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$75+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Feb 4 — Feb 111
Tue 2/4
Tue 2/11
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Florida Keys (zzEOA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 30, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$245
(Mytrip)

One-way from

$75
(Frontier)

Popular in

March

Cheapest in

September

Average price

$417
Provider with most accurate pricing for Des Moines-Miami flight deals.
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From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in January 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2025.

This Frontier deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/218:41 pmDSM - MIA
1 stop7h 35mFrontier
Fri 2/286:25 amMIA - DSM
1 stop14h 16mFrontier
Deal found 1/30$250
This Delta deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/101:31 pmDSM - MIA
1 stop8h 20mDelta
Thu 5/156:00 amMIA - DSM
1 stop5h 16mDelta
Deal found 1/29$257
This United Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:00 amDSM - EYW
1 stop6h 06mUnited Airlines
Fri 11/214:05 pmEYW - DSM
1 stop6h 31mUnited Airlines
Deal found 1/30$269
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/13:04 pmDSM - MIA
1 stop12h 56mMultiple Airlines
Mon 3/36:15 amMIA - DSM
2 stops18h 10mMultiple Airlines
Deal found 1/29$270
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/272:06 pmDSM - MIA
1 stop5h 47mAmerican Airlines
Thu 3/67:40 pmMIA - DSM
Nonstop3h 51mAmerican Airlines
Deal found 1/30$272
This United deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/268:00 amDSM - MIA
2 stops11h 26mUnited Airlines
Tue 3/44:07 pmMIA - DSM
1 stop6h 16mUnited Airlines
Deal found 1/29$276
This Southwest deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/38:30 amDSM - MIA
2 stops12h 45mSouthwest
Wed 5/77:55 amMIA - DSM
1 stop4h 40mSouthwest
Deal found 1/30$287
This American Airlines deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/287:25 amDSM - EYW
2 stops10h 31mAmerican Airlines
Tue 3/48:02 amEYW - DSM
1 stop6h 26mAmerican Airlines
Deal found 1/30$299
This Delta deal was found by Cheapflights users on 1/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1510:15 amDSM - EYW
2 stops8h 31mDelta
Fri 11/217:00 amEYW - DSM
1 stop7h 23mDelta
Deal found 1/30$354
This Mytrip deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/123:40 pmDSM - EYW
2 stops24h 00mMultiple Airlines
Fri 2/285:09 pmEYW - DSM
1 stop5h 57mMultiple Airlines
Deal found 1/29$429

Find flights from Des Moines to Florida Keys within your budget

Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 3/29

8:00 am-2:25 pm

1 stop5h 25m

Key West

Sat 4/5

3:04 pm-9:51 pm

1 stop7h 47m

$245

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 3/24

5:45 am-1:45 pm

1 stop7h 00m

Miami

Sat 3/29

6:00 am-10:40 am

1 stop5h 40m

$257

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 4/1

6:50 am-3:25 pm

1 stop7h 35m

Key West

Tue 4/8

8:00 am-1:13 pm

1 stop6h 13m

$269

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 4/14

8:17 pm-5:21 am

1 stop8h 04m

Miami

Fri 4/18

6:25 am-7:17 pm

1 stop13h 52m

$270

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Thu 2/27

2:06 pm-8:53 pm

1 stop5h 47m

Miami

Thu 3/6

7:40 pm-10:31 pm

Nonstop3h 51m

$272

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 2/26

11:29 am-6:35 pm

1 stop6h 06m

Miami

Tue 3/4

6:15 am-5:31 pm

2 stops12h 16m

$276

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 5/3

8:30 am-10:15 pm

2 stops12h 45m

Miami

Wed 5/7

7:55 am-11:35 am

1 stop4h 40m

$287

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 3/3

1:32 pm-6:15 pm

3 stops27h 43m

Miami

Fri 3/7

9:28 am-11:15 pm

2 stops14h 47m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 4/25

2:14 pm-8:29 pm

1 stop5h 15m

Key West

Mon 4/28

7:00 am-1:26 pm

1 stop7h 26m

$384

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 2/12

3:40 pm-4:40 pm

2 stops24h 00m

Key West

Fri 2/28

5:09 pm-10:06 pm

1 stop5h 57m

$429

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Showing 1-10 of 20 results
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from Des Moines to Florida Keys

Get recent, data-driven insights about flights from Des Moines to Florida Keys including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $526). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to EOA?

Find hourly flight availability from Des Moines to Florida Keys. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Florida Keys as you normally would.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated January 30, 2025.
Read through reviews of airlines operating flights from Des Moines to Florida Keys, such as Southwest, Alaska Airlines and Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Southwest
8.1
Very good
4,585 reviews
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Alaska Airlines
8.0
Very good
9,686 reviews
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Delta
8.0
Very good
8,450 reviews
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

United Airlines
7.4
Good
8,906 reviews
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Allegiant Air
7.3
Good
790 reviews
Southwest
8.1
Very good
4,585 reviews

Entertainment

7.7

Overall

8.1

Crew

8.7

Boarding

8.2

Food

7.1

Comfort

8.1

Reviews

1 / 20

6.0
Good

Lauren,Dec 2024

MCI - DCA

We BARELY made the connection and when we got onboard we were treated like disobedient children who should have arrived earlier because we had to ask other passengers to move so we could sit with our kids. The flight attendants on the first flight were nice but the second one, they were snippy and fairly rude.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $75 on Frontier. Other airlines that offer cheap prices include Southwest from $110 and American Airlines from $119 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $526). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Florida Keys

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Top 3 airlines flying from Des Moines to Florida Keys

Discover the top 3 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$247Average$382FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$510FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$290Average$508FlexibilityNo cancel feeOn-time69%
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