What are the cheapest airlines to fly from Iowa to Florida Keys one-way?

The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $110. However, be on the lookout for offers from United Airlines and Frontier, as they are both options that can get you from Iowa to Florida Keys for a low price.

How far in advance should I book a flight from Iowa to Florida Keys?

To save on the cost of your flight from Iowa to Florida Keys, book at least 15 days before your planned departure. Booking around this time can save you about 35% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $364 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $453.

What is the cheapest month to fly from Iowa to Florida Keys?

Flights from Iowa to Florida Keys lean towards being more expensive in December. Prices are generally better when you fly from Iowa to Florida Keys in September, with the cheapest ticket starting at $280.

Can I find deals for flights from Iowa to Florida Keys that include hotel bookings?

Yes. In addition to deals on Iowa to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Iowa to Florida Keys?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florida Keys.

Can I find deals for business class flights from Iowa to Florida Keys?

Yes. Cheapflights offers flight deals from Iowa to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$110+ Flights from Iowa to Florida Keys

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Cheap flight deals from Iowa to Florida Keys

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$214 (American Airlines)
One-way from	$110 (Southwest)
Popular in	December
Cheapest in	September
Average price	$403

Provider with most accurate pricing for Des Moines-Miami flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Miami flights.

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From Iowa to Florida Keys

Search Deals

One-way flight from Iowa to Florida Keys

Search Deals

Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

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Find flight deals from Iowa to Florida Keys

Cheapest flights from Iowa to Florida Keys
Explore the most affordable flight options available from Iowa to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

Sun 5/257:20 amDSM - EYW

2 stops8h 32mAmerican Airlines

Fri 5/3012:49 pmEYW - DSM

1 stop5h 54mAmerican Airlines

Deal found 3/31

$214

Wed 5/711:17 amOMA - EYW

1 stop7h 50mDelta

Tue 5/136:25 pmEYW - OMA

1 stop6h 33mDelta

Deal found 4/1

$217

Wed 5/76:35 amOMA - EYW

2 stops9h 17mAmerican Airlines

Tue 5/1311:28 amEYW - OMA

2 stops10h 23mAmerican Airlines

Deal found 4/1

$219

Tue 4/295:45 amDSM - MIA

1 stop7h 05mDelta

Tue 5/67:00 amMIA - DSM

1 stop8h 11mDelta

Deal found 3/31

$238

Fri 8/227:21 amCID - EYW

1 stop6h 59mAmerican Airlines

Tue 8/263:03 pmEYW - CID

1 stop7h 27mAmerican Airlines

Deal found 3/31

$239

Mon 4/218:17 pmDSM - MIA

1 stop7h 37mFrontier

Wed 4/306:00 amMIA - DSM

1 stop13h 37mFrontier

Deal found 4/1

$248

Wed 4/92:15 pmOMA - MIA

1 stop5h 50mSouthwest

Sat 4/125:05 amMIA - OMA

1 stop5h 30mSouthwest

Deal found 4/1

$259

Thu 5/297:54 pmDSM - EYW

1 stop12h 39mAllegiant Air

Sun 6/18:53 amEYW - DSM

1 stop24h 30mAllegiant Air

Deal found 4/1

$260

Tue 6/106:00 amDSM - MIA

2 stops8h 44mUnited Airlines

Wed 6/253:28 pmMIA - DSM

1 stop9h 26mUnited Airlines

Deal found 4/1

$262

Fri 5/168:16 pmCID - MIA

1 stop8h 06mFrontier

Sun 5/256:00 amMIA - CID

1 stop14h 13mFrontier

Deal found 4/1

$268

Thu 6/268:08 pmCID - EYW

1 stop12h 25mAllegiant Air

Mon 6/305:28 pmEYW - CID

1 stop24h 38mAllegiant Air

Deal found 3/31

$271

Wed 5/711:17 amOMA - MIA

1 stop6h 08mDelta

Sat 5/175:35 amMIA - OMA

1 stop5h 39mDelta

Deal found 4/1

$277

Best flights from Iowa to Florida Keys
Discover carefully curated flight deals from Iowa to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 2, 2025.

