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Florida Keys

$110+ Cheap flights from Iowa to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Iowa to Florida Keys

Keep the following information in mind while searching for Iowa to Florida Keys flight deals. Data was last updated April 29, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$228
(Frontier)

One-way from

$110
(United Airlines)

Popular in

March

Cheapest in

September

Average price

$411
Provider with most accurate pricing for Des Moines-Miami flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Miami flights.
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From Iowa to Florida Keys
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One-way flight from Iowa to Florida Keys
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Highest demand for flights based on searches. 4% potential increase in price ($21 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Iowa to Florida Keys

Cheapest flights from Iowa to Florida Keys
Explore the most affordable flight options available from Iowa to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:20 pmDSM - MIA
1 stop9h 02mFrontier
Wed 5/216:00 amMIA - DSM
1 stop13h 30mFrontier
Deal found 4/28$228
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/37:01 amDSM - MIA
1 stop5h 42mDelta
Tue 6/1012:46 pmMIA - DSM
1 stop8h 51mDelta
Deal found 4/28$237
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/285:00 amMLI - EYW
1 stop6h 10mAmerican Airlines
Wed 6/42:20 pmEYW - MLI
1 stop8h 04mAmerican Airlines
Deal found 4/28$239
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/177:11 amCID - EYW
1 stop6h 53mAmerican Airlines
Tue 9/233:01 pmEYW - CID
1 stop7h 21mAmerican Airlines
Deal found 4/27$251
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/151:45 pmOMA - MIA
1 stop8h 34mAmerican Airlines
Sat 7/196:22 amMIA - OMA
1 stop5h 31mAmerican Airlines
Deal found 4/28$257
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/87:07 amDSM - MIA
1 stop8h 29mAmerican Airlines
Thu 7/1712:04 pmMIA - DSM
1 stop8h 19mAmerican Airlines
Deal found 4/28$257
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/71:15 pmDSM - MIA
1 stop21h 18mMultiple Airlines
Sun 6/152:35 pmMIA - DSM
1 stop23h 11mMultiple Airlines
Deal found 4/28$265
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:05 amOMA - EYW
1 stop7h 39mDelta
Wed 11/126:00 pmEYW - OMA
1 stop6h 56mDelta
Deal found 4/28$269
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:45 amDSM - EYW
1 stop6h 24mDelta
Wed 7/96:27 pmEYW - DSM
1 stop5h 31mDelta
Deal found 4/27$269
This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/199:02 pmOMA - MIA
1 stop7h 20mFrontier
Sun 5/256:00 amMIA - OMA
1 stop14h 06mFrontier
Deal found 4/28$271
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:00 amOMA - EYW
2 stops9h 48mAmerican Airlines
Sat 9/135:22 pmEYW - OMA
1 stop5h 34mAmerican Airlines
Deal found 4/27$274
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:47 amDSM - EYW
2 stops8h 24mAmerican Airlines
Sat 12/135:40 pmEYW - DSM
1 stop7h 06mAmerican Airlines
Deal found 4/27$274

Cheapflights Fare Finder

Customize your flight search to find flights from Iowa to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Iowa to Florida Keys that are best for you.

Fly from

Iowa

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/16

7:20 pm-5:22 am

1 stop9h 02m

Miami

Wed 5/21

6:00 am-6:30 pm

1 stop13h 30m

$228

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 6/3

7:01 am-1:43 pm

1 stop5h 42m

Miami

Tue 6/10

12:46 pm-8:37 pm

1 stop8h 51m

$237

MolineKey West

MLI - EYW

MLIEYW

Moline Quad-City

Wed 5/28

5:00 am-12:10 pm

1 stop6h 10m

Key West

Wed 6/4

2:20 pm-9:24 pm

1 stop8h 04m

$239

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Tue 7/22

6:00 am-1:08 pm

1 stop6h 08m

Key West

Tue 7/29

6:27 pm-10:44 pm

1 stop5h 17m

$251

OmahaMiami

OMA - MIA

OMAMIA

Omaha Eppley Airfield

Tue 7/15

1:45 pm-11:19 pm

1 stop8h 34m

Miami

Sat 7/19

6:22 am-10:53 am

1 stop5h 31m

$257

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 7/8

7:07 am-4:36 pm

1 stop8h 29m

Miami

Thu 7/17

12:04 pm-7:23 pm

1 stop8h 19m

$257

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 6/7

1:15 pm-11:33 am

1 stop21h 18m

Miami

Sun 6/15

2:35 pm-12:46 pm

1 stop23h 11m

$265

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

5:45 am-1:09 pm

1 stop6h 24m

Key West

Wed 7/9

6:27 pm-10:58 pm

1 stop5h 31m

$269

OmahaMiami

OMA - MIA

OMAMIA

Omaha Eppley Airfield

Mon 5/19

9:02 pm-5:22 am

1 stop7h 20m

Miami

Sun 5/25

6:00 am-7:06 pm

1 stop14h 06m

$271

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 7/11

6:30 am-7:21 pm

2 stops11h 51m

Key West

Tue 7/15

12:47 pm-8:32 pm

2 stops8h 45m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 53 results
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Best time to book a flight from Iowa to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florida Keys

What is the cheapest month to book a flight from Iowa to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Iowa to Florida Keys (average of $328). Flying from Iowa to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to EOA?

Find hourly flight availability from Iowa to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

When flying from Iowa to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 29, 2025.
See what other customers who have flown with Alaska Airlines, Southwest and Delta from Iowa to Florida Keys have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,949 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,292 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,929 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,949 reviews

Entertainment

7.1

Comfort

7.9

Boarding

8.2

Food

7.1

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Iowa to Florida Keys one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $110. However, be on the lookout for offers from Frontier and Delta, as they are both options that can get you from Iowa to Florida Keys for a low price.

  • Can I find deals for flights from Iowa to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Iowa to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florida Keys.

  • Can I find deals for business class flights from Iowa to Florida Keys?

    Yes. Cheapflights offers flight deals from Iowa to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Iowa to Florida Keys (average of $328). Flying from Iowa to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Iowa to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Florida Keys

Discover the top 3 airlines that operate flights from Iowa to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$241Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$453FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$543FlexibilityNo cancel feeOn-time69%

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