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$149+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Apr 2 — Apr 91
Wed 4/2
Wed 4/9
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Durham are usually found in May or August, booked 84 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated March 28, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$257
(Mytrip)

One-way from

$149
(Delta)

Popular in

December

Cheapest in

May

Average price

$363
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
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From Des Moines to Durham
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One-way flight from Des Moines to Durham
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Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in March 2025
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Find flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2025.

This Mytrip deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/118:17 pmDSM - RDU
1 stop19h 07mFrontier
Sun 4/137:42 pmRDU - DSM
1 stop24h 37mFrontier
Deal found 3/26$257
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/108:00 amDSM - RDU
1 stop6h 54mUnited Airlines
Sat 5/176:30 amRDU - DSM
1 stop5h 04mUnited Airlines
Deal found 3/26$297
This Mytrip deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/81:27 pmDSM - RDU
2 stops24h 31mMultiple Airlines
Sun 5/117:55 pmRDU - DSM
2 stops28h 18mMultiple Airlines
Deal found 3/25$311
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/255:30 pmDSM - RDU
1 stop3h 55mSouthwest
Mon 4/287:35 pmRDU - DSM
1 stop4h 30mSouthwest
Deal found 3/26$317
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/232:01 pmDSM - RDU
1 stop4h 36mAmerican Airlines
Wed 6/49:15 amRDU - DSM
1 stop5h 33mAmerican Airlines
Deal found 3/27$332
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/184:45 pmDSM - RDU
1 stop5h 38mDelta
Fri 5/25:26 pmRDU - DSM
1 stop4h 19mDelta
Deal found 3/26$337

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Des Moines

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 4/11

8:17 pm-4:24 pm

1 stop19h 07m

Raleigh-Durham

Sun 4/13

7:42 pm-7:19 pm

1 stop24h 37m

$257

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 5/10

8:00 am-3:54 pm

1 stop6h 54m

Raleigh-Durham

Sat 5/17

6:30 am-10:34 am

1 stop5h 04m

$297

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 5/8

1:27 pm-2:58 pm

2 stops24h 31m

Raleigh-Durham

Sun 5/11

7:55 pm-11:13 pm

2 stops28h 18m

$311

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 4/25

5:30 pm-10:25 pm

1 stop3h 55m

Raleigh-Durham

Mon 4/28

7:35 pm-11:05 pm

1 stop4h 30m

$317

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 5/23

2:01 pm-7:37 pm

1 stop4h 36m

Raleigh-Durham

Wed 6/4

9:15 am-1:48 pm

1 stop5h 33m

$332

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 4/18

4:45 pm-11:23 pm

1 stop5h 38m

Raleigh-Durham

Fri 5/2

5:26 pm-8:45 pm

1 stop4h 19m

$337

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 4/26

10:20 am-4:41 pm

1 stop5h 21m

$149

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 4/26

5:43 am-1:54 pm

2 stops7h 11m

$154

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 5/8

1:27 pm-2:58 pm

2 stops24h 31m

$170

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 4/17

6:00 am-12:05 pm

2 stops5h 05m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/26

Showing 1-10 of 11 results
1
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Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

How far ahead should I book a flight from Des Moines to Durham?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Durham. Price data was last updated on March 21, 2025.

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Durham. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $206). Flying from Des Moines to Durham in March is currently the most expensive (average of $300). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to DU8?

Find hourly flight availability from Des Moines to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Durham as you normally would.

Rainfall in Durham by month

Plan your trip to Durham by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Durham ranges from 2.9 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. April is typically the driest time to visit Durham when rainfall is around 2.9 in.

Temperature in Durham by month

Plan your trip to Durham by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Durham, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated March 28, 2025.
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.1
Very good
4,274 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,897 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,603 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Frontier
6.0
Okay
3,271 reviews
Southwest
8.1
Very good
4,274 reviews

Boarding

8.2

Entertainment

7.6

Crew

8.7

Food

7.1

Comfort

8.1

Overall

8.1

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • What are the cheapest airlines to fly from Des Moines to Durham one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $149. Users have also found prices from $154 and $229 on American Airlines and Southwest, respectively.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $206). Flying from Des Moines to Durham in March is currently the most expensive (average of $300). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$233Average$329FlexibilityNo cancel feeOn-time71%
DeltaCheapest$245Average$341FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$268Average$399FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$312Average$431FlexibilityNo cancel feeOn-time63%
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