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$109+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Apr 29 — May 61
Tue 4/29
Tue 5/6
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated April 24, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$208
(Frontier)

One-way from

$109
(Frontier)

Popular in

March

Cheapest in

September

Average price

$411
Provider with most accurate pricing for Des Moines-Miami flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Miami flights.
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From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2025.

This Frontier deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/167:20 pmDSM - MIA
1 stop9h 02mFrontier
Wed 5/216:00 amMIA - DSM
1 stop13h 30mFrontier
Deal found 4/23$208
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/211:07 pmDSM - MIA
1 stop8h 48mDelta
Wed 5/282:48 pmMIA - DSM
1 stop7h 18mDelta
Deal found 4/23$228
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/17:05 amDSM - EYW
1 stop8h 06mAmerican Airlines
Wed 7/94:46 pmEYW - DSM
1 stop7h 15mAmerican Airlines
Deal found 4/23$239
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1812:32 pmDSM - MIA
2 stops30h 40mMultiple Airlines
Thu 5/2212:28 pmMIA - DSM
1 stop11h 59mMultiple Airlines
Deal found 4/23$240
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/36:07 amDSM - MIA
1 stop8h 37mUnited Airlines
Tue 6/101:21 pmMIA - DSM
2 stops9h 01mUnited Airlines
Deal found 4/23$262
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:17 pmDSM - MIA
1 stop5h 11mAmerican Airlines
Sat 8/97:45 pmMIA - DSM
Nonstop3h 31mAmerican Airlines
Deal found 4/23$327
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/15:45 amDSM - EYW
1 stop6h 24mDelta
Wed 7/96:00 pmEYW - DSM
1 stop5h 22mDelta
Deal found 4/23$349
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/215:40 amDSM - MIA
2 stops10h 45mSouthwest
Wed 5/287:55 amMIA - DSM
1 stop4h 40mSouthwest
Deal found 4/23$357
This Trip.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/168:30 amDSM - EYW
1 stop8h 35mMultiple Airlines
Mon 5/198:45 amEYW - DSM
1 stop8h 08mMultiple Airlines
Deal found 4/23$398
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/16:24 amDSM - EYW
3 stops24h 36mUnited Airlines
Wed 7/92:45 pmEYW - DSM
2 stops24h 56mUnited Airlines
Deal found 4/23$530

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/16

7:20 pm-5:22 am

1 stop9h 02m

Miami

Wed 5/21

6:00 am-6:30 pm

1 stop13h 30m

$208

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 5/21

1:07 pm-10:55 pm

1 stop8h 48m

Miami

Wed 5/28

2:48 pm-9:06 pm

1 stop7h 18m

$228

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

7:05 am-4:11 pm

1 stop8h 06m

Key West

Wed 7/9

4:46 pm-11:01 pm

1 stop7h 15m

$239

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 5/18

12:32 pm-8:12 pm

2 stops30h 40m

Miami

Thu 5/22

12:28 pm-11:27 pm

1 stop11h 59m

$240

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 6/3

6:07 am-3:44 pm

1 stop8h 37m

Miami

Tue 6/10

1:21 pm-9:22 pm

2 stops9h 01m

$262

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 8/5

5:17 pm-11:28 pm

1 stop5h 11m

Miami

Sat 8/9

7:45 pm-10:16 pm

Nonstop3h 31m

$327

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

5:45 am-1:09 pm

1 stop6h 24m

Key West

Wed 7/9

6:00 pm-10:22 pm

1 stop5h 22m

$349

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 5/21

5:40 am-5:25 pm

2 stops10h 45m

Miami

Wed 5/28

7:55 am-11:35 am

1 stop4h 40m

$357

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 5/16

8:30 am-6:05 pm

1 stop8h 35m

Key West

Mon 5/19

8:45 am-3:53 pm

1 stop8h 08m

$398

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 7/1

6:24 am-8:00 am

3 stops24h 36m

Key West

Wed 7/9

2:45 pm-2:41 pm

2 stops24h 56m

$530

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/23

Showing 1-10 of 16 results
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated April 24, 2025.
Read through reviews of airlines operating flights from Des Moines to Florida Keys, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,286 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,920 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,685 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Frontier
6.0
Okay
3,283 reviews
Southwest
8.0
Very good
4,286 reviews

Crew

8.6

Boarding

8.2

Entertainment

7.6

Overall

8.0

Comfort

8.0

Food

7.1

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $109 on Frontier. Other airlines that offer cheap prices include Delta from $150 and Southwest from $159 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Des Moines to Florida Keys

Discover the top 3 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$255Average$406FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$509FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$508FlexibilityNo cancel feeOn-time69%

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