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$119+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
4月 6 — 4月 131
週日 4/6
週日 4/13
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated 4月 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$214
(American Airlines)

One-way from

$119
(Frontier)

Popular in

December

Cheapest in

September

Average price

$403
Provider with most accurate pricing for Des Moines-Miami flight deals.
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From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on 4月 1, 2025.

This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週日 5/257:20 amDSM - EYW
2 stops8h 32mAmerican Airlines
週五 5/3012:49 pmEYW - DSM
1 stop5h 54mAmerican Airlines
Deal found 3/31$214
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週三 5/141:07 pmDSM - MIA
1 stop8h 48mDelta
週三 5/215:35 amMIA - DSM
1 stop6h 06mDelta
Deal found 3/31$237
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週日 4/201:27 pmDSM - MIA
1 stop19h 33mMultiple Airlines
週四 4/241:53 pmMIA - DSM
2 stops34h 20mMultiple Airlines
Deal found 3/31$247
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週三 5/143:20 pmDSM - MIA
1 stop6h 09mUnited Airlines
週三 5/211:29 pmMIA - DSM
2 stops11h 10mUnited Airlines
Deal found 3/31$262
This Frontier deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週一 4/287:27 pmDSM - MIA
1 stop8h 54mFrontier
週一 5/56:00 amMIA - DSM
1 stop13h 30mFrontier
Deal found 3/31$268
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週一 4/146:30 amDSM - EYW
2 stops30h 14mAllegiant Air
週五 4/185:10 pmEYW - DSM
1 stop6h 11mAllegiant Air
Deal found 3/31$298
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週四 11/136:54 amDSM - MIA
Nonstop3h 26mAmerican Airlines
週二 11/189:00 pmMIA - DSM
Nonstop3h 45mAmerican Airlines
Deal found 3/31$315
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週四 9/411:04 amDSM - EYW
1 stop7h 42mDelta
週四 9/117:00 amEYW - DSM
1 stop7h 28mDelta
Deal found 3/31$339
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週二 10/144:45 pmDSM - MIA
1 stop4h 30mSouthwest
週五 10/1711:50 amMIA - DSM
2 stops12h 35mSouthwest
Deal found 3/31$346
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週二 4/158:00 amDSM - EYW
1 stop6h 04mUnited Airlines
週五 4/188:45 amEYW - DSM
2 stops30h 46mUnited Airlines
Deal found 3/31$470
This Mytrip deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
週日 5/182:36 pmDSM - EYW
3 stops25h 05mMultiple Airlines
週六 5/243:52 pmEYW - DSM
2 stops32h 35mMultiple Airlines
Deal found 3/31$536

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated 4月 1, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

週日 5/25

7:20 am-4:52 pm

2 stops8h 32m

Key West

週五 5/30

12:49 pm-5:43 pm

1 stop5h 54m

$214

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週三 5/14

1:07 pm-10:55 pm

1 stop8h 48m

Miami

週三 5/21

5:35 am-10:41 am

1 stop6h 06m

$237

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週日 4/20

1:27 pm-10:00 am

1 stop19h 33m

Miami

週四 4/24

1:53 pm-11:13 pm

2 stops34h 20m

$247

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週三 5/14

3:20 pm-10:29 pm

1 stop6h 09m

Miami

週三 5/21

1:29 pm-11:39 pm

2 stops11h 10m

$262

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週一 4/28

7:27 pm-5:21 am

1 stop8h 54m

Miami

週一 5/5

6:00 am-6:30 pm

1 stop13h 30m

$268

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

週一 4/14

6:30 am-1:44 pm

2 stops30h 14m

Key West

週五 4/18

5:10 pm-10:21 pm

1 stop6h 11m

$298

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

週四 9/4

11:04 am-7:46 pm

1 stop7h 42m

Key West

週四 9/11

7:00 am-1:28 pm

1 stop7h 28m

$339

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週六 7/12

6:45 am-11:09 am

Nonstop3h 24m

Miami

週一 7/21

11:55 am-4:16 pm

1 stop5h 21m

$356

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

週六 5/10

8:30 am-2:05 pm

1 stop4h 35m

Miami

週日 5/18

5:15 am-4:00 pm

2 stops11h 45m

$371

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

週二 4/15

8:00 am-3:04 pm

1 stop6h 04m

Key West

週五 4/18

8:45 am-2:31 pm

2 stops30h 46m

$470

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/30

Showing 1-10 of 19 results
1
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.

Temperature in Florida Keys by month

Plan your trip to Florida Keys by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated 4月 1, 2025.
Read through reviews of airlines operating flights from Des Moines to Florida Keys, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,277 reviews
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,898 reviews
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,615 reviews
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Allegiant Air
7.3
Good
731 reviews
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,277 reviews

Comfort

8.0

Boarding

8.2

Crew

8.7

Entertainment

7.6

Food

7.1

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $119 on Frontier. Other airlines that offer cheap prices include American Airlines from $160 and United Airlines from $165 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Florida Keys

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Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated 4月 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$96Average$254FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$249Average$397FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$501FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$508FlexibilityNo cancel feeOn-time69%
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