Sun 5/257:20 amDSM - EYW

2 stops8h 32mAmerican Airlines

Fri 5/3012:49 pmEYW - DSM

1 stop5h 54mAmerican Airlines

Deal found 3/31

$214

Wed 5/711:17 amOMA - EYW

1 stop7h 50mDelta

Tue 5/136:25 pmEYW - OMA

1 stop6h 33mDelta

Deal found 3/31

$217

Sun 4/201:27 pmDSM - MIA

1 stop19h 33mMultiple Airlines

Thu 4/241:53 pmMIA - DSM

2 stops34h 20mMultiple Airlines

Deal found 3/31

$247

Mon 4/218:17 pmDSM - MIA

1 stop7h 37mFrontier

Wed 4/306:00 amMIA - DSM

1 stop13h 37mFrontier

Deal found 4/1

$248

Sat 4/125:48 pmCID - EYW

1 stop13h 25mAllegiant Air

Thu 4/179:03 amEYW - CID

1 stop10h 51mAllegiant Air

Deal found 4/2

$257

Sat 4/264:30 pmOMA - MIA

1 stop4h 50mSouthwest

Wed 4/308:30 amMIA - OMA

1 stop9h 50mSouthwest

Deal found 4/1

$259

Wed 5/143:20 pmDSM - MIA

1 stop6h 09mUnited Airlines

Wed 5/211:29 pmMIA - DSM

2 stops11h 10mUnited Airlines

Deal found 3/31

$262

Wed 5/75:00 amOMA - EYW

2 stops10h 52mAmerican Airlines

Tue 5/1311:28 amEYW - OMA

2 stops8h 28mAmerican Airlines

Deal found 4/1

$219

Wed 5/141:07 pmDSM - MIA

1 stop8h 48mDelta

Wed 5/215:35 amMIA - DSM

1 stop6h 06mDelta

Deal found 3/31

$237

Thu 5/297:54 pmDSM - EYW

1 stop12h 39mAllegiant Air

Sun 6/18:53 amEYW - DSM

1 stop24h 30mAllegiant Air

Deal found 4/1

$260

Fri 5/168:16 pmCID - MIA

1 stop8h 06mFrontier

Thu 5/296:00 amMIA - CID

1 stop14h 13mFrontier

Deal found 3/30

$268

Mon 4/283:05 pmOMA - MIA

1 stop6h 32mUnited Airlines

Thu 5/81:29 pmMIA - OMA

2 stops10h 46mUnited Airlines

Deal found 4/1

$295

Last-minute flights from Iowa to Florida Keys
Discover last-minute flight deals from Iowa to Florida Keys. Data last updated April 2, 2025 and is based on user searches.

