYS - MIA
1 stop14h 41mMultiple Airlines
Sat 5/39:20 pmMIA - TYS
1 stop15h 33mMultiple Airlines
Deal found 4/4$259
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/256:04 amTYS - MIA
Nonstop2h 10mAmerican Airlines
Sat 6/2810:11 pmMIA - TYS
Nonstop2h 13mAmerican Airlines
Deal found 4/2$263
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/227:03 amTYS - EYW
1 stop6h 30mAmerican Airlines
Wed 8/274:00 pmEYW - TYS
2 stops5h 35mAmerican Airlines
Deal found 4/3$299
This Trip.com deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1011:00 amTYS - EYW
1 stop7h 05mMultiple Airlines
Sun 5/188:45 amEYW - TYS
1 stop11h 24mMultiple Airlines
Deal found 4/4$306
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/35:00 pmTYS - MIA
1 stop6h 37mDelta
Thu 5/85:35 amMIA - TYS
1 stop4h 05mDelta
Deal found 4/3$333
This United Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/189:00 amTYS - EYW
2 stops33h 05mUnited Airlines
Tue 4/228:45 amEYW - TYS
2 stops28h 37mUnited Airlines
Deal found 4/3$454
This United Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/207:00 amTYS - MIA
2 stops10h 10mUnited Airlines
Sat 8/236:35 amMIA - TYS
2 stops10h 16mUnited Airlines
Deal found 4/2$467

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Knoxville

Fly to

Florida Keys

Route

Depart

Return

Price

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 4/25

4:54 pm-2:56 pm

1 stop22h 02m

Key West

Wed 4/30

4:23 pm-10:09 am

1 stop17h 46m

$218

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 4/18

12:46 pm-5:21 am

1 stop16h 35m

Miami

Sun 4/20

6:30 am-3:46 pm

1 stop9h 16m

$230

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 5/1

7:15 am-9:56 pm

1 stop14h 41m

Miami

Sat 5/3

9:20 pm-12:53 pm

1 stop15h 33m

$259

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Wed 6/25

6:04 am-8:14 am

Nonstop2h 10m

Miami

Sat 6/28

10:11 pm-12:24 am

Nonstop2h 13m

$263

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sat 5/10

11:00 am-6:05 pm

1 stop7h 05m

Key West

Sun 5/18

8:45 am-8:09 pm

1 stop11h 24m

$306

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 4/11

11:02 am-4:40 pm

1 stop5h 38m

Key West

Mon 4/14

7:29 pm-11:29 pm

1 stop4h 00m

$309

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sat 5/3

5:00 pm-11:37 pm

1 stop6h 37m

Miami

Thu 5/8

5:35 am-9:40 am

1 stop4h 05m

$333

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Sun 6/1

4:22 pm-8:07 pm

1 stop3h 45m

Key West

Tue 7/1

6:29 pm-11:54 pm

1 stop5h 25m

$409

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 4/18

9:00 am-6:05 pm

2 stops33h 05m

Key West

Tue 4/22

8:45 am-1:22 pm

2 stops28h 37m

$454

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Fri 5/2

7:05 am-3:54 pm

1 stop8h 49m

Miami

Fri 5/9

1:05 pm-8:06 pm

1 stop7h 01m

$475

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/3

Showing 1-10 of 21 results
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Best time to book a flight from Knoxville to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Florida Keys

What is the cheapest month to book a flight from Knoxville to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to EOA?

Find hourly flight availability from Knoxville to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Florida Keys as you normally would.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 4, 2025.
Read through reviews of airlines operating flights from Knoxville to Florida Keys, such as Alaska Airlines, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Alaska Airlines
8.0
Very good
9,837 reviews
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Delta
8.0
Very good
7,899 reviews
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
United Airlines
7.4
Good
8,618 reviews
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
Allegiant Air
7.3
Good
732 reviews
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them
American Airlines
7.2
Good
10,000 reviews
Alaska Airlines
8.0
Very good
9,837 reviews

Entertainment

7.1

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Food

7.1

Reviews

1 / 20
10.0
Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Florida Keys?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Florida Keys. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • What are the cheapest airlines to fly from Knoxville to Florida Keys one-way?

    $116 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $126 and $142, respectively.

  • Can I find deals for flights from Knoxville to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Knoxville to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Florida Keys.

  • Can I find deals for business class flights from Knoxville to Florida Keys?

    Yes. Cheapflights offers flight deals from Knoxville to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Florida Keys (average of $328). Flying from Knoxville to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Florida Keys

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Top 3 airlines flying from Knoxville to Florida Keys

Discover the top 3 airlines that operate flights from Knoxville to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$78Average$142FlexibilityNo cancel feeOn-time88%
DeltaCheapest$208Average$476FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$441FlexibilityNo cancel feeOn-time71%

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