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$109+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Apr 22 — Apr 291
Tue 4/22
Tue 4/29
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Durham are usually found in August or May, booked 84 days in advance, depart on a Wednesday or Tuesday and return on a Friday

Cheap flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated April 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$109
(Mytrip)

Popular in

December

Cheapest in

August

Average price

$361
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
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From Des Moines to Durham
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One-way flight from Des Moines to Durham
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Highest demand for flights based on searches. 8% potential increase in price ($34 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 17, 2025.

This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/136:45 amDSM - RDU
1 stop4h 57mAmerican Airlines
Tue 5/205:02 amRDU - DSM
1 stop8h 19mAmerican Airlines
Deal found 4/17$271
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:15 pmDSM - RDU
2 stops25h 57mMultiple Airlines
Sun 6/83:55 pmRDU - DSM
1 stop23h 50mMultiple Airlines
Deal found 4/17$281
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/258:00 amDSM - RDU
1 stop5h 10mUnited Airlines
Tue 7/19:23 amRDU - DSM
1 stop6h 18mUnited Airlines
Deal found 4/17$284
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:30 pmDSM - RDU
1 stop3h 45mSouthwest
Wed 6/187:35 amRDU - DSM
1 stop4h 25mSouthwest
Deal found 4/17$300
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/246:10 amDSM - RDU
1 stop4h 54mDelta
Mon 6/308:15 amRDU - DSM
1 stop7h 45mDelta
Deal found 4/17$332

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Des Moines

Fly to

Durham

Route

Depart

Return

Price

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 5/13

6:45 am-12:42 pm

1 stop4h 57m

Raleigh-Durham

Tue 5/20

5:02 am-12:21 pm

1 stop8h 19m

$271

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sun 6/1

7:15 pm-10:12 pm

2 stops25h 57m

Raleigh-Durham

Sun 6/8

3:55 pm-2:45 pm

1 stop23h 50m

$281

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Wed 6/25

8:00 am-2:10 pm

1 stop5h 10m

Raleigh-Durham

Tue 7/1

9:23 am-2:41 pm

1 stop6h 18m

$284

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 6/12

6:30 pm-11:15 pm

1 stop3h 45m

Raleigh-Durham

Wed 6/18

7:35 am-11:00 am

1 stop4h 25m

$300

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 6/24

6:10 am-12:04 pm

1 stop4h 54m

Raleigh-Durham

Mon 6/30

8:15 am-3:00 pm

1 stop7h 45m

$332

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Mon 6/16

8:35 am-5:41 pm

1 stop8h 06m

$109

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Wed 5/21

7:30 pm-4:32 pm

1 stop20h 02m

$116

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 5/10

7:01 am-2:13 pm

1 stop6h 12m

$136

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 5/10

5:45 am-5:41 pm

2 stops10h 56m

$141

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 7/1

6:25 am-4:00 pm

2 stops8h 35m

$181

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

How far ahead should I book a flight from Des Moines to Durham?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Durham. Price data was last updated on April 11, 2025.

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from Des Moines to Durham. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $206). Flying from Des Moines to Durham in March is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to DU8?

Find hourly flight availability from Des Moines to Durham. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Durham as you normally would.

Rainfall in Durham by month

Plan your trip to Durham by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Durham ranges from 2.9 - 4.7 inches per month. July is typically the wettest month, when rainfall can reach 4.7 in. April is typically the driest time to visit Durham when rainfall is around 2.9 in.

Temperature in Durham by month

Plan your trip to Durham by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Durham, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated April 17, 2025.
Read reviews from past customers who have flown Southwest, Delta and United Airlines from Des Moines to Durham. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Southwest
8.0
Very good
4,280 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Delta
8.0
Very good
7,917 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
United Airlines
7.4
Good
8,667 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.
Frontier
6.0
Okay
3,281 reviews
Southwest
8.0
Very good
4,280 reviews

Boarding

8.2

Crew

8.6

Food

7.1

Entertainment

7.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Ila,Mar 2025

HOU - DAL

Our original flight was delayed. We were able to change our flight and got home at close to the same time. Looking forward to when you have assigned seating.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • What are the cheapest airlines to fly from Des Moines to Durham one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $116. Users have also found prices from $136 and $141 on Delta and United Airlines, respectively.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $206). Flying from Des Moines to Durham in March is currently the most expensive (average of $295). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$233Average$325FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$347FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$268Average$405FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$312Average$431FlexibilityNo cancel feeOn-time63%

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