Mon 4/74:01 pmOMA - MIA

1 stop11h 53mFrontier

Fri 4/116:25 amMIA - OMA

1 stop9h 29mFrontier

Deal found 4/1

$308

Mon 4/75:45 amDSM - MIA

1 stop5h 10mSouthwest

Wed 4/97:55 amMIA - DSM

1 stop4h 40mSouthwest

Deal found 4/1

$442

Mon 4/71:31 pmDSM - MIA

2 stops19h 42mMultiple Airlines

Wed 4/97:22 amMIA - DSM

2 stops32h 32mMultiple Airlines

Deal found 4/1

$448

Tue 4/87:00 amCID - EYW

1 stop8h 16mAmerican Airlines

Tue 4/153:06 pmEYW - CID

1 stop7h 53mAmerican Airlines

Deal found 4/1

$335

Tue 4/85:50 amMLI - MIA

1 stop5h 35mDelta

Tue 4/86:10 pmMIA - MLI

1 stop5h 18mDelta

Deal found 3/31

$351

Tue 4/84:26 pmMLI - MIA

1 stop6h 59mAmerican Airlines

Sat 4/125:10 pmMIA - MLI

1 stop6h 05mAmerican Airlines

Deal found 3/31

$431

Wed 4/92:15 pmOMA - MIA

1 stop5h 50mSouthwest

Sat 4/125:05 amMIA - OMA

1 stop5h 30mSouthwest

Deal found 4/1

$259

Wed 4/96:00 amOMA - MIA

2 stops8h 50mUnited Airlines

Sat 4/127:54 amMIA - OMA

2 stops10h 43mUnited Airlines

Deal found 4/1

$391

Thu 4/108:26 pmCID - MIA

1 stop7h 29mFrontier

Sun 4/136:30 amMIA - CID

1 stop14h 06mFrontier

Deal found 4/1

$328

Thu 4/1011:26 amCID - MIA

1 stop5h 02mAmerican Airlines

Sat 4/1211:30 amMIA - CID

2 stops7h 43mAmerican Airlines

Deal found 4/1

$463

Fri 4/118:17 pmDSM - MIA

1 stop8h 04mFrontier

Mon 4/216:21 amMIA - DSM

1 stop13h 58mFrontier

Deal found 4/1

$298

Sat 4/125:48 pmCID - EYW

1 stop13h 25mAllegiant Air

Thu 4/179:03 amEYW - CID

1 stop10h 51mAllegiant Air

Deal found 4/2

$257

One-way flights from Iowa to Florida Keys
Search for one-way flight options from Iowa to Florida Keys. Find affordable one-way fares based on user searches. Data last updated April 2, 2025.

Wed 6/254:20 pmOMA - MIA

1 stop5h 00mSouthwest

Deal found 4/1

$110

Sat 5/38:00 amOMA - MIA

2 stops12h 51mUnited Airlines

Deal found 4/1

$115

Mon 5/199:02 pmOMA - MIA

1 stop7h 20mFrontier

Deal found 4/1

$119

Fri 5/98:16 pmCID - MIA

1 stop8h 06mFrontier

Deal found 4/1

$120

Fri 5/167:20 pmDSM - MIA

1 stop9h 02mFrontier

Deal found 4/1

$120

Mon 5/511:38 amOMA - MIA

2 stops24h 55mMultiple Airlines

Deal found 4/1

$153

Wed 5/285:27 pmDSM - MIA

1 stop6h 11mAmerican Airlines

Deal found 4/1

$160

Wed 5/287:11 amDSM - MIA

1 stop8h 29mDelta

Deal found 4/1

$170

Wed 4/1611:14 amOMA - EYW

1 stop5h 03mDelta

Deal found 4/1

$176

Wed 4/235:05 pmMLI - MIA

1 stop6h 43mDelta

Deal found 3/31

$176

Wed 5/286:40 amDSM - MIA

2 stops13h 15mSouthwest

Deal found 4/1

$185

Sat 4/56:53 pmCID - EYW

1 stop12h 10mAllegiant Air

Deal found 3/30

$191

Cheapflights Fare Finder

Use the filters below to find and compare flights from Iowa to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sun 5/25

7:20 am-4:52 pm

2 stops8h 32m

Key West

Fri 5/30

12:49 pm-5:43 pm

1 stop5h 54m

$214

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 5/7

11:17 am-8:07 pm

1 stop7h 50m

Key West

Tue 5/13

6:25 pm-11:58 pm

1 stop6h 33m

$217

OmahaKey West

OMA - EYW

OMAEYW

Omaha Eppley Airfield

Wed 5/7

6:35 am-4:52 pm

2 stops9h 17m

Key West

Tue 5/13

11:28 am-8:51 pm

2 stops10h 23m

$219

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 4/29

5:45 am-1:50 pm

1 stop7h 05m

Miami

Tue 5/6

7:00 am-2:11 pm

1 stop8h 11m

$238

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 4/21

8:17 pm-4:54 am

1 stop7h 37m

Miami

Wed 4/30

6:00 am-6:37 pm

1 stop13h 37m

$248

OmahaMiami

OMA - MIA

OMAMIA

Omaha Eppley Airfield

Sat 4/26

4:30 pm-10:20 pm

1 stop4h 50m

Miami

Wed 4/30

8:30 am-5:20 pm

1 stop9h 50m

$259

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 5/29

7:54 pm-9:33 am

1 stop12h 39m

Key West

Sun 6/1

8:53 am-8:23 am

1 stop24h 30m

$260

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 6/10

6:00 am-3:44 pm

2 stops8h 44m

Miami

Wed 6/25

3:28 pm-11:54 pm

1 stop9h 26m

$262

Cedar RapidsMiami

CID - MIA

CIDMIA

Cedar Rapids

Fri 5/16

8:16 pm-5:22 am

1 stop8h 06m

Miami

Sun 5/25

6:00 am-7:13 pm

1 stop14h 13m

$268

Cedar RapidsKey West

CID - EYW

CIDEYW

Cedar Rapids

Thu 6/26

8:08 pm-9:33 am

1 stop12h 25m

Key West

Mon 6/30

5:28 pm-5:06 pm

1 stop24h 38m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Showing 1-10 of 59 results

...

Best time to book a flight from Iowa to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Iowa with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florida Keys

What is the cheapest month to book a flight from Iowa to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Iowa to Florida Keys (average of $328). Flying from Iowa to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to EOA?

When flying from Iowa to Florida Keys, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Florida Keys by month

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

See what other customers who have flown with Alaska Airlines, Southwest and Delta from Iowa to Florida Keys have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Alaska Airlines

8.0

Very good

9,820 reviews

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Southwest

8.0

Very good

4,272 reviews

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Delta

8.0

Very good

7,898 reviews

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

United Airlines

7.4

Good

8,616 reviews

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Allegiant Air

7.3

Good

731 reviews

Alaska Airlines

8.0

Very good

9,820 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

What are the cheapest airlines to fly from Iowa to Florida Keys one-way?
The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $110. However, be on the lookout for offers from United Airlines and Frontier, as they are both options that can get you from Iowa to Florida Keys for a low price.
Can I find deals for flights from Iowa to Florida Keys that include hotel bookings?
Yes. In addition to deals on Iowa to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Iowa to Florida Keys?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Florida Keys.
Can I find deals for business class flights from Iowa to Florida Keys?
Yes. Cheapflights offers flight deals from Iowa to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Iowa to Florida Keys?
Currently, August is the cheapest month in which you can book a flight from Iowa to Florida Keys (average of $328). Flying from Iowa to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Iowa to Florida Keys

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$96	Average$254	FlexibilityNo cancel fee	On-time88%
American Airlines	Cheapest$238	Average$409	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$268	Average$444	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$281	Average$554	FlexibilityNo cancel fee	On-time69%

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$110+ Cheap flights from Iowa to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Iowa to Florida Keys with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Iowa to Florida Keys

Keep the following information in mind while searching for Iowa to Florida Keys flight deals. Data was last updated April 2, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Iowa to Florida Keys

Cheapest flights from Iowa to Florida KeysExplore the most affordable flight options available from Iowa to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

Explore the most affordable flight options available from Iowa to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Iowa to Florida Keys that are best for you.

Best time to book a flight from Iowa to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Iowa with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Florida Keys

What is the cheapest month to book a flight from Iowa to Florida Keys?

What is the cheapest time of day to fly from IA to EOA?

Find hourly flight availability from Iowa to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 2, 2025.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

Reviews of airlines servicing Florida Keys

See what other customers who have flown with Alaska Airlines, Southwest and Delta from Iowa to Florida Keys have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines to fly from Iowa to Florida Keys one-way?

Can I find deals for flights from Iowa to Florida Keys that include hotel bookings?

How can I find direct flights from Iowa to Florida Keys?

Can I find deals for business class flights from Iowa to Florida Keys?

What is the cheapest month to book a flight from Iowa to Florida Keys?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Iowa to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Iowa to Florida Keys

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Cheapest flights from Iowa to Florida Keys
Explore the most affordable flight options available from Iowa to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 2, 2